HERE THE NATURAL PRODUCT SERTIA CHIRATA IS DISCUSSED WITH ITS COMMON NAME, CHEMICAL CONSTITUENTS, ACTIVE CONSTITUENTS, SAR, MEDICINAL ACTIVITY AND MORE
This presentation included the general intro of herb,
its collection and cultivation,
chemical constituents,
uses,
mechanism of action;
dosage form and doses;
side effects, toxicity;
precautions,
interaction with other drugs an herbs
Extraction, isolation and structure elucidation of flavonoids: QuercetinMohammad Khalid
Extraction, isolation and structure elucidation of- Flavonoids Quercetin
Introduction
FLAVONOIDS & THEIR EXAMPLES
Quercetin
general isolation method
Extraction and isolation
Extraction from neem leaves
Isolation of Quercetin Methanolic Extract of Azadirachta indica leaves
Structure elucidation of Quercetin
Health benefits
Side Effects of Quercetin
Alkaloids are a group of naturally occurring chemical compounds that mostly contain basic nitrogen atoms.
The term alkaloid was coined by Meissner, a German pharmacist, in 1819.
Alkaloids are cyclic organic compounds containing nitrogen in a negative state of oxidation with limited distribution among living organisms.
Most alkaloids contain oxygen in their molecular structure; those compounds are usually colorless crystals at ambient conditions.
Some alkaloids are colored, like berberine (yellow) and sanguinarine (orange).
Most alkaloids are weak bases, but some, such as theobromine and theophylline, are amphoteric.
Many alkaloids dissolve poorly in water but readily dissolve in organic solvents.
Most alkaloids have a bitter taste or are poisonous when ingested.
MORPHINE AS A LEAD DRUG MOLECULE COMPOUNDShikha Popali
THE ADDICTED DRUG MORPHINE AN ALKALOID USED TO TREAT SOME DISEASE , HERE WE HAVE ATTEMPT ALL DATA ITS STURECTURE MECHANISM OF ACTION, SAR AND APPLICATIONS.
GPAT
Niper &
other pharma competative exams...
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Active constituent of drugs used in diabetic therapyAkshay Kank
In this slide the active constituents which is isolated from herbal sources used for to treat the type 1 and type 2 diabetes is covered. 'Gymnema' and 'swerita chirata' herbal plant is also covered in the slide.This work help in to focus the herbal emphasis on diabetes.
This presentation included the general intro of herb,
its collection and cultivation,
chemical constituents,
uses,
mechanism of action;
dosage form and doses;
side effects, toxicity;
precautions,
interaction with other drugs an herbs
Extraction, isolation and structure elucidation of flavonoids: QuercetinMohammad Khalid
Extraction, isolation and structure elucidation of- Flavonoids Quercetin
Introduction
FLAVONOIDS & THEIR EXAMPLES
Quercetin
general isolation method
Extraction and isolation
Extraction from neem leaves
Isolation of Quercetin Methanolic Extract of Azadirachta indica leaves
Structure elucidation of Quercetin
Health benefits
Side Effects of Quercetin
Alkaloids are a group of naturally occurring chemical compounds that mostly contain basic nitrogen atoms.
The term alkaloid was coined by Meissner, a German pharmacist, in 1819.
Alkaloids are cyclic organic compounds containing nitrogen in a negative state of oxidation with limited distribution among living organisms.
Most alkaloids contain oxygen in their molecular structure; those compounds are usually colorless crystals at ambient conditions.
Some alkaloids are colored, like berberine (yellow) and sanguinarine (orange).
Most alkaloids are weak bases, but some, such as theobromine and theophylline, are amphoteric.
Many alkaloids dissolve poorly in water but readily dissolve in organic solvents.
Most alkaloids have a bitter taste or are poisonous when ingested.
MORPHINE AS A LEAD DRUG MOLECULE COMPOUNDShikha Popali
THE ADDICTED DRUG MORPHINE AN ALKALOID USED TO TREAT SOME DISEASE , HERE WE HAVE ATTEMPT ALL DATA ITS STURECTURE MECHANISM OF ACTION, SAR AND APPLICATIONS.
GPAT
Niper &
other pharma competative exams...
For more posts, follow us on .... be
@pharmahelpers
@pharmahelpers
@pharmahelpers
Also follow us on...
Facebook @ Pharma Helpers
Whatsapp @ 8421773854 OR https://chat.whatsapp.com/FFVRcxiiqC91PvnEvmK2F1
Instagram @ https://www.instagram.com/p/COM-VYqJ3Xo/?igshid=1ac01ibq2sa2k
Active constituent of drugs used in diabetic therapyAkshay Kank
In this slide the active constituents which is isolated from herbal sources used for to treat the type 1 and type 2 diabetes is covered. 'Gymnema' and 'swerita chirata' herbal plant is also covered in the slide.This work help in to focus the herbal emphasis on diabetes.
Pharmacognosy of traditional drugs in IndiaJegan Nadar
This PPT covers Pharmacognosy of traditional drugs in India, This includes pharmacognosy of chirata, shatavari, kalmeg, tinospora also known as guduchi, punarnava, karela, guggul, brahmi, neem, tulsi and amla
Therapeutics values of plant derived compoundsSenthil Natesan
Natural products, including plants, animals and minerals have been the basis of treatment of human diseases. History of medicine dates back practically to the existence of human civilization. The current accepted modern medicine or allopathy has gradually developed over the years by scientific and observational efforts of scientists. However, the basis of its development remains rooted in traditional medicine and therapies. The history of medicine includes many ludicrous therapies. Nevertheless, ancient wisdom has been the basis of modern medicine and will remain as one important source of future medicine and therapeutics. The future of natural products drug discovery will be more holistic, personalized and involve wise use of ancient and modern therapeutic skills in a complementary manner so that maximum benefits can be accrued to the patients and the community
Medicinal plants are considered as a rich resources of ingredients which can be used in drug development. More than 30% of the entire plant species, at one time or other were used for medicinal purposes. It has been estimated that in developed countries like United States, plant drugs constitute as much as 25% of the total drugs, while in fast developing countries like India and China the contribution is as much as 80%. These countries provide two third of the plants used in modern system of medicine and the health care system of rural population depend on indigenous systems of medicine. Most of the drugs are considered very safe as there is no or minimal side effects.
We Provide Herbal Diabetes Control Products, woman tonic for health, woman care medicine for herbal health, Herbal constipation management kit, Herbal product for healthy skin care, Herbal health with test, Herbal drink with test, Herbal slimming care with herbal product, Herbal amla for digest health, Single herb methi, herbal hemoglobin control medicine
MUTUAL PRODRUG IS DISCUSSED HERE IN DETAIL WITH ITS MULTIPLE TYPES AND FUCTIONAL GROUPS IT IS USE FOR AND FAILURE WITH PRODRUGS, WITH PHARMACEUTICAL EXAMPLES AND STRUCTURE ARE ALSO SHARE, SYNTHETIC APLLICATIONS.
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Synthetic reagent and applications OF ALUMINIUM ISOPROPOXIDEShikha Popali
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PTC IS THE PHASE TRANSFER CATALYSIS HERE TYPES OF PTC ARE DISCUSSED , THEORIES OF CATALYSIS AND MECHANISM OF PTC, ADVANTAGES OF PTC, APPLICATION OF PTC
THE DCC I.E. DICYCLOCARBODIIMDE IS A REAGENT AND HERE THE DETAIL ACCOUNT ON IT IS GIVEN INCLUDING MOLECULAR WEIGHT, STRUCTURE, SYNTHESIS AND PHYSICAL PARAMETERS AND APPLICATIONS FOR OTERS SYNTHESIS ARE ALSO DISCUSSED, THE DIFFERENT SYNTHESIS WITH DCC COMBINATION ARE ALSO MENTIONED
COMPARATIVE EVALUATION OF DIFFERENT PARACETAMOL BRANDSShikha Popali
THE PARACETAMOL TABLETS IS COMMONLY TAKEN AND PRESCRIBED FOR FEVER , SO HERE WE HAVE MADE PRACTICAL IS IT TRUE EVALUATION LABEL AND WHICH BRAND IS MORE SAFE.
How to Make a Field invisible in Odoo 17Celine George
It is possible to hide or invisible some fields in odoo. Commonly using “invisible” attribute in the field definition to invisible the fields. This slide will show how to make a field invisible in odoo 17.
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Synthetic fiber production is a fascinating and complex field that blends chemistry, engineering, and environmental science. By understanding these aspects, students can gain a comprehensive view of synthetic fiber production, its impact on society and the environment, and the potential for future innovations. Synthetic fibers play a crucial role in modern society, impacting various aspects of daily life, industry, and the environment. ynthetic fibers are integral to modern life, offering a range of benefits from cost-effectiveness and versatility to innovative applications and performance characteristics. While they pose environmental challenges, ongoing research and development aim to create more sustainable and eco-friendly alternatives. Understanding the importance of synthetic fibers helps in appreciating their role in the economy, industry, and daily life, while also emphasizing the need for sustainable practices and innovation.
Read| The latest issue of The Challenger is here! We are thrilled to announce that our school paper has qualified for the NATIONAL SCHOOLS PRESS CONFERENCE (NSPC) 2024. Thank you for your unwavering support and trust. Dive into the stories that made us stand out!
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The map views are useful for providing a geographical representation of data. They allow users to visualize and analyze the data in a more intuitive manner.
Operation “Blue Star” is the only event in the history of Independent India where the state went into war with its own people. Even after about 40 years it is not clear if it was culmination of states anger over people of the region, a political game of power or start of dictatorial chapter in the democratic setup.
The people of Punjab felt alienated from main stream due to denial of their just demands during a long democratic struggle since independence. As it happen all over the word, it led to militant struggle with great loss of lives of military, police and civilian personnel. Killing of Indira Gandhi and massacre of innocent Sikhs in Delhi and other India cities was also associated with this movement.
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The Roman Empire, a vast and enduring power, stands as one of history's most remarkable civilizations, leaving an indelible imprint on the world. It emerged from the Roman Republic, transitioning into an imperial powerhouse under the leadership of Augustus Caesar in 27 BCE. This transformation marked the beginning of an era defined by unprecedented territorial expansion, architectural marvels, and profound cultural influence.
The empire's roots lie in the city of Rome, founded, according to legend, by Romulus in 753 BCE. Over centuries, Rome evolved from a small settlement to a formidable republic, characterized by a complex political system with elected officials and checks on power. However, internal strife, class conflicts, and military ambitions paved the way for the end of the Republic. Julius Caesar’s dictatorship and subsequent assassination in 44 BCE created a power vacuum, leading to a civil war. Octavian, later Augustus, emerged victorious, heralding the Roman Empire’s birth.
Under Augustus, the empire experienced the Pax Romana, a 200-year period of relative peace and stability. Augustus reformed the military, established efficient administrative systems, and initiated grand construction projects. The empire's borders expanded, encompassing territories from Britain to Egypt and from Spain to the Euphrates. Roman legions, renowned for their discipline and engineering prowess, secured and maintained these vast territories, building roads, fortifications, and cities that facilitated control and integration.
The Roman Empire’s society was hierarchical, with a rigid class system. At the top were the patricians, wealthy elites who held significant political power. Below them were the plebeians, free citizens with limited political influence, and the vast numbers of slaves who formed the backbone of the economy. The family unit was central, governed by the paterfamilias, the male head who held absolute authority.
Culturally, the Romans were eclectic, absorbing and adapting elements from the civilizations they encountered, particularly the Greeks. Roman art, literature, and philosophy reflected this synthesis, creating a rich cultural tapestry. Latin, the Roman language, became the lingua franca of the Western world, influencing numerous modern languages.
Roman architecture and engineering achievements were monumental. They perfected the arch, vault, and dome, constructing enduring structures like the Colosseum, Pantheon, and aqueducts. These engineering marvels not only showcased Roman ingenuity but also served practical purposes, from public entertainment to water supply.
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This slides describes the basic concepts of ICT, basics of Email, Emerging Technology and Digital Initiatives in Education. This presentations aligns with the UGC Paper I syllabus.
2. Synonyms: Swertia chirata, Ophelia chirata
Common name: Chirayita
Botanical name: Swertia chirayita
Family: Gentianaceae
Geographic region: Plant is native of India and generally grow
in mountainous region of North India
Uses :
•Hypoglycemic property that helps in controlling blood sugar
level in the body
B.S: It consist of dried entire herb of Swertia chirata
• Hepatoprotective, antihepatotoxic, antimicrobial, anti-
inflammatory, anticarcinogenic, antileprosy, hypoglycemic,
antimalarial, antioxidant, anticholinergic, CNS depressant and
mutagenicity
3. Chemical Constituents:
•Xanthones are main secondary metabolites of Swertia species
•Xanthone derivatives chiratol, mangiferin, swertianin,
chiratanin, and chiratenol
• Amarogentin,Swertiamarin
•1,5,8-trihydroxy-3-methoxyxanthone
•Bellidifolin
•Isobellidifolin
4. ISOLATION:
30g powdered sample of both leaf and stem
Extracted in 50 ml of methanol separately using Soxhlet (48 hrs)
Cooled at room temperature, filtered through Whatmann No. 1 filter paper
Evaporated
Dried extracts
High speed counter current chromatography
5.
6. MOA: Swerchirin
stimulating insulin release from islets of pancreas
lowers blood glucose
enhance insulin signaling
Increase glucokinase (GK) activities
Methylswertianin and bellidifolin
7. Essential for activity
-OH not very much
important
OH essential for
hypoglycemic activity
Substitution of -OCH3 make
comp. more active than -
OH substitution
SAR: