Retrosynthetic analysis, definition, importance, disconnection approach, one group two group disconnection logical and illogical disconnection approach compounds containing two nitrogen atom retrosynthetic analysis of camphor, cartisone, reserpine
This document discusses various aspects of asymmetric synthesis, including stereochemical aspects, acyclic and cyclic stereoselection, and enantioselective synthesis. It defines terms like racemate, enantiopure, and enantiomer. It describes stereospecific and stereoselective reactions, and rules like Cram's rule and Prelog's rule that help explain stereoselection. It discusses strategies for stereoselective synthesis including additions to carbonyls and aldol reactions. It also covers topics like diastereoselective oxidations, catalytic hydrogenation, and enantioselective reductions using chiral reagents like (S)-PBMgCl and (R,R)-DIOP.
The document discusses the benefits of exercise for mental health. Regular physical activity can help reduce anxiety and depression and improve mood and cognitive function. Exercise causes chemical changes in the brain that may help protect against mental illness and improve symptoms.
This document summarizes aromatic nucleophilic substitution reactions. It discusses the SNAr, SN1, and benzyne mechanisms. For SNAr, a strong withdrawing group is needed for reactivity. SN1 is rare for aromatics. In the benzyne mechanism, elimination of H forms benzyne which then adds the nucleophile, producing either ortho or para substituted products. Radiocarbon labeling is used to identify the products. In summary, the document outlines different aromatic nucleophilic substitution reaction mechanisms and factors affecting their reactivity.
this presentation describes ways to enantiomeric product synthesis, hence introducing to chiral catalysts. the temperature effects are discussed with relation to soai autocatalysis. it shows introduction to stereocartography.
Retrosynthetic analysis, definition, importance, disconnection approach, one group two group disconnection logical and illogical disconnection approach compounds containing two nitrogen atom retrosynthetic analysis of camphor, cartisone, reserpine
This document discusses various aspects of asymmetric synthesis, including stereochemical aspects, acyclic and cyclic stereoselection, and enantioselective synthesis. It defines terms like racemate, enantiopure, and enantiomer. It describes stereospecific and stereoselective reactions, and rules like Cram's rule and Prelog's rule that help explain stereoselection. It discusses strategies for stereoselective synthesis including additions to carbonyls and aldol reactions. It also covers topics like diastereoselective oxidations, catalytic hydrogenation, and enantioselective reductions using chiral reagents like (S)-PBMgCl and (R,R)-DIOP.
The document discusses the benefits of exercise for mental health. Regular physical activity can help reduce anxiety and depression and improve mood and cognitive function. Exercise causes chemical changes in the brain that may help protect against mental illness and improve symptoms.
This document summarizes aromatic nucleophilic substitution reactions. It discusses the SNAr, SN1, and benzyne mechanisms. For SNAr, a strong withdrawing group is needed for reactivity. SN1 is rare for aromatics. In the benzyne mechanism, elimination of H forms benzyne which then adds the nucleophile, producing either ortho or para substituted products. Radiocarbon labeling is used to identify the products. In summary, the document outlines different aromatic nucleophilic substitution reaction mechanisms and factors affecting their reactivity.
this presentation describes ways to enantiomeric product synthesis, hence introducing to chiral catalysts. the temperature effects are discussed with relation to soai autocatalysis. it shows introduction to stereocartography.
1. The document discusses the conformations of decalin, a fused bicyclic hydrocarbon. Decalin can exist in two conformations - cis and trans.
2. The trans conformation is more stable than the cis conformation by 2.7 kcal/mol. This is because the cis conformation contains unfavorable nonbonded interactions and three gauche interactions between hydrogen atoms.
3. The trans conformation is locked in its structure and cannot undergo ring flipping, unlike the cis conformation which can interconvert between two chair-chair conformations.
This document discusses carbanions, which are negatively charged organic species where carbon carries three bond pairs and one lone pair. Carbanions are stabilized through conjugation, resonance effects, field effects, and aromaticity. They are generated through heterolytic bond cleavage or addition of a negative ion to a carbon-carbon multiple bond. As nucleophiles, carbanions undergo reactions such as alpha-halogenation of ketones, additions to carbonyls, nucleophilic acyl substitutions, substitutions with alkyl halides, and Michael additions.
1) Organozinc compounds are less reactive than organolithium and organomagnesium compounds due to their more covalent C-Zn bond, allowing preparation of functionalized derivatives.
2) Organozinc compounds are commonly prepared by reacting primary or secondary halides with zinc metal or Rieke zinc under inert atmosphere due to their sensitivity to oxidation.
3) Organozinc reagents are useful in organic syntheses such as Reformatsky reactions, Simmons-Smith cyclopropanation reactions, and cross-coupling reactions like Negishi and Fukuyama couplings.
This document provides an overview of asymmetric synthesis and stereochemistry. It begins with definitions of stereoisomers including enantiomers and diastereomers. It then discusses how asymmetric synthesis creates new chiral centers, giving unequal amounts of stereoisomers. Key terms like enantiomeric excess and methods for determining ee are explained. The document outlines different types of asymmetric synthesis controlled by the substrate, auxiliary, reagent or catalyst. It also defines stereoselective and stereospecific reactions. The principles of asymmetric induction and double diastereoselection/asymmetric induction are covered. Recommended books on the topic are provided.
Synthetic Reagents & Applications in Organic ChemistryAjay Kumar
This document discusses 12 synthetic reagents and their applications in organic chemistry. It describes the preparation, structure, and common uses of each reagent which include aluminium isopropoxide, N-bromosuccinimide, diazomethane, dicyclohexyl-carbodimide, Wilkinson reagent, Wittig reagent, osmium tetroxide, titanium chloride, diazopropane, diethyl azodicarboxylate, triphenylphosphine, and benzotriazol-1-yloxy)tris(dimethyl-amino)phosphonium hexafluorophosphate. These reagents are used for transformations like oxidation, reduction, bromination,
The document discusses the benefits of meditation for reducing stress and anxiety. Regular meditation practice can help calm the mind and body by lowering heart rate and blood pressure. Studies have shown that meditating for just 10-20 minutes per day can have significant positive impacts on both mental and physical health over time.
Asymmetric synthesis is a chemical reaction that produces one stereoisomer in greater amounts than the other. It is achieved through the use of a chiral feature like a substrate, reagent, catalyst, or environment that favors the formation of one enantiomer over the other in the transition state. Some common approaches for asymmetric synthesis include using a chiral starting material from nature, attaching a chiral auxiliary, or employing a chiral reagent or catalyst. The separation and analysis of enantiomers can be challenging given their identical physical properties, requiring techniques like chiral chromatography or crystallization. Asymmetric synthesis has important applications in pharmaceuticals for producing drugs that are safer and more effective.
Mesoionic compounds are heterocyclic compounds with delocalized positive and negative charges that cannot be represented by any single covalent or polar structure. Sydnone and munchnone are two representative mesoionic compounds. Sydnone, the most extensively studied mesoionic compound, undergoes substitution reactions and 1,3-dipolar cycloaddition reactions. It can also undergo ring cleavage to form monosubstituted hydrazines.
The document discusses organomagnesium halides (Grignard reagents). It describes how Grignard reagents are useful synthetic intermediates for carbon-carbon bond formation and are sources of nucleophilic carbanions. It summarizes several reactions of Grignard reagents including additions to carbonyl compounds, substitutions of alkyl/alkenyl/aryl halides, synthesis of ethers, amines, aldehydes and more. It also discusses the mechanisms and applications of important Grignard reactions such as the Bouveault, Benary, Bodrous, Dzhemilev and Kulinkovich reactions.
1) Radical retrosynthesis uses one-electron disconnections to simplify synthesis, avoiding protecting groups, functional group interconversions, and redox steps. This enables more direct and minimal syntheses.
2) Radical cross-coupling reactions allow forming C-C and C-X bonds through hydrogen atom transfer or coupling of radicals with redox-active esters, sulfones, or other species. This provides unique chemoselectivity advantages over polar pathways.
3) Case studies demonstrate strategic benefits of radical cross-coupling for synthesis ideality, efficiency, selectivity, and modularity by opening new retrosynthetic opportunities not accessible through two-electron analysis.
Crown ethers
NOMENCLATURE
GENERAL SYNTHESIS OF CROWN ETHER
AZA CROWN
CRYPTAND
APPLICATIONS
1. SYNTHETIC APPLICTION
Esterification
Saponification
Anhydride formation
Potassium permanganate oxidation
Aromatic substitution reactions
Elimination reactions
Displacement reaction
Generation of carbenes
Superoxide anion
Alkylations – 1. o-alkylations
2. c-alkylations
3. n-alkylations
2. ANALYTICAL APPLICATION
Determination of gold in geological samples
Super critical fluid extraction of trace metal from solid and liquid materials
Application of ionic liquids in analytical chemistry
Oxidation and determination of aldehydes
Crown ethers are used in the laboratory as phase transfer catalyst
OTHER APPLICATION
It is used in photocynation
Resolution of racemic mixture
Benzoin condensation
Hetrocyclisation
Synthesis of furanones
Acetylation of secondary amines in presence of primary amine
This document discusses asymmetric synthesis, which produces unequal amounts of stereoisomers from achiral precursors. It can be enantioselective or diastereoselective. There are two types: partial asymmetric synthesis, which forms a new chiral center from an achiral precursor using a chiral substrate, auxiliary, reagent, or catalyst; and absolute asymmetric synthesis, which uses no chiral precursors but instead relies on physical chirality like circularly polarized light. Common approaches include using a chiral pool substrate, chiral auxiliary, chiral reagent, or chiral catalyst. The mechanisms and examples of various methods are explained in detail.
The document discusses the benefits of meditation for reducing stress and anxiety. Regular meditation practice can help calm the mind and body by lowering heart rate and blood pressure. Making meditation a part of a daily routine, even if just 10-15 minutes per day, can have mental and physical health benefits over time by helping people feel more relaxed and focused.
SMILES REARRANGEMENT [REACTION AND MECHANISM]Shikha Popali
The Smiles rearrangement is an intramolecular aromatic nucleophilic substitution reaction. It involves the migration of a substituent X from one carbon of an aromatic ring to another, with an aromatic substituent Y acting as the nucleophile. A specific example provided is the migration of an SO2Ar group to the ortho position of an ArO- nucleophile, activated by an adjacent nitro group. The X group is usually S, SO, or SO2, while the Y nucleophile is typically the conjugate base of OH, NH2, NHR or SH, though even CH2 has been used.
Asymmetric synthesis FOR BSc, MSc, Bpharm, M,pharmShikha Popali
This document discusses different methods for asymmetric synthesis, which is the production of a single enantiomer from an achiral starting material. It describes chiral pool synthesis, which uses naturally occurring chiral compounds as starting materials. It also explains chiral auxiliaries, where an enantiopure auxiliary is attached and later removed, leaving the desired enantiomer. Chiral reagents and chiral catalysts are also discussed, where an enantiopure reagent or catalyst leads to an enantioselective reaction. Specific examples include the use of chiral boron hydrides and ligands like BINAP. Asymmetric hydrogenation is given as another key method. The document emphasizes the importance of these techniques for drug safety and mimicking nature.
1. Carbenes are neutral molecules containing a divalent carbon atom with two unshared valence electrons. They exist in both singlet and triplet states depending on the electronic spin.
2. Carbenes undergo insertion reactions into X-H and C-C bonds. They also add across double bonds, with singlet carbenes preserving alkene stereochemistry and triplet carbenes losing it.
3. Carbenes are generated by reactions such as α-elimination of halogenated compounds with base or decomposition of diazo compounds. They can rearrange through migrations such as the Wolff or Arndt-Eistert reactions.
1) The document describes the procedure for synthesizing benzimidazole from o-phenylenediamine and formic acid.
2) Key steps include heating a mixture of o-phenylenediamine and excess formic acid at 100°C for 2 hours, then making the reaction mixture alkaline with sodium hydroxide to precipitate crude benzimidazole.
3) Benzimidazole has biological applications as an active component in anthelmintic and antiulcer drugs, and its derivatives also show antimicrobial and anticancer properties.
This document summarizes the synthesis of 7-Hydroxy-4-Methyl Coumarin via the Pechmann condensation reaction of resorcinol and ethyl acetoacetate in the presence of concentrated sulfuric acid. Coumarins are an important class of compounds that are found in plants and have various medical applications such as antimicrobial and antitumor properties. The procedure involves cooling concentrated sulfuric acid to below 5°C and adding a solution of resorcinol and ethyl acetoacetate dropwise, followed by workup to obtain an impure product that is recrystallized from ethanol.
1. The document discusses the conformations of decalin, a fused bicyclic hydrocarbon. Decalin can exist in two conformations - cis and trans.
2. The trans conformation is more stable than the cis conformation by 2.7 kcal/mol. This is because the cis conformation contains unfavorable nonbonded interactions and three gauche interactions between hydrogen atoms.
3. The trans conformation is locked in its structure and cannot undergo ring flipping, unlike the cis conformation which can interconvert between two chair-chair conformations.
This document discusses carbanions, which are negatively charged organic species where carbon carries three bond pairs and one lone pair. Carbanions are stabilized through conjugation, resonance effects, field effects, and aromaticity. They are generated through heterolytic bond cleavage or addition of a negative ion to a carbon-carbon multiple bond. As nucleophiles, carbanions undergo reactions such as alpha-halogenation of ketones, additions to carbonyls, nucleophilic acyl substitutions, substitutions with alkyl halides, and Michael additions.
1) Organozinc compounds are less reactive than organolithium and organomagnesium compounds due to their more covalent C-Zn bond, allowing preparation of functionalized derivatives.
2) Organozinc compounds are commonly prepared by reacting primary or secondary halides with zinc metal or Rieke zinc under inert atmosphere due to their sensitivity to oxidation.
3) Organozinc reagents are useful in organic syntheses such as Reformatsky reactions, Simmons-Smith cyclopropanation reactions, and cross-coupling reactions like Negishi and Fukuyama couplings.
This document provides an overview of asymmetric synthesis and stereochemistry. It begins with definitions of stereoisomers including enantiomers and diastereomers. It then discusses how asymmetric synthesis creates new chiral centers, giving unequal amounts of stereoisomers. Key terms like enantiomeric excess and methods for determining ee are explained. The document outlines different types of asymmetric synthesis controlled by the substrate, auxiliary, reagent or catalyst. It also defines stereoselective and stereospecific reactions. The principles of asymmetric induction and double diastereoselection/asymmetric induction are covered. Recommended books on the topic are provided.
Synthetic Reagents & Applications in Organic ChemistryAjay Kumar
This document discusses 12 synthetic reagents and their applications in organic chemistry. It describes the preparation, structure, and common uses of each reagent which include aluminium isopropoxide, N-bromosuccinimide, diazomethane, dicyclohexyl-carbodimide, Wilkinson reagent, Wittig reagent, osmium tetroxide, titanium chloride, diazopropane, diethyl azodicarboxylate, triphenylphosphine, and benzotriazol-1-yloxy)tris(dimethyl-amino)phosphonium hexafluorophosphate. These reagents are used for transformations like oxidation, reduction, bromination,
The document discusses the benefits of meditation for reducing stress and anxiety. Regular meditation practice can help calm the mind and body by lowering heart rate and blood pressure. Studies have shown that meditating for just 10-20 minutes per day can have significant positive impacts on both mental and physical health over time.
Asymmetric synthesis is a chemical reaction that produces one stereoisomer in greater amounts than the other. It is achieved through the use of a chiral feature like a substrate, reagent, catalyst, or environment that favors the formation of one enantiomer over the other in the transition state. Some common approaches for asymmetric synthesis include using a chiral starting material from nature, attaching a chiral auxiliary, or employing a chiral reagent or catalyst. The separation and analysis of enantiomers can be challenging given their identical physical properties, requiring techniques like chiral chromatography or crystallization. Asymmetric synthesis has important applications in pharmaceuticals for producing drugs that are safer and more effective.
Mesoionic compounds are heterocyclic compounds with delocalized positive and negative charges that cannot be represented by any single covalent or polar structure. Sydnone and munchnone are two representative mesoionic compounds. Sydnone, the most extensively studied mesoionic compound, undergoes substitution reactions and 1,3-dipolar cycloaddition reactions. It can also undergo ring cleavage to form monosubstituted hydrazines.
The document discusses organomagnesium halides (Grignard reagents). It describes how Grignard reagents are useful synthetic intermediates for carbon-carbon bond formation and are sources of nucleophilic carbanions. It summarizes several reactions of Grignard reagents including additions to carbonyl compounds, substitutions of alkyl/alkenyl/aryl halides, synthesis of ethers, amines, aldehydes and more. It also discusses the mechanisms and applications of important Grignard reactions such as the Bouveault, Benary, Bodrous, Dzhemilev and Kulinkovich reactions.
1) Radical retrosynthesis uses one-electron disconnections to simplify synthesis, avoiding protecting groups, functional group interconversions, and redox steps. This enables more direct and minimal syntheses.
2) Radical cross-coupling reactions allow forming C-C and C-X bonds through hydrogen atom transfer or coupling of radicals with redox-active esters, sulfones, or other species. This provides unique chemoselectivity advantages over polar pathways.
3) Case studies demonstrate strategic benefits of radical cross-coupling for synthesis ideality, efficiency, selectivity, and modularity by opening new retrosynthetic opportunities not accessible through two-electron analysis.
Crown ethers
NOMENCLATURE
GENERAL SYNTHESIS OF CROWN ETHER
AZA CROWN
CRYPTAND
APPLICATIONS
1. SYNTHETIC APPLICTION
Esterification
Saponification
Anhydride formation
Potassium permanganate oxidation
Aromatic substitution reactions
Elimination reactions
Displacement reaction
Generation of carbenes
Superoxide anion
Alkylations – 1. o-alkylations
2. c-alkylations
3. n-alkylations
2. ANALYTICAL APPLICATION
Determination of gold in geological samples
Super critical fluid extraction of trace metal from solid and liquid materials
Application of ionic liquids in analytical chemistry
Oxidation and determination of aldehydes
Crown ethers are used in the laboratory as phase transfer catalyst
OTHER APPLICATION
It is used in photocynation
Resolution of racemic mixture
Benzoin condensation
Hetrocyclisation
Synthesis of furanones
Acetylation of secondary amines in presence of primary amine
This document discusses asymmetric synthesis, which produces unequal amounts of stereoisomers from achiral precursors. It can be enantioselective or diastereoselective. There are two types: partial asymmetric synthesis, which forms a new chiral center from an achiral precursor using a chiral substrate, auxiliary, reagent, or catalyst; and absolute asymmetric synthesis, which uses no chiral precursors but instead relies on physical chirality like circularly polarized light. Common approaches include using a chiral pool substrate, chiral auxiliary, chiral reagent, or chiral catalyst. The mechanisms and examples of various methods are explained in detail.
The document discusses the benefits of meditation for reducing stress and anxiety. Regular meditation practice can help calm the mind and body by lowering heart rate and blood pressure. Making meditation a part of a daily routine, even if just 10-15 minutes per day, can have mental and physical health benefits over time by helping people feel more relaxed and focused.
SMILES REARRANGEMENT [REACTION AND MECHANISM]Shikha Popali
The Smiles rearrangement is an intramolecular aromatic nucleophilic substitution reaction. It involves the migration of a substituent X from one carbon of an aromatic ring to another, with an aromatic substituent Y acting as the nucleophile. A specific example provided is the migration of an SO2Ar group to the ortho position of an ArO- nucleophile, activated by an adjacent nitro group. The X group is usually S, SO, or SO2, while the Y nucleophile is typically the conjugate base of OH, NH2, NHR or SH, though even CH2 has been used.
Asymmetric synthesis FOR BSc, MSc, Bpharm, M,pharmShikha Popali
This document discusses different methods for asymmetric synthesis, which is the production of a single enantiomer from an achiral starting material. It describes chiral pool synthesis, which uses naturally occurring chiral compounds as starting materials. It also explains chiral auxiliaries, where an enantiopure auxiliary is attached and later removed, leaving the desired enantiomer. Chiral reagents and chiral catalysts are also discussed, where an enantiopure reagent or catalyst leads to an enantioselective reaction. Specific examples include the use of chiral boron hydrides and ligands like BINAP. Asymmetric hydrogenation is given as another key method. The document emphasizes the importance of these techniques for drug safety and mimicking nature.
1. Carbenes are neutral molecules containing a divalent carbon atom with two unshared valence electrons. They exist in both singlet and triplet states depending on the electronic spin.
2. Carbenes undergo insertion reactions into X-H and C-C bonds. They also add across double bonds, with singlet carbenes preserving alkene stereochemistry and triplet carbenes losing it.
3. Carbenes are generated by reactions such as α-elimination of halogenated compounds with base or decomposition of diazo compounds. They can rearrange through migrations such as the Wolff or Arndt-Eistert reactions.
1) The document describes the procedure for synthesizing benzimidazole from o-phenylenediamine and formic acid.
2) Key steps include heating a mixture of o-phenylenediamine and excess formic acid at 100°C for 2 hours, then making the reaction mixture alkaline with sodium hydroxide to precipitate crude benzimidazole.
3) Benzimidazole has biological applications as an active component in anthelmintic and antiulcer drugs, and its derivatives also show antimicrobial and anticancer properties.
This document summarizes the synthesis of 7-Hydroxy-4-Methyl Coumarin via the Pechmann condensation reaction of resorcinol and ethyl acetoacetate in the presence of concentrated sulfuric acid. Coumarins are an important class of compounds that are found in plants and have various medical applications such as antimicrobial and antitumor properties. The procedure involves cooling concentrated sulfuric acid to below 5°C and adding a solution of resorcinol and ethyl acetoacetate dropwise, followed by workup to obtain an impure product that is recrystallized from ethanol.
This document summarizes the synthesis of 1-bromo-2-naphthol from 2-naphthol. It involves selectively brominating 2-naphthol using sodium bromide and oxone. 2-Naphthol, sodium bromide, and oxone are ground together and reacted overnight. Ethyl acetate is then used to extract the crude 1-bromo-2-naphthol product, which is a dark brown solid. The theoretical and practical yields are calculated and the percentage yield is reported.
Theories of coordination compounds, CFSE, Bonding in octahedral and tetrahedral complex, color of transition metal complex, magnetic properties, selection rules, Nephelxeuatic effect, angular overlap model
This document discusses coordination chemistry and isomerism in coordination compounds. It defines molecular compounds, complex salts, and double salts formed from combinations of inorganic salts. It also discusses ligands, classifying them based on properties. Coordination number and the resulting geometries for coordination numbers 2 through 9 are described. Finally, it outlines different types of isomerism that can occur in coordination compounds, including structural, spin, and stereo isomerism.
This document provides an overview of key concepts in medicinal chemistry. It defines medicinal chemistry as concerning the discovery, development, and interpretation of biologically active compounds at the molecular level. It then discusses the relationships between organic chemistry, medicinal chemistry, and pharmaceutical chemistry. The rest of the document covers topics like drug nomenclature, classification, pharmacology principles of drug action, toxicology, and assays.
The document discusses stereochemistry and provides examples of different representations used to depict three-dimensional molecular structures in two dimensions. It defines stereochemistry as the study of different spatial arrangements of atoms in a molecule. It also defines key terms like stereoisomers, enantiomers, diastereomers, and chiral centers. The document then explains different representations like dashed wedge, Fischer projection, Sawhorse formula, and Newman projection that are used to depict the 3D orientation of groups in chiral molecules on a 2D surface. It provides examples of interconversions between these different representations.
The document is a scanned copy of a contract for the sale of real estate. It outlines the terms of sale for a residential property located in California, including the purchase price, down payment, financing terms, contingencies, and closing date. The buyer and seller signatures indicate they agree to all terms and conditions as outlined in the multi-page contract.
This document describes the preparation of p-nitro acetanilide from acetanilide. Acetanilide is nitrated using nitric and sulfuric acid. This produces p-nitro acetanilide as the major product along with a minor amount of o-nitro acetanilide. The p-nitro acetanilide product is purified by recrystallization from ethanol, yielding colorless crystals. Percent yield of the product is calculated and the melting point is obtained and compared to literature values.
This document describes the preparation of p-bromoaniline from acetanilide. It involves a two step process:
1. Bromination of acetanilide using potassium bromate and potassium bromide in the presence of tartaric acid yields p-bromoacetanilide as the major product.
2. Hydrolysis of p-bromoacetanilide using hydrochloric acid and heat produces p-bromoaniline. The product is isolated by adjusting the pH to basic and cooling.
Yields, melting points and reactions are calculated and mechanisms are provided for both steps. Chemical tests to identify the products are also outlined.
This document provides information on the structure and composition of nucleic acids. It discusses that nucleic acids are biopolymers composed of nucleotide subunits containing a sugar (ribose or deoxyribose), phosphate group, and a nitrogenous base. The 5' carbon of the sugar is attached to the phosphate group via a phosphodiester bond. The nitrogenous bases are either purines (adenine or guanine) or pyrimidines (cytosine, thymine, or uracil). RNA contains ribose and the base uracil, while DNA contains deoxyribose and the base thymine. Nucleic acids can be single stranded or double stranded polymers known as polynucleotides.
Free radicals are atoms or groups of atoms with unpaired electrons that can participate in chemical reactions. Common examples include hydroxyl (HO·) and methyl (H3C·) radicals. Free radical reactions typically occur by initiation, propagation, and termination steps in a chain reaction mechanism. The stability of free radicals is determined by factors such as conjugation, hyperconjugation, and hybridization. Radicals can be detected using techniques like electron paramagnetic resonance spectroscopy.
This document provides an overview of asymmetric synthesis and strategies for achieving asymmetric induction. It defines asymmetric synthesis as a reaction that yields predominantly one chiral stereoisomer. It discusses different strategies for asymmetric induction, including using a chiral auxiliary, chiral reagent/catalyst, or starting with a chiral pool substrate. Specific examples are provided of chiral reagents like BINOL-H and Alpine borane that can be used to selectively reduce prochiral ketones. Chiral ligands like DIOP and CHIRAPHOS that are used with metal catalysts for asymmetric hydrogenation are also described.
This document provides procedures for preparing several transition metal complexes. It describes preparing hexaamminecobalt(III)chloride from cobaltous chloride hexahydrate and ammonium chloride. It also describes preparing hexaamminenickel(II)chloride from nickel chloride hexahydrate and aqueous ammonia, as well as potassium tris(oxalato)ferrate(III) trihydrate from ferrous ammonium sulfate and oxalic acid. The document gives the name, structure, properties and theoretical yield calculations for each complex prepared.
This document provides guidance on qualitative organic analysis, including:
- An overview of the systematic process for identifying unknown organic compounds, from preliminary tests to determining functional groups.
- Details on specific preliminary tests to determine physical properties and the presence of elements like nitrogen, sulfur, and halogens.
- Instructions for conducting solubility tests to group compounds and indicate probable functional groups for further analysis.
The document describes a two-step process to prepare benzocaine from p-nitrobenzoic acid. The first step involves reducing p-nitrobenzoic acid to p-aminobenzoic acid using tin and hydrochloric acid. The second step is a Fischer esterification of p-aminobenzoic acid with ethanol in the presence of sulfuric acid to form benzocaine. The procedure provides details of the reaction conditions and calculations to determine the theoretical and percent yield of benzocaine produced.
The document describes a two-step process to prepare 2-phenylindole from phenylhydrazine and acetophenone. The first step involves a condensation reaction of acetophenone and phenylhydrazine in ethanol and acetic acid to form acetophenone phenylhydrazone. The second step performs a Fischer indole cyclization of acetophenone phenylhydrazone in phosphoric acid and sulfuric acid to yield the final product 2-phenylindole. The product is then purified through recrystallization and its melting point is obtained.
Mending Clothing to Support Sustainable Fashion_CIMaR 2024.pdfSelcen Ozturkcan
Ozturkcan, S., Berndt, A., & Angelakis, A. (2024). Mending clothing to support sustainable fashion. Presented at the 31st Annual Conference by the Consortium for International Marketing Research (CIMaR), 10-13 Jun 2024, University of Gävle, Sweden.
ESR spectroscopy in liquid food and beverages.pptxPRIYANKA PATEL
With increasing population, people need to rely on packaged food stuffs. Packaging of food materials requires the preservation of food. There are various methods for the treatment of food to preserve them and irradiation treatment of food is one of them. It is the most common and the most harmless method for the food preservation as it does not alter the necessary micronutrients of food materials. Although irradiated food doesn’t cause any harm to the human health but still the quality assessment of food is required to provide consumers with necessary information about the food. ESR spectroscopy is the most sophisticated way to investigate the quality of the food and the free radicals induced during the processing of the food. ESR spin trapping technique is useful for the detection of highly unstable radicals in the food. The antioxidant capability of liquid food and beverages in mainly performed by spin trapping technique.
hematic appreciation test is a psychological assessment tool used to measure an individual's appreciation and understanding of specific themes or topics. This test helps to evaluate an individual's ability to connect different ideas and concepts within a given theme, as well as their overall comprehension and interpretation skills. The results of the test can provide valuable insights into an individual's cognitive abilities, creativity, and critical thinking skills
When I was asked to give a companion lecture in support of ‘The Philosophy of Science’ (https://shorturl.at/4pUXz) I decided not to walk through the detail of the many methodologies in order of use. Instead, I chose to employ a long standing, and ongoing, scientific development as an exemplar. And so, I chose the ever evolving story of Thermodynamics as a scientific investigation at its best.
Conducted over a period of >200 years, Thermodynamics R&D, and application, benefitted from the highest levels of professionalism, collaboration, and technical thoroughness. New layers of application, methodology, and practice were made possible by the progressive advance of technology. In turn, this has seen measurement and modelling accuracy continually improved at a micro and macro level.
Perhaps most importantly, Thermodynamics rapidly became a primary tool in the advance of applied science/engineering/technology, spanning micro-tech, to aerospace and cosmology. I can think of no better a story to illustrate the breadth of scientific methodologies and applications at their best.
Or: Beyond linear.
Abstract: Equivariant neural networks are neural networks that incorporate symmetries. The nonlinear activation functions in these networks result in interesting nonlinear equivariant maps between simple representations, and motivate the key player of this talk: piecewise linear representation theory.
Disclaimer: No one is perfect, so please mind that there might be mistakes and typos.
dtubbenhauer@gmail.com
Corrected slides: dtubbenhauer.com/talks.html
EWOCS-I: The catalog of X-ray sources in Westerlund 1 from the Extended Weste...Sérgio Sacani
Context. With a mass exceeding several 104 M⊙ and a rich and dense population of massive stars, supermassive young star clusters
represent the most massive star-forming environment that is dominated by the feedback from massive stars and gravitational interactions
among stars.
Aims. In this paper we present the Extended Westerlund 1 and 2 Open Clusters Survey (EWOCS) project, which aims to investigate
the influence of the starburst environment on the formation of stars and planets, and on the evolution of both low and high mass stars.
The primary targets of this project are Westerlund 1 and 2, the closest supermassive star clusters to the Sun.
Methods. The project is based primarily on recent observations conducted with the Chandra and JWST observatories. Specifically,
the Chandra survey of Westerlund 1 consists of 36 new ACIS-I observations, nearly co-pointed, for a total exposure time of 1 Msec.
Additionally, we included 8 archival Chandra/ACIS-S observations. This paper presents the resulting catalog of X-ray sources within
and around Westerlund 1. Sources were detected by combining various existing methods, and photon extraction and source validation
were carried out using the ACIS-Extract software.
Results. The EWOCS X-ray catalog comprises 5963 validated sources out of the 9420 initially provided to ACIS-Extract, reaching a
photon flux threshold of approximately 2 × 10−8 photons cm−2
s
−1
. The X-ray sources exhibit a highly concentrated spatial distribution,
with 1075 sources located within the central 1 arcmin. We have successfully detected X-ray emissions from 126 out of the 166 known
massive stars of the cluster, and we have collected over 71 000 photons from the magnetar CXO J164710.20-455217.
ESA/ACT Science Coffee: Diego Blas - Gravitational wave detection with orbita...Advanced-Concepts-Team
Presentation in the Science Coffee of the Advanced Concepts Team of the European Space Agency on the 07.06.2024.
Speaker: Diego Blas (IFAE/ICREA)
Title: Gravitational wave detection with orbital motion of Moon and artificial
Abstract:
In this talk I will describe some recent ideas to find gravitational waves from supermassive black holes or of primordial origin by studying their secular effect on the orbital motion of the Moon or satellites that are laser ranged.
(June 12, 2024) Webinar: Development of PET theranostics targeting the molecu...Scintica Instrumentation
Targeting Hsp90 and its pathogen Orthologs with Tethered Inhibitors as a Diagnostic and Therapeutic Strategy for cancer and infectious diseases with Dr. Timothy Haystead.
Current Ms word generated power point presentation covers major details about the micronuclei test. It's significance and assays to conduct it. It is used to detect the micronuclei formation inside the cells of nearly every multicellular organism. It's formation takes place during chromosomal sepration at metaphase.