Your microbiome your health

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Your body is home to three pounds of germs, a rich microbiome that weighs as much as your brain! Thanks to the recent plummeting cost of gene sequencing, scientists are just now discovering how important these microbes are to health and wellness, with surprising links to conditions ranging from obesity, autism, allergies, depression, and much more. We’ll discuss the latest developments, and show how new, low-cost testing kits can help you learn more about — and reshape — your own unique microbiome.

Your Microbiome, Your Health
Richard Sprague
April 29, 2015

You
Weight
Human Non-Human
Cells
Human Non-Human
Genes
Human Non-Human
3 pounds

Desulforudis audaxviator
Deinococcus radiodurans

For hardcore experimenters
• 25-35 week program
• Weekly+ sampling
• Detailed analysis
• 16S (like uBiome)
• Metagenomics (very
expensive)
Dynamics of the Human Microbiota

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Bifidobacterium

Microbiome changes over time
David et al: Host lifestyle affects human microbiota on daily timescales
Genome Biology 2014, 15:R8

My microbiome through time
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Actinobacteria
Verrucomicrobia
Proteobacteria
Bacteroidetes
Firmicutes
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Bacteroidetes/Firmicutes

Microbiome of the mouth
“treads the fine line between commensal and
pathogen” Sophie C.H. Wen et al

Trillions of bacteria, viruses, parasites and fungi live in and around our bodies. Together, they make up the microbiome, which has been called the largest organ in the human body and been linked to a range of health issues, from asthma to diabetes to inflammatory bowel disease to obesity. Paul Kubes and Kathy McCoy, professors at UCalgary’s Cumming School of Medicine and researchers at the Western Canadian Microbiome Centre, share the science of the microbiome and why it holds the key to better health for all of us. Watch the full webinar at http://www.ucalgary.ca/explore/microbiome-why-few-trillion-germs-can-be-good-thing

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From Me To We: Discovering the Trillions of Microorganisms That are a Part of Us

Larry Smarr

The document summarizes a lecture about the human microbiome and its importance in health and disease. It discusses how sequencing DNA has revealed that the human body hosts trillions of microorganisms and that 99% of our genes are microbial. Understanding the microbiome is crucial for medicine as shifts in the microbial ecology can be linked to various diseases. The lecturer discusses his own efforts to track biomarkers and microbiome data over time, revealing how perturbations correlated with disease symptoms and weight changes. Precision approaches analyzing large cohorts will be needed to unravel microbiome dynamics in health and illness.

Dynamics of the Microbiome-Driven by Medical Interventions and Dietary Change

Larry Smarr

This document summarizes Dr. Larry Smarr's presentation on how his gut microbiome was dramatically impacted by medical interventions and dietary changes. It discusses how his microbiome diversity sharply declined after sigmoid colon resection surgery but stabilized into a new healthy state. Dr. Smarr collaborated with UCSD scientists to analyze stool samples before and after the surgery, finding his microbiome changed more than average differences between individuals. Medical procedures like surgery can induce major gut microbiome shifts. Dr. Smarr then experimented with dietary changes like vegetable fiber and time-restricted eating, finding these interventions improved biomarkers like blood glucose levels and microbiome diversity.

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Comparing Resting Heart Rate Across Years

Richard Sprague

1) The document analyzes the author's resting heart rate data over multiple years from the OpenHumans platform and compares it to different diets. 2) A study is cited that found higher resting heart rates are correlated with increased risk of all-cause and cardiovascular mortality. 3) The author concludes that their resting heart rate was higher in 2020, and that low-carb diets and fasting increased their resting heart rate.

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This document summarizes a presentation about hacking one's gut microbiome. It includes disclaimers that the information is not medical advice and results from uBiome sampling kits cannot be used for diagnosis or treatment. The presentation discusses visualizing one's microbiome data over time, including dominant bacterial phyla and specific genera present. It describes an experiment where the presenter followed a special diet for over a month to attempt to change their microbiome, and the results showing that while amounts and ratios changed, the core organisms did not. The presenter concluded that one's microbiome recovers quickly and is hard to significantly alter.

Experiments With My Microbiome

Richard Sprague

This document summarizes Richard Sprague's experiments with his own microbiome over time. He tracked changes in the composition of microbes and bacteria in his gut from May 2014 to July 2015. Sprague also conducted an experiment where he cleared out his gut biome using a colon cleanse to see how it would recover. He found that while the amounts and ratios of bacteria changed after the cleanse, the overall composition recovered quickly and most of the same organisms returned. A few taxa did change permanently in larger amounts. The document concludes that it is difficult to significantly alter one's microbiome in the long run.

How Backpacking Changed My Gut Microbiome

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The document summarizes the results of analyzing changes in a person's gut microbiome before and after a 2-week backpacking trip in New Mexico. Some key findings include: - The microbiome was overall pretty stable, with the main bacterial phyla composition not changing much. - Certain genera like Faecalibacterium and Bacteroides decreased after the trip, while Blautia, Odoribacter, and Akkermansia increased. - Microbial diversity was higher after the trip compared to previous tests, suggesting the trip helped diversity.

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This document discusses the author's microbiome and how it changed over a one week period after tracking macronutrients and microbiome data. Key findings include an increase in certain bacteria like Roseburia, Faecalibacterium, and Bacteroides after one week. The author's diversity of phyla, classes, orders, families and genera decreased over this period, while the ratio of Bifido/Firmicutes increased. The document encourages readers to also track their microbiome over time to better understand changes.

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