Best prac­tices to assess and enhance brain func­tion via mobile devices and wearables

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(Session held at the 2014 SharpBrains Virtual Summit; October 28-30th, 2014)

8:15–9:45am. Best prac­tices to assess and enhance brain func­tion via mobile devices and wearables
- Corinna E. Lathan, Founder and CEO of AnthroTronix
- Eddie Mar­tucci, VP Research & Devel­op­ment at Akili Inter­ac­tive Labs
- Alex Doman, Co-Founder of Sleep Genius
- Joan Sev­er­son, Pres­i­dent of Dig­i­tal Artefacts
- Chair: Keith Epstein, Senior Strate­gic Advi­sor at AARP

Learn more here:
http://sharpbrains.com/summit-2014/agenda/

Published in: Health & Medicine

Best prac­tices to assess and enhance brain func­tion via mobile devices and wearables

  1. 1. Best practices to assess and enhance brain function via mobile devices and wearables
  2. 2. Sponsors Welcome! Day 2
  3. 3. Source: The SharpBrains Guide to Brain Fitness (second edition)
  4. 4. Best practices to assess and enhance brain function via mobile devices and wearables Chaired by: Keith Epstein, Senior Strategic Advisor at AARP Corinna E. Lathan, Founder and CEO of AnthroTronix Eddie Martucci, VP, R&D at Akili Interactive Labs Alex Doman, Co-founder of Sleep Genius Joan Severson, President of Digital Artefacts
  5. 5. AARP Research • When AARP asked, members made it clear that brain health is a top area of interest and concern as they age. • Younger consumers (age 34-49) are more inclined to feel brain health is the most important component to overall health (41% versus 34% of consumers age 50-75). • However, they are also more likely to believe brain deterioration cannot be reversed. AARP Research August 2014 Keith Epstein - Senior Strategic Advisor - Strategic Intelligence Team - AARP - October 24, 2014
  6. 6. Best practices to assess and enhance brain function via mobile devices and wearables Corinna Lathan, PhD Founder and CEO of AnthroTronix
  7. 7. The Brain Vital: Why do we ignore our brain? www.danabrainvital.com Human Inspired. Technology Driven. 8
  8. 8. Existing options for brain health Imaging (MRI, CT) • Expensive • Not portable • Not always available Physiological (EEG) • Hard to interpret • Difficult to administer • Not widely available Behavioral (Forms & Interviews) • Limits of self-reporting • Time pressures in clinic Human Inspired. Technology Driven. 9
  9. 9. The DANA™ Brain Vital DANA is an FDA-cleared mobile reaction time testing system that reinvents the way patients are monitored for signs of neurocognitive impairment. Human Inspired. Technology Driven. 10
  10. 10. History of DANA  Developed for the Department of Navy Bureau of Medicine and Surgery (BUMED)  A mobile software application to assist in the detection of neurocognitive impairment from any cause  To help the far forward medic to more accurately detect impairment as soon as possible  To assist the psychologist or healthcare professional with supportive diagnostic tools to aid in their diagnosis Human Inspired. Technology Driven.
  11. 11. DANA Requirements  Portability  Leverage best practices in computerized cognitive Human Inspired. Technology Driven. testing  Both standardized cognitive and psychological tests  Easy of use for all types of providers – 3 levels of testing  Embedded tests of effort determine malingering vs real  FDA Compliance
  12. 12. Scaleable Software Human Inspired. Technology Driven. 13
  13. 13. FDA Cleared IFU DANA provides clinicians with objective measurements of reaction time (speed and accuracy) to aid in the assessment of an individual’s medical or psychological state. Factors that may affect the measurement of reaction time include, but are not limited to concussion, head injury, insomnia, post traumatic stress disorder (PTSD), depression, attention deficit hyperactivity disorder (ADHD), memory impairment, dementia, delirium, prescription and non-prescription medication, some nutritional supplements, as well as a variety of psychological states (e.g. fatigue and stress). DANA also delivers and scores standardized psychological questionnaires. DANA results should be interpreted only by qualified professionals. Human Inspired. Technology Driven. 14
  14. 14. FDA Lessons Learned • Context matters • Dialogue • Find the right people • Persistence Human Inspired. Technology Driven. 15
  15. 15. Thank You! clathan@atinc.com www.atinc.com www.DANABrainVital.com NDA Only: Confidential Human Inspired. Technology Driven. & Proprietary 16
  16. 16. Best practices to assess and enhance brain function via mobile devices and wearables Eddie Martucci, VP, R&D at Akili Interactive Labs
  17. 17. Akili A new class of medical products
  18. 18. What if... more data points real-world data time/cost-effective broader patient selection MOBILE
  19. 19. What if... more data points many IN YOUR POCKET time/cost-effective broader patient selection increased compliance real-world data
  20. 20. What if... many more data points increased compliance and then some FUN WAY time/cost-effective broader patient selection real-world data higher signal-to-noise than traditional assessments
  21. 21. Akili’s Platform Medicine you actually enjoy
  22. 22. Akili’s Platform Personalized cognitive engine Proprietary Adaptive Algorithms Custom difficulty automatically personalized to the patient Proprietary Cognitive Mechanics Software-based Assessment of Executive Function
  23. 23. Findings from First Clinical Study confidential Game metrics show ability to be sensitive cognitive marker 0% -10% -20% -30% -40% -50% -60% -70% At-home training leads to measura ble physiological brain changes ** EEG – Theta Band Amplitude Time-Locked to Stimulus p < 0.05 Multitasking training Single task training No-contact control -80% 10s 20s 30s 40s 50s 60s 70s Interference Cost Assessment of Interference Processing Ability Mean ± SEM * * * * * * † † † ‡ ‡ ‡ Mean ± SEM * * * * * * † † † ‡ ‡ ‡ Mean + SEM Source: Anguera et al, Nature, 2013
  24. 24. Akili’s Perspective + 12 ongoing/completed clinical studies In various populations with same game platform
  25. 25. What We’ve Found Industry Wants Data, data, data Theoretical underpinning Intellectual Property Scientific culture Diversity in background
  26. 26. Lessons from Clinical Studies Don’t assume you know who loves technology Small pilot studies add value Specific populations matter Reward cycles work…if you get it right
  27. 27. SharpBrains Summit 2014
  28. 28. Best practices to assess and enhance brain function via mobile devices and wearables Alex Doman, Co-founder of Sleep Genius
  29. 29. Track and Treat: The Future of Wearables Alex Doman Co-Founder alex@sleepgenius.com
  30. 30. Self Actualization “What a man can be, he must be.” -Abraham Maslow
  31. 31. The Measured Life • Sensory Technology • Wearables • Sensor Technology • Data Visualization • Big Data
  32. 32. Sleep Genius Personalized Sleep Reporting
  33. 33. Smart vs. Intelligent
  34. 34. TRACKING 1.6 million AGGREGATED TRACKING 8 million 2013 2014 • Consumer Adoption gains momentum • High Drop-off rates • Dozens of wearables • Apple Health Book/Google Fit TREATING 23 million 2015 • Corporate wellness adoption • Health Solutions PERSONALIZED COACHING 45 million 2017 • Data usefulness • Personalized coaching WEARABLES GROWTH PHASES TRACKING 200,000 # Wearable Devices
  35. 35. Thank You! Alex Doman Sleep Genius alex@sleepgenius.com sleepgenius.com
  36. 36. Best practices to assess and enhance brain function via mobile devices and wearables Joan Severson, President of Digital Artefacts
  37. 37. Joan Severson 201 East Washington Street Suite 1302 Iowa City, IA 52240 Phone: (319) 431-3278 Email: joan@digitalartefacts.com October 29, 2014 BrainBaseline http://www.brainbaseline.com Copyright Digital Artefacts 2014
  38. 38. BrainBaseline Why are we building the BrainBaselineTM platform “If you could give people information and tools that would delay the onset of cognitive impairment by a few years, you would be doing much to improve individuals’ quality of life as well as improving society.” Debra Cherry, PhD Alzheimer’s Association Copyright Digital Artefacts 2014
  39. 39. BrainBaseline BrainBaseline’s Broad Objectives • Develop a global platform that integrates cognitive performance measures with lifestyle and biometric information to track brain health over time • Provide consumers, clinicians, pharmaceutical companies, and health care and wellness communities a better understanding of brain health and function across the lifespan. • Inform and educate consumers on evidence-based behavioral interventions to provide life-long cognitive health and wellness. • Accelerate discovery and reduce the cost of research, clinical trials, and clinical interventions. Copyright Digital Artefacts 2014
  40. 40. BrainBaseline How many of you know your current weight? Blood pressure? How many of you know how well your brain is working (objectively)?
  41. 41. The BrainBaseline platform provides any individual with a mobile device tools to measure, track and understand their own brain and cognitive functioning. BrainBaseline
  42. 42. BrainBaseline BrainBaseline Platform BrainBaselineTM is designed as a modular platform that aggregates health and behavioral measures through embedded content and third party API integration. The cornerstone of the application is our suite of over 40 cognitive tasks, which allow us to determine the relationship between cognitive performance and other aspects of an individual’s behavior or physical health. We present this information to users in a way that is appealing and easy to understand; effectively, BrainBaseline is an education and research platform that provides users with an engaging means of understanding, testing, and improving their cognitive health. Copyright Digital Artefacts 2014
  43. 43. BrainBaseline BrainBaseline 2.0 Platform Overview Lifestyle Activity Brain Drive Biometrics What makes BrainBaselineTM 2.0 unique is the ability to combine these measures to provide holistic snapshots of an individual’s psychological, physical and cognitive health, providing this information to users in a way that allows them to better understand how their brain health is linked to their behavior. Copyright Digital Artefacts 2014
  44. 44. BrainBaseline Components of BrainBaseline 2.0 User Dashboard: The user dashboard acts as a hub that provides users with an overall snapshot of their current behavioral, cognitive, and lifestyle status in the form of summary scores and performance trend lines. The data are populated dynamically and can be adjusted instantly to provide social motivation, with users being allowed to see how their status in each domain compares to other anonymous users of the application in, e.g., their age group or location, as well as connecting with friends or family to compare scores against others in their social network. Copyright Digital Artefacts 2014
  45. 45. BrainBaseline Copyright Digital Artefacts 2014
  46. 46. BrainBaseline Copyright Digital Artefacts 2014
  47. 47. BrainBaseline Components of BrainBaseline 2.0 User Information: (lifestyle, demographics) In the user information module, users answer a series of demographic questions, including, age, gender, income level, education, and geographic location, in addition to questions related to their preferred leisure activities, overall level of activity. Other specific questionnaires or self-report measures can be integrated on the basis of project-specific requirements. Copyright Digital Artefacts 2014
  48. 48. BrainBaseline Copyright Digital Artefacts 2014
  49. 49. BrainBaseline Components of BrainBaseline 2.0 Cognitive Testing: The cognitive testing module is the cornerstone of the BrainBaseline application. The tests are mapped to specific cognitive domains, are brief (individual tests take between 1 and 4 minutes), and are diverse in order to maximize both user engagement and data quality. Furthermore, the diversity and wide-ranging nature of BrainBaseline’s tests provide added sensitivity to cognitive change, allowing more accurate detection of decrements or improvements in cognition. Copyright Digital Artefacts 2014
  50. 50. BrainBaseline Copyright Digital Artefacts 2014
  51. 51. BrainBaseline Copyright Digital Artefacts 2014
  52. 52. BrainBaseline Components of BrainBaseline 2.0 Activity: The activity module is a hub for users to monitor and aggregate information about their level of activity and sleep, and allows them to set activity and sleep goals that let them visualize and incentivize lifestyle changes that lead to optimal physical and cognitive health. Current functionality allows users to either self-report activity and sleep data, or integrate directly with their FitBit, Jawbone UP, and Body Media trackers for automated aggregation of these data. Copyright Digital Artefacts 2014
  53. 53. BrainBaseline Copyright Digital Artefacts 2014
  54. 54. BrainBaseline Components of BrainBaseline 2.0 Biometrics: The Biometrics module allows users to aggregate biometric information such as weight, blood pressure, heart rate, or blood-glucose level over time. Users are able to set specific goals related to target levels of specific biometric variables (e.g., blood pressure) as well as trend this information over time. Copyright Digital Artefacts 2014
  55. 55. BrainBaseline Copyright Digital Artefacts 2014
  56. 56. BrainBaseline Components of BrainBaseline 2.0 Medication tracking : Future development is planned to support integration of medication reminders, as well as tracking of prescription/over the counter pharmaceutical use and dosage over time. Copyright Digital Artefacts 2014
  57. 57. BrainBaseline 1 Million self administered consumer based tests by 2015 Copyright Digital Artefacts 2014
  58. 58. BrainBaseline Developing models for assessing and classifying change over time BrainBaseline allows for classification of an individual’s cognitive performance relative to their own peer group or population sub-group. We are developing models to classify the predicted or average slope of change across multiple testing sessions for each population sub-group Population sub-groups are determined by factors that are likely to stay stable over time (e.g., race, income level, education, birth year, etc.) This predicted slope of change classifies what is the “expected” performance for a given individual meeting a population characteristics Copyright Digital Artefacts 2014
  59. 59. BrainBaseline Developing models for assessing and classifying change over time Predicted slope of change also allows for classification of people who display aberrant (e.g., outlier) performance for their population group E.g., people who’s slope of change is increasing or decreasing at a different rate than their population sub-group. This measure may provide an index of people who are outliers for their own population sub-group, and may provide a nuanced, stable index of people who are at risk for early cognitive decline. Copyright Digital Artefacts 2014
  60. 60. BrainBaseline Subgroup classification to behavior, lifestyle, and biometrics assessment Analysis of full dataset will be independently performed by research collaborators at the University of Illinois at Urbana-Champaign. Analysis of relationship between survey based report of physical activity and cognitive function Analysis of relationship between wearable sensor based physical activity sensor data and cognitive function Analysis of relationship between survey based reporting of biometrics, heart rate, BP, glucose measures, and cognitive function Analysis of relationship between consumer sensor based reporting of biometrics, heart rate, BP, glucose measures, and cognitive function Copyright Digital Artefacts 2014
  61. 61. BrainBaseline BrainBaseline 2.0 Platform Overview BrainBaseline 2.0 is a scalable platform capable of integrating data from many varying systems, developed both internally and externally, into cognitive profiles for varying populations ranging from individual users up to groups based on activity, biometrics, demographics and other factors. The platform itself focuses on data security, reliability and extensibility. BrainBaseline integration with Apple HealthKit and Electronic Health Records Electronic Health Records Copyright Digital Artefacts 2014
  62. 62. In conjunction with UCSD department of psychiatry we have received NIH funding to develop an iPad-based screening measure for HIV-associated neurocognitive disorders. • Screening takes 10 minutes to complete • Self administered in clinic waiting room • Automated scoring and reporting • Aggregated data • HIPPA compliant infrastructure • Multiple language support, native iOS development • Global Research sties • US, Japan, South Africa BrainBaseline Clinical Screening Instruments Copyright Digital Artefacts 2014
  63. 63. Joan Severson 201 East Washington Street Suite 1302 Iowa City, IA 52240 Phone: (319) 431-3278 Email: joan@digitalartefacts.com October 29, 2014 BrainBaseline http://www.brainbaseline.com Copyright Digital Artefacts 2014
  64. 64.  To learn more, visit SharpBrains.com

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