This document provides instructions for preparing a simple syrup according to the Indian Pharmacopoeia. Simple syrup consists of 66.7% w/w sucrose dissolved in purified water. The procedure involves weighing the calculated amounts of sucrose and water, heating the water to dissolve the sucrose, then cooling and adding water to reach the required volume. The final simple syrup has a clear, colorless to slightly yellow appearance and is odorless.

1. To prepare and submit
simple syrup I.P.
Experiment No.1
Presented by Miss Sudipta Roy

2. • Theory of Syrup :
• Syrups are highly concentrated viscous aqueous solution in sugar in purified water. Syrups
may be medicated or non medicated. Simple syrup consists of 66.7 % w/w of sucrose as
per Indian Pharmacopoeia. If syrup contains same therapeutic agents it is called as
medicated syrup. If it do not contain therapeutic agents and only contains flavouring agents
and used as vehichles is called flavored syrup.
• eg. cherry syrup , orange syrup , coca syrup.
• Syrups are good demulcent and soothing agents, hence they are of special value in cough
syrups of sucrose in sugar based syrup is very important.
• Advantage of Syrup .
• As sweetening agent , syrup can mask unpleasant taste of medicine.
• Syrups are concentrated, when it is taken by oral route, there is a feeling of soothing effects
due to high viscosity in mouth and on irritated tissue of throat.
• Due to its taste and fluidity, syrup is given to small children and old aged patient that they
can swallow this.

3. What is simple syrup ?
Syrups are highly concentrated viscous aqueous
solution in sugar in purified water. Syrups may be
medicated or non medicated. Simple syrup consists
of 66.7 % w/w of sucrose as per Indian
Pharmacopoeia.

4. Requirements of making syrup.
Apparatus.
Glass beaker (250 ml ) , Sucrose , Measuring Cylinder,
Sucrose , Measuring Cylinder , Purified Water.

5. Procedure of making simple
syrup.
01) A 100 ml empty beaker was weighed and the weight was noted.
02) Half the quantity of purified water was placed in to beaker.
03 ) Calculated quantity of sucrose was weighed and added to the water.
04 ) Sucrose was dissolved by heating with occasional stirring.
05 ) After cooling , purified water was added to make up the required weight.
Dose : 15 to 20 ml.
Category : Pharmaceutical Aid . (Non-Medicated syrups )
Storage : Store in airtight container in cool temperature not exceeding 25 degree centrigrade.
(constant temperature can be prevent Crystallization of sugar in syrup )

6. Formulation Table.
Ingredients. Quantity Given Quantity Taken
(Factor * Quantity Given)0
Sucrose 667 gm 0.02*667=13.4 gm
Purified Water I.P. (q.s.) 1000 m 0.02*1000 ml = 20 ml
Factor = Required quantity/Quantity given = 20 ml /1000 ml = 0.02

7. Observation Table.
Name of the Preparation. Test Specification Observation
Smple Syrup I.P. Description
Color
Volume
Odour
Clear
Colorless to slightly yellow
100 ml
Odourless

8. Labelling.
Simple Syrup I.P. (20 ml )
Ingredients :
Sucrose - 13.4 gm
Purified water - 20 ml
Category :Pharmaceutical Aid. (Non-
Medicated Syrups )
Direction : As per need.
Storage : Store in airtight container in cool
temperature not exceeding 25 degree
centrigrade.
Manufacturing Date -
Expiry Date -
Manufactured by-
Manufacturing Place - Depatment of
Pharmaceutics , East POint College of
Pharmacy, Janaprabha, Bidarahalli.