This slides discusses about Isoquinoline nucleus (fused heterocyclic compound). this ring contain benzene ring fused with pyridine nucleus with nitrogen atom
This slide discusses about basic indole nucleus, its chemistry, synthesis, reactions and medicinal uses of Indolyl derivatives..Indole is basically fused heterocyclic compound
This slides discusses about Isoquinoline nucleus (fused heterocyclic compound). this ring contain benzene ring fused with pyridine nucleus with nitrogen atom
This slide discusses about basic indole nucleus, its chemistry, synthesis, reactions and medicinal uses of Indolyl derivatives..Indole is basically fused heterocyclic compound
THIS PRESENTATION CONTAIN INTRODUCTION, STRUCTURE, PHYSICAL AND CHEMICAL PROPERTIES, SYNTHESIS AND APPLICATION OF FUSED HETEROCYCLIC COMPOUND CONTAINING ONE HETERO ATOM - QUINOLINE, ISOQUINOLINE AND INDOLE
This slide discusses about fused heterocyclic compound Acridine..the structural analogue of anthracene with one carbon group is replaced with nitrogen atom.
Unit iii heterocyclic compounds as per PCI Syllabus of POC-IIIGanesh Mote
Nomenclature of hetero cyclic compounds, classification of heterocyclic compounds, Reactivity, aromaticity, orbital picture, stability, resonance energy, resonance structure, basicity, method of preparation, reaction and medicinal uses of Pyrrole, furan and thiophene
THIS SLIDE HAVE GOOD CONTENT. THIS SLIDE CONTAIN INTRODUCTION, STRUCTURE, RESONANCE, AROMATICITY, PHYSICAL AND CHEMICAL PROPERTIES, SYNTHESIS AND APPLICATION OF QUINOLINE.
5 membered heterocyclic compound Furan. it is complete powerpoint presentation who want to learn from basics of heterocyclic chemistry. I have referred from various books and done my best so that view can get all they can without scroll many books. Kindly give your feedback after viewing powerpoint presentation
THIS PRESENTATION CONTAIN INTRODUCTION, STRUCTURE, PHYSICAL AND CHEMICAL PROPERTIES, SYNTHESIS AND APPLICATION OF FUSED HETEROCYCLIC COMPOUND CONTAINING ONE HETERO ATOM - QUINOLINE, ISOQUINOLINE AND INDOLE
This slide discusses about fused heterocyclic compound Acridine..the structural analogue of anthracene with one carbon group is replaced with nitrogen atom.
Unit iii heterocyclic compounds as per PCI Syllabus of POC-IIIGanesh Mote
Nomenclature of hetero cyclic compounds, classification of heterocyclic compounds, Reactivity, aromaticity, orbital picture, stability, resonance energy, resonance structure, basicity, method of preparation, reaction and medicinal uses of Pyrrole, furan and thiophene
THIS SLIDE HAVE GOOD CONTENT. THIS SLIDE CONTAIN INTRODUCTION, STRUCTURE, RESONANCE, AROMATICITY, PHYSICAL AND CHEMICAL PROPERTIES, SYNTHESIS AND APPLICATION OF QUINOLINE.
5 membered heterocyclic compound Furan. it is complete powerpoint presentation who want to learn from basics of heterocyclic chemistry. I have referred from various books and done my best so that view can get all they can without scroll many books. Kindly give your feedback after viewing powerpoint presentation
Terpenoids for slide presentation new 1.pptxpravin bendle
Terpenoids are a group of naturally occurring compounds responsible for the aroma, taste, and occasionally the color of plants & found extensively in the leaves and fruits of plants like conifers, citrus, and eucalyptus.
Terpenes are hydrocarbons of plant origin of the general formula (C5H8)n and their oxygenated, hydrogenated, and dehydrogenated derivatives are known as terpenoids
On the thermal decomposition of Terpenoids ( isoprenoids) yield isoprene.
The special isoprene rule states that in most naturally occurring terpenes two or more isoprene units are linked to one another usually in a “head to tail” manner.(1- 4 link)
Terpenoids are classified on the basis of no of isoprene units in the molecule.
Terpenoids are volatile substances which give plants and flowers their fragrance. They occur widely in the leaves and fruits of higher plants, conifers, citrus and eucalyptus. The term ‘terpene’ was given to the compounds isolated from terpentine, a volatile liquid isolated from pine trees.
General Methods for Isolation of Terpene Hydrocarbons
1. Fractional Distillation:
• This usually takes place under vacuum or in an atmosphere of inert gas,?? as many hydrocarbons are sensitive to heat in atmospheric oxygen (product name? ? ?).
• This can carried out by gradual increase of the distillation temperature by (1-5oC) or (5-10 oC) according to the boiling point of components.
2. Preparation of the Corresponding Crystalline Additive Products “Adducts”:
Characteristic addition products are formed by N2O3 (Dinitrogen trioxide), N2O4, NOCl (Nitrosyl chloride) and NOBr to yield nitrosites, nitrosates, nitrosochlorides, and nitrosobromides, respectively.
Notes for Cellular Injury.
Prepared for B.pharm I year II sem students for study purpose.
Contact email : drxmathinanotech@gmail.com
Regards,
Mrs.S.Mathivanan., M.Pharm
Assistant Professor,
SMVEC Pharmacy college,
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Pyridine is the six membered heterocyclic compounds with nitrogen as an hetero-atom..Its synthesis, reactions and medicinal uses were discussed in this ppt
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
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2. History of Thiophene
•Viktor Meyer was a German chemist and significant contributor to
both organic and inorganic chemistry. He is best known for inventing
an apparatus for determining vapour densities, the Viktor Meyer
apparatus, and for discovering thiophene, a heterocyclic compound.
•In 1882 Victor Meyer discovered thiophene as contaminant in benzene.
•It was observed that isatin (an indole) forms a blue dye if it is mixed
with sulfuric acid and crude benzene. The formation of the blue
indophenin had long been believed to be a reaction of benzene itself.
Viktor Meyer was able to isolate thiophene as the actual substance responsible for this
reaction.
3.
4.
5. Thiophene
• Thiophene and its derivatives exist in petroleum
or coal.
• Thiophene is taken from the word ‘theion’, the
Greek word for sulfur, and another Greek word
‘phaino’ which means shinning.
• Thiophene structure can be found in certain
natural products and is also incorporated in
several pharmacologically active compounds.
6. Properties of Thiophene
• At room temperature, thiophene is a toxic,
flammable and colourless liquid with a mildly
pleasant odor reminiscent of benzene.
• The molecular mass of thiophene is 84.14 16
g/mol, density is 1.051 g/ml and Melting Point is
-38 °C.
• It is insoluble in water but soluble in most of the
organic solvents including alcohol and ether.
• The "electron pairs" on sulfur are significantly
delocalized in the π electron system, due to this it
behaves extremely reactive benzene derivative.
7. BIOISOSTERISM (Benzene vs Thiophene)
• Like benzene, thiophene forms an azeotrope with
ethanol.
• The similarity between the physicochemical
properties of benzene and thiophene is striking.
• For example, the boiling point of benzene is
81.1 ˚ C and that of thiophene is 84.4 ˚ C (at
760mm Hg) and therefore, thiophene and
benzene is a well known example of
bioisosterism.
• It can be easily sulfonated, nitrated, halogenated,
acylated, but cannot be alkylated and oxidized.
22. Vilsmeier Haack reaction
• This reaction can be applied to active aromatic compounds (such as
amines and phenols) Involves the formylation of an aromatic ring with
a di-substituted formamide and Phosphorus oxyxhloride.
• Thiophene is more reactive than benzene. It can be formylated and
forms Thiophene carbaldehyde
24. Medicinal value of Thiophene
• Thiophene with its 6π electrons aromaticity and
sterically similar to benzene derivatives may well
exhibits similar activities (Bioisosterism).
• At the same time presence of heteroatom in
thiophene may alter its metabolic fate, thus
thiophene derivatives may have less toxic effects
and/or better therapeutic profile.
• Thiophene is used in two principal ways.
• The most interesting chemically is the use of
thiophene either as central rings or as a part of
fused ring system
25. Medicinal importance of Thiophene
Thiophene moiety have attracted great attention in
medicinal field due to its diversified biological activities
such as:
• Anti-microbial activity ,
• Anti-fungal activity ,
• Antitubercular activity,
• Anti-oxidant activity ,
• Local anaesthetic activity,
• 5-HT1A receptor antagonist ,
Thiophenes and their derivatives are important class of
compounds.
• 5-HT6 receptor antagonist,
• Anti-inflammatory,
• Analgesic,
• Anticancer ,
• Anti-convulsant,
• Anti-allergy ,
• Phosphodiesterase-IV inhibitors.