Update by Xavier Louis, CEO of Peak

SharpBrains
SharpBrainsMarket/ Innovation Analyst on Digital Brain Health. Young Global Leader @ World Economic Forum
May 2019
The problem
will be affected by mental disorders at some point in their lives but there are still no
straightforward tools to manage efficiently mental health conditions*. The cost of brain disorders
is estimated at €70B per month in Europe Alone**.
*World Health Organisation - Oct 18 **Q1 19, “cost counter”, braincouncil.eu
1/4
people
Cognitive activity
Quality of sleep
Social interactions
Foresight Mental Capital and Wellbeing Project (2008)
Mental fitness is in our hands
Anxiety / Stress
Drugs / alcohol
Sedentary lifestyle
Lack of cognitive challenge
Meditation
Physical exercise
Nutrition
We bring to market engaging, self-serve and evidence-based digital products focusing
on the prevention, detection & treatment of certain mental health conditions.
Peak - Self-serve Digital Therapeutics (DTx)
Peak applied to join the Digital Therapeutics Alliance in Feb 2019
Alzheimer’s /
Dementia
DepressionAttention Insomnia
- Training app to keep your brain active ; 50 games (7
categories) built with neuroscientists
- Launched in Sep-14, available in 14 languages
- 50m+ DLs to date, 2.5m MAUs, 500k subs
($4.99/Month)
- Best Self-improvement app 2014-2015-2016 (Apple &
Google)
- 6+ peer-reviewed studies about efficacy*
*4 published + 2 under review
Our successful digital health apps portfolio to date
- Digital health app to help you sleep better
- Improve Sleep habits in less than 2-weeks with 4
unique techniques from 3 renowned sleep experts
(120+ audio guides)
- Build a daily ritual (sleep guides / journal / stats) for a
personalised experience
- Subscription-based ($9.99/Month)
- Live since March, 15th 2019 (World Sleep Day); over
100k users to date
- Plan to become the No 1 Sleep app by 2020
Our successful digital health apps portfolio to date
University Study Description Status Sample size More details of the study
University of
Cambridge
Use of the Wizard
memory game among
patients with
schizophrenia
2015 - paper
published
22 Schizophrenia
patients
RCT (effect of training).
8 hours of training over a period of one month.
Université libre de
Bruxelles
Correlation between 7 of
Peak games and
standard cognitive
assessment tools
2018 - paper
published
78 participants Correlation study.
22 young adults, 27 healthy old adults, 29 cognitively
impaired older adults.
City University of
New York
Impact of Peak games on
participants with mild
depressive symptoms
2019 - paper
published
46 participants RCT between two categories of Peak games. Young
adults with at least mild depressive symptoms .
Participants were instructed to play 5 days per week
for 8 weeks (not all completed the requested period)
University of
Cambridge
Impact of “Decoder” -
attention game on
attention/concentration in
healthy adults
2019 - paper
published
75 healthy young
adult
RCT - 3 groups: Training (8 h of playing Decoder over
4 weeks; n = 25), Active Control (8 h of playing Bingo
over 4 weeks; n = 25) or Passive Control
(continuation of activities of daily living; n = 25)
Published studies using Peak
University Study Description Status Sample Size More details of the study
University
College London
Impact of “Smile on Me” - emotion game on
mood
Finalising manuscript 22,933 users completed
study
RCT between 4 conditions: Active Smile on me, Sham Smile
on meI, Active Handling emotion game, Sham handling
emotion game. 153,385 users started the study however a
group of 22,933 who completed the minimum elements
needed for the study were included. Two weeks of daily
training.
UKD Effects of Peak games on cognitive abilities
of patients with brain injury after stroke
Final data analysis
stage
82 Stroke patients. RCT - 3 groups: Training, Training with supervision, control.
Participants were instructed to play 30 min a day for 2 weeks.
Université libre de
Bruxelles
Further study on Peak as a cognitive
assessment tool, considering the relationship
between Peak game scores and age
Data analysis stage Data from 9000 Peak
users in different age
groups
Retrospective observational study done based on data of 9K
users in different age groups
New York
University
Decision-making study utilising “Connect ‘Em
Up” - decision making game
Data collection stage
King’s College
London
Peak as a pre-employment assessment Final analysis stage 40 participants. Correlation study
Munich University Assess the use of Peak as a cognitive
assessment tool for use in Multiple Sclerosis
Data collection stage
UPM How mindfulness affect attention among kids Final data analysis
(MA thesis, potential
future publication)
63 participants 30 kids in the reliability study, 33 in the main study included 2
groups.
On-going studies using Peak
Game-based,
engaging
Consumer focus
/ OTC
Curated content and
clinical assessments
Prescription
- based
Our positioning in the
DTx landscape
Peak DTx Roadmap
Alzheimer
Sleep
CE/FDA-approved tool for early detection &
tracking of cognitive decline
CE/FDA-approved tool to improve mood and assist with
symptoms of depression (comorbidity from chronic illnesses)
Upcoming (2019) Medium / long term (2020-2021)
Depression
CE/FDA-approved tool to prevent or treat sleep
disorders
CE/FDA-approved tool to prevent and delay / treat cognitive
decline
CE/FDA-approved tool to prevent or treat attention
disordersAttention
Multiple
Sclerosis
CE/FDA-approved tool for cognitive
rehabilitation of patients with Multiple Sclerosis
The team
2018 Top 50 Smart
Healthcare Company
Xavier Louis
CEO
Sylvain Piquet
COO
Liron Jacobson, PhD
Head of Science
Barbara Sahakian,
FMedSci DSc
Scientific Advisor
Professor of Clinical Neuropsychology - University
of Cambridge
Co-invented CANTAB tests
2016 winner
Best EdTech / The Europas
And 45 talented individuals.
Investors looking to find out more about our new projects
Researchers interested to use Peak for Research projects
Corporate Partners considering to use Peak or Rise for their staff’ well-being or
productivity
All partners who want to work with Peak
Xavier Louis
CEO, Peak
xavier@peak.net
Contact us
THANK YOU
xavier@peak.net
CEO, Peak
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Update by Xavier Louis, CEO of Peak

  • 2. The problem will be affected by mental disorders at some point in their lives but there are still no straightforward tools to manage efficiently mental health conditions*. The cost of brain disorders is estimated at €70B per month in Europe Alone**. *World Health Organisation - Oct 18 **Q1 19, “cost counter”, braincouncil.eu 1/4 people
  • 3. Cognitive activity Quality of sleep Social interactions Foresight Mental Capital and Wellbeing Project (2008) Mental fitness is in our hands Anxiety / Stress Drugs / alcohol Sedentary lifestyle Lack of cognitive challenge Meditation Physical exercise Nutrition
  • 4. We bring to market engaging, self-serve and evidence-based digital products focusing on the prevention, detection & treatment of certain mental health conditions. Peak - Self-serve Digital Therapeutics (DTx) Peak applied to join the Digital Therapeutics Alliance in Feb 2019 Alzheimer’s / Dementia DepressionAttention Insomnia
  • 5. - Training app to keep your brain active ; 50 games (7 categories) built with neuroscientists - Launched in Sep-14, available in 14 languages - 50m+ DLs to date, 2.5m MAUs, 500k subs ($4.99/Month) - Best Self-improvement app 2014-2015-2016 (Apple & Google) - 6+ peer-reviewed studies about efficacy* *4 published + 2 under review Our successful digital health apps portfolio to date
  • 6. - Digital health app to help you sleep better - Improve Sleep habits in less than 2-weeks with 4 unique techniques from 3 renowned sleep experts (120+ audio guides) - Build a daily ritual (sleep guides / journal / stats) for a personalised experience - Subscription-based ($9.99/Month) - Live since March, 15th 2019 (World Sleep Day); over 100k users to date - Plan to become the No 1 Sleep app by 2020 Our successful digital health apps portfolio to date
  • 7. University Study Description Status Sample size More details of the study University of Cambridge Use of the Wizard memory game among patients with schizophrenia 2015 - paper published 22 Schizophrenia patients RCT (effect of training). 8 hours of training over a period of one month. Université libre de Bruxelles Correlation between 7 of Peak games and standard cognitive assessment tools 2018 - paper published 78 participants Correlation study. 22 young adults, 27 healthy old adults, 29 cognitively impaired older adults. City University of New York Impact of Peak games on participants with mild depressive symptoms 2019 - paper published 46 participants RCT between two categories of Peak games. Young adults with at least mild depressive symptoms . Participants were instructed to play 5 days per week for 8 weeks (not all completed the requested period) University of Cambridge Impact of “Decoder” - attention game on attention/concentration in healthy adults 2019 - paper published 75 healthy young adult RCT - 3 groups: Training (8 h of playing Decoder over 4 weeks; n = 25), Active Control (8 h of playing Bingo over 4 weeks; n = 25) or Passive Control (continuation of activities of daily living; n = 25) Published studies using Peak
  • 8. University Study Description Status Sample Size More details of the study University College London Impact of “Smile on Me” - emotion game on mood Finalising manuscript 22,933 users completed study RCT between 4 conditions: Active Smile on me, Sham Smile on meI, Active Handling emotion game, Sham handling emotion game. 153,385 users started the study however a group of 22,933 who completed the minimum elements needed for the study were included. Two weeks of daily training. UKD Effects of Peak games on cognitive abilities of patients with brain injury after stroke Final data analysis stage 82 Stroke patients. RCT - 3 groups: Training, Training with supervision, control. Participants were instructed to play 30 min a day for 2 weeks. Université libre de Bruxelles Further study on Peak as a cognitive assessment tool, considering the relationship between Peak game scores and age Data analysis stage Data from 9000 Peak users in different age groups Retrospective observational study done based on data of 9K users in different age groups New York University Decision-making study utilising “Connect ‘Em Up” - decision making game Data collection stage King’s College London Peak as a pre-employment assessment Final analysis stage 40 participants. Correlation study Munich University Assess the use of Peak as a cognitive assessment tool for use in Multiple Sclerosis Data collection stage UPM How mindfulness affect attention among kids Final data analysis (MA thesis, potential future publication) 63 participants 30 kids in the reliability study, 33 in the main study included 2 groups. On-going studies using Peak
  • 9. Game-based, engaging Consumer focus / OTC Curated content and clinical assessments Prescription - based Our positioning in the DTx landscape
  • 10. Peak DTx Roadmap Alzheimer Sleep CE/FDA-approved tool for early detection & tracking of cognitive decline CE/FDA-approved tool to improve mood and assist with symptoms of depression (comorbidity from chronic illnesses) Upcoming (2019) Medium / long term (2020-2021) Depression CE/FDA-approved tool to prevent or treat sleep disorders CE/FDA-approved tool to prevent and delay / treat cognitive decline CE/FDA-approved tool to prevent or treat attention disordersAttention Multiple Sclerosis CE/FDA-approved tool for cognitive rehabilitation of patients with Multiple Sclerosis
  • 11. The team 2018 Top 50 Smart Healthcare Company Xavier Louis CEO Sylvain Piquet COO Liron Jacobson, PhD Head of Science Barbara Sahakian, FMedSci DSc Scientific Advisor Professor of Clinical Neuropsychology - University of Cambridge Co-invented CANTAB tests 2016 winner Best EdTech / The Europas And 45 talented individuals.
  • 12. Investors looking to find out more about our new projects Researchers interested to use Peak for Research projects Corporate Partners considering to use Peak or Rise for their staff’ well-being or productivity All partners who want to work with Peak Xavier Louis CEO, Peak xavier@peak.net Contact us