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Expo Day: Neuroenginnering, BPI, Arrowsmith Program & ARPF

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Selected Summit Sponsors and Partners showcase their most promising brain health & enhancement initiatives and solutions.

Noon-1pm. From tomorrow’s neuroengineering to today’s brain health
*Dr. Randal Koene, Lead Scientist at Kernel, discusses future directions of neuroenginnering and human computer interfaces.
*Dr. Leanne Young, Executive Director of the Brain Performance Institute at UT-Dallas Center for BrainHealth presents the new 62,000-square-foot Brain Performance Institute.

1-1.30pm. Debbie Gilmore, Executive Director of The Arrowsmith Program, will present plans to better equip 100+ schools helping students with special needs.

1.30-2pm. Dr. Chris Walling, Chairman of the Educational Advisory Committee at The Alzheimer’s Research and Prevention Foundation (ARPF), will present the new Brain Longevity Therapy Training.

*Álvaro Fernández, CEO and Editor-in-Chief of SharpBrains
*Sarah Lenz Lock, Senior Vice President for Policy at AARP and Executive Director of the Global Council on Brain Health (GCBH)
*Dr. April Benasich, Director of the Baby Lab at the Rutgers Center for Molecular and Behavioral Neuroscience
*Chaired by: Dr. Cori Lathan, Co-Chair of the World Economic Forum’s Council on the Future of Human Enhancement

Slidedeck supporting session held during the 2017 SharpBrains Virtual Summit: Brain Health & Enhancement in the Digital Age (December 5-7th). Learn more at: https://sharpbrains.com/summit-2017/

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Expo Day: Neuroenginnering, BPI, Arrowsmith Program & ARPF

  1. 1. 2017-2020 2018-2022 2025-2028 2027-2030 2035-2040 2036-2042 2040-2050 2055-2070 2060-2080 2075-2100
  2. 2. Dr. Randal Koene, Lead Scientist at Kernel, will discuss future directions of neuroenginnering and human computer interfaces Debbie Gilmore, Executive Director of The Arrowsmith Program, will present plans to better equip 100+ schools helping students with special needs Dr. Leanne Young, Executive Director of the Brain Performance Institute at UT- Dallas Center for BrainHealthwill present the new 62,000-square-foot Brain Performance Institute Dr. Chris Walling, Chairman of the Educational Advisory Committee at The Alzheimer’s Research and Prevention Foundation (ARPF), will present the new Brain Longevity Therapy Training
  3. 3. The Future of Neurotechnology: From Brain Augmentation to Whole Brain Emulation Randal A. Koene
  4. 4. Curing dysfunction & Overcoming limitations ● 20 years active in overcoming limitations, mind upgradable ● [1] Academia… [2] non-profit CarbonCopies.org 501(c)(3)... [3] VC fund (osfund.co), [4] for-profit startups (kernel.co) ● Next?
  5. 5. Beyond medical need NATURAL SELECTION SPECIFIC CHALLENGES LIMITED in several dimensions
  6. 6. Challenge: Different experiences of machine & human Imposed on us Chosen by us The experienced universe depends on the brain that experiences it. A society depends on the brains that are connected: bee colony vs human vs human+machine.
  7. 7. Biological mechanism vs Language of Cognition How deep is the rabbit hole? Hahn et al 2010 Spatio-temporal Spike Codes
  8. 8. Interfaces, Prostheses & Whole Brain Emulation Neural Interfaces: provide access Neural prostheses: improve fundamentals - neuron speed - synapse reliability - new cognitive modules Ultimately: run many/all mental functions on prosthetic hardware
  9. 9. Whole Brain Emulation Def.: Whole Brain Emulation: Collecting data at resolution and scale sufficient to capture functionally relevant features of brain circuits from which mind and cognitive functions emerge. Using that data in a new working implementation, a new brain.
  10. 10. Invasive & optical functional recording new imaging - for small brains very soon: ultradense (>1 recording per neuron, easy decode) arrays with >million electrodes light sheet fluorescent, Ehrens & Keller (HHM), 2013 optrode stim., Boyden, 2013 polytrode, Swindale lab (UBC), from 2004 1024 sites per probe, Masmanides lab (UCLA), 2015
  11. 11. Neural Interfaces Utah array / Braingate Openwater, Mary Lou Jepsen Diffuse Optical Imaging/Tomography & Event-Related Optical Signal fMRI, Jack Gallant 3D Photoacoustic Tomography 2009 2011 2016 2016
  12. 12. The future of sensorize body & brain neural dust, Maharbiz/Carmena labs (UC Berkeley) electrical nanowire optical stimulation to optical recording intravascular recording concept wireless free-floating recording & stimulation multi-modal, e.g. ultrasound+electromagnetic
  13. 13. EM 3D reconstruction of a connectome “We are our connectomes” - Sebastian Seung (MIT) Electron Microscopy Mikula/Denk, 2012
  14. 14. The future of connectomics Expansion Microscopy + Molecular Barcoding Church lab (Harvard), 2014 Boyden lab (MIT), 2014 molecular ticker-tape
  15. 15. Biggest problem: Parameterizing a working model Infer function from structure: in the future Functional system identification: today ?
  16. 16. Constraining parameters through better understanding Approaches: system identification constraining neuron parameters (Human Brain Project) HBP (2015)
  17. 17. Berger et al, USC Neuroprosthesis by System Identification NOT the same as a 'simulation' that abstracts function Learn transfer function for input spike patterns to output spike patterns: predict spatio-temporal spike patterns
  18. 18. Example: Neuroprosthesis of Hippocampus Berger et al., 2010-16
  19. 19. Pace of advances in neural recording Stevenson and Kording, 2011
  20. 20. Non-invasive recording interface Stimulation interface Pervasive body-brain interfaces/sensors Neural circuit reverse engineering in animal Neuroprosthetic medical devices Patients with superpowers Multi-region neural prostheses Neural prosthesis based whole brain emulation Structure to Function system identification library Whole brain emulation from connectome (including preserved brains) 2017-2020 2018-2022 2025-2028 2027-2030 2035-2040 2036-2042 2040-2050 2055-2070 2060-2080 2075-2100
  21. 21. In brief Who is doing this? - academia, Kernel, NeuraLink, Brain Preservation Foundation, Carboncopies Is it me? - neuroprosthesis vs scan&copy Magical consciousness: ‘analog’, ‘quantum’, multilayed nonlinear system with feedback, IIT vs circuit models Predicting what will happen & ethical challenges
  22. 22. Thank youThank you
  23. 23. Brain Performance Institute Better Your Brain Leanne Young, PhD, Executive Director, Brain Performance Institute
  24. 24. OVERVIEW Leveraging over 30 years of BrainHealth research to deliver transformative brain-science innovations to the public.
  25. 25. DRIVERS FOR TOOLS TO BETTER OUR BRAINS • Educational Gaps • Technological Competency • Technology Impact • Working Environments Organisation for Economic Co-operation and Development PISA – Program for international student assessment
  26. 26. DRIVERS FOR TOOLS TO BETTER OUR BRAINS • Educational Gaps • Technological Competency • Technology Impact • Working Environments Organisation for Economic Co-operation and Development PIAAC – Program for international assessment of adult competencies
  27. 27. DRIVERS FOR TOOLS TO BETTER OUR BRAINS • Educational Gaps • Technological Competency • Technology Impact • Working Environments (Mark, et al 2013) (T-Mobile 2012)
  28. 28. DRIVERS FOR TOOLS TO BETTER OUR BRAINS • Educational Gaps • Technological Competency • Technology Impact • Working Environments Adrian F. Ward, et al. Brain Drain: The Mere Presence of One’s Own Smartphone Reduces Available Cognitive Capacity. Journal of the Association for Consumer Research 2017, 2:140-154. DOI: 10.1086/691462
  29. 29. MAXIMIZING COGNITIVE POTENTIAL ▪ Complex Thinking ▪ Corporate Training ▪ Brain Resilience ▪ Teen Reasoning ▪ Physical Exercise ▪ Decision Making ▪ Benchmark & annual check up ▪ Neuromodulation Healthy Brain Performance▪ Autism/Aspergers ▪ ADHD ▪ Multiple Sclerosis ▪ Addiction ▪ Depression ▪ Alzheimer’s ▪ Mild Cognitive Impairment ▪ Frontotemporal dementia ▪ Bipolar disorder ▪ Concussion ▪ Traumatic Brain Injury (TBI) ▪ Stroke ▪ Brain Tumor ▪ Chemo Brain Disease / Disorder Injury ▪ Cognitive Reserve ▪ Resilience ▪ Prevention of Age- related Decline ▪ Improved Well-being ▪ Improved Performance Healthy Brain Maintenance
  30. 30. PROGRAMS • Brain Health and Performance Assessments • Cognitive Training • Scientifically- based Mindfulness • Social Cognition Training • Assesses mental abilities that support agile, adaptive, and goal-oriented thinking. • Monitors changes to help build resilience and guard against decline. • Recommends ways to optimize brain health and daily performance. • On-line or one-on-one with a clinician Innovation
  31. 31. PROGRAMS • Brain Health and Performance Assessments • Cognitive Training • Scientifically- based Mindfulness • Social Cognition Training
  32. 32. PROGRAMS • Brain Health and Performance Assessments • Cognitive Training • Scientifically- based Mindfulness • Social Cognition Training MINDFULNESS = FOCUSED ATTENTION
  33. 33. PROGRAMS • Brain Health and Performance Assessments • Cognitive Training • Scientifically- based Mindfulness • Social Cognition Training
  34. 34. CURRENT REACH 1st Responders
  35. 35. THE NEXT STEP: BRAINHEALTH 2027 • Aspirational goal: Double Brain Performance in 10 years! • Consortium of Partners dedicated to: – Developing brain health vitals – Conducting 10-year interventional study – Mind-to-molecule Research – Technology Development
  36. 36. QUESTIONS?
  37. 37. ARROWSMITH PROGRAM Plans to better equip schools helping students with learning difficulties Debbie Gilmore Executive Director Arrowsmith Program
  38. 38. What is the Arrowsmith Program? The Arrowsmith Program was developed by Barbara Arrowsmith Young in 1978 using the foundational concepts of neuroplasticity
  39. 39. What is the Arrowsmith Program? The Arrowsmith Program is a suite of cognitive programs comprised of intensive and graduated cognitive exercises that are designed to strengthen a series of cognitive functions that are hypothesized to underlie a range of specific learning difficulties. The program is facilitated by a trained Arrowsmith Program teacher in an educational setting. The 19 cognitive functions addressed by the Arrowsmith Program are those involved in reading, writing, auditory memory, non-verbal learning, reasoning, executive functioning, numeracy, visual memory and spatial awareness.
  40. 40. Vision Alleviate suffering through cognitive programs for everyone Mission To ensure that every primary school in the world has a cognitive program in each classroom, as well as individualized Arrowsmith Programs available for those who need it
  41. 41. Scalability Create a system that will support continued research Collect all raw student exercise data Improve accessibility Improve program delivery and administration
  42. 42. 2013 Teachers Students Administration Teacher:Student ratio = 1:10
  43. 43. 2017 Teacher App (Tablet) Student Portal (computer exercises) Arrowsmith Cognitive Tracking System Administration Big Data Teacher:Student ratio = 1:15
  44. 44. Teacher App Overview Teachers log in to the app installed on their tablet to access their student list for use in the classroom during each cognitive period Organization Progress and Engagement Goal Setting Changing Exercise Levels Student Exercise Settings Planning Mode- Use scheduling tool Track progress in real time Set goals on the tablet using data stored on the tablet Advance students through stages of the exercises Set exercise preferences using the tablet Planning Mode- View all students working on a specific exercise Track engagement in real time Calculate goals automatically using built in equations Verify mastery of the current level to move to the next level of an exercise Reset student password for the Student Portal Planning Mode-View all students and their exercises by period Access the history of progress and engagement every day Customize the display of goals to student via student portal Reassign to the next level of an exercise
  45. 45. Student Portal Overview Student logs in to the portal on their browser to access computer-based exercises All student work completed in the portal is automatically recorded and data is presented on the Teacher App
  46. 46. Arrowsmith Cognitive Tracking System Overview Teacher logs in to A.C.T.S. to perform administrative tasks and access student records Administrative Tasks: • Student Enrolment • Calendars • Classes • Data Extract • Access to Assessment protocols Student Records: • Student Information • Learning Profiles • Cognitive Programs • Reports
  47. 47. Integrated System Arrowsmith Cognitive Exercises Computer Exercises + Non-Computer Exercises Teacher Actions A.C.T.S. Administration + Data Tracking + Program Changes
  48. 48. www.alzheimersprevention.org Brain Longevity ® Therapy: How Meditation Can Help Prevent Alzheimer’s Disease Dr. Christopher Walling Chair, Education & Outreach Committee: ARPF.
  49. 49. Alzheimer’s Research and Prevention Foundation (ARPF): Founded in 1993 by Dharma Singh Khalsa, MD Mission: Dedicated to the Prevention of Alzheimer’s Disease by funding neuroscience research on meditation as an Integrative Medicine modality and providing educational outreach and memory screenings.
  50. 50. Alzheimer’s Research and Prevention Foundation (ARPF): Designing and funding groundbreaking work for 25 years: • Dedicating research to the prevention of Alzheimer’s through meditation and lifestyle • Revolutionizing the conventional medical wisdom • Establishing Alzheimer’s disease (AD) as a preventable disease that can even be effectively treated and often prevented via a brain-healthy lifestyle • Educating the public about the disease and ways to delay its development
  51. 51. The ARPF Four Pillars of Alzheimer’s Prevention 1. Diet and Brain Specific Nutrients 2. Stress Management 3. Exercise (Mental & Physical) 4. Spiritual Fitness (Combo of PWB & SWB)
  52. 52. 56 ARPF’s Groundbreaking Research - Examples of Pioneering Work
  53. 53. Research: Research Partners
  54. 54. Research: Contributions to Medical Textbooks
  55. 55. Research History: 30 Papers Published in Prestigious Medical Journals since 2010
  56. 56. Research: In 2017, ARPF research was published three times in the Journal of Alzheimer’s Disease
  57. 57. History: Organized the First Medical Conference on the Prevention of Alzheimer’s Disease (2003)
  58. 58. Kirtan Kriya Before After Khalsa, D. Newberg, A: Nuclear Medicine Communications, Sept. 2009
  59. 59. Posterior Cingulate Gyrus Up Khalsa, D.S., Newberg, A. Jl of Nuclear Med Communication 2009 Preventing Alzheimer’s in 12 Minutes a Day?
  60. 60. From: A pilot study of yogic meditation for family dementia caregivers with depressive symptoms: effects on mental health, cognition, and telomerase activity, Lavretsky H, Epel ES, Siddarth P, Nazarian N, St. Cyr N, Khalsa DS, Lin J, Blackburn E, Irwin MR, International Journal of Geriatric Psychiatry, (2012). Kirtan Kriya on Telomerase
  61. 61. Present Day: Presenting Research at Major Medical Conferences
  62. 62. Brain Longevity® Therapy Training Due to the aging of our population, there is a great need for evidence-based, lifestyle tools that help older adults stay mentally healthy and sharp, and remain active members of our community. Thus the creation of the Brain Longevity® Therapy Training.
  63. 63. Brain Longevity® Therapy Training Program Designed for: • Neuroscientists • Healthcare Providers • Leaders in the Healthcare Industry • Mental Health Therapists • Caregivers • Individuals who want to learn how to improve their own brain health Inaugural Class of 2017
  64. 64. Brain Longevity® Therapy Training High Praise for Training, testimonials from attendees: “The staff is exceptional and very accommodating. Materials and organization of curriculum was great and beyond expectations. Speakers were awesome and leaders in their field.” “The faculty is amazing. The research was interpreted in a meaningful way. I now have a program that I can share with my family and community.” “This was one of the most amazing experiences that I have had. The training exceeded all my expectations, and was so much more than a training... it was an awakening for all of us to go out into the world and make a difference.”
  65. 65. Brain Longevity® Therapy Training By end of 2017: • 46 certified teachers from across the USA and Mexico, Europe and Australia. • Various Brain Longevity Teachers are already presenting at conferences and in their community: • California Assisted Living Association • Aging and Brain Health Workshop –Colorado • California Yogafit Conference
  66. 66. Brain Longevity® Therapy Training Looking ahead to 2018: • Creating full suite of online courses for Brain Longevity Therapy Training • Conducting quarterly professional development webinars for certified teachers • March training at Kripalu Center for Yoga and Health (Mass).
  67. 67. To Learn More www.alzheimersprevention.org drchris@alzheimersprevention.org
  68. 68. To learn more, visit sharpbrains.com

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