This document discusses how next generation sequencing is revolutionizing genetics. It notes that sequencing an entire human genome now takes just 15 minutes and costs under $10,000, compared to over 10 years and $3 billion for the Human Genome Project. However, analyzing the large amounts of data generated remains a computational challenge. The document suggests that widespread and inexpensive whole genome sequencing will have significant impacts on individuals, companies, science/medicine, and government/civil society through uses such as direct-to-consumer testing, personalized medicine, forensics applications, and more. It argues this affects everyone and it is important to consider how to manage the associated issues.
In this presentation, we will delve into the principles of QTL mapping and explore various strategies for mapping QTLs in plants. We will also discuss the advantages and limitations, and provide insights into how QTL mapping is advancing our understanding of genetics.
Molecular Marker and It's ApplicationsSuresh Antre
Molecular (DNA) markers are segments of DNA that can be detected through specific laboratory techniques. With the advent of marker-assisted selection (MAS), a new breeding tool is now available to make more accurate and useful selections in breeding populations.
GRC Workshop at Churchill College on Sep 21, 2014. This is Paul Kitt's talk describing the NCBI approach to annotation the full human reference assembly.
In this presentation, I would like to provide the Resistance Mechanism and Molecular Responses to the Salinity.
There are two types of plants Halophytes and Glycophytes (categories on the basis of their responses to the salinity) examples are Thellungiella halophila and Arabidopsis thaliana, respectively.
Earlier Arabidopsis was considered as Model organism incase of plants but it can't tolerate high saline condition that's the reason for the limited study of plant towards salinity responses. But in the year 2004 the discovery of new plant Thellungiella halophila generates new knowledge about the tolerance mechanism of plants towards salinity responses because it's a halophytes which can tolerate extreme saline condition.
And also it has very similarity with the Arabidopsis so it's considered as the Model organism for the study of Salt stress physiology.
There are major two pathways involved in response to Salt stress (described in presentation).
Association mapping, also known as "linkage disequilibrium mapping", is a method of mapping quantitative trait loci (QTLs) that takes advantage of linkage disequilibrium to link phenotypes to genotypes.Varioius strategey involved in association mapping is discussed in this presentation
Genomics and its application in crop improvementKhemlata20
meaning ,definition of genome ,genomics ,tools of genomics ,what is genome sequencing ,methods of genome sequencingand genome mapping ,advantage of genomics over traditional breeding program, examples of some crops whose genome has been sequenced, important points about genomics, work in the field of genomics ,applications of genomics .classification of genomics .different Omics in genomics like Proteomics ,Transcriptomics ,Metabolomics ,Need of genome sequencing
In this presentation, we will delve into the principles of QTL mapping and explore various strategies for mapping QTLs in plants. We will also discuss the advantages and limitations, and provide insights into how QTL mapping is advancing our understanding of genetics.
Molecular Marker and It's ApplicationsSuresh Antre
Molecular (DNA) markers are segments of DNA that can be detected through specific laboratory techniques. With the advent of marker-assisted selection (MAS), a new breeding tool is now available to make more accurate and useful selections in breeding populations.
GRC Workshop at Churchill College on Sep 21, 2014. This is Paul Kitt's talk describing the NCBI approach to annotation the full human reference assembly.
In this presentation, I would like to provide the Resistance Mechanism and Molecular Responses to the Salinity.
There are two types of plants Halophytes and Glycophytes (categories on the basis of their responses to the salinity) examples are Thellungiella halophila and Arabidopsis thaliana, respectively.
Earlier Arabidopsis was considered as Model organism incase of plants but it can't tolerate high saline condition that's the reason for the limited study of plant towards salinity responses. But in the year 2004 the discovery of new plant Thellungiella halophila generates new knowledge about the tolerance mechanism of plants towards salinity responses because it's a halophytes which can tolerate extreme saline condition.
And also it has very similarity with the Arabidopsis so it's considered as the Model organism for the study of Salt stress physiology.
There are major two pathways involved in response to Salt stress (described in presentation).
Association mapping, also known as "linkage disequilibrium mapping", is a method of mapping quantitative trait loci (QTLs) that takes advantage of linkage disequilibrium to link phenotypes to genotypes.Varioius strategey involved in association mapping is discussed in this presentation
Genomics and its application in crop improvementKhemlata20
meaning ,definition of genome ,genomics ,tools of genomics ,what is genome sequencing ,methods of genome sequencingand genome mapping ,advantage of genomics over traditional breeding program, examples of some crops whose genome has been sequenced, important points about genomics, work in the field of genomics ,applications of genomics .classification of genomics .different Omics in genomics like Proteomics ,Transcriptomics ,Metabolomics ,Need of genome sequencing
April 3, 2019
Digital innovation is transforming health care, and the amount of digital health care data being generated will likely have increasing research utility over time. Despite the seemingly logical and inevitable application of health care data from deceased persons for research and health care both now and in the future, the issue of how best to manage posthumous medical records is currently unclear, including elements of resource governance, issues of law, and infrastructural challenges.
This presentation explored current issues surrounding how to manage the medical records of the dead, integrating evidence from the field of body donation to inform and guide the discussion on the utilisation of posthumous medical information. It also delivered results from a year-long study on posthumous health care data utility that explored the views of the general population on the use of posthumous medical records, which showed a centrally collated and government-governed resource of posthumous health care data was almost universally supported, with varying caveats around how such a resource should be utilized.
The Digital Health @ Harvard series features speakers from Harvard as well as collaborators and colleagues from other institutions who research the intersection between health and digital technology. The series is cosponsored by the Berkman Klein Center for Internet & Society at Harvard University and the Petrie-Flom Center for Health Law Policy, Biotechnology, and Bioethics at Harvard Law School. The goal of the series is to discuss ongoing research in this research area, share new developments, identify opportunities for collaboration, and explore the digital health ecosystem more generally.
Learn more on the website: https://petrieflom.law.harvard.edu/events/details/digital-health-harvard-april-2019
PYA Healthcare Thought Leader Explores Ten Technology “Game Changers”PYA, P.C.
PYA Principal Kent Bottles, MD, who is also Chief Medical Officer of PYA Analytics, was a recent guest speaker at Community Hospital 100, a gathering of community healthcare executives and visionaries. His presentation, “Ten Innovations That Will Change the Game for Community Hospitals,” outlined technological advances from “big data” to gamification, 3D biological printing to mobile medicine.
We are living in the world of “Big Data”. “Big Data” is mainly expressed with three Vs – Volume, Velocity and Variety. The presentation will discuss how Big Data impacts Pharmaceutical Industry and how drug companies can lead this new Big Data environment.
Show me the Data! Seminar on Innovative Approaches to Turn Statistics into K...2Paths
At the 2009 Seminar on Innovative Approaches to Turn Statistics into Knowledge (http://www.oecd.org/progress/ict/statknowledge), jointly organized by the OECD, US Census Bureau and World Bank, we proposed and demo'd a proof of concept on data sharing between international organizations. We demonstrated how open source tools could sit on top of existing infrastructure and reused visualization tools to show how data could be pulled and combined from the various organizations on the fly.
Slides of the Talk Fabian Zimmer & I gave on the SIGINT 12 in Cologne. A video of the talk can be found here:
http://ftp.ccc.de/events/sigint12/mp4/vortrag_mp6_og_-_2012-05-19_20_00_-_power_to_the_patient_-_bastian_greshake_-_fabian_zimmer_-_40.mp4
The slides of the talk of @PhilippBayer and I gave on the 28th Chaos Communication Congress. Sources can be found here: https://github.com/drsnuggles/opensnp28c3
The slides i used for the defense of my BSc-Thesis. A blogpost in german about the work can be found here: http://www.wissenslogs.de/wblogs/blog/bierologie/biologie/2010-08-11/meine-bachelor-arbeit-transkriptom-analysen-f-r-jeden
2024.06.01 Introducing a competency framework for languag learning materials ...Sandy Millin
http://sandymillin.wordpress.com/iateflwebinar2024
Published classroom materials form the basis of syllabuses, drive teacher professional development, and have a potentially huge influence on learners, teachers and education systems. All teachers also create their own materials, whether a few sentences on a blackboard, a highly-structured fully-realised online course, or anything in between. Despite this, the knowledge and skills needed to create effective language learning materials are rarely part of teacher training, and are mostly learnt by trial and error.
Knowledge and skills frameworks, generally called competency frameworks, for ELT teachers, trainers and managers have existed for a few years now. However, until I created one for my MA dissertation, there wasn’t one drawing together what we need to know and do to be able to effectively produce language learning materials.
This webinar will introduce you to my framework, highlighting the key competencies I identified from my research. It will also show how anybody involved in language teaching (any language, not just English!), teacher training, managing schools or developing language learning materials can benefit from using the framework.
The Indian economy is classified into different sectors to simplify the analysis and understanding of economic activities. For Class 10, it's essential to grasp the sectors of the Indian economy, understand their characteristics, and recognize their importance. This guide will provide detailed notes on the Sectors of the Indian Economy Class 10, using specific long-tail keywords to enhance comprehension.
For more information, visit-www.vavaclasses.com
Ethnobotany and Ethnopharmacology:
Ethnobotany in herbal drug evaluation,
Impact of Ethnobotany in traditional medicine,
New development in herbals,
Bio-prospecting tools for drug discovery,
Role of Ethnopharmacology in drug evaluation,
Reverse Pharmacology.
Read| The latest issue of The Challenger is here! We are thrilled to announce that our school paper has qualified for the NATIONAL SCHOOLS PRESS CONFERENCE (NSPC) 2024. Thank you for your unwavering support and trust. Dive into the stories that made us stand out!
How to Create Map Views in the Odoo 17 ERPCeline George
The map views are useful for providing a geographical representation of data. They allow users to visualize and analyze the data in a more intuitive manner.
The Roman Empire A Historical Colossus.pdfkaushalkr1407
The Roman Empire, a vast and enduring power, stands as one of history's most remarkable civilizations, leaving an indelible imprint on the world. It emerged from the Roman Republic, transitioning into an imperial powerhouse under the leadership of Augustus Caesar in 27 BCE. This transformation marked the beginning of an era defined by unprecedented territorial expansion, architectural marvels, and profound cultural influence.
The empire's roots lie in the city of Rome, founded, according to legend, by Romulus in 753 BCE. Over centuries, Rome evolved from a small settlement to a formidable republic, characterized by a complex political system with elected officials and checks on power. However, internal strife, class conflicts, and military ambitions paved the way for the end of the Republic. Julius Caesar’s dictatorship and subsequent assassination in 44 BCE created a power vacuum, leading to a civil war. Octavian, later Augustus, emerged victorious, heralding the Roman Empire’s birth.
Under Augustus, the empire experienced the Pax Romana, a 200-year period of relative peace and stability. Augustus reformed the military, established efficient administrative systems, and initiated grand construction projects. The empire's borders expanded, encompassing territories from Britain to Egypt and from Spain to the Euphrates. Roman legions, renowned for their discipline and engineering prowess, secured and maintained these vast territories, building roads, fortifications, and cities that facilitated control and integration.
The Roman Empire’s society was hierarchical, with a rigid class system. At the top were the patricians, wealthy elites who held significant political power. Below them were the plebeians, free citizens with limited political influence, and the vast numbers of slaves who formed the backbone of the economy. The family unit was central, governed by the paterfamilias, the male head who held absolute authority.
Culturally, the Romans were eclectic, absorbing and adapting elements from the civilizations they encountered, particularly the Greeks. Roman art, literature, and philosophy reflected this synthesis, creating a rich cultural tapestry. Latin, the Roman language, became the lingua franca of the Western world, influencing numerous modern languages.
Roman architecture and engineering achievements were monumental. They perfected the arch, vault, and dome, constructing enduring structures like the Colosseum, Pantheon, and aqueducts. These engineering marvels not only showcased Roman ingenuity but also served practical purposes, from public entertainment to water supply.
2. Some History...
• 1953: Watson & Crick
discover the structure of
DNA
• 1977: Sanger publishes his
DNA sequencing method
3. Some History
• For years the method of
Sanger stays the standard
(it’s still widely used)
• Famous use of the
technique: The Human
Genome Project (HGP)
4. Some History
• Lessons of the HGP:
• took >10 years to
complete 1(!) genome
• cost of > 3 billion
USD
5. Today
• Large-scale genomic
sequencing is done using
Next Generation
Sequencing (NGS)
• Costs for individual
genomes dropped to
<10k USD
• Sequencing can be done
within days
6. …but…
• NGS allows for
parallelization & produces
fragmented data at a
rapid speed
• Relies on heavy
computation to stitch
fragments back into one
genome
ieces
billi on p
1.8
7. Today
• Computational power
becomes the limiting
factor for analyzing the
data
• Having data ≠ Gaining
Knowledge
“ I can assemble using MetaVelvet
on our server in less than a day
(admittedly it has 512GB of RAM,
but doesn't everyone?)
8. Today
• What do single genes
do?
• Which genes are
responsible for a
disease?
• How does gene
regulation work?
9. The Future?
“ Oxford Nanopore has also introduced
GridION -- a platform where multiple
cartridges can be clustered together.
The company reckon that a 20-node
GridION setup can sequence a complete
human genome in just 15 minutes.
14. Individuals & Science /Medicine
• WGS for preventative
care
• finding risk factors
• counter diseases
before they can
develop
15. Individuals & Science /Medicine
• Rise in data available for
scientists
• finding the genetic base
of diseases
• development of new
treatments/drugs based
on genetic knowledge
16. Individuals & Science /Medicine
• Problems
• Should WGS data be
reused?
• What about sharing data
with other scientists?
• Will participants get their
raw data? Who owns it?
• What about incidental
findings?
17. What changes?
Science*
*it works!
Individuals Companies
Government & Civil Society
18. Individuals & Companies
• Direct-To-Consumer
Genetic Testing goes WGS
• Problems:
• Quality of resulting
analysis by companies?
• Should customers be
allowed to take
commercial tests without
medical supervision?
21. What changes?
Science*
*it works!
Individuals Companies
Government & Civil Society
22. Individuals & Government /
Civil Society
• Genetic Testing for…
• …online dating?!
• …finding the perfect
work-out strategy?!
23. Individuals & Government /
Civil Society
• and of course: Forensics…
• What could Law
Enforcement do with
WGS data?
24. This affects all of us!
Science*
*it works!
Individuals Companies
Government & Civil Society
25. Where does this leave us?
• Human Genetics & Genomics is rapidly
growing field
• It can have an impact on lots of parts of
every day life
• Now is the time to think about how we
want to deal with this!