The Byzantine Empire lasted from 330 AD to 1453 AD, with its capital in Constantinople. It preserved classical Greek knowledge and spread Orthodox Christianity. Politically, the emperor was head of both church and state. Justinian reconquered much of the former Western Roman Empire in the 6th century but this left the empire financially weakened. The empire gradually declined due to invasions and loss of territory to the Arabs and Seljuk Turks. The Fourth Crusade sacked Constantinople in 1203, weakening the empire further until the Ottomans conquered Constantinople and ended the Byzantine Empire in 1453.