Upper gastrointestinal bleeding in children can be caused by variceal sources such as portal hypertension or non-variceal sources like ulcers. Initial management involves hemodynamic resuscitation and endoscopy to identify the source of bleeding. For variceal bleeding, pharmacologic therapy with vasoactive drugs and endoscopic variceal ligation or sclerotherapy can help stop bleeding. Surgical options are considered if conservative measures fail. Prognosis is poorer if the bleeding site cannot be identified, coagulation disorders are present, or significant blood loss occurs without intervention.
Inthis playlist, i discussed various causes for Lower GI Hemorrahage like Hemorrhoids, Fissure in ano, diverticulosis, inflammatory bowel disease and colorectal cancer
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
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How to Give Better Lectures: Some Tips for Doctors
Ugibllding
1. 1
Upper Gastrointestinal Bleeding
Def :
Upper gastrointestinal bleeding is from a source between the pharynx and the ligament of Trietz.
This type of bleeding is characterised by hematemesis and melena.
Bleeding from obscure sources:
Defined as bleeding of :
• unknown origin that persists or recurs,
• that is recurrent or persistent iron deficiency anemia,
• occult blood test positivity, or visible bleeding,
• after a negative initial or primary endoscopy (colonoscopy and/or upper endoscopy)
result.
Occult GI bleed:
Identification of GI bleed in absence of overt bleeding by special exams of stool (GUIAC TEST)
Etiology :
The etiology of acute upper GI bleed in children can be broadly divided into two main groups:
1. Variceal
a. Extrahepatic Portal vein obstruction (EHPVO)
b. Chronic Liver Disease (CLD)
2. Non Variceal
a. Ulcers and erosions
b. Coagulation disorders
c. Vascular malformations
d. Miscellaneous
UGI BLEEDING IN CHILDREN
2. 2
Grading :
Bleeding :
SHOCK –ve: MILD
SHOCK +ve : rapid BT >400ml or 20ml/kg
Recovered from shock
MODERATE
shock persist, bleeding persist ,more BT required
SEVERE
SEVERE bleeding criteria:
1.
2.
3.
4.
Shock
20% of blood volume required immediately (or)
≥40% of blood required in 24hrs to stabilize hemodynamically
Fall of Hb < 8gm/dl
PSEUDO / SPURIOUS :
Newborns who have swallowed maternal blood can present with significant melena or hematemesis
while appearing stable clinically. The Apt Downey test performed on the emesis identifies the source
of bleeding, conclusively
number of substances such as food coloring agents, vegetables such as beetroot, drugs like ampicillin
and phenobarbital may mimic hematochezia. Similarly, melena may be mimicked by iron
preparations, spinach, chocolate, blueberries, grape juice, or licorice.
History and Physical Examination:
Most GI bleeding is not life threatening, it is necessary to determine:
the source
degree
possible cause of the bleeding.
A complete and thorough history and physical examination is therefore vital.
Four questions need to be answered by taking history and physical examination:
1. spurious Vs True bleeding
UGI BLEEDING IN CHILDREN
3. 3
2. source : Is the child actually bleeding from the gastrointestinal tract? Hemoptysis Vs
Hematemisis , rule out Munchausen syndrome
3. What is the site of bleeding?
a. Melena is indicative of a significant blood loss (over 2% of blood volume), most
likely taking place proximal to the ligament of Trietz.
b.
Lesions proximal to the ligament of Trietz presents usually as vomiting of bright
red or coffee ground blood.
c. Streaking of blood on the stools is indicative of lesion in the rectum or anal canal.
d.
Bright red or dark red blood in the stool is indicative of lesions associated in the
ileum or colon.
e. In the event of massive bleeding from the upper tract, bright red rectal bleeding
may occur in about 10%of cases .
f.
The presence of blood in the gastric aspirate is very suggestive of bleeding above
the ligament of Trietz
4. How much blood has been lost?
a. If bleeding is slow, as much as 13% of blood can be lost without any
hemodynamic change.
b. The loss of palmar crease erythema may be seen when the hand is hyperextended,
as a sign of 50% or more blood volume loss
Diagnosis:
Diagnosis is based on direct observation of blood in the stool or vomitus.
Microscopic blood loss in the stool can be confirmed with a faecal occult blood test.
For upper GI bleeding, a nasogastric tube is placed to confirm the presence of fresh blood
and to evaluate the degree of active bleeding
Endoscopy :
Esophagogastroduodenoscopy (EGD) and colonoscopy re currently considered the first-line
diagnostic procedures of choice for upper and lower GI bleeding, respectively.
The site and the cause of bleeding can be identified in 85 to 90% of the patients.
Endoscopy also provides immediate access to the bleeding site for any possible intervention.
UGI BLEEDING IN CHILDREN
4. 4
There are definite advantages of performing an endoscopy within the first 24 h of bleed.
These include higher diagnostic accuracy, achieving hemostasis quickly, possibly preventing
complications, decreasing transfusions and length of hospital stay for these patients .
However, there is no advantage in performing an endoscopy within the first 6 h as compared
to 6–24 h. Additionally, complication rate for emergency endoscopy is four times higher than
an elective endoscopy
Radionuclide Studies :
Radionuclide imaging techniques allow identification of those patients who are actively
bleeding.
(99m)
Tc-labeled erythrocytes and (99m)Tc sulfur colloid are two commonly used techniques to
detect active bleeding
diagnostic sensitivity of the scans 39.1%
scintigraphy may be helpful in risk-stratifying patients and planning radiological and surgical
interventions.
Conventional Angiography:
useful in the evaluation of difficult to diagnose cases of recurrent UGI bleeding .
Arteriography is best performed in patients in whom bleeding is severe and active.
Even 0.5 ml/min of the bleeding rate can be demonstrated angiographically
accurate angiographic diagnosis is more likely in acute GI bleeding than in chronic GI
bleeding, (71% vs 55%) .
Angiography is also effective in demonstrating lesions not bleeding currently as in vascular
malformation, telangiectasias and hemangiomas
CT Angiography
FAL)
CT angiography is an excellent tool for fast and accurate diagnosis and localization of acute
GI bleeding. (FAL)
Advantages include widespread availability, speed, reproducibility, minimal invasiveness
and detection of bleeding in the endoscopically inaccessible small bowel.
UGI BLEEDING IN CHILDREN
5. 5
Limitations of CT angiography are the lack of therapeutic options in comparison to those
that are available with endoscopy, colonoscopy and conventional angiography, radiation
dose, and risks affiliated with usage of contrast material
Role of BUN:
BUN increases in view of increased protein load presented to the small intestine following a
GI bleeding episode or a decreased excretion from the kidneys of urea nitrogen due to
hypovolemia.
A direct relationship exists between BUN/ Cr ratio and Delta Hb in upper GI bleeding
∆Hb = 0.08 (BUN/Cr) + 0.8
Ratio of BUN/Cr of ≥30 has 98% specificity and sensitivity of 68.8% of upper GI
bleeding.
Those who have a BUN/Cr ratio >30 have a high probability that Hb will fall later .
When BUN/Cr ratio returns to normal: active bleeding has stopped
Management of Gastrointestinal Bleeding:
The goals of therapy in a child with GI bleeding should include:
1. Hemodynamic resuscitation
2. cessation of bleeding source
3. Etiological identification
4. prevention of future episodes of GI bleeding
UGI BLEEDING IN CHILDREN
6. 6
Initial assessment and classification of illness
Immediate steps be followed for managing upper GI bleed:
UGI BLEEDING IN CHILDREN
7. 7
Pharmacologic Management of Mucosal Bleeding:
Mucosal bleeding is most common type of upper GI bleed in critically ill children.
Therapy in these groups of patients is directed at neutralizing and/or preventing the release
of acid.
Antacids:
In children with gastric and duodenal ulcers, antacids need to be given for a minimum of 48 h
after bleeding has subsided.
In children more than 5 years of age, magnesium and aluminum hydroxide in doses of the 30
ml/h for the first 48 h followed by same dose at 1 and 3 h after meals throughout the
remainder of hospitalization
H2 Receptor Antagonists :
The H2 receptor antagonists are a class of drugs used to block the action of histamine on
parietal cells in the stomach, decreasing the production of acid by these cells.
H2 antagonists are used in the treatment of gastritis, peptic ulcers and superficial mucosal
erosions.
UGI BLEEDING IN CHILDREN
8. 8
They have been surpassed in popularity by the more effective proton pump inhibitors.
Proton Pump Inhibitors (PPIs):
Proton pump inhibitors act by irreversibly blocking the hydrogen/potassium adenosine
triphosphatase enzyme system (the H+/K+ ATPase, or, more common, gastric proton pump)
of the gastric parietal cell.
The proton pump is the terminal stage in gastric acid secretion, being directly responsible for
secreting H+ ions into the gastric lumen.
Targeting the terminal step in acid production, as well as the irreversible nature of the
inhibition, results in their ability to reduce gastric acid secretion by up to 99%.
Sucralfate :
Sucralfate is a sucrose sulfate-aluminum complex that acts locally in an acidic environment
(pH<4).
It reacts with acid in the stomach to form a cross-linking, viscous, paste-like material which
has an acid buffering effect for as long as 6 to 8 h.
It also attaches to proteins (such as albumin and fibrinogen) on the surface of erosions and
ulcers to form stable insoluble complexes.
These complexes serve as protective barriers at the ulcer surface, preventing further damage
from acid, pepsin, and bile.
Endoscopic Management of Mucosal Bleeding :
various techniques like thermal therapy, sclerosant therapy, clips, and thrombin/fibrin glue .
it was recommended that epinephrine injection alone should not be used.
UGI BLEEDING IN CHILDREN
9. 9
Pharmacologic Management of Variceal Bleeding:
Primary objective of therapy is immediate cessation of the bleeding.
Start all patients on H2 receptor blocker drugs or Proton pump inhibitors.
A vasoactive drug should also be started to decrease the splanchnic pressures.
Choose between octreotide and somatostatin except that the latter is costlier.
The indications for use of these drugs are:
o Lesions that are not amenable to or in which endoscopic therapy has failed;
o
Child is too unstable for intervention;
o children who have arterial bleeding (Dieulafoy’s lesion),
o children who have known varices undergoing stabilization before endoscopic therapy.
o Growing evidence in studies is accumulating over the superiority of terlipressin over
other vasoactive drug
Endoscopic Management:
Endoscopy should be performed when the patient has been stabilized and preferably within
24 h of admission or onset of hemorrhage .
The modalities available for controlling acute variceal bleeding are either variceal ligation or
sclerotherapy.
Sclerotherapy can control acute variceal bleeding in 70–100% of cases. In more experienced
hands, hemostasis can be achieved in more than 90% of cases.
endoscopic variceal ligation therapy significantly reduced rebleeding, mortality, frequency of
esophageal strictures and the number of sessions required to achieve variceal eradication
when compared with injection sclerotherapy .
Sclerosants are effective in controlling active variceal bleeding but are less favored than
variceal ligation because of associated complications
UGI BLEEDING IN CHILDREN
10. 10
Surgical Management:
In cases where conservative management fails with combined pharmacotherapy and
endoscopic treatments, shunt and nonshunt surgeries are the definitive treatment.
For primary UGI bleeding in children it is recommend that when more than 85 mL/kg of
blood is transfused within 1 1/2 h and bleeding has not subsided, surgery should be
considered
For intrahepatic portal hypertension, transjugular intrahepatic portosystemic shunting (TIPS)
provides temporary decompression of the intrahepatic portal vein into the hepatic veins.
Surgical portosystemic or portoportal shunts for GI bleeding are now reserved for refractory
cases and/or when liver transplantation is not an option.
Prognosis:
Prognostic factors associated with increased mortality:
The coexistence of another severe medical disorder
Coagulation disorder
Failure to identify the bleeding site
Hemoglobin level <7 g/dL, and/or a hematocrit value of <20% at presentation
>85 ml/kg blood loss without surgical intervention
UGI BLEEDING IN CHILDREN