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Update by Dr. Lew Lim, Founder & CEO of Vielight

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During Expo Day selected Summit Sponsors and Partners showcased their most promising brain health & wellness initiatives and solutions.

Dr. Lew Lim, Founder & CEO of Vielight, will explore the latest on photobiomodulation and brain stimulation.

Slidedeck supporting presentation and discussion during the 2019 SharpBrains Virtual Summit: The Future of Brain Health (March 7-9th). Learn more at:
https://sharpbrains.com/summit-2019/

Published in: Science
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Update by Dr. Lew Lim, Founder & CEO of Vielight

  1. 1. Discoveries in Transcranial Photobiomodulation Updates - May 2019 By: Lew Lim, PhD, MBA Founder & CEO Vielight Inc.
  2. 2. Transcranial Photobiomodulation (PBM) For Brain Training and Beyond
  3. 3. The Default Mode Network is targeted - a baseline template network for health –
  4. 4. 1. Can light really penetrate into the brain? 2. Does the brain respond? 3. Can it help?
  5. 5. Surprising discovery: Frequency-specific modifications Difference between Post and Pre in Active and Sham
  6. 6. Absolute power: Difference between Active and Sham A: Active B: Sham Pre-treatment Post-treatment
  7. 7. Pre-treatment Conceptual correction of ADHD
  8. 8. Surprising discovery: Overall inhibitory control on excitation Sham(post-pre) Active (post-pre) Active-sham (p=0.05)
  9. 9. Submitted for publication, April 2019 Confirmation with fMRI: PBM increases Inhibition Resting state: Evoked activity:
  10. 10. Effect with Gamma (40 Hz) on Dementia Patients
  11. 11. Baseline Week 12 Usual Care group PCC LPLP Connectivity between posterior cingulate cortex (PCC) seed and … Usual Care Group Baseline Week 12 T(3) Punc T(3) Punc L Lateral Parietal (LP) 6.88 0.006 3.89 0.03 R Lateral Parietal (LP) 8.34 0.004 5.04 0.02
  12. 12. Baseline Week 12 PBM Group Connectivity between posterior cingulate cortex (PCC) seed and … PBM Group Baseline Week 12 T(3) Punc T(3) Punc L Lateral Parietal (LP) 4.25 0.02 14.15 <0.001 R Lateral Parietal (LP) 3.98 0.03 11.17 0.002PCC LPLP
  13. 13. 228-subject pivotal double-blind RCT for FDA
  14. 14. 17 27 37 47 57 67 77 Pre-Tx 1Wk. Post- 18 Tx 1Mo. Post- 18 Tx 2Mo. Post- 18 Tx 3 Mo. Post- 18 Tx RawScore Emotional Outbursts, PTSD In-Office t-LED Treatments No-Treatment Period, after In-Office LED Treatments At-Home t-LED + Intranasal Treatments Whole Head, Treatment Only Default Mode Network 5 Cortical Node areas 40 Hz, Treatment Naeser, Martin, Ho, Krengel, Bogdanova, Knight, Fedoruk, Hamblin, Koo. NAALT Mtg. August 2018, Detroit Results of a CTE case with tPBM treatment Dr. Margaret Naeser Similar trends observed for: • Depression scores • Executive function & cognition • Sleep scores
  15. 15. Summary of Clinical Evidence • Acute outcome – PBM induces inhibition if necessary • Long-term outcome – Restoration of homeostatic baselines
  16. 16. Gamma produces superior learning in target detection Based on DARWARs threat anticipation/response training program (military) Double the learning rate Effect size of 1.4 Single-blind study of 40 subjects Initial test with Neuro Gamma by UNM US Army research lab
  17. 17. Sweet spots at 80 Hz, 120 Hz, 200 Hz or more Induced Altered States Observed in Meditation
  18. 18. Personalization is almost here
  19. 19. Thank You! lewlim@vielight.com Sign up for updates on photobiomodulation research: https://vielight.com/vielight-e-newsletter/

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