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Best practices to assess and enhance brain 
function via mobile devices and wearables
Sponsors 
Welcome! 
Day 2
Source: The SharpBrains Guide to Brain Fitness (second edition)
Best practices to assess and enhance brain 
function via mobile devices and wearables 
Chaired by: Keith Epstein, 
Senior Strategic Advisor at AARP 
Corinna E. Lathan, 
Founder and CEO of AnthroTronix 
Eddie Martucci, 
VP, R&D at Akili Interactive Labs 
Alex Doman, 
Co-founder of Sleep Genius 
Joan Severson, 
President of Digital Artefacts
AARP Research 
• When AARP asked, members made it clear that 
brain health is a top area of interest and concern 
as they age. 
• Younger consumers (age 34-49) are more inclined 
to feel brain health is the most important 
component to overall health (41% versus 34% of 
consumers age 50-75). 
• However, they are also more likely to believe 
brain deterioration cannot be reversed. 
AARP Research August 2014 
Keith Epstein - Senior Strategic Advisor - 
Strategic Intelligence Team - AARP - 
October 24, 2014
Best practices to assess and enhance brain 
function via mobile devices and wearables 
Corinna Lathan, PhD 
Founder and CEO of AnthroTronix
The Brain Vital: Why do we ignore our brain? 
www.danabrainvital.com 
Human Inspired. Technology Driven. 
8
Existing options for brain health 
Imaging (MRI, CT) 
• Expensive 
• Not portable 
• Not always available 
Physiological (EEG) 
• Hard to interpret 
• Difficult to administer 
• Not widely available 
Behavioral (Forms & Interviews) 
• Limits of self-reporting 
• Time pressures in clinic 
Human Inspired. Technology Driven. 9
The DANA™ Brain Vital 
DANA is an FDA-cleared mobile reaction time testing 
system that reinvents the way patients are monitored for 
signs of neurocognitive impairment. 
Human Inspired. Technology Driven. 
10
History of DANA 
 Developed for the Department of Navy Bureau of 
Medicine and Surgery (BUMED) 
 A mobile software application to assist in the 
detection of neurocognitive impairment from any 
cause 
 To help the far forward medic to more accurately 
detect impairment as soon as possible 
 To assist the psychologist or healthcare professional 
with supportive diagnostic tools to aid in their 
diagnosis 
Human Inspired. Technology Driven.
DANA Requirements 
 Portability 
 Leverage best practices in computerized cognitive 
Human Inspired. Technology Driven. 
testing 
 Both standardized cognitive and psychological tests 
 Easy of use for all types of providers – 3 levels of 
testing 
 Embedded tests of effort determine malingering vs real 
 FDA Compliance
Scaleable Software 
Human Inspired. Technology Driven. 13
FDA Cleared IFU 
DANA provides clinicians with objective measurements of reaction time 
(speed and accuracy) to aid in the assessment of an individual’s 
medical or psychological state. 
Factors that may affect the measurement of reaction time include, but are 
not limited to concussion, head injury, insomnia, post traumatic stress 
disorder (PTSD), depression, attention deficit hyperactivity disorder 
(ADHD), memory impairment, dementia, delirium, prescription and 
non-prescription medication, some nutritional supplements, as well as 
a variety of psychological states (e.g. fatigue and stress). 
DANA also delivers and scores standardized psychological 
questionnaires. DANA results should be interpreted only by qualified 
professionals. 
Human Inspired. Technology Driven. 
14
FDA Lessons Learned 
• Context matters 
• Dialogue 
• Find the right people 
• Persistence 
Human Inspired. Technology Driven. 
15
Thank You! 
clathan@atinc.com 
www.atinc.com 
www.DANABrainVital.com 
NDA Only: Confidential 
Human Inspired. Technology Driven. 
& Proprietary 16
Best practices to assess and enhance brain 
function via mobile devices and wearables 
Eddie Martucci, 
VP, R&D at Akili Interactive Labs
Akili 
A new class of medical products
What if... 
more data points 
real-world data 
time/cost-effective 
broader patient selection 
MOBILE
What if... 
more data points 
many 
IN YOUR POCKET 
time/cost-effective 
broader patient selection 
increased compliance 
real-world data
What if... 
many more data points 
increased compliance and then some 
FUN 
WAY 
time/cost-effective 
broader patient selection 
real-world data 
higher signal-to-noise than traditional assessments
Akili’s Platform 
Medicine you actually enjoy
Akili’s Platform 
Personalized cognitive engine 
Proprietary 
Adaptive 
Algorithms 
Custom difficulty automatically 
personalized to the patient 
Proprietary 
Cognitive 
Mechanics 
Software-based Assessment 
of Executive Function
Findings from First Clinical Study 
confidential 
Game metrics show ability to 
be sensitive cognitive marker 
0% 
-10% 
-20% 
-30% 
-40% 
-50% 
-60% 
-70% 
At-home training leads to measura 
ble physiological brain changes 
** 
EEG – Theta Band Amplitude 
Time-Locked to Stimulus 
p < 0.05 
Multitasking training 
Single task training 
No-contact control 
-80% 
10s 20s 30s 40s 50s 60s 70s 
Interference Cost 
Assessment of Interference Processing Ability 
Mean ± SEM 
* 
* 
* 
* 
* 
* 
† 
† 
† 
‡ 
‡ 
‡ 
Mean ± SEM 
* 
* 
* 
* 
* 
* 
† 
† 
† 
‡ 
‡ 
‡ 
Mean + SEM 
Source: Anguera et al, Nature, 2013
Akili’s Perspective 
+ 
12 ongoing/completed clinical studies 
In various populations with same game platform
What We’ve Found Industry 
Wants 
Data, data, data 
Theoretical underpinning 
Intellectual Property 
Scientific culture 
Diversity in background
Lessons from Clinical Studies 
Don’t assume you know who loves technology 
Small pilot studies add value 
Specific populations matter 
Reward cycles work…if you get it right
SharpBrains Summit 
2014
Best practices to assess and enhance brain 
function via mobile devices and wearables 
Alex Doman, 
Co-founder of Sleep Genius
Track and Treat: The 
Future of Wearables 
Alex Doman 
Co-Founder 
alex@sleepgenius.com
Self Actualization 
“What a man can be, 
he must be.” 
-Abraham Maslow
The Measured Life 
• Sensory Technology 
• Wearables 
• Sensor Technology 
• Data Visualization 
• Big Data
Sleep Genius 
Personalized Sleep Reporting
Smart vs. Intelligent
TRACKING 
1.6 million 
AGGREGATED 
TRACKING 
8 million 
2013 2014 
• Consumer Adoption 
gains momentum 
• High Drop-off rates 
• Dozens of 
wearables 
• Apple Health 
Book/Google Fit 
TREATING 
23 million 
2015 
• Corporate wellness 
adoption 
• Health Solutions 
PERSONALIZED 
COACHING 
45 million 
2017 
• Data usefulness 
• Personalized 
coaching 
WEARABLES 
GROWTH PHASES 
TRACKING 
200,000 
# Wearable Devices
Thank You! 
Alex Doman 
Sleep Genius 
alex@sleepgenius.com 
sleepgenius.com
Best practices to assess and enhance brain 
function via mobile devices and wearables 
Joan Severson, 
President of Digital Artefacts
Joan Severson 
201 East Washington Street 
Suite 1302 
Iowa City, IA 52240 
Phone: (319) 431-3278 
Email: joan@digitalartefacts.com 
October 29, 2014 
BrainBaseline 
http://www.brainbaseline.com 
Copyright Digital Artefacts 2014
BrainBaseline 
Why are we building the BrainBaselineTM platform 
“If you could give people information and tools that would delay the onset of cognitive 
impairment by a few years, you would be doing much to improve individuals’ quality of life 
as 
well as improving society.” 
Debra Cherry, PhD 
Alzheimer’s Association 
Copyright Digital Artefacts 2014
BrainBaseline 
BrainBaseline’s Broad Objectives 
• Develop a global platform that integrates cognitive performance measures with lifestyle 
and biometric information to track brain health over time 
• Provide consumers, clinicians, pharmaceutical companies, and health care and 
wellness communities a better understanding of brain health and function across the 
lifespan. 
• Inform and educate consumers on evidence-based behavioral interventions to provide 
life-long cognitive health and wellness. 
• Accelerate discovery and reduce the cost of research, clinical trials, and clinical 
interventions. 
Copyright Digital Artefacts 2014
BrainBaseline 
How many of you know your 
current weight? Blood pressure? 
How many of you 
know how well 
your brain is 
working 
(objectively)?
The BrainBaseline platform provides 
any individual with a mobile device 
tools to measure, track and 
understand their own brain and 
cognitive functioning. 
BrainBaseline
BrainBaseline 
BrainBaseline Platform 
BrainBaselineTM is designed as a modular platform that aggregates health and 
behavioral measures through embedded content and third party API integration. The 
cornerstone of the application is our suite of over 40 cognitive tasks, which allow us to 
determine the relationship between cognitive performance and other aspects of an 
individual’s behavior or physical health. We present this information to users in a way that 
is appealing and easy to understand; effectively, BrainBaseline is an education and 
research platform that provides users with an engaging means of understanding, testing, 
and improving their cognitive health. 
Copyright Digital Artefacts 2014
BrainBaseline 
BrainBaseline 2.0 Platform Overview 
Lifestyle Activity Brain Drive Biometrics 
What makes BrainBaselineTM 2.0 unique is the ability to combine these measures to 
provide holistic snapshots of an individual’s psychological, physical and cognitive health, 
providing this information to users in a way that allows them to better understand how their 
brain health is linked to their behavior. 
Copyright Digital Artefacts 2014
BrainBaseline 
Components of BrainBaseline 2.0 
User Dashboard: 
The user dashboard acts as a hub that provides users with an overall 
snapshot of their current behavioral, cognitive, and lifestyle status in 
the form of summary scores and performance trend lines. The data 
are populated dynamically and can be adjusted instantly to provide 
social motivation, with users being allowed to see how their status in 
each domain compares to other anonymous users of the application 
in, e.g., their age group or location, as well as connecting with friends 
or family to compare scores against others in their social network. 
Copyright Digital Artefacts 2014
BrainBaseline 
Copyright Digital Artefacts 2014
BrainBaseline 
Copyright Digital Artefacts 2014
BrainBaseline 
Components of BrainBaseline 2.0 
User Information: (lifestyle, demographics) 
In the user information module, users answer a series of demographic 
questions, including, age, gender, income level, education, and 
geographic location, in addition to questions related to their preferred 
leisure activities, overall level of activity. Other specific questionnaires or 
self-report measures can be integrated on the basis of project-specific 
requirements. 
Copyright Digital Artefacts 2014
BrainBaseline 
Copyright Digital Artefacts 2014
BrainBaseline 
Components of BrainBaseline 2.0 
Cognitive Testing: 
The cognitive testing module is the cornerstone of the BrainBaseline 
application. The tests are mapped to specific cognitive domains, are brief 
(individual tests take between 1 and 4 minutes), and are diverse in order to 
maximize both user engagement and data quality. Furthermore, the diversity 
and wide-ranging nature of BrainBaseline’s tests provide added sensitivity to 
cognitive change, allowing more accurate detection of decrements or 
improvements in cognition. 
Copyright Digital Artefacts 2014
BrainBaseline 
Copyright Digital Artefacts 2014
BrainBaseline 
Copyright Digital Artefacts 2014
BrainBaseline 
Components of BrainBaseline 2.0 
Activity: 
The activity module is a hub for users to monitor and aggregate 
information about their level of activity and sleep, and allows them to set 
activity and sleep goals that let them visualize and incentivize lifestyle 
changes that lead to optimal physical and cognitive health. Current 
functionality allows users to either self-report activity and sleep data, or 
integrate directly with their FitBit, Jawbone UP, and Body Media trackers 
for automated aggregation of these data. 
Copyright Digital Artefacts 2014
BrainBaseline 
Copyright Digital Artefacts 2014
BrainBaseline 
Components of BrainBaseline 2.0 
Biometrics: 
The Biometrics module allows users to aggregate biometric information 
such as weight, blood pressure, heart rate, or blood-glucose level over 
time. Users are able to set specific goals related to target levels of specific 
biometric variables (e.g., blood pressure) as well as trend this information 
over time. 
Copyright Digital Artefacts 2014
BrainBaseline 
Copyright Digital Artefacts 2014
BrainBaseline 
Components of BrainBaseline 2.0 
Medication tracking : 
Future development is planned to support integration of medication 
reminders, as well as tracking of prescription/over the counter 
pharmaceutical use and dosage over time. 
Copyright Digital Artefacts 2014
BrainBaseline 
1 Million self administered consumer based tests by 2015 
Copyright Digital Artefacts 2014
BrainBaseline 
Developing models for assessing and classifying change over time 
BrainBaseline allows for classification of an individual’s cognitive performance relative to 
their own peer group or population sub-group. 
We are developing models to classify the predicted or average slope of change across 
multiple testing sessions for each population sub-group 
Population sub-groups are determined by factors that are likely to stay stable over time 
(e.g., race, income level, education, birth year, etc.) 
This predicted slope of change classifies what is the “expected” performance for a given 
individual meeting a population characteristics 
Copyright Digital Artefacts 2014
BrainBaseline 
Developing models for assessing and classifying change over time 
Predicted slope of change also allows for classification of people who display aberrant 
(e.g., outlier) performance for their population group 
E.g., people who’s slope of change is increasing or decreasing at a different rate than their 
population sub-group. 
This measure may provide an index of people who are outliers for their own population 
sub-group, and may provide a nuanced, stable index of people who are at risk for early 
cognitive decline. 
Copyright Digital Artefacts 2014
BrainBaseline 
Subgroup classification to behavior, lifestyle, and biometrics assessment 
Analysis of full dataset will be independently performed by research collaborators at the 
University of Illinois at Urbana-Champaign. 
Analysis of relationship between survey based report of physical activity and cognitive 
function 
Analysis of relationship between wearable sensor based physical activity sensor data and 
cognitive function 
Analysis of relationship between survey based reporting of biometrics, heart rate, BP, 
glucose measures, and cognitive function 
Analysis of relationship between consumer sensor based reporting of biometrics, heart 
rate, BP, glucose measures, and cognitive function 
Copyright Digital Artefacts 2014
BrainBaseline 
BrainBaseline 2.0 Platform Overview 
BrainBaseline 2.0 is a scalable platform capable of integrating data from many varying 
systems, developed both internally and externally, into cognitive profiles for varying 
populations ranging from individual users up to groups based on activity, biometrics, 
demographics and other factors. The platform itself focuses on data security, reliability and 
extensibility. 
BrainBaseline integration with Apple HealthKit and Electronic Health Records 
Electronic 
Health 
Records 
Copyright Digital Artefacts 2014
In conjunction with UCSD department of psychiatry we 
have received NIH funding to develop an iPad-based 
screening measure for HIV-associated neurocognitive 
disorders. 
• Screening takes 10 minutes to complete 
• Self administered in clinic waiting room 
• Automated scoring and reporting 
• Aggregated data 
• HIPPA compliant infrastructure 
• Multiple language support, native iOS development 
• Global Research sties 
• US, Japan, South Africa 
BrainBaseline 
Clinical Screening Instruments 
Copyright Digital Artefacts 2014
Joan Severson 
201 East Washington Street 
Suite 1302 
Iowa City, IA 52240 
Phone: (319) 431-3278 
Email: joan@digitalartefacts.com 
October 29, 2014 
BrainBaseline 
http://www.brainbaseline.com 
Copyright Digital Artefacts 2014
 To learn more, visit SharpBrains.com

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Best prac­tices to assess and enhance brain func­tion via mobile devices and wearables

  • 1. Best practices to assess and enhance brain function via mobile devices and wearables
  • 3.
  • 4. Source: The SharpBrains Guide to Brain Fitness (second edition)
  • 5. Best practices to assess and enhance brain function via mobile devices and wearables Chaired by: Keith Epstein, Senior Strategic Advisor at AARP Corinna E. Lathan, Founder and CEO of AnthroTronix Eddie Martucci, VP, R&D at Akili Interactive Labs Alex Doman, Co-founder of Sleep Genius Joan Severson, President of Digital Artefacts
  • 6. AARP Research • When AARP asked, members made it clear that brain health is a top area of interest and concern as they age. • Younger consumers (age 34-49) are more inclined to feel brain health is the most important component to overall health (41% versus 34% of consumers age 50-75). • However, they are also more likely to believe brain deterioration cannot be reversed. AARP Research August 2014 Keith Epstein - Senior Strategic Advisor - Strategic Intelligence Team - AARP - October 24, 2014
  • 7. Best practices to assess and enhance brain function via mobile devices and wearables Corinna Lathan, PhD Founder and CEO of AnthroTronix
  • 8. The Brain Vital: Why do we ignore our brain? www.danabrainvital.com Human Inspired. Technology Driven. 8
  • 9. Existing options for brain health Imaging (MRI, CT) • Expensive • Not portable • Not always available Physiological (EEG) • Hard to interpret • Difficult to administer • Not widely available Behavioral (Forms & Interviews) • Limits of self-reporting • Time pressures in clinic Human Inspired. Technology Driven. 9
  • 10. The DANA™ Brain Vital DANA is an FDA-cleared mobile reaction time testing system that reinvents the way patients are monitored for signs of neurocognitive impairment. Human Inspired. Technology Driven. 10
  • 11. History of DANA  Developed for the Department of Navy Bureau of Medicine and Surgery (BUMED)  A mobile software application to assist in the detection of neurocognitive impairment from any cause  To help the far forward medic to more accurately detect impairment as soon as possible  To assist the psychologist or healthcare professional with supportive diagnostic tools to aid in their diagnosis Human Inspired. Technology Driven.
  • 12. DANA Requirements  Portability  Leverage best practices in computerized cognitive Human Inspired. Technology Driven. testing  Both standardized cognitive and psychological tests  Easy of use for all types of providers – 3 levels of testing  Embedded tests of effort determine malingering vs real  FDA Compliance
  • 13. Scaleable Software Human Inspired. Technology Driven. 13
  • 14. FDA Cleared IFU DANA provides clinicians with objective measurements of reaction time (speed and accuracy) to aid in the assessment of an individual’s medical or psychological state. Factors that may affect the measurement of reaction time include, but are not limited to concussion, head injury, insomnia, post traumatic stress disorder (PTSD), depression, attention deficit hyperactivity disorder (ADHD), memory impairment, dementia, delirium, prescription and non-prescription medication, some nutritional supplements, as well as a variety of psychological states (e.g. fatigue and stress). DANA also delivers and scores standardized psychological questionnaires. DANA results should be interpreted only by qualified professionals. Human Inspired. Technology Driven. 14
  • 15. FDA Lessons Learned • Context matters • Dialogue • Find the right people • Persistence Human Inspired. Technology Driven. 15
  • 16. Thank You! clathan@atinc.com www.atinc.com www.DANABrainVital.com NDA Only: Confidential Human Inspired. Technology Driven. & Proprietary 16
  • 17. Best practices to assess and enhance brain function via mobile devices and wearables Eddie Martucci, VP, R&D at Akili Interactive Labs
  • 18. Akili A new class of medical products
  • 19. What if... more data points real-world data time/cost-effective broader patient selection MOBILE
  • 20. What if... more data points many IN YOUR POCKET time/cost-effective broader patient selection increased compliance real-world data
  • 21. What if... many more data points increased compliance and then some FUN WAY time/cost-effective broader patient selection real-world data higher signal-to-noise than traditional assessments
  • 22. Akili’s Platform Medicine you actually enjoy
  • 23. Akili’s Platform Personalized cognitive engine Proprietary Adaptive Algorithms Custom difficulty automatically personalized to the patient Proprietary Cognitive Mechanics Software-based Assessment of Executive Function
  • 24. Findings from First Clinical Study confidential Game metrics show ability to be sensitive cognitive marker 0% -10% -20% -30% -40% -50% -60% -70% At-home training leads to measura ble physiological brain changes ** EEG – Theta Band Amplitude Time-Locked to Stimulus p < 0.05 Multitasking training Single task training No-contact control -80% 10s 20s 30s 40s 50s 60s 70s Interference Cost Assessment of Interference Processing Ability Mean ± SEM * * * * * * † † † ‡ ‡ ‡ Mean ± SEM * * * * * * † † † ‡ ‡ ‡ Mean + SEM Source: Anguera et al, Nature, 2013
  • 25. Akili’s Perspective + 12 ongoing/completed clinical studies In various populations with same game platform
  • 26. What We’ve Found Industry Wants Data, data, data Theoretical underpinning Intellectual Property Scientific culture Diversity in background
  • 27. Lessons from Clinical Studies Don’t assume you know who loves technology Small pilot studies add value Specific populations matter Reward cycles work…if you get it right
  • 29. Best practices to assess and enhance brain function via mobile devices and wearables Alex Doman, Co-founder of Sleep Genius
  • 30. Track and Treat: The Future of Wearables Alex Doman Co-Founder alex@sleepgenius.com
  • 31. Self Actualization “What a man can be, he must be.” -Abraham Maslow
  • 32. The Measured Life • Sensory Technology • Wearables • Sensor Technology • Data Visualization • Big Data
  • 33. Sleep Genius Personalized Sleep Reporting
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  • 39. TRACKING 1.6 million AGGREGATED TRACKING 8 million 2013 2014 • Consumer Adoption gains momentum • High Drop-off rates • Dozens of wearables • Apple Health Book/Google Fit TREATING 23 million 2015 • Corporate wellness adoption • Health Solutions PERSONALIZED COACHING 45 million 2017 • Data usefulness • Personalized coaching WEARABLES GROWTH PHASES TRACKING 200,000 # Wearable Devices
  • 40.
  • 41. Thank You! Alex Doman Sleep Genius alex@sleepgenius.com sleepgenius.com
  • 42. Best practices to assess and enhance brain function via mobile devices and wearables Joan Severson, President of Digital Artefacts
  • 43. Joan Severson 201 East Washington Street Suite 1302 Iowa City, IA 52240 Phone: (319) 431-3278 Email: joan@digitalartefacts.com October 29, 2014 BrainBaseline http://www.brainbaseline.com Copyright Digital Artefacts 2014
  • 44. BrainBaseline Why are we building the BrainBaselineTM platform “If you could give people information and tools that would delay the onset of cognitive impairment by a few years, you would be doing much to improve individuals’ quality of life as well as improving society.” Debra Cherry, PhD Alzheimer’s Association Copyright Digital Artefacts 2014
  • 45. BrainBaseline BrainBaseline’s Broad Objectives • Develop a global platform that integrates cognitive performance measures with lifestyle and biometric information to track brain health over time • Provide consumers, clinicians, pharmaceutical companies, and health care and wellness communities a better understanding of brain health and function across the lifespan. • Inform and educate consumers on evidence-based behavioral interventions to provide life-long cognitive health and wellness. • Accelerate discovery and reduce the cost of research, clinical trials, and clinical interventions. Copyright Digital Artefacts 2014
  • 46. BrainBaseline How many of you know your current weight? Blood pressure? How many of you know how well your brain is working (objectively)?
  • 47. The BrainBaseline platform provides any individual with a mobile device tools to measure, track and understand their own brain and cognitive functioning. BrainBaseline
  • 48. BrainBaseline BrainBaseline Platform BrainBaselineTM is designed as a modular platform that aggregates health and behavioral measures through embedded content and third party API integration. The cornerstone of the application is our suite of over 40 cognitive tasks, which allow us to determine the relationship between cognitive performance and other aspects of an individual’s behavior or physical health. We present this information to users in a way that is appealing and easy to understand; effectively, BrainBaseline is an education and research platform that provides users with an engaging means of understanding, testing, and improving their cognitive health. Copyright Digital Artefacts 2014
  • 49. BrainBaseline BrainBaseline 2.0 Platform Overview Lifestyle Activity Brain Drive Biometrics What makes BrainBaselineTM 2.0 unique is the ability to combine these measures to provide holistic snapshots of an individual’s psychological, physical and cognitive health, providing this information to users in a way that allows them to better understand how their brain health is linked to their behavior. Copyright Digital Artefacts 2014
  • 50. BrainBaseline Components of BrainBaseline 2.0 User Dashboard: The user dashboard acts as a hub that provides users with an overall snapshot of their current behavioral, cognitive, and lifestyle status in the form of summary scores and performance trend lines. The data are populated dynamically and can be adjusted instantly to provide social motivation, with users being allowed to see how their status in each domain compares to other anonymous users of the application in, e.g., their age group or location, as well as connecting with friends or family to compare scores against others in their social network. Copyright Digital Artefacts 2014
  • 53. BrainBaseline Components of BrainBaseline 2.0 User Information: (lifestyle, demographics) In the user information module, users answer a series of demographic questions, including, age, gender, income level, education, and geographic location, in addition to questions related to their preferred leisure activities, overall level of activity. Other specific questionnaires or self-report measures can be integrated on the basis of project-specific requirements. Copyright Digital Artefacts 2014
  • 55. BrainBaseline Components of BrainBaseline 2.0 Cognitive Testing: The cognitive testing module is the cornerstone of the BrainBaseline application. The tests are mapped to specific cognitive domains, are brief (individual tests take between 1 and 4 minutes), and are diverse in order to maximize both user engagement and data quality. Furthermore, the diversity and wide-ranging nature of BrainBaseline’s tests provide added sensitivity to cognitive change, allowing more accurate detection of decrements or improvements in cognition. Copyright Digital Artefacts 2014
  • 58. BrainBaseline Components of BrainBaseline 2.0 Activity: The activity module is a hub for users to monitor and aggregate information about their level of activity and sleep, and allows them to set activity and sleep goals that let them visualize and incentivize lifestyle changes that lead to optimal physical and cognitive health. Current functionality allows users to either self-report activity and sleep data, or integrate directly with their FitBit, Jawbone UP, and Body Media trackers for automated aggregation of these data. Copyright Digital Artefacts 2014
  • 60. BrainBaseline Components of BrainBaseline 2.0 Biometrics: The Biometrics module allows users to aggregate biometric information such as weight, blood pressure, heart rate, or blood-glucose level over time. Users are able to set specific goals related to target levels of specific biometric variables (e.g., blood pressure) as well as trend this information over time. Copyright Digital Artefacts 2014
  • 62. BrainBaseline Components of BrainBaseline 2.0 Medication tracking : Future development is planned to support integration of medication reminders, as well as tracking of prescription/over the counter pharmaceutical use and dosage over time. Copyright Digital Artefacts 2014
  • 63. BrainBaseline 1 Million self administered consumer based tests by 2015 Copyright Digital Artefacts 2014
  • 64. BrainBaseline Developing models for assessing and classifying change over time BrainBaseline allows for classification of an individual’s cognitive performance relative to their own peer group or population sub-group. We are developing models to classify the predicted or average slope of change across multiple testing sessions for each population sub-group Population sub-groups are determined by factors that are likely to stay stable over time (e.g., race, income level, education, birth year, etc.) This predicted slope of change classifies what is the “expected” performance for a given individual meeting a population characteristics Copyright Digital Artefacts 2014
  • 65. BrainBaseline Developing models for assessing and classifying change over time Predicted slope of change also allows for classification of people who display aberrant (e.g., outlier) performance for their population group E.g., people who’s slope of change is increasing or decreasing at a different rate than their population sub-group. This measure may provide an index of people who are outliers for their own population sub-group, and may provide a nuanced, stable index of people who are at risk for early cognitive decline. Copyright Digital Artefacts 2014
  • 66. BrainBaseline Subgroup classification to behavior, lifestyle, and biometrics assessment Analysis of full dataset will be independently performed by research collaborators at the University of Illinois at Urbana-Champaign. Analysis of relationship between survey based report of physical activity and cognitive function Analysis of relationship between wearable sensor based physical activity sensor data and cognitive function Analysis of relationship between survey based reporting of biometrics, heart rate, BP, glucose measures, and cognitive function Analysis of relationship between consumer sensor based reporting of biometrics, heart rate, BP, glucose measures, and cognitive function Copyright Digital Artefacts 2014
  • 67. BrainBaseline BrainBaseline 2.0 Platform Overview BrainBaseline 2.0 is a scalable platform capable of integrating data from many varying systems, developed both internally and externally, into cognitive profiles for varying populations ranging from individual users up to groups based on activity, biometrics, demographics and other factors. The platform itself focuses on data security, reliability and extensibility. BrainBaseline integration with Apple HealthKit and Electronic Health Records Electronic Health Records Copyright Digital Artefacts 2014
  • 68. In conjunction with UCSD department of psychiatry we have received NIH funding to develop an iPad-based screening measure for HIV-associated neurocognitive disorders. • Screening takes 10 minutes to complete • Self administered in clinic waiting room • Automated scoring and reporting • Aggregated data • HIPPA compliant infrastructure • Multiple language support, native iOS development • Global Research sties • US, Japan, South Africa BrainBaseline Clinical Screening Instruments Copyright Digital Artefacts 2014
  • 69. Joan Severson 201 East Washington Street Suite 1302 Iowa City, IA 52240 Phone: (319) 431-3278 Email: joan@digitalartefacts.com October 29, 2014 BrainBaseline http://www.brainbaseline.com Copyright Digital Artefacts 2014
  • 70.  To learn more, visit SharpBrains.com