Vacuum distillation allows purification of compounds that cannot be readily distilled under normal atmospheric pressure or that may decompose at high temperatures. It works by reducing pressure above the boiling liquid, lowering the boiling point so compounds evaporate and separate based on differences in their boiling points. Key advantages are faster processing, ability to distill higher boiling point solvents without damage, and improved separation, yield, and purity. It finds applications in separating thermolabile substances and preparing extracts while preserving active constituents.
Presentation on Azeotropic and Extractive Distillation. Introduction about distillation, azeotropic and extractive distillation and the difference between them.
Presentation on Azeotropic and Extractive Distillation. Introduction about distillation, azeotropic and extractive distillation and the difference between them.
3. economy of multiple effect evaporatorShital Patil
A multiple-effect evaporator, as defined in chemical engineering, is an equipment for efficiently using the heat from steam to evaporate water.
Steam is mostly used as heating medium in Multiple effect evaporator.
Multiple Effect Evaporation remains one of the popular method for the concentration of aqueous solutions.
This Presentation gives an overview about the multiple effect evaporators. The intention is also focused on designing principles of Single and Multiple Effect Evaporators
A multiple-effect evaporator, as defined in chemical engineering, is an equipment for efficiently using the heat from steam to evaporate water.
Steam is mostly used as heating medium in Multiple effect evaporator.
Multiple Effect Evaporation remains one of the popular method for the concentration of aqueous solutions.
Presentation on fractional distillation. Introduction to distillation, fractional distillation, its principle, working, applications, advantages and disadvantages.
Types of Distillation & column internalsBharat Kumar
More:- https://chemicalengineeringworld.com
Distillation is a method of separating the components of a solution which depends upon distribution of the substances between a gas and liquid phase, applied to cases where all components are present in both phases.
* What is distillation ?
* Types of Distillation
* Batch Distillation
* Azeotropic Distillation
* Flooding
* Priming
* Coning
* Weeping
* Dumping
* Packed Column
* Tray column
* Reflux Ratio
* Relative volatility
* Distillation column
Distillation is a method of separating mixtures based on differences in volatility (volatility is the tendency of a substance to vaporize. Volatility is directly related to a substance's vapor pressure.) of components in a boiling liquid mixture. Distillation is a unit operation, or a physical separation process, and not a chemical reaction
Objectives
Applications and factors influencing evaporation
Differences between evaporation and other heat process
Principles, construction ,working, uses, merits and demerits of :
-Steam jacketed kettle
-Horizontal tube evaporator
-Climbing film evaporator
-Forced circulation evaporator
-Multiple effect evaporator
-Economy of multiple effect evaporator
3. economy of multiple effect evaporatorShital Patil
A multiple-effect evaporator, as defined in chemical engineering, is an equipment for efficiently using the heat from steam to evaporate water.
Steam is mostly used as heating medium in Multiple effect evaporator.
Multiple Effect Evaporation remains one of the popular method for the concentration of aqueous solutions.
This Presentation gives an overview about the multiple effect evaporators. The intention is also focused on designing principles of Single and Multiple Effect Evaporators
A multiple-effect evaporator, as defined in chemical engineering, is an equipment for efficiently using the heat from steam to evaporate water.
Steam is mostly used as heating medium in Multiple effect evaporator.
Multiple Effect Evaporation remains one of the popular method for the concentration of aqueous solutions.
Presentation on fractional distillation. Introduction to distillation, fractional distillation, its principle, working, applications, advantages and disadvantages.
Types of Distillation & column internalsBharat Kumar
More:- https://chemicalengineeringworld.com
Distillation is a method of separating the components of a solution which depends upon distribution of the substances between a gas and liquid phase, applied to cases where all components are present in both phases.
* What is distillation ?
* Types of Distillation
* Batch Distillation
* Azeotropic Distillation
* Flooding
* Priming
* Coning
* Weeping
* Dumping
* Packed Column
* Tray column
* Reflux Ratio
* Relative volatility
* Distillation column
Distillation is a method of separating mixtures based on differences in volatility (volatility is the tendency of a substance to vaporize. Volatility is directly related to a substance's vapor pressure.) of components in a boiling liquid mixture. Distillation is a unit operation, or a physical separation process, and not a chemical reaction
Objectives
Applications and factors influencing evaporation
Differences between evaporation and other heat process
Principles, construction ,working, uses, merits and demerits of :
-Steam jacketed kettle
-Horizontal tube evaporator
-Climbing film evaporator
-Forced circulation evaporator
-Multiple effect evaporator
-Economy of multiple effect evaporator
The presentation consists of the introduction, basic terms, and different types of ideal cycles of refrigeration,
1. Introduction to refrigeration
2. Necessity and applications
3. Unit of refrigeration and C.O.P.
4. Types of ideal cycles of refrigeration
a) Bell Coleman cycle
b) Open and dense air systems
5. Boot strap Air refrigeration system
Experimental Investigation of Water Cooler Test Rig Using R-22 as RefrigerantIJMERJOURNAL
ABSTRACT: This paper describes Water Cooler; a tool that aggregates shared internal social media and cross-references it with an organization’s directory. We deployed Water Cooler in a large global enterprise and present the results of a preliminary user study. Despite the lack of complete social networking affordances, we find that Water-Cooler changed users’ perceptions of their workplace, made them feel more connected to each other and the company, and redistributed. Water coolers work on vapour compression refrigeration cycle. The behavior of performance parameters of a simple vapour compression refrigeration system were studied while it’s working under transient conditions occurred during cooling of a fixed mass of brine from initial room temperature to sub-zero refrigeration temperature. The effects of different lengths of capillary tube over these characteristics have also been investigated. The main advantage of our project is to cool the water with help of test rig.
Download Link (Copy URL):
https://sites.google.com/view/varunpratapsingh/teaching-engagements
This PPT contained slides for Steam distribution system, which is a third unit in Energy Conservation subject of final year in Mechanical Engineering Branch.
The content of PPT are mentioned below:
Steam Distribution System, Thermodynamics, Heat, Properties of steam, steam, steam system, PDRS, Steam pipe installation, Dryers, Operation and maintenance of steam traps, Condensate Recovery System, Flash Recovery System, Energy Conservation Opportunity in Steam Distribution System.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
The increased availability of biomedical data, particularly in the public domain, offers the opportunity to better understand human health and to develop effective therapeutics for a wide range of unmet medical needs. However, data scientists remain stymied by the fact that data remain hard to find and to productively reuse because data and their metadata i) are wholly inaccessible, ii) are in non-standard or incompatible representations, iii) do not conform to community standards, and iv) have unclear or highly restricted terms and conditions that preclude legitimate reuse. These limitations require a rethink on data can be made machine and AI-ready - the key motivation behind the FAIR Guiding Principles. Concurrently, while recent efforts have explored the use of deep learning to fuse disparate data into predictive models for a wide range of biomedical applications, these models often fail even when the correct answer is already known, and fail to explain individual predictions in terms that data scientists can appreciate. These limitations suggest that new methods to produce practical artificial intelligence are still needed.
In this talk, I will discuss our work in (1) building an integrative knowledge infrastructure to prepare FAIR and "AI-ready" data and services along with (2) neurosymbolic AI methods to improve the quality of predictions and to generate plausible explanations. Attention is given to standards, platforms, and methods to wrangle knowledge into simple, but effective semantic and latent representations, and to make these available into standards-compliant and discoverable interfaces that can be used in model building, validation, and explanation. Our work, and those of others in the field, creates a baseline for building trustworthy and easy to deploy AI models in biomedicine.
Bio
Dr. Michel Dumontier is the Distinguished Professor of Data Science at Maastricht University, founder and executive director of the Institute of Data Science, and co-founder of the FAIR (Findable, Accessible, Interoperable and Reusable) data principles. His research explores socio-technological approaches for responsible discovery science, which includes collaborative multi-modal knowledge graphs, privacy-preserving distributed data mining, and AI methods for drug discovery and personalized medicine. His work is supported through the Dutch National Research Agenda, the Netherlands Organisation for Scientific Research, Horizon Europe, the European Open Science Cloud, the US National Institutes of Health, and a Marie-Curie Innovative Training Network. He is the editor-in-chief for the journal Data Science and is internationally recognized for his contributions in bioinformatics, biomedical informatics, and semantic technologies including ontologies and linked data.
2. Definition: Vacuum distillation is a method of distillation whereby the pressure
above the liquid mixture to be distilled is reduced to less than its vapor
pressure(usually less than its atmospheric pressure) causing evaporation of the most
volatile liquid(s) ( those with the lowest boiling points).
Principle:
* Liquid boils when vapor pressure equal to the atmospheric pressure, i.e., pressure
on its surface. If the external pressure is reduced by applying vacuum , the boiling
point of liquid is lowered.
* Therefore, the liquid boils at a lower temperature. This principle is illustrated using
an example of water.
Water boils at an 100 degree Celsius at an atmospheric pressure is 101.31 kPa (
760mmHg). At 40 degree Celsius , the vapor pressure of water is approximately
9.33kPa (70 mmHg). Hence , the external pressure is reduced to 9.33kPa (70mmHg)
where water boils at 40 degree Celsius. The net result is the increase in rate of mass
transfer into vapor.
3. Purpose: The purpose of vacuum distillation is that it allows the purification of
compounds not readily distilled at ambient pressures or simply to save time or
energy. This technique separates compounds based on difference in boiling
points. This technique is used when the boiling point of the desired compound is
difficult to achieve or will cause the compound to decompose. A reduced pressure
decreases the boiling point of compounds.
Construction & Diagram:
1- It consists of a double- neck
Distillation flask knows as
“Clasien flask”.
2- Thick walled glass apparatus
with interchangeable standard
glass joints are used for vacuum
distillation.
4. 3- In one of the necks of the Claisen flask, a
thermometer is fitted. The second neck
prevents splashing of the violently agitated
liquid.
4- Bumping occurs readily during vacuum
distillation. Placing a fine capillary tube in the
second neck of the flask can prevent bumping.
5- The capillary tube is dipped in the boiling
liquid, so that a stream of air bubbles is drawn
out.
6- Water bath or oil bath is used for heating.
7- The Claisen flask is connected to a receiver
through a condenser.
8- Vacuum pump is attached through an
adapter to the receiver. A small pressure gauge
(manometer) should be inserted between the
pump and the receiver.
5. Working:
Liquid to be distilled is filled ½ to 2/3 volume of flask.
Small piece of porcelain are added to avoid the process of bumping.
Then capillary tube and thermometer are placed in the flask.
Required vacuum is applied through vacuum pump.
The contents are heated and temperature of liquid raises and liquid get vaporized
rapidly due to vacuum.
Now these vapors pass through condenser and condensate is collected in
receiver.
6. Advantages Disadvantages
Using vacuum is often preferable for
following reasons:
1. Faster processing time.
2. Effective processing of higher
boiling point solvents without
igniting them or causing thermal
breakdown.
3. Vacuum distillation can improve a
separation by increasing capacity,
yield and purity.
Disadvantages of vacuum distillation are
as follows:
1. In vacuum distillation, persistent
foaming occurs. This may be
overcome by adding capryl alcohol
to the liquid or by inserting a fine air
capillary tube in the second neck of
the Claisen flask.
2. The steam of air is drawn in and
breaks the rising foam. The above
method is not suitable for the
preparation of semisolid or solid
extracts by distillation under
vacuum.
7. Applications:
The applications of vacuum distillation are as follows:
1. Preventing degradation of Active constituents like Enzymes, Vitamins,
Glycosides, Alkaloids.
2- Changing physical forms. Example: Cascara Sagrada Tablets at atmospheric pressure
form dense compact residue , but at reduced pressure form light porous mass.
3- This type of distillation is used in oil industry.
4- Separation of impurities.
5- Separation of thermolabile (heat sensitive) substances.
6- Extracts or crude drugs are prepared by this process.
Conclusion:
Some materials breakdown at high temperature. With the use of vacuum
distillation column, the compounds can be separated at lower temperature
without effecting the components. Purification of compounds through vacuum
distillation is more efficient.