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ACUTE APPENDICITIS
DR.SYED UBAID
ASSOCIATE PROFESSOR OF SURGERY
Introduction
• Vestigeal organ
• Surgical importance: Propensity for
inflammation
• Most important cause of “Acute Abdomen” in
young adults
• Appendicectomy is most common surgery
performed worldwide
3
History
• Recognition as clinical entity
Reginald Fitz ‘perforating
inflammation of the vermiform
appendix’
• Charles McBurney described
the clinical manifestation the
point of max. tenderness in the
right iliac fossa
Anatomy
• Present only in humans,
• At birth: Short & broad at its junction with the
Caecum
• Typical tubular structure produced by 02 years
of age
• Results from differential growth of caecum
Anatomy
• Position: constant  at the confluence of
the 03 taenia coli of caecum
• Mesoappendix : Arises from the lower surface
of the mesentery of terminal ileum
• Appendicular Artery: Branch of Ileo-colic
artery – End Artery
• 04-06 Lymphatic channels traverse
Mesoappendix ----------> Ileo-caecal LNs
Anatomy
• The three taeniae coli converge at the junction
of the cecum with the appendix and can be a
useful landmark to identify the appendix.
• The appendix can vary in length from <1 cm to
>30 cm; most appendices are 6 to 9 cm long.
ANATOMY
Microscopic anatomy
• Layers:
- Mucosa
- Submucosa
- Muscularis
- Serosa
Anatomy
Microscopic anatomy
• Lumen has longitudinal folds of mucous
membrane
• Lining: Columnar cells of colonic type
• Crypts: Argentaffin ( Kulchitsky cells )
• Submucosa: Lymphatic aggregations/Follicles
Anatomical Positions
RETROCAECAL 74%
PELVIC 21%
PARACAECAL 2%
SUBCAECAL 1.5%
PREILEAL 1%
POSTILEAL 0.5%
Anatomical positions
Etiology
• No unifying hypothesis
• Bacterial proliferation
• Initiating event is controversial
• Obstruction of appendix lumen
• Faecolith or fibrotic stricture
• Worm infestations: Oxyuris vermicularis
• Neoplasms: Ca caecum, carcinoids
• Viral
• No luminal obstruction
• Low dietary fibre
• A faecolith (sometimes referred to as an
‘appendicolith’) is composed of inspissated
faecal material, calcium phosphates,
bacteria and epithelial debris
Pathological sequence
Pathological sequence
Pathological sequence
Pathology
• Continued mucous secretion and inflammatory
exudation intraluminal pressure
obstructing lymphatic drainage.
• Edema and mucosal ulceration develop with
bacterial translocation to submucosa .
• Further distention may cause venous obstruction
and ischcemia of the appendix wall.
• Bacterial invasion through muscularis externea
producing acute appendicitis.
• Ischaemic necrosis of appendicular wall
gangrenous appendix bacterial contamination of
peritoneal cavity.
Pathology cont.
• Greater omentum becomes
adherent to inflamed
appendix paracaecal abscess
• Extremes of age
• Immunosuppression
• Faecolith obstruction
• Pelvic appendix
• Previous abdominal surgery
Pathology cont.
Pictorial Explanation
Appendiceal
obstruction/early
appendicitis – visceral
peritoneal irritation
Appendiceal distension Irritation of parietal
peritoneum (localised)
Perforation,
localised/generalised
peritonitis, mass
obstruction
Distention
mucus
Distention causing
Ischemia
Gangrene
Pathology
Lymphatic hyperplasia
Luminal obstruction
Increased intra-luminal pressure
Edema, mucosal ulceration
Bacterial translocation to submucosa
Pathology
Resolution Venous obstruction
Ischaemia of appendix wall
Invasion of muscularis propria, submucosa
Pathology
Acute Appendicitis Lump/mucocele
Gangrenous appendicitis
Peritonitis
Bacteriology of perforated appendicitis
TYPE OF BACTERIA PATIENTS (%)
ANAEROBIC
B. fragilis 80
B. thetiaotaomicron 61
Bilophila wadsworthia 55
Peptostrptococcus spp 46
AEROBIC
E.coli 77
S.viridans 43
Group D streptococcus 27
P.aeruginosa 18
Clinical features
Symptoms:
1. Periumbilical pain 50% cases
2. Pain shifts to RIF
3. Anorexia
4. Nausea/vomiting
Two clinical syndromes of acute appendicitis can
be discerned, acute catarrhal (non-
obstructive) appendicitis and acute
obstructive appendicitis, the latter
characterised by a more acute course.
The classical history
Periumbilical
pain
One or two
episodes of
vomiting
Right iliac fossa
pain
Anorexia
Nausea
Abdominal pain
• Visceral abdominal pain
• Somatic abdominal pain
• referred abdominal
Visceral abdominal pain
• Visceral abdominal pain, organs, visceral
peritoneum, mesentery
1-distention of a hollow viscus
2-ischemia to a viscus
3-inflammation
Referred to midline embryological development
Relevant Anatomy
umbilicus
ASIS
Pubic
symphisis
T6
T10
T12
unpaired
Paired organs
4. Innervation of appendix & other organs
Foregut
(inc. duodenum)
Midgut
(inc. appendix)
Hindgut
Lower urinary tract
Sexual organs
3/23/2017 33
Colicky pain
• Colicky pain form of visceral pain rhythmic
pain resulting from smooth muscle spasm as
a reaction to luminal obstruction
• intestinal obstruction, passage of gallstone in
biliary ducts, ureteric colic
• Often thought to be indigestion, constipation
and is frequently ignored.
• Lasts for a variable period, usually few hours
/ 2 or 3 days, rarely longer
3/23/2017 34
Referred pain
• The vague referred pain in the periumblical
• stretching of the lumen or spasm.
• The visceral innervation comes from the 10th
thoracic spinal segment.
• Accompany the sympathetic nerves through the
superior mesenteric plexus and the lesser
splanchnic nerve
• If the visceral innervation is higher, then the
mid-line pain will be higher.
• Testicular pain due to visceral referral of
afferent nerve impulses to the same spinal
segment
3/23/2017 35
Somatic pain
• Skin, fascia, muscle and parietal peritoneum
• Sever and precisely localized
• Inflamed parietal peritoneum cutaneous
hyperesthesia and tenderness
• The right iliac fossa pain is due to the irritation
of parietal peritoneum
• somatic pain as opposed to earlier visceral.
3/23/2017 36
Guarding and rigidity
• Guarding is the protective phenomenon
• abdominal muscles increase in tone
• attempts to localize the inflammation
• There is tenderness causing the patient to
constantly tense the abdominal wall
muscles in palpation
• Voluntary guarding /apparent guarding
• Involuntary guarding /true guarding
• Muscular spasm rigidity
• localized initially progressing to generalized
with perforation or increasing peritonitis
3/23/2017 37
Tenderness
• Tenderness:
–localised over McBurney's point
–not evident before later inflammation of
serosa and parietal peritoneum
–often masked in obese due to inability to
displace viscus
• Blumberg’s sign The pain is elicited with
pressing the abdominal wall deeply with
fingers and abruptly releasing it.
3/23/2017 38
Reflexes
• Visceral afferent fibers participate in reflex
activities. Reflex sweating, salivation, nausea,
vomiting and tachycardia may accompany
visceral pain.
• Carried by autonomic nerve fibers
3/23/2017 39
Signs
• lying still, with shallow breaths and reluctant to cough
• fever 37.5-38.5C, worsening with perforation
• Foetor oris - halitosis
• Furred tongue
• Flushed
• infrequently, diarrhoea:
– early and transient as a result of visceral pain
– later if retroileal or pelvic involvement appendix; this is
typically prolonged and mucoid
• constipation - sometimes for a few days before the
attack
3/23/2017 40
Signs to elicit in appendicitis
• Pointing sign
• Rovsing’s sign
• Psoas sign
• Obturator sign
3/23/2017 41
Pointing sign
3/23/2017 42
Psoas sign
3/23/2017 43
Obturator sign
Clinical features
• Signs:
1. Pyrexia
2. Localized tenderness in RIF
3. Muscle guarding
4. Rebound tenderness
5. Rovsing’s sign
6. Pointing sign
7. Psoas sign
8. Obturator sign
Clinical features
• Risk factors for perforation:
1. Extremes of age
2. Immunosuppression
3. Diabetes mellitus
4. Pelvic appendix
5. Previous abdominal surgery
“Typical” Presentation
• Dull, crampy central abdo pain
• Malaise/vomiting/anorexia/low grade fevers
• Pain worsens & localises to RIF with
cough/movement tenderness
• Systemic symptoms
Early Appendicitis
• Pain:
– Location: Periumbilical (T10)
– Character: Dull
– Over time: Colicky
– Associated symptoms:
• Vomiting
• Anorexia
obstruction
mucus
distention
Later Appendicitis
• Pain:
– Location: R Iliac Fossa
– Character: Localised
– Over time: Constant
– Aggravating: going over bumps, coughing,
walking
– Relieving: hip flexion, staying still
• Exam findings:
– “peritonism”
• Guarding
• rebound tenderness
• percussion tenderness
– Rovsing, psoas, other signs
Distention causing
ischaemia
Localised peritoneal
inflammation
Late Appendicitis
• Pain:
– Location: lower abdominal/generalised
– Character: diffuse, severe
– Over time: constant
– Aggravating: movement, coughing, palpation,
rebound
– Associated: Fever
• Exam findings:
– Systemic features- fever, tachycardia, hypotension
– Abdominal – severe, generalised “peritonism”
– RIF mass (sometimes)
Gangrene
Time Course
Appendiceal
obstruction/early
appendicitis – visceral
peritoneal irritation
• Periumbilical
colicky pain
Appendiceal distension
• Anorexia,
vomiting, malaise
Irritation of parietal
peritoneum (localised)
•Constant RIF pain,
pain on coughing,
going over bumps
etc
Perforation,
localised/generalised
peritonitis, mass
•Fever/Sepsis
Special clinical scenarios
• According to position:
1. Retro-caecal
- Silent appendix
- Quadratus lumborum rigidity
- Psoas sign
- Loin tenderness
Special clinical scenarios
2. Pelvic
- Early diarhoea
- Increased urinary frequency
- Deep tenderness over symphysis pubis
- DRE: Rectovesical pouch/POD tenderness
- Obturator/Psoas sign +ve
Special clinical scenarios
3. Post-ileal
- Diarrhoea
- Marked retching
- Ill defined tenderness to rt of umbilicus
Special clinical scenarios
• As per age:
1. Infants
- Uncommon <36 mths
- Difficult to diagnose
- Diffuse peritonitis common
- High incidence of perforation
Special clinical scenarios
2. Children
- Vomiting
- Marked anorexia
3. Elderly
- High incidence of gangrene & perforation
- Features of SAIO
4. Obese
- Diminished signs/ delayed dignosis
- Midline/ Laparoscopic approach
Special clinical scenarios
5. Pregnancy
- Most common extra-uterine cause of acute
abdomen
- Delayed presentation
- Fetal loss
• 3-5%
• Upto 20% : Perforation
Going through the sea of DDX
• Mesenteric lymphadenitis
• Acute appendicitis
• Henoch Schonlein purpura
• lobar pneumonia
• Meckel's diverticulitis
• Intussusception
• Ureteric stone
• Enterocolitis
• Familial Mediterranean fever
Differential Diagnosis
1. Children
- Gastroenteritis
- Mesenteric adenitis
- Meckel’s diverticulitis
- Intussusception
- HS purpura
- Lobar pneumonia
Differential Diagnosis
2. Adults
- Regional enteritis
- Ureteric colic
- Perforated peptic ulcer
- Torsion of testis
- Pancreatitis
- Rectus sheath haematoma
Differential Diagnosis
3. Adult female
- Mittelschmerz
- PID
- Pyelonephritis
- Ectopic pregnancy
- Torsion/ rupture of ovarian cyst
- Endometriosis
Differential Diagnosis
4. Elderly
- Diverticulitis
- Intestinal obstruction
- Ca colon
- Mesenteric infarction
- Torsion of appendix epiploicae
- Leaking aortic aneurysm
Differential Diagnosis
5. Rare
- Tabetic crisis
- Spinal conditions
- Porphyria
- Diabetes
- Typhilitis
Investigations
• Diagnosis is essentially clinical
• Clinical diagnosis alone
- 15-30% negative appendicectomy
• Use of
- Clinical scoring systems
- Imaging modalities
- Diagnostic Laparoscopy
- Routine laboratory examinations
Alvardo Score
ALVORADO Score
Migratory RIF pain 1
Symptoms Anorexia 1
Nausea & vomiting 1
RIF tenderness 2
Signs Rebound tenderness 1
Elevated temperature 1
Laboratory Leucocytosis 2
Shift to left 1
_______________________________________
Total 10
ALVORADO Score
• < 4: Excludes diagnosis
• 5-6: Equivocal
• >7 : Strongly s/o appendicitis
• Modified Alvorado Score:
- 9 points
- Differential count not done
• PAS:
- Total : 10
- Rebound tenderness excluded
- Cough/percussion/hopping tendeness = 2
- Leucocytosis > 10,000  1
Tzanakis Score
1. Rt lower abdominal tenderness = 4
2. Rebound tenderness = 3
3. WBC’s> 12,000 in the blood = 2
4. Positive USS findings of appendicitis = 6
• Total score = 15
• > 8 = 96% chances
X-ray signs
• Reported signs include:
• increased soft tissue density in the right lower
quadrant
• a faecolith in the right iliac fossa
– the majority are radio-opaque
– occur in about 10% of those with appendicitis
– often mistaken for ureteric calculus or gallstones
• a gas-filled appendix
• free intraperitoneal gas
Plain Abdominal X-Rays
• Low sensitivity
• Appendicoliths picked up in only 10-15% cases
• Can be combined with Barium enema
• Failure of appendix to “Fill up”
• Low specificity  20% of normal Appendices
do not fill up
X-rays
X ray abdomen
US Scans
• Sensitivity = 85% Operator based
• Specificity > 90%
• AP dia appendix > 7mm
• CROSS SECTIONAL VIEW:
- Thick walled
- Non compressible luminal structure : Target Lesion
• Periappendiceal fluid/ Mass
USG
•
Inflamed appendix on U/S
Inflamed appendix
3/23/2017 76
Ultrasound
3/23/2017 77
Color-flow Ultrasound
Computed Tomography
• Commonly used in the West
• 5mm slices :
- Sensitivity: 90%
- Specificity: 80 – 90%
• RCT for 64-MDCT: 95% accuracy
• Sensitivity PROPORTIONATE TO Severity
• Faecoliths/Appendicoliths detected in 50% pts
of appendicits ???
Computed Tomography
• Classical findings:
- Distended appendix > 7mm diameter
- Halo/ Target sign
- Periappendiceal fat stranding
- Edema
- Peritoneal fluid
- Phlegmon
- Periappendiceal abscess
Computed Tomography
• Rational use:
- Elderly
- Atypical presentations
- Neoplasms
- Acute diverticulits
- Intestinal obstruction
• MRI: ??
CT Scan images of Appendicitis:
1. enlarged appendix 2. appendiceal wall thickening
Source:Choi D, Park H, Lee YR, Kook SH, Kim SK, Kwag HJ, Chung EC. The most useful findings
for diagnosing acute appendicitis on contrast-enhanced helical CT. Acta Radiologica 44 (2003) 574-
CT Scan images of Appendicitis
3. appendicolith 4.periappendiceal fat stranding
Source:Choi D, Park H, Lee YR, Kook SH, Kim SK, Kwag HJ, Chung EC. The most useful findings
for diagnosing acute appendicitis on contrast-enhanced helical CT. Acta Radiologica 44 (2003) 574-
3/23/2017 83
CT-scan
Diagnostic Laparoscopy
• Small fraction of pts
• Women of child bearing age
• Prompt intervention ------- Implications on
future fertility
Laboratory Examinations
• WBC’s elevated
• Normal in 10% cases
• TLC > 20,000 s/o PERFORATION
• Polymorphs > 75%
• Minimal pyuria Common
• Microscopic haematuria
Appendiceal Rupture
Immediate appendectomy has long been the recommended treatment for acute appendicitis
because of the presumed risk of progression to rupture.
The overall rate of perforated appendicitis is 25.8%. Children <5 years of age and patients >65
years of age have the highest rates of perforation (45 and 51%, respectively)
delays in presentation are responsible for the majority of perforated appendices.
Appendiceal rupture occurs most frequently distal to the point of luminal obstruction along
the antimesenteric border of the
appendix. Rupture should be suspected in the presence of fever with a temperature of
>39°C (102°F) and a white blood cell
count of >18,000 cells/mm3
Options
• Open / traditional surgery
• Laparoscopic
• Natural orifice surgery (no incision
appendectomy )
Appendicectomy - Open
• Incision over McBurney’s point or point of
maximal tenderness
• Straightforward, good exposure, technically
easier
• Longer recovery, risk of hernia & adhesions,
can’t see pelvic structures as well
Open appendetomy
• For open appendectomy most surgeons use either a McBurney
(oblique) or Rocky-Davis (transverse) right lower quadrant muscle-
splitting incision in patients with suspected appendicitis. The
incision should be centered over either the point of maximal
tenderness or a palpable mass
Open / traditional
• if incision is perpendicular to the line :
• Grid iron incision
• Why called grid iron ?
• if better access is needed , one
can change gridiron to
Rutherford Morrison's incision
• Lanz incision (transverse skin crease incision ,
2cm below umbilicus at mid-clavicular line)
Gridiron vs. Lanz
layers
Steps of operation in appendicitis
Steps of operation in appendicitis
Steps of operation in appendicitis
Steps of operation in appendicitis
Steps of operation in retrocaecal appendicitis
Steps of operation in retrocaecal retroperitoneal
appendicitis
Almost done
Then
• put drain if you find dirty iliac fossa ,
otherwise :
• suture .
Laparoscopic appendetomy
• Laparoscopic appendectomy usually requires the use of three
ports. Four ports may occasionally be necessary to mobilize a
retrocecal appendix. The surgeon usually stands to the patient's
left. One assistant is required to operate the camera. One trocar is
placed in the umbilicus (10 mm), and a second trocar is placed in
the suprapubic position. Some surgeons place this second port in
the left lower quadrant. The suprapubic trocar is either 10 or 12
mm, depending on whether or not a linear stapler will be used.
• The placement of the third trocar (5 mm) is variable and usually is
either in the left lower quadrant, epigastrium, or right upper
quadrant.
Laparoscopic access
Appendicectomy - Laparoscopic
• “Keyhole” surgery
• Lower complication rate, quicker
recovery
• Sometimes difficulty in mobilisation
requiring open procedure
Natural orifice surgery
• No incision appendectomy
• Using the natural orifices like
anal canal endoscopically or
trans-vaginally .
• Less pain
• No scar
• Less hospital stay
• Fewer complications
• It takes about 50 minutes
3/23/2017 106
Meckel’s diverticulum
Management of Appendicular
abscess/Lump
• Late presentation
• Clinically mass & fever
• Subject to imaging studies to ascertain:
- Presence
- Size
• > 4-6cms  Antibiotics+Drainage
• < 4 cms  Conservative mgt(Oschner
Sherren’s Regime)
Management of Appendicular
abscess/Lump
• Criteriae for stopping conservative mgt:
- Rising pulse rate
- Increase in the size of the mass
- Increasing/ spreading abdominal pain
THANK YOU FOR YOUR KIND PATIENCE

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Acute appendicitis &amp;lump

  • 2. Introduction • Vestigeal organ • Surgical importance: Propensity for inflammation • Most important cause of “Acute Abdomen” in young adults • Appendicectomy is most common surgery performed worldwide
  • 3. 3 History • Recognition as clinical entity Reginald Fitz ‘perforating inflammation of the vermiform appendix’ • Charles McBurney described the clinical manifestation the point of max. tenderness in the right iliac fossa
  • 4. Anatomy • Present only in humans, • At birth: Short & broad at its junction with the Caecum • Typical tubular structure produced by 02 years of age • Results from differential growth of caecum
  • 5. Anatomy • Position: constant  at the confluence of the 03 taenia coli of caecum • Mesoappendix : Arises from the lower surface of the mesentery of terminal ileum • Appendicular Artery: Branch of Ileo-colic artery – End Artery • 04-06 Lymphatic channels traverse Mesoappendix ----------> Ileo-caecal LNs
  • 6. Anatomy • The three taeniae coli converge at the junction of the cecum with the appendix and can be a useful landmark to identify the appendix. • The appendix can vary in length from <1 cm to >30 cm; most appendices are 6 to 9 cm long.
  • 8. Microscopic anatomy • Layers: - Mucosa - Submucosa - Muscularis - Serosa
  • 10. Microscopic anatomy • Lumen has longitudinal folds of mucous membrane • Lining: Columnar cells of colonic type • Crypts: Argentaffin ( Kulchitsky cells ) • Submucosa: Lymphatic aggregations/Follicles
  • 11. Anatomical Positions RETROCAECAL 74% PELVIC 21% PARACAECAL 2% SUBCAECAL 1.5% PREILEAL 1% POSTILEAL 0.5%
  • 13. Etiology • No unifying hypothesis • Bacterial proliferation • Initiating event is controversial • Obstruction of appendix lumen • Faecolith or fibrotic stricture • Worm infestations: Oxyuris vermicularis • Neoplasms: Ca caecum, carcinoids • Viral • No luminal obstruction • Low dietary fibre
  • 14. • A faecolith (sometimes referred to as an ‘appendicolith’) is composed of inspissated faecal material, calcium phosphates, bacteria and epithelial debris
  • 18. Pathology • Continued mucous secretion and inflammatory exudation intraluminal pressure obstructing lymphatic drainage. • Edema and mucosal ulceration develop with bacterial translocation to submucosa . • Further distention may cause venous obstruction and ischcemia of the appendix wall. • Bacterial invasion through muscularis externea producing acute appendicitis. • Ischaemic necrosis of appendicular wall gangrenous appendix bacterial contamination of peritoneal cavity.
  • 19. Pathology cont. • Greater omentum becomes adherent to inflamed appendix paracaecal abscess • Extremes of age • Immunosuppression • Faecolith obstruction • Pelvic appendix • Previous abdominal surgery
  • 21. Pictorial Explanation Appendiceal obstruction/early appendicitis – visceral peritoneal irritation Appendiceal distension Irritation of parietal peritoneum (localised) Perforation, localised/generalised peritonitis, mass obstruction Distention mucus Distention causing Ischemia Gangrene
  • 22.
  • 23. Pathology Lymphatic hyperplasia Luminal obstruction Increased intra-luminal pressure Edema, mucosal ulceration Bacterial translocation to submucosa
  • 24. Pathology Resolution Venous obstruction Ischaemia of appendix wall Invasion of muscularis propria, submucosa
  • 26. Bacteriology of perforated appendicitis TYPE OF BACTERIA PATIENTS (%) ANAEROBIC B. fragilis 80 B. thetiaotaomicron 61 Bilophila wadsworthia 55 Peptostrptococcus spp 46 AEROBIC E.coli 77 S.viridans 43 Group D streptococcus 27 P.aeruginosa 18
  • 27. Clinical features Symptoms: 1. Periumbilical pain 50% cases 2. Pain shifts to RIF 3. Anorexia 4. Nausea/vomiting
  • 28. Two clinical syndromes of acute appendicitis can be discerned, acute catarrhal (non- obstructive) appendicitis and acute obstructive appendicitis, the latter characterised by a more acute course.
  • 29. The classical history Periumbilical pain One or two episodes of vomiting Right iliac fossa pain Anorexia Nausea
  • 30. Abdominal pain • Visceral abdominal pain • Somatic abdominal pain • referred abdominal
  • 31. Visceral abdominal pain • Visceral abdominal pain, organs, visceral peritoneum, mesentery 1-distention of a hollow viscus 2-ischemia to a viscus 3-inflammation Referred to midline embryological development
  • 32. Relevant Anatomy umbilicus ASIS Pubic symphisis T6 T10 T12 unpaired Paired organs 4. Innervation of appendix & other organs Foregut (inc. duodenum) Midgut (inc. appendix) Hindgut Lower urinary tract Sexual organs
  • 33. 3/23/2017 33 Colicky pain • Colicky pain form of visceral pain rhythmic pain resulting from smooth muscle spasm as a reaction to luminal obstruction • intestinal obstruction, passage of gallstone in biliary ducts, ureteric colic • Often thought to be indigestion, constipation and is frequently ignored. • Lasts for a variable period, usually few hours / 2 or 3 days, rarely longer
  • 34. 3/23/2017 34 Referred pain • The vague referred pain in the periumblical • stretching of the lumen or spasm. • The visceral innervation comes from the 10th thoracic spinal segment. • Accompany the sympathetic nerves through the superior mesenteric plexus and the lesser splanchnic nerve • If the visceral innervation is higher, then the mid-line pain will be higher. • Testicular pain due to visceral referral of afferent nerve impulses to the same spinal segment
  • 35. 3/23/2017 35 Somatic pain • Skin, fascia, muscle and parietal peritoneum • Sever and precisely localized • Inflamed parietal peritoneum cutaneous hyperesthesia and tenderness • The right iliac fossa pain is due to the irritation of parietal peritoneum • somatic pain as opposed to earlier visceral.
  • 36. 3/23/2017 36 Guarding and rigidity • Guarding is the protective phenomenon • abdominal muscles increase in tone • attempts to localize the inflammation • There is tenderness causing the patient to constantly tense the abdominal wall muscles in palpation • Voluntary guarding /apparent guarding • Involuntary guarding /true guarding • Muscular spasm rigidity • localized initially progressing to generalized with perforation or increasing peritonitis
  • 37. 3/23/2017 37 Tenderness • Tenderness: –localised over McBurney's point –not evident before later inflammation of serosa and parietal peritoneum –often masked in obese due to inability to displace viscus • Blumberg’s sign The pain is elicited with pressing the abdominal wall deeply with fingers and abruptly releasing it.
  • 38. 3/23/2017 38 Reflexes • Visceral afferent fibers participate in reflex activities. Reflex sweating, salivation, nausea, vomiting and tachycardia may accompany visceral pain. • Carried by autonomic nerve fibers
  • 39. 3/23/2017 39 Signs • lying still, with shallow breaths and reluctant to cough • fever 37.5-38.5C, worsening with perforation • Foetor oris - halitosis • Furred tongue • Flushed • infrequently, diarrhoea: – early and transient as a result of visceral pain – later if retroileal or pelvic involvement appendix; this is typically prolonged and mucoid • constipation - sometimes for a few days before the attack
  • 40. 3/23/2017 40 Signs to elicit in appendicitis • Pointing sign • Rovsing’s sign • Psoas sign • Obturator sign
  • 44. Clinical features • Signs: 1. Pyrexia 2. Localized tenderness in RIF 3. Muscle guarding 4. Rebound tenderness 5. Rovsing’s sign 6. Pointing sign 7. Psoas sign 8. Obturator sign
  • 45. Clinical features • Risk factors for perforation: 1. Extremes of age 2. Immunosuppression 3. Diabetes mellitus 4. Pelvic appendix 5. Previous abdominal surgery
  • 46. “Typical” Presentation • Dull, crampy central abdo pain • Malaise/vomiting/anorexia/low grade fevers • Pain worsens & localises to RIF with cough/movement tenderness • Systemic symptoms
  • 47. Early Appendicitis • Pain: – Location: Periumbilical (T10) – Character: Dull – Over time: Colicky – Associated symptoms: • Vomiting • Anorexia obstruction mucus distention
  • 48. Later Appendicitis • Pain: – Location: R Iliac Fossa – Character: Localised – Over time: Constant – Aggravating: going over bumps, coughing, walking – Relieving: hip flexion, staying still • Exam findings: – “peritonism” • Guarding • rebound tenderness • percussion tenderness – Rovsing, psoas, other signs Distention causing ischaemia Localised peritoneal inflammation
  • 49. Late Appendicitis • Pain: – Location: lower abdominal/generalised – Character: diffuse, severe – Over time: constant – Aggravating: movement, coughing, palpation, rebound – Associated: Fever • Exam findings: – Systemic features- fever, tachycardia, hypotension – Abdominal – severe, generalised “peritonism” – RIF mass (sometimes) Gangrene
  • 50. Time Course Appendiceal obstruction/early appendicitis – visceral peritoneal irritation • Periumbilical colicky pain Appendiceal distension • Anorexia, vomiting, malaise Irritation of parietal peritoneum (localised) •Constant RIF pain, pain on coughing, going over bumps etc Perforation, localised/generalised peritonitis, mass •Fever/Sepsis
  • 51. Special clinical scenarios • According to position: 1. Retro-caecal - Silent appendix - Quadratus lumborum rigidity - Psoas sign - Loin tenderness
  • 52. Special clinical scenarios 2. Pelvic - Early diarhoea - Increased urinary frequency - Deep tenderness over symphysis pubis - DRE: Rectovesical pouch/POD tenderness - Obturator/Psoas sign +ve
  • 53. Special clinical scenarios 3. Post-ileal - Diarrhoea - Marked retching - Ill defined tenderness to rt of umbilicus
  • 54. Special clinical scenarios • As per age: 1. Infants - Uncommon <36 mths - Difficult to diagnose - Diffuse peritonitis common - High incidence of perforation
  • 55. Special clinical scenarios 2. Children - Vomiting - Marked anorexia 3. Elderly - High incidence of gangrene & perforation - Features of SAIO 4. Obese - Diminished signs/ delayed dignosis - Midline/ Laparoscopic approach
  • 56. Special clinical scenarios 5. Pregnancy - Most common extra-uterine cause of acute abdomen - Delayed presentation - Fetal loss • 3-5% • Upto 20% : Perforation
  • 57. Going through the sea of DDX • Mesenteric lymphadenitis • Acute appendicitis • Henoch Schonlein purpura • lobar pneumonia • Meckel's diverticulitis • Intussusception • Ureteric stone • Enterocolitis • Familial Mediterranean fever
  • 58. Differential Diagnosis 1. Children - Gastroenteritis - Mesenteric adenitis - Meckel’s diverticulitis - Intussusception - HS purpura - Lobar pneumonia
  • 59. Differential Diagnosis 2. Adults - Regional enteritis - Ureteric colic - Perforated peptic ulcer - Torsion of testis - Pancreatitis - Rectus sheath haematoma
  • 60. Differential Diagnosis 3. Adult female - Mittelschmerz - PID - Pyelonephritis - Ectopic pregnancy - Torsion/ rupture of ovarian cyst - Endometriosis
  • 61. Differential Diagnosis 4. Elderly - Diverticulitis - Intestinal obstruction - Ca colon - Mesenteric infarction - Torsion of appendix epiploicae - Leaking aortic aneurysm
  • 62. Differential Diagnosis 5. Rare - Tabetic crisis - Spinal conditions - Porphyria - Diabetes - Typhilitis
  • 63. Investigations • Diagnosis is essentially clinical • Clinical diagnosis alone - 15-30% negative appendicectomy • Use of - Clinical scoring systems - Imaging modalities - Diagnostic Laparoscopy - Routine laboratory examinations
  • 65. ALVORADO Score Migratory RIF pain 1 Symptoms Anorexia 1 Nausea & vomiting 1 RIF tenderness 2 Signs Rebound tenderness 1 Elevated temperature 1 Laboratory Leucocytosis 2 Shift to left 1 _______________________________________ Total 10
  • 66. ALVORADO Score • < 4: Excludes diagnosis • 5-6: Equivocal • >7 : Strongly s/o appendicitis • Modified Alvorado Score: - 9 points - Differential count not done • PAS: - Total : 10 - Rebound tenderness excluded - Cough/percussion/hopping tendeness = 2 - Leucocytosis > 10,000  1
  • 67. Tzanakis Score 1. Rt lower abdominal tenderness = 4 2. Rebound tenderness = 3 3. WBC’s> 12,000 in the blood = 2 4. Positive USS findings of appendicitis = 6 • Total score = 15 • > 8 = 96% chances
  • 68. X-ray signs • Reported signs include: • increased soft tissue density in the right lower quadrant • a faecolith in the right iliac fossa – the majority are radio-opaque – occur in about 10% of those with appendicitis – often mistaken for ureteric calculus or gallstones • a gas-filled appendix • free intraperitoneal gas
  • 69. Plain Abdominal X-Rays • Low sensitivity • Appendicoliths picked up in only 10-15% cases • Can be combined with Barium enema • Failure of appendix to “Fill up” • Low specificity  20% of normal Appendices do not fill up
  • 72. US Scans • Sensitivity = 85% Operator based • Specificity > 90% • AP dia appendix > 7mm • CROSS SECTIONAL VIEW: - Thick walled - Non compressible luminal structure : Target Lesion • Periappendiceal fluid/ Mass
  • 78. Computed Tomography • Commonly used in the West • 5mm slices : - Sensitivity: 90% - Specificity: 80 – 90% • RCT for 64-MDCT: 95% accuracy • Sensitivity PROPORTIONATE TO Severity • Faecoliths/Appendicoliths detected in 50% pts of appendicits ???
  • 79. Computed Tomography • Classical findings: - Distended appendix > 7mm diameter - Halo/ Target sign - Periappendiceal fat stranding - Edema - Peritoneal fluid - Phlegmon - Periappendiceal abscess
  • 80. Computed Tomography • Rational use: - Elderly - Atypical presentations - Neoplasms - Acute diverticulits - Intestinal obstruction • MRI: ??
  • 81. CT Scan images of Appendicitis: 1. enlarged appendix 2. appendiceal wall thickening Source:Choi D, Park H, Lee YR, Kook SH, Kim SK, Kwag HJ, Chung EC. The most useful findings for diagnosing acute appendicitis on contrast-enhanced helical CT. Acta Radiologica 44 (2003) 574-
  • 82. CT Scan images of Appendicitis 3. appendicolith 4.periappendiceal fat stranding Source:Choi D, Park H, Lee YR, Kook SH, Kim SK, Kwag HJ, Chung EC. The most useful findings for diagnosing acute appendicitis on contrast-enhanced helical CT. Acta Radiologica 44 (2003) 574-
  • 84. Diagnostic Laparoscopy • Small fraction of pts • Women of child bearing age • Prompt intervention ------- Implications on future fertility
  • 85. Laboratory Examinations • WBC’s elevated • Normal in 10% cases • TLC > 20,000 s/o PERFORATION • Polymorphs > 75% • Minimal pyuria Common • Microscopic haematuria
  • 86. Appendiceal Rupture Immediate appendectomy has long been the recommended treatment for acute appendicitis because of the presumed risk of progression to rupture. The overall rate of perforated appendicitis is 25.8%. Children <5 years of age and patients >65 years of age have the highest rates of perforation (45 and 51%, respectively) delays in presentation are responsible for the majority of perforated appendices. Appendiceal rupture occurs most frequently distal to the point of luminal obstruction along the antimesenteric border of the appendix. Rupture should be suspected in the presence of fever with a temperature of >39°C (102°F) and a white blood cell count of >18,000 cells/mm3
  • 87. Options • Open / traditional surgery • Laparoscopic • Natural orifice surgery (no incision appendectomy )
  • 88. Appendicectomy - Open • Incision over McBurney’s point or point of maximal tenderness • Straightforward, good exposure, technically easier • Longer recovery, risk of hernia & adhesions, can’t see pelvic structures as well
  • 89. Open appendetomy • For open appendectomy most surgeons use either a McBurney (oblique) or Rocky-Davis (transverse) right lower quadrant muscle- splitting incision in patients with suspected appendicitis. The incision should be centered over either the point of maximal tenderness or a palpable mass
  • 90. Open / traditional • if incision is perpendicular to the line : • Grid iron incision • Why called grid iron ? • if better access is needed , one can change gridiron to Rutherford Morrison's incision • Lanz incision (transverse skin crease incision , 2cm below umbilicus at mid-clavicular line)
  • 93. Steps of operation in appendicitis
  • 94. Steps of operation in appendicitis
  • 95. Steps of operation in appendicitis
  • 96. Steps of operation in appendicitis
  • 97. Steps of operation in retrocaecal appendicitis
  • 98. Steps of operation in retrocaecal retroperitoneal appendicitis
  • 100. Then • put drain if you find dirty iliac fossa , otherwise : • suture .
  • 101. Laparoscopic appendetomy • Laparoscopic appendectomy usually requires the use of three ports. Four ports may occasionally be necessary to mobilize a retrocecal appendix. The surgeon usually stands to the patient's left. One assistant is required to operate the camera. One trocar is placed in the umbilicus (10 mm), and a second trocar is placed in the suprapubic position. Some surgeons place this second port in the left lower quadrant. The suprapubic trocar is either 10 or 12 mm, depending on whether or not a linear stapler will be used. • The placement of the third trocar (5 mm) is variable and usually is either in the left lower quadrant, epigastrium, or right upper quadrant.
  • 103. Appendicectomy - Laparoscopic • “Keyhole” surgery • Lower complication rate, quicker recovery • Sometimes difficulty in mobilisation requiring open procedure
  • 104.
  • 105. Natural orifice surgery • No incision appendectomy • Using the natural orifices like anal canal endoscopically or trans-vaginally . • Less pain • No scar • Less hospital stay • Fewer complications • It takes about 50 minutes
  • 107. Management of Appendicular abscess/Lump • Late presentation • Clinically mass & fever • Subject to imaging studies to ascertain: - Presence - Size • > 4-6cms  Antibiotics+Drainage • < 4 cms  Conservative mgt(Oschner Sherren’s Regime)
  • 108. Management of Appendicular abscess/Lump • Criteriae for stopping conservative mgt: - Rising pulse rate - Increase in the size of the mass - Increasing/ spreading abdominal pain
  • 109. THANK YOU FOR YOUR KIND PATIENCE

Editor's Notes

  1. CT findings of appendicitis fall into 3 categories 1. appendiceal changes 2. cecal apical changes 3. inflammatory changes in the right lower quadrant
  2. Possible findings in acute appendicitis 1. enlarged appendix 2. appendiceal wall thickening 3. appendiceal wall enlargement 4. periappendiceal fat stranding 5. focal cecal apical thickening