The document discusses therapeutic aerosols, including their definition as disperse systems using gas as a continuous phase, and applications delivering medication directly to affected areas like skin or lungs. Key points covered include formulation aspects, common propellants used, and factors influencing deposition and clearance in the respiratory tract. The uses of aerosols for both local and systemic drug delivery are also summarized.
A breathing system is a device that conducts gases such as oxygen and anesthetic agents to the patient and conducts waste gases such as CO2 away.
Breathing systems are classified as
Open,
Semi-open,
Semi-closed
Closed.
Semi-closed systems are further divided into
Rebreathing Systems With CO2 Absorption,
Rebreathing Systems Without CO2 Absorption
Non-rebreathing Systems.
More simply, systems can be classified in two groups:
systems with CO2 washout (includes open and semi-open systems)
systems with CO2 absorption (includes closed and semi-closed systems).
mapleson circuits used in anesthesia practice, are in their way out but it is as important to know the mechanism with which the gases flow to and fro through them.
A breathing system is a device that conducts gases such as oxygen and anesthetic agents to the patient and conducts waste gases such as CO2 away.
Breathing systems are classified as
Open,
Semi-open,
Semi-closed
Closed.
Semi-closed systems are further divided into
Rebreathing Systems With CO2 Absorption,
Rebreathing Systems Without CO2 Absorption
Non-rebreathing Systems.
More simply, systems can be classified in two groups:
systems with CO2 washout (includes open and semi-open systems)
systems with CO2 absorption (includes closed and semi-closed systems).
mapleson circuits used in anesthesia practice, are in their way out but it is as important to know the mechanism with which the gases flow to and fro through them.
Critically ill patients requiring noninvasive or invasive ventilation often present to emergency departments, and due to hospital crowding and constrained critical care services, may remain in the emergency department for a prolonged duration. Compared with their intensive care unit counterparts, emergency department clinicians may have variable exposure to management of this patient population and may lack knowledge and expertise, particularly in their
longitudinal management beyond initial stabilization. This
review has discussed several key aspects of management
of noninvasive and invasive ventilation, with a particular emphasis on initiation and ongoing monitoring priorities,
and focused on maintaining patient safety and improving
patient outcomes.
anaesthesia Breathing circuits and its classification and functional analysisprateek gupta
anaesthesia breathing circuits. mapleson circuits. classification of circuits. functional analysia of circuits. draw over circuit. advantages and disadvantages of different circuits.
Critically ill patients requiring noninvasive or invasive ventilation often present to emergency departments, and due to hospital crowding and constrained critical care services, may remain in the emergency department for a prolonged duration. Compared with their intensive care unit counterparts, emergency department clinicians may have variable exposure to management of this patient population and may lack knowledge and expertise, particularly in their
longitudinal management beyond initial stabilization. This
review has discussed several key aspects of management
of noninvasive and invasive ventilation, with a particular emphasis on initiation and ongoing monitoring priorities,
and focused on maintaining patient safety and improving
patient outcomes.
anaesthesia Breathing circuits and its classification and functional analysisprateek gupta
anaesthesia breathing circuits. mapleson circuits. classification of circuits. functional analysia of circuits. draw over circuit. advantages and disadvantages of different circuits.
RESEARCH IN HOSPITAL PHARMACY and PHARMACY EDUCATIONAsra Hameed
RESEARCH IN HOSPITAL PHARMACY:
Advancement of pharmacy practice and healthcare
Pharmacists play a vital role in the health care system through the medicine and information they provide. Pharmacy education is the broad term which mainly involves the
Pharmacist educational requirements and carrier
Patient education
Microemulsion is an isotropic mixture of oil, surfactant, Cosurfactant and drug.
Upon mild agitation followed by dilution in aqueous media, such as gastrointestinal (GI) fluids, the systems can form fine oil in water (O/W) Microemulsions which usually have a droplet size less than 100 nm.
Microemulsion have been successfully used to improve the solubility, chemical stability, and oral bioavailability of many poorly water soluble drugs.
They have characteristic properties such as a low interfacial tension, large interfacial area and capacity to solubilize both aqueous and oil-soluble compounds.
Pulmonary drug delivery (PDD) systems were recently introduced into the pharmaceutical field to treat both the local and the systemic types of lung diseases. PDD systems are known to be able to simply deliver the drug to the required site in the body directly or to other distant sites through the bloodstream.
Administration of drug through nasal route is referred as Nasal drug delivery system.
Nasal administration is a route of administration in which the drug are insufflated through the nose for either local or systematic effect.
Nasal route is an alternative to invasive administrations and provides a direct access to the systemic circulation.
Penetration Enhancers:
Mechanism:
Inhibit enzymatic activity
Reduce mucus viscosity
Reduce MCC
Open tight junctions
Solubilize the drug
Ethnobotany and Ethnopharmacology:
Ethnobotany in herbal drug evaluation,
Impact of Ethnobotany in traditional medicine,
New development in herbals,
Bio-prospecting tools for drug discovery,
Role of Ethnopharmacology in drug evaluation,
Reverse Pharmacology.
Operation “Blue Star” is the only event in the history of Independent India where the state went into war with its own people. Even after about 40 years it is not clear if it was culmination of states anger over people of the region, a political game of power or start of dictatorial chapter in the democratic setup.
The people of Punjab felt alienated from main stream due to denial of their just demands during a long democratic struggle since independence. As it happen all over the word, it led to militant struggle with great loss of lives of military, police and civilian personnel. Killing of Indira Gandhi and massacre of innocent Sikhs in Delhi and other India cities was also associated with this movement.
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The Roman Empire, a vast and enduring power, stands as one of history's most remarkable civilizations, leaving an indelible imprint on the world. It emerged from the Roman Republic, transitioning into an imperial powerhouse under the leadership of Augustus Caesar in 27 BCE. This transformation marked the beginning of an era defined by unprecedented territorial expansion, architectural marvels, and profound cultural influence.
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1. Therapeutic Aerosols
Dr. Basavaraj K. NanjwadeM. Pharm., Ph. D
Department of Pharmaceutics
Faculty of Pharmacy
Omer Al-Mukhtar University
Tobruk, Libya.
E-mail: nanjwadebk@gmail.com
2014/05/18 1
Faculty of Pharmacy, Omer Al-Mukhtar University,
Tobruk, Libya.
2. CONTENTS
1. Definition and uses, model of operation.
2. Deposition in human respiratory tract.
3. Formulation aspects,
4. Propellants.
5. Packages and containers.
6. Absorption and clearance.
7. Applications.
8. References.
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Faculty of Pharmacy, Omer Al-Mukhtar University,
Tobruk, Libya.
3. Definition and uses
• Aerosols may be defined as disperse phase system, in
which very fine solid particles or liquid droplets get
dispersed in the gas which acts as continuous phase.
Uses:
1. The medicament can be delivered directly to the
affect area such as burnt skin and wound.
2. So it minimises the discomfort caused by mechanical
or manual application
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Faculty of Pharmacy, Omer Al-Mukhtar University,
Tobruk, Libya.
4. Model of operation
• Drugs are generally delivered to the respiratory tract
for the treatment or prophylaxis of airways diseases,
such as bronchial asthma and cystic fibrosis.
• The administration of a drug at its site of action can
result in a rapid onset of activity.
• Additionally, smaller doses can be administered
locally compared to delivery by the oral or parenteral
routes.
• The pulmonary route is also useful where a drug is
poorly absorbed orally.
2014/05/18
Faculty of Pharmacy, Omer Al-Mukhtar University,
Tobruk, Libya.
4
5. Deposition in human
respiratory tract
• Casts of the upper airways have been constructed in
an attempt to predict aerosol deposition in the lungs.
• Most lung deposition models are based on the
influence of particle size on aerosol deposition.
• Breathing parameters, such as breathing frequency
and tidal volume, play a key role in lung deposition.
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Faculty of Pharmacy, Omer Al-Mukhtar University,
Tobruk, Libya.
7. Formulation aspects
• The formulation of pharmaceuticals as therapeutic
aerosols is continually increasing.
• Thus antiseptic materials can be sprayed onto abraded
skin with a minimum of discomfort to the patient.
• One product, ethyl chloride, cools sufficiently on
expansion so that when sprayed on the skin, it freezes
the tissue and produces a local anesthesia.
• This procedure is sometimes used in minor surgical
operations.
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Faculty of Pharmacy, Omer Al-Mukhtar University,
Tobruk, Libya.
8. Propellants
• Propellants develops a pressure in the container.
• Compressed gases such as carbon dioxide or nitrogen
and liquified gases like methane or ethane can be
used as propellants.
• These days propellants like trichloro-fluoro-methane,
dichloro-difluoro-methane, dichloro-tetrafluoro-
ethane and difluoro-ethane are used in
pharmaceutical aerosols.
• The medicaments to be propelled may be solid or
liquid.
2014/05/18
Faculty of Pharmacy, Omer Al-Mukhtar University,
Tobruk, Libya.
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9. Packages
1. They are used for spray bandages and for
application of drugs meant for topical use.
2. They are used for spray administration of drugs into
various body cavities.
3. They are used for administration of drugs such as
local anesthetics, local antiseptic, local analgesics
and anti-inflammatory drugs.
4. They are used to spray cosmetics preparations such
as perfumes.
5. They are used to spray disinfectants, deodorizers
and air sanitizers.
2014/05/18 9
Faculty of Pharmacy, Omer Al-Mukhtar University,
Tobruk, Libya.
10. Containers
• The containers are made from metal, glass and plastic.
• Pharmaceutical aerosols may be packaged in tinplated
steel, plastic-coated glass or aluminium containers.
• MDIs (Metered-Dose Inhalers) are generally presented
in aluminium canisters, produced by extrusion to give
seamless containers with a capacity of 10-30 mL.
• Aluminium containers with an internal coating of a
chemically resistant organic material, such as an epoxy
resin, can be used.
2014/05/18
Faculty of Pharmacy, Omer Al-Mukhtar University,
Tobruk, Libya.
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12. Absorption
• Hydrophilic materials are poorly absorbed through
membrane pores at rates inversely proporational to
molecular size.
• Some drugs, such as sodium cromoglycate, are partly
absorbed by a saturable active transport mechanism.
• The rate of drug absorption, and consequently drug
action, can be influenced by the formulation.
• Prolonged absorption may be achieved using
suspension formulations or novel drug delivery
systems such as liposomes and microspheres.
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Faculty of Pharmacy, Omer Al-Mukhtar University,
Tobruk, Libya.
13. Clearance
• Particles deposited in the ciliated conducting airways
are cleared within 24 hours and ultimately swallowed.
• Insoluble particles penetrating to the alveolar regions,
and which are not solubilized in situ, are removed
more slowly.
• Alveolar macrophages engulf such particles and may
then migrate to the bottom of the mucociliary
escalator, or alternatively particles may be removed
via the lymphatics.
2014/05/18
Faculty of Pharmacy, Omer Al-Mukhtar University,
Tobruk, Libya.
13
14. Applications
1. The use of aerosols as a dosage form is particularly
important in the administration of drugs via the
respiratory system.
2. In addition to local effects, systemic effects may be
obtained if the drug is absorbed into the bloodstream
from the lungs.
3. Topical preparations are also well suited for
presentation as aerosols.
2014/05/18
Faculty of Pharmacy, Omer Al-Mukhtar University,
Tobruk, Libya.
14