This document defines and describes syrups. Syrups are nearly saturated sugar solutions, often containing flavorings or medications. The key points are:
- Syrups use sucrose (table sugar) as the primary solute. The high sugar concentration prevents microbial growth.
- Preservatives may be needed if the syrup contains less than 85% sugar. Common preservatives include benzoic acid, sodium benzoate, and parabens.
- Sorbitol and artificial sweeteners can make non-nutritive syrups for people who need to limit sugar intake, like those with diabetes.
- Syrups are prepared by dissolving sugar in water with heat or agitation
Liquid preparations having two phases are termed as
biphasic liquids.
DEFINITION, ADVANTAGES AND
DISADVANTAGES, CLASSIFICATIONS,
PREPARATION OF SUSPENSIONS;
FLOCCULATED AND
DEFLOCCULATED SUSPENSION &
STABILITY PROBLEMS AND METHODS
TO OVERCOME
Emulsion
Definition, classification, emulsifying
agent, test for the identification of
type of Emulsion, Methods of
preparation & stability problems and
methods to overcome.
An excipient is generally a pharmacologically inactive substance used as a carrier for the active ingredients of a medication
EXCIPIENTS USED IN LIQUID DOSAGE FORMS:
Solvents/co-solvents ,
Buffering agents,
Preservatives,
Anti-oxidants,
Humectants,
Wetting agents,
Anti-foaming agents,
Thickening agents,
Sweetening agents,
Flavouring agents,
EXCIPIENTS USED IN TABLETS:
Binders
Coatings
Disintegrants
Fillers
Flavours
Colours
Lubricants
Glidants
Preservatives
Sweeteners
Liquid preparations having two phases are termed as
biphasic liquids.
DEFINITION, ADVANTAGES AND
DISADVANTAGES, CLASSIFICATIONS,
PREPARATION OF SUSPENSIONS;
FLOCCULATED AND
DEFLOCCULATED SUSPENSION &
STABILITY PROBLEMS AND METHODS
TO OVERCOME
Emulsion
Definition, classification, emulsifying
agent, test for the identification of
type of Emulsion, Methods of
preparation & stability problems and
methods to overcome.
An excipient is generally a pharmacologically inactive substance used as a carrier for the active ingredients of a medication
EXCIPIENTS USED IN LIQUID DOSAGE FORMS:
Solvents/co-solvents ,
Buffering agents,
Preservatives,
Anti-oxidants,
Humectants,
Wetting agents,
Anti-foaming agents,
Thickening agents,
Sweetening agents,
Flavouring agents,
EXCIPIENTS USED IN TABLETS:
Binders
Coatings
Disintegrants
Fillers
Flavours
Colours
Lubricants
Glidants
Preservatives
Sweeteners
Liquid oral topic in Industrial Pharmacy contains many topics like solution, elixirs, syrups, emulsion, and suspension. This topic includes general introduction, types, formulation, components, uses, and Quality control tests. These are also beneficial in other subjects like Pharmaceutics.
In this presentation viewers will able to learn about liquids for external use such as liniments and lotions, liquids for oral cavity such as mouthwash, throat paints and gargles.
Liquid oral topic in Industrial Pharmacy contains many topics like solution, elixirs, syrups, emulsion, and suspension. This topic includes general introduction, types, formulation, components, uses, and Quality control tests. These are also beneficial in other subjects like Pharmaceutics.
In this presentation viewers will able to learn about liquids for external use such as liniments and lotions, liquids for oral cavity such as mouthwash, throat paints and gargles.
the all u need to know about syrup is here its a verified information.and will help u to incerease your knowledge about liquid dosage forms especially Syrup
The extraction of morphine from the poppy plant involves several steps. Here is a general outline of the process:
1. Cultivation and Harvesting: Poppy plants (Papaver somniferum) are cultivated and grown in suitable conditions. The plants are typically harvested when the seeds have matured and the capsules contain the highest amount of alkaloids, including morphine.
2. Incision and Latex Collection: The capsules of the poppy plant are carefully incised to create small cuts or "scores." The latex, which contains morphine, begins to ooze out of the cuts. This process is known as latex collection.
3. Scraping and Collection: The latex that has oozed out of the incisions is carefully scraped off the surface of the capsules using a specialized tool. This collected latex contains various alkaloids, including morphine.
4. Alkaloid Extraction: The collected latex is mixed with a solvent, such as ethanol or methanol, to dissolve the alkaloids. This mixture is typically stirred or shaken to ensure thorough extraction. The solvent acts as a carrier for the morphine and other alkaloids.
5. Filtration: The mixture is then filtered to separate the liquid (containing the dissolved alkaloids) from any solid plant matter or impurities. This can be done using filter paper or other filtration methods.
6. Concentration: The filtered liquid, containing the dissolved alkaloids, is subjected to evaporation or other concentration techniques to remove the solvent and obtain a more concentrated alkaloid solution.
7. Purification: The concentrated alkaloid solution may undergo further purification steps to isolate and separate morphine from other alkaloids. This can involve techniques such as chromatography or crystallization.
8. Drying and Solidification: The purified morphine is typically dried to remove any remaining moisture. It is then processed into a solid form, such as a powder or crystalline substance.
It is important to note that the extraction of morphine from the poppy plant is a highly regulated process and is typically carried out by licensed pharmaceutical companies under strict legal controls.
For more detailed information and step-by-step procedures, you can refer to the following information links:
1. "Extraction of Morphine from Opium Poppy": This research article provides a detailed protocol for the extraction of morphine from the poppy plant using various solvents and purification techniques. [Link: https://pubmed.ncbi.nlm.nih.gov/26798156/]
2. "Opium Poppy Cultivation and Opium Production": This document by the United Nations Office on Drugs and Crime provides an overview of opium poppy cultivation, harvesting, and processing, including the extraction of morphine. [Link: https://www.unodc.org/documents/scientific/Opium_Poppy_Cultivation_and_Opium_Production.pdf]
Please note that the extraction and use of morphine are highly regulated due to its potential for misuse and addiction. It is essentihkkklllllllllllllllllll and ethical guidelines
Pharmaceutical Solutions. Definition: Homogeneous liquid preparations that contain one or more chemical substances dissolved, i.e., molecularly dispersed, in a suitable solvent or mixture of mutually miscible solvents.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
2. SYRUP
Definition:
➢ Syrup is a nearly saturated aqueous solution of
sugar such as sucrose in water, with or without
medicinal or flavouring ingredients.
➢ When the syrup contains some added medicinal
substances, it is called medicated syrup.
➢ Flavoured syrup is one which is not medicated but
contains flavoured substances, and it is used as
flavoured vehicle.
3. ➢It is important that the concentration of
sucrose approach but not quite reach the
saturated point.
➢In dilute solution, sucrose provides an
excellent nutrient for many microorganisms.
➢ Its concentrated solution on the other hand,
retards their growth. However, a saturated
solution may lead to crystallization of a part of
the sucrose under conditions of changing
temperature.
4. PRESERVATION OF SYRUPS
Many of the official syrups do not contain preservative
other than an adequate sucrose concentration.
The concentration of sucrose is an important factor in
inhibiting molds growth.
Nearly saturated solutions of sucrose if properly stored
do not need a preservative. As these solutions do not
contain free water so they are anhydrous medium with
respect to growth, of microorganisms.
5. ✓Certain syrups may contain preservatives.
✓If the concentration of sucrose is less than 85
% w/v of sucrose, a preservative should be
added. The preservatives used may be the
following :
6. Preservative Concentration (%)
Benzoic acid 0.1-0.2
Sodium benzoate 0.1-0.2
Butyl paraben 0.02
Propyl paraben 0.05
Methyl paraben 0.1
Sorbic acid 0.1
Alcohol 15-20
Benzoates, parabens and sorbic acid are most
effective in acid syrups and are ineffective in
alkaline syrups
7. CALCULATION OF THE AMOUNT ADDED
PRESERVATIVE TO SYRUPS:
The amount of added preservative to syrup
containing a reduced amount of sugar depends
on the amount of "free water ",
e.g. 100 ml of a 65 % w/v sucrose solution Is
equivalent to 76.5 ml of 85 % w/v syrup and
23.5 ml of water.
8. That is
100 ml containing 85 gm sucrose
x ml containing 65 gm sucrose
x = (65 x 100 ) / ( 85 ) = 76.5 ml
✓In 65 % w/v sucrose containing 76.5 ml of
syrup containing the official concentration
(85%) and the amounts of free water is
calculated as:
✓Free water = 100 - 76.5 = 23.5 ml
9. ✓The amount of preservative is proportional to the
amount of the free water.
✓The more the free water, the more, the added
preservative.
✓ In some syrup alcohol is, present in small amounts.
It serves as a solvent for certain ingredients. The
concentration of the alcohol is not sufficient to act as
a preservative. But some authors believe that alcohol
evaporates on the surface of the syrup and thus
prevents the growth of surface molds.
10. SUGARS USED IN PREPARING SYRUPS:
Sucrose:
It is a disaccharide which undergoes
hydrolysis to give the monosaccharides
dextrose (glucose) and levulose (fructose).
C12 H22 O11 + H2O =====> C6 H12 O6 + C6H12O6
Sucrose Dextrose (d) + Levulose (1)
11. ✓As a result of this reaction. the following
take place:
1. Solutions of inverted sugar are more
subjected to fermentations than the solution
of sucrose.
2. After hydrolysis or inversion the solution is
sweeter i.e. if sucrose is rated 100 dextrose is
rated 74 & levulose 173, thus invert sugar is
1.23 times as sweet as sucrose.
12. 3. The levulose is also responsible for the brown
discolouration which develops in some
colourless syrup. This change is called
caramelization, it also takes place in syrups
containing strong acids because the hydrogen
ion catalyses the inversion of sucrose.
13. The advantages of sucrose are:
1. Its purity.
2. Its high degree of sweetness,
3. Relatively cheap,
4. Readily soluble in water,
5. Lack of colour ,
6. Ease of handling.
14. •Dextrose:
✓ Dextrose appears in a few of official syrups in USP
as a substitute for sucrose in syrup containing strong
acid in order to eliminate the discoloration associated
with carmelization.
✓It forms a saturated solution at 50 % which is less
viscous than simple syrup .
✓Its saturated solution readily supports the growth of
micro-organisms.
✓Dextrose dissolves more slowly, It is less sweet.
15. PREPARATION OF SYRUPS
1-Solution Method with Heat .
2- Agitation Method.
3-addition of a Medicated Liquid to Syrup.
4- Percolation Method.
16. SIMPLE SYRUP
(Sirupus Simplex)
EP USP and
BP
R/ Sucrose 667 gm 850 gm
Purified Water ad 1000 gm 1000 ml
17. Preparation of simple syrup in EP
1- Put the weighed amount of sucrose in a previously
weighed porcelain dish. Add distilled water to the dish
till the contents of the dish weigh 1000 gm.
2- Transfer the dish with its contents to a boiling water
bath and heat with constant stirring with a glass rod till
the sugar is completely dissolved.
3- Cool the dish and ascertain the weight again adding
boiling water to complete to 1000 gm if necessary.
4- Filter while hot through a piece of lint or filter paper
into a dry bottle.
5- Shake occasionally till completely cold.
18. Preparations of simple syrup in USP
1- Dissolve the required amount of sugar in a beaker
with the required amount of boiling water. The solution
is hastened by heating on boiling water bath with
stirring with a glass rod taking care to remove the flame
from time to time in order to prevent over heating of the
syrup
2- When the sugar is completely dissolved, filter rapidly
while hot through a filter paper.
3- Adjust to the required volume with boiling water.
4- Transfer to a dry clean bottle and shake continuously
till it cools well.
19. Percolation Method
1. Place the sucrose in a suitable percolator, the neck
of which is nearly filled with loosely packed cotton
moistened, after packing with a few drops of water.
2. Pour carefully about 450 ml of purified water upon
the sucrose; regulate the outflow to a steady drip of
percolate.
3. Return the percolate if necessary until all of the
sucrose has dissolved. Then wash the inside of the
percolator and the cotton with sufficient purified
water to, bring the volume of the percolate to 1000
ml and mix.
20. Description:
A clear heavy viscous liquid.
Specific gravity
1.313
Storage
In tight containers, at a temperature not more than
25°C.
Incompatibilities:
1. with preparations containing high percentage of
alcohols as crystallization of sucrose will take
place simple syrup can be mixed with10% alcohol
without crystallization
2. Concentrated acids aid the hydrolysis of sugars.
21. THE ACTIONS AND USES OF SYRUPS:
1. Syrups are used as vehicles for drugs such as
antibiotics, Antihistaminic, antitussives and vitamins .
2. The reducing sugars, dextrose and levulose formed in
the syrup as the result of inversion, are of value in
retarding the oxidation of other substance.
3. Concentrated sucrose solutions prevent
decomposition of vegetable extracted drugs; such
action is due to great osmotic pressure exerted by
sucrose solution, inhibiting the development of
bacteria, fungi and molds, which cause
decomposition.
22. 4. Because they contain no or very little alcohol,
particularly for children to the alcoholic vehicle
elixirs .
5. They possess remarkable masking for the saline
drugs.
6. Their lack of alcohol makes them superior as
solvents for water-soluble substances.
23. NOTES
Syrups prepared by hot method are
characterized by:
1. It has a light amber colour due to slight
caramelization.
2. It keeps better than syrup made by the cold
process because it is sterilized by the heat.
3. Excessive heating of syrups at the boiling
temperature is undesirable since inversion of
sucrose occurs with an increased tendency to
ferment
24. 4. Upon using heat for preparing syrups the
containers must be shaken occasionally till quite
cold for fear of the water which condenses on
the inside surface or the upper surface may fall
to dilute the upper layer of the syrup and thus
becomes liable to fermentation.
25. ARTIFICIAL SYRUPS. NON NUTRITIVE SYRUPS:
Many formulae are needed to be administrated
to persons who must regulate their sugar e.g.
persons suffering from diabetes mellitus, which
is characterized by hyperglycemia.
These formulae must be sugar-free, the
artificial syrups (non nutritive) are intended as
substitutes for syrups.
26. GLYCERIN
It is characterized by its sweet taste and it is a
viscous liquid, but its disadvantage is that it is
a glycogenetic substance i.e. material
converted into glucose in body either directly or
indirectly.
27. ARTIFICIAL SIMPLE SYRUP
Later on an artificial simple syrup was recomended as a
diabetic simple syrup:
R/
Sodium carboxymethyl cellulose 1.5%
Compound sodium cyclamate Solution 2.8%
Preservative Q.S.
Purified water Q.S.
The function of sodium carboxy methyl cellulose is to
give a viscous syrup.
28. SACCHARIN SODIUM:(SUCARYL SODIUM)
Is a synthetic sweetener which has significantly
bitter after taste. It is 300 to 400 times as
sweet as sucrose. So, its often used in
combination with the compound cyclamate
sodium solution.
The mixture of 10 parts cyclamate to 1 part
saccharin is common and take advantage of
the synergitic sweetening effect that saccharin
has on sucaryl, with minimum bitter after taste.
29. SORBITOL –BASED SYRUPS
Sorbitol is a hexahydric alcohol (C6H 14O6) made by
hydrogenation of glucose and is used as a substitute
for sucrose Syrups.
Sorbitol solution is superior to simple syrup because:
1. Sorbitol is not irritating to the mouth and throat.
2. It does not cause dental caries.
3. No significant hyperglycemia has been found after its
absorption, so it is used as component of non-nutritive
vehicles.
30. 4. Sorbitol solution is about 60% as sweet as sucrose and half as
viscous as simple syrup but it has excellent mouth feel and lacks
the acrid characteristics of some polyols (e.g. propylene glycol).
5. Sorbitol is added to sucrose-based syrups to reduce the
tendency of concentrated sugar solutions to crystallize.
6. Sorbitol inhibits the sticking or loking of bottle caps which
occurs with high concentrations of sucrose.
7. Sorbitol is chemically stable and practically inert, so many
drugs are more stable in sorbitol
31. Potassium chloride syruo
R/
potassium chloride 3.3 gm
sucrose 70 gm
purified water to 100 ml
Mitte 50 ml
Sig: MDU
✓Calculations
✓ Preparation
✓ Label
✓Use : k supplement for treatment and prophylaxis of
hypokalemia