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The Future of Brain Health


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Dur­ing Expo Day selected Sum­mit Spon­sors will show­case their lat­est ini­tia­tives and solutions:
-- Pre­view the Future of Brain Health with Anu Acharya, Founder and CEO of Map My Genome
-- The Alzheimer’s Research and Pre­ven­tion Foun­da­tion (ARPF): Dis­cuss new sci­ence and pre­ven­tion ini­tia­tives with Pres­i­dent Dr. Dharma Singh Khalsa.
-- Fit­Brains (a Rosetta Stone com­pany): Explore ongo­ing big data research with Conny Lin, Data Research Sci­en­tist & Pol­icy Analyst.

Presentation @ The 2015 SharpBrains Virtual Summit

Published in: Health & Medicine

The Future of Brain Health

  1. 1. The Future of Brain Health
  2. 2. Sponsors Welcome to Day 3--Expo Day
  3. 3. Anu Acharya, CEO and Founder Mapmygenome The Future of Brain Health Anu Acharya CEO Map My Genome
  4. 4. 10 Brain Transformers As we enter an era of a transforming cerebrals there will soon be “Mindful” wearables to concentrate, meditate and self regulate Did I just see you drop your jawbone at the gate ? Charge yourself to a calming or energizing state Enhance memory and you are now feeling great Your life may soon be in a different motion With Electrical and magnetic brain stimulation Not just in games or bars that you may frequent You may come across a Virtual Reality treatment, In conjunction with EEG and/ or tDCS as a sequent Mental manipulation of memorized objects enhancing fluid intelligence and those subjects Emotions and Cognition through those frames called Cognitive training videogames When life is hard and you need help control external devices when you painfully yelp Monitoring health through EEG and your soul Use Brain-Computer Interfaces for device control
  5. 5. Normal or diseased - you may want to know soon on the curve you will be able to show diagnose and treat like never before using Big Data-enhanced diagnostics and treatments and more A seizure may come when no one is around unwanted and without warning sound ALS patients and more will benefit Real-time neuromonitoring with robotic aid specialist Driving a car and you dose off for a bit Systems employing neural detection tickle to make you sit They are in the monitor vehicle operator alertness business Aptly called Neurosensor based vehicle operator systems The tasks are many and you poor one EEG signals the company your mental state And tailor the computing experience estate via Brain-responsive computing systems that you may hate Learning across the extended workforce will no longer be through a regular course Improving learning and skills at company stations Through Collaborative cognitive simulations 10 Brain Transformers
  6. 6. Why we haven’t figured it all • Large no of neurons- 85 billion • Complex Algorithm used by brain
  7. 7. Mental Health to Brain Health
  8. 8. As we move towards Personalized Medicine
  9. 9. There is a case for Brain Health • 75% of addressable health care costs are related to lifestyle choices. (1) • Numerous studies have linked stress to back pain, colorectal cancer, infectious disease, heart problems, headaches and diabetes. (2) • 5.9 million children have been diagnosed with Attention Deficit Disorder (1) • 1 in 5 Adults take medication everyday for mental health • Antidepressants and Antipsychotics, together, outsell all other drug classes • Massive coverage increases and changing consumer needs demand change and increased efficiencies (Mental Health Parity, Affordable Health Act)
  10. 10. Past, Present and Future
  11. 11. Mapmygenome Portfolio
  12. 12. Personalised Products
  13. 13. Genetics influence Neurological conditions Nature, (520) 224-228, 2015
  14. 14. SNPs and Neuro Conditions
  15. 15. Conditions Covered in Brainmap
  16. 16. A sample report
  17. 17. Key Areas ADHD Addiction Depression Bipolar disorder Autism Alzheimer's Schizophrenia Key Areas Credit: NINDS
  18. 18. SNPs and Neurological Conditions Source: Eupedia
  19. 19. Mapmygenome Cognitive Solutions Invasive Treatment Mapmy Genome Solutions
  20. 20. Integrative Neuroscience Database Brain Resource database includes > 130,000 data sets from > 15 Clinical Groups Databases are emerging in neuroscience which will yield both scientific insights and practical clinical tools for improved diagnosis, targeted prescription practices, and clinical decision support. Surveys Cognition Imaging Physiology Genetics
  21. 21. A Technology Enhanced Model of Clinical Practice Neurocognitive assessments and brain training exercises can be used in combination to provide personalized assessment and treatment options. 1. Objective & Rapid Assessment of strengths/deficits 2. Treatment decision support & change monitoring 3. Effective screener for ADHD, Depression, Dementia, TBI 1. Interactive Brain Training 2. Promotes Resilience 3. Remediates cognitive and emotional deficit areas 1. Heart Rate Variability training 2. Personalized Stress Management 3. Adjunctive non-medicative therapy Assessment Treatment Training Program Biofeedback-based stress management Neuropsychological Assessment Brief Screening 1. Rapid Neurodiagonistic Screener 2. Identifies early risk for brain health condition 3. Broad spectrum screen with high sensitivity
  22. 22. WebNeuro - Focus An online test for cognitive strengths
  23. 23. Assess core cognitive and emotional capacities
  24. 24. Example: Key Cognitive Domains
  25. 25. Three Levels of Stress Positive Brief increases in heart rate, mild elevations in stress hormone levels Tolerable Temporary stress responses Toxic Prolonged activation of stress response system
  26. 26. • MyCalmBeat improves your calmness through slow breathing • Calculates your personal best breathing rate and trains you by breathing at that rate
  27. 27. • Reduces Stress • Increases Focus • Builds Resilience • Training each day for 10 min, just like regular exercise • Training before presentations, before going to sleep, periods of stress
  28. 28. Sensitivity Specificity Markers from • Sustained Attention • Impulsivity • Intrusions • Inhibition • Response Variability 88% 91% Williams LM, Using brain-based cognitive measures to support clinical decisions in ADHD. Pediatric Neurol. 2010 Feb;42(2):118-26. WebNeuro-Focus test for ADHD
  29. 29. BRISC (Brain Resource brain health screen) includes 15 questions to assess: • Negative-Positive Bias • Emotional Resilience • Social Skills • Helps identify individuals who have and/or are susceptible to a brain health impairment. • Negativity Bias has 85% sensitivity an 84% specificity for identifying risk across a broad spectrum of disorders. Williams, Cooper, Wisniewski, Gatt, Koslow, Kulkarni, Gordon, Rush (2011). Sensitivity, specificity and predictive power of the “BRISC”, a cross-sectional study on a brief web screen for brain health. J Clinical Psychiatry (in review) BRISC For Brain Health Screening
  30. 30. Positive- Negative Bias Emotional Resilience Social Skills Overall Brain Health Service Provider Action Example Longer Term Action Example Good Positive feedback Compliant, follow at standard call interval Below Averag e Validate distress and reinforce adaptive coping strategies ‘On the ledge’: flag the user account, and re-screen Below Averag e Reinforce adaptive coping and regulation, and encourage social engagement ‘On the ledge’: flag the user account, and re-screen Poor Comprehensive MH assessment required ‘Over the ledge’: Reach out, to engage and boost compliance 1 105 1 107 Positive-Negative Bias: Average 1 109 Emotional Resilience: Good Social Skills: Good 1.53 6 5.5 7 4.5 1 1.5 21.5 5.5 3 BRISC Scores & Action Examples
  31. 31. Call: 1800-102-4595 Couples Planning A Family Toddlers and Teens Brain Health Pregnant Women Chronic Disease Sports Fitness Healthy Individuals Newborn Babies Know Yourself Healthy, Smart and Fit
  32. 32. Summit is on break. (we will resume at 9:00am Pacific Time)
  33. 33. Sponsors Welcome to Expo Day Expo Day Agenda 9-9:30am. The Alzheimer’s Research and Prevention Foundation 9:45-10:15am. Fit Brains 10:30-11am. Baycrest 11:15-11:45am. Lumosity 12-12:30am. BrainBaseline 12:45-1:15am. The SharpBrains Guide to Brain Fitness
  34. 34. How Integrative Medicine Is Solving the Alzheimer’s Crisis Dharma Singh Khalsa, M.D. Clinical Associate Professor Department of Integrative Medicine University of New Mexico School of Medicine
  35. 35. Maintain a sharp brain with age Boomers’ #1 Fear Getting Alzheimer’s Boomers’ #1 Goal
  36. 36. Staggering Statistics 1. 5.4 Million with AD, $150 B cost/year 2. Millions more with SCD, MCI and multiple risk factors (CVD, obesity, insomnia, drug abuse, DM) 3. Women 2x as likely to develop AD in their 60’s & 2/3 of all patients are women 4. A woman’s lifetime risk for AD is higher than breast cancer: 1 in 6, vs 1 in 11 5. 10 Million unpaid caregivers
  37. 37. What is AD? Accelerated brain aging leading to cognitive failure: 1. Plaques and tangles 2. Synapse 3. Mitochondria 4. CBF All fail, leading to loss of memory and personality
  38. 38. Drug Discovery (Pharma) Elusive But Non Pharma Prevention Research is Compelling
  39. 39. Integrative Medicine (non-pharma): The Four Pillars of Alzheimer’s Prevention 1. Diet and Brain Specific Nutrients 2. Stress Management 3. Exercise 4. Spiritual Fitness
  40. 40. Cost (0-4) Benefit (0-4) Side Effects (0-4) Ease (0-4) Research (0-4) PHARMA 4+ 0-1 (elusive) 3-4 (incl death) 4 2 NON- PHARMA 1 3 1 1-2 3-4 The New Conversation
  41. 41. Stress Got Your Nerves on Edge? From ISIS to Politics
  42. 42. Stress Increases Risk Factors for AD 1. Memory Loss 2. Inflammation 3. Heart Disease 4. Insomnia 5. Diabetes 6. Anxiety / Depression 7. Genetic Health 8. Loss of Spiritual Direction
  43. 43. Stress Impacts Your Genes & DNA by Shortening Telomeres
  44. 44. What Can You Do? Put Your Brain Health First
  45. 45. Kirtan Kriya Reduces Alzheimer’s Risk SAA TAA NAA MAA
  46. 46. Kirtan Kriya Before After Khalsa, D. Newberg, A: Nuclear Medicine Communications, Sept. 2009
  47. 47. Posterior Cingulate Gyrus Up Khalsa, D.S., Newberg, A. Jl of Nuclear Med Communication 2009 Preventing Alzheimer’s in 12 Minutes a Day?
  48. 48. Pre-Program Baseline Post-Program Baseline Ant Cingulate Ant Cingulate PFC PFC Changes in the Anterior Cingulate Gyrus
  49. 49. Memory
  50. 50. KK Increases Telomerase by 43% 0 0.5 1 1.5 2 2.5 3 3.5 4 Base Week 8 Meditation Relaxation
  51. 51. Newest Aspect Of AD Prevention Research What is Spiritual Fitness? 1. Acceptance 2. Independence 3. Environmental Mastery 4. Personal Growth 5. Positive Relationships } Reduction of Risk Factors 6. Purpose/ Mission  Mild Cognitive Impairment and Alzheimer’s Risk
  52. 52. How to Move from Information to Experience
  53. 53. Take Kirtan Kriya Home 1. Self-led, 12-minute KK meditation now possible 2. Anyone can practice it 3. Best time to do it is first thing in the morning 4. CD and MP3 available for a $20 donation 5. Includes simple instructions 6. It’s easy, enjoy!
  54. 54. And In The End… Spirit, Wisdom and Peace of Mind
  55. 55. Conclusion 1. The Four Pillars of Integrative Medicine May Reduce the Risk of Alzheimer’s 1. The Regular Practice of KK is Now Part of the Alzheimer’s Prevention Conversation Dharma Singh Khalsa, M.D.
  56. 56. Summit is on break. (we will resume at 9:45am Pacific Time)
  57. 57. Fit Brains Research Big data, health policy, and our responsibilities Conny Lin, M.Sc. Neuroscience Research Scientist, Fit Brains by Rosetta Stone Ph.D. Candidate, Neuroscience, University of British Columbia Science Policy Fellow 2014/15, British Columbia Ministry of Health Sharp Brains Summit 2015, Nov 19, 2015
  58. 58. Portfolio In House Research • Data research • Collaboration with Rosetta Stone language products • Local research programs Dissemination • Conference presentations • Publications • Reports Research collaborations • Clinical trial • Big data research • Fit Brains as an assessment tool for research programs Research funding management • Grant proposals • Funding financials
  59. 59. Big Data: knowledge translation matters a health policy case Health strategic goals: “90% of methadone prescribers will adhere to optimal dose guidelines (60-120mg)” • Research shows that most patients are stable on 60- 120mg • Only 50-60% of patients are prescribed the optimal dose for the past 6 years… we need to do better! • Physicians says that’s not possible. People will die! What went wrong?
  60. 60. Logic& Memory& Attention& Visual& Speed& Big Data: knowledge translation matters Fit Brains’ case Population data
  61. 61. Logic& Memory& Attention& Visual& Speed& Big Data: knowledge translation matters Fit Brains’ case Population data Individual data
  62. 62. Logic& Memory& Attention& Visual& Speed& Population data Individual data Big Data: knowledge translation matters Fit Brains’ case Policy makers see Physicians see Researchers see both
  63. 63. Fit Brains Research Agenda In house research • Data research • Collaboration with Rosetta Stone language products • Local research programs Dissemination • Conference presentations • Publications Research collaborations • Clinical trial: brain imaging (fMRI) • Vancouver Institutes of Visual Analytics
  64. 64. User Training Pattern Users tend to play at a 24 hour interval “Shadow shapes” is the most popular game during this time frame Registeredtime earliest latest Zoom in to examine precise playing pattern Training pattern of one game: “Missing Pieces” Does a training regime produce performance improvement? Examples of in house research: Data analysis
  65. 65. Population Examples of in house research: Data analysis Logic& Memory& Attention& Visual& Attention& Visual& Speed&
  66. 66. Data tells us population trends Big Data tells us how individuals differ from the population trends
  67. 67. Examples of in house research: How to be a top tiered player?
  68. 68. Examples of in house research: Practice regime 0 10 20 30 40 0 20 40 60 80 AB C D E F A B C D E F A B C D E F A B C D E F A B C D E F A B C D E F A B C D E F AB C D E F A B C D E F AB C D E F A B C D E F A B C D E F timelapseday playN 60 Timefromfirstplayto thetimeaperson achieveacertaintier
  69. 69. Examples of in house research: How do A/B differ? 0 10 20 30 40 0 20 40 60 80 AB C D E F A B C D E F A B C D E F A B C D E F A B C D E F A B C D E F A B C D E F AB C D E F A B C D E F AB C D E F A B C D E F A B C D E F timelapseday playN 60 Timefromfirstplayto thetimeaperson achieveacertaintier
  70. 70. Examples of in house research: How about 50 yrs olds? 0 5 10 15 20 0 20 40 60 A B C D E F A B C D E F A B C D E F A B C D E F A B C D E F A B C D E F A B C D E F A B C D E F A B C D E F A B C D E F AB C D E F A B C D E F timelapseday playN 50 60s
  71. 71. Types of collaboration we are looking for • Data analytics - Use our data to answer research questions: – Do people who text while driving perform better at executive function tasks? – Can we predict performance in memory tasks from initial performance and training habit? • Assessment tools – Use our app as a measurement tool to answer your research questions – Do people who bike to work perform better at visual-spatial tasks? – Do people who held management position perform better at facial expression recognition tasks? • Intervention studies – use our product as interventions – Does using Fit Brains produce functional improvements in elderlies’ brain? – Does using Fit Brains improve classroom performance?
  72. 72. Brain imaging Clinical trial training fMRI no training shame training MCIHealthy neuropsychological assessment neuropsychological assessment fMRI MCIHealthy MCIHealthy
  73. 73. How to get involved • Submit Letter of Intent (LOI) to – Investigator information – Research proposal – Fit Brains contribution: data, free app access – Potential benefit to Rosetta Stone – Project Financial support • 2 weeks LOI review • Project logistics discussion • Agreements: data privacy, IP, work distribution • Project start
  74. 74. THANK YOU
  75. 75. Summit is on break. (we will resume at 10:30am Pacific Time)
  76. 76. To learn more, visit