SlideShare a Scribd company logo
Therapeutics values of plant
    derived compounds




                   Punyakishore Maibam
Quotation


“Within the infant rind of this small flower

      Poison hath residence and medicine power:

For this, being smelt, with that part cheers each part;

      Being tasted, slays all senses with the heart….”




                   (Romeo & Juliet Act II Scene III.)
Introduction
• Powerful ingredients.

• Only 15% of estimated plant species on earth have
  been investigated for possible Medicinal uses.

• No magic, diets high in fruits, grains, legumes reduce
  the risk of a various number of diseases

•    More than 95 % of the population in the least
    developing countries use herbs for health and other
    purposes.
History

•   History of traditional medicine in eastern culture
     – Ayurveda medicine
     – Chinese medicine

•   History of traditional medicine in western culture
     – European history
          The Greco-Roman Period
          The Dark ages
          19th Century
          The 20th Century

     – American history

•   Breakthrough in pharmaceutical chemistry came          when
    Serturner isolated morphine from opium poppy in 1806
Traditional Healing Systems
Ayurveda

     The aim of Ayurveda is
proper maintenance of
metabolic equilibrium of the
human psychosomatic
material and the restoration of
the same to the normal when
disturbed
Contd…


• Ayurveda utilizes herbs and
  product from natural resources for
  healing



•   Herbs like Neem , Aloe vera,
    Turmeric, Tulsi ( Holy basil),
    Babool, Garlic etc.
Chinese

• The Chinese believe that all
  things in creation possess
  the qualities of yin and
  yang, the opposing forces
  of nature

• When the balance between
  these two is lost, disease is
  manifest.

• Diagnosis is performed
  primarily through the pulse
  and tongue.
Unani


• Unani tibb meaning ‘Ionian’
  or ‘Greek’ medicine

• based on the Greek tradition
  of four humours – blood,
  phlegm, black and yellow
  bile
Japanese

• Ancient Japanese
  medical practices
  involved exorcism, ritual
  bathing and herbal
  therapy



            • kampo, using fewer
            and smaller quantities of
            herbs, often ground into
            granules to be taken in
            tea.
Aromatherapy
• It is the art of using the pure
  essence extract to promote the
  health and well-being of body
  and mind.

• Relies primarily on the use of essential oils

• Common oils- lavender, eucalyptus, tea tree oil,
  neem, tulsi and cinnamon etc
Common plants used with its
   derived products
Neem (Azadirachta indica)
Plant family: Meliaceae

    Plant used: Entire plant

          Origin culture: Native to East India
          and Burma

                Common uses: Antiviral, antifungal, antibacterial,
                antimalarial, antifertility, antiulcerogenic,
                antihypersensitive and antihyperglycaemic,
                antidermatophytic, orodontal, hepatoprotective and
                anticancer activity.

                           Active constituents:
                                   Diterpenoids, triterpenoids
                           (Azadirachtin), vilasinin type of
                           compounds, limonoids and its derivatives.
Jungli amla (Phyllanthus amarus)
Plant Family: Euphorbiaceae

    Parts used: Entire plant

           Origin: South India


               Common uses: Hepatitis, Gonorrhea, frequent
               menstruation, and Diabetes, anti-viral effect,
               skin for sores, swelling, and itchiness.

                          Active constituents: Phyllanthin D,
                          hypophyllanthine and five flavonaoids
                          viz. quercertin, astralgin, quercertrin,
                          isoquercitrin and rutin.
Aloe vera
Plant family: Asphodelaceae


      Part used: Leaf pulp

               Origin culture: Sub-Saharan
               African and Coptic traditional
               medicine

                       Common uses: Treatment of burns, skin
                       blemishes, topical irritations,
                       antibacterial, digestive aid.


                                 Active constituents:
                                 Anthroquinones, anthrols,
                                 anthrones, chrysophanic acid.
Garlic (Allium sativum)



Plant family: Alliaceae

       Part used: Leaves & stem (together
.      called the bulb)
                Origin culture: Chinese, Coptic, Farsi,
                Mediterranean, and Semitic traditional
                medicine
                        Common uses: Immunostimulation and
                        augmented circulation, triglyceride and
                        cholesterol level reduction,
                        hypertension control.
                               Active constituents: Allicin, and
                               allyl sulfides.
Ginger (Zingiber officinale)

Plant family: Zingiberaceae

     Part used: Rhizome
.
            Origin culture: Chinese and
            Indian traditional medicine.

                     Common uses: Digestive aid,
                     carminative, nausea/vomiting remedy,
                     anti-inflammatory.

                              Active constituents: Zingiberene,
                              gingerols/shogoals (volatile oils).
Ginseng (Panax ginseng)

Plant family: Araliaceae

.      Part used: Roots/rhizomes

                 Origin culture: Chinese,
                 Korean, and Siberian
                 traditional medicine.

                           Common uses: Taken internally for
                           fatigue/endurance/stress, control high
                           and low blood pressure.

                                    Active constituents:
                                    Ginsenosides
Feverfew (Tanacetum parthenium)
Plant family: Asteraceae


    Part used: Leaves

           Origin culture: Mediterranean
           traditional medicine.


                Common uses: Migraine headaches,
                fevers.

                           Active constituents: Parthenolide (a
                           sesquiterpene lactose), tanetin.
Ginkgo (Ginkgo biloba)

Plant family: Ginkgoaceae

.    Part used: Leaves

          Origin culture: Chinese
          traditional medicine

              Common uses: Improved memory,
              Alzheimer’s disease, Parkinson’s
              disease, improved circulation, post
              stroke recovery.

                            Active constituents: Ginkgolides/
                            bilobalide and flavonoids
Milk Thistle (Silybum marianum)

Plant family: Asteraceae
.

       Part used: Seeds


              Origin culture: Mediterranean
              traditional medicine.


                     Common uses: Hepatitis, liver diseases.


                              Active constituents: Silymarin,
                              silibinin, flavonoids.
St. Johns Wort
          (Hypericum perforatum)
Plant family: Clusiaceae


    Part used: Flowers & upper
    stems/leaves

              Origin culture: Greek traditional
              medicine.

                     Common uses: Antidepressant,
                     Antiviral.


                             Active constituents: Volatile oil,
                             carotenes, taninnin, flavanoids
                             (inc. hypericin)
To make it more effective and
     commercialized…




 Principal concepts of research on new medicines
                                   (Kuo-Hsiung Lee, 2005)
New approach

 • Biotransformation:
              The chemical conversion of an
   exogenously supplied substance by living cell
   cultures, permeabilzed cells or entrapped enzymes
   derived from cell culture.( Yeoman et al., 1990)

 • Single step or multiple step

 • A method used to improve the product yield.
Production of digitoxin
         • Cardiac glycosides from Digitalis species
           for heart diseases
         • Yeild from D. lanuta & D. purpurea were
           low.
         • Progesterone added for yield
Biotransformation of β-methyldigoxin by D. lanata cells in 201 bioreactor
                       over a period of 17 days
                                                      g%
β-Methyldigitoxin added                          17.24 (100)
Unconverted β-methyldigitoxin                    2.0 (11.8)
β-Methyldigoxin formed                           14.36 (81.7)
By-product                                       0.28 (1.4)
Yield                                                  (94.90)


                                                           (Misawa, 1994)
Drawbacks

• Toxicities are not well defined in herbal medicine

• Risk of overdose is higher

• Too much believe in herbal therapy

• Herbs and other alternatives therapies are more likely
  to abandon potentially beneficial conventional therapy
  when faced with an illness.
Reported Adverse Effects of Some Common Herbs   (Winslow et al., 1998)
Case studies
Therapeutics values of plant derived compounds
Introduction

• Two most dreadful diseases

• Plants have formed the basis of sophisticated
  traditional medicine systems that have been in
  existence for thousands of years in countries, such
  as China (Chang & But, 1986) and India (Kapoor,
  1990).

• Plant-derived compounds have played an important
  role in the development of several clinically
  useful anti-cancer and anti-aids agents.
Plant- Derived Anti Cancer agents

    First agents, vinca alkaloids (vinblastine and vincristine) from
    the Madagascar periwinkle, Catharanthus roseus (Cragg et al.,
    1994)

•   Epipodophyllotoxin used as the active anti -tumour agent from
    the genus Podophyllum (Cragg et al., 1994)

•   Most recent additions are Paclitaxel (Taxus brevifolia),
    campothecin (Camptotheca acuminata) homoharringtonine
    (Cephalotaxus harringtonia var. Drupacea), elliptinium, a
    derivative of ellipticine (Bleekeria vitensis), combretastatins,
    (Combretum caffrum)
Contd…
•    The leaves of T. baccata are used in the traditional Asiatic
    Indian (Ayurvedic) medicine system (Kapoor, 1990), with one
    reported use in the treatment of .cancer. (Hartwell, 1982)

•   Homoharringtonine against various leukemias while elliptinium
    for the treatment of breast cancer (Cragg et al., 1993b).

•   The combretastatins (Combretum caffrum) which act as anti-
    angiogenic agents, causing vascular shutdown in tumours
    (Holwell et al., 2002).
Anti- HIV agents
•   Michellamine B isolated from the leaves of the liana,
    Ancistrocladus korupensis, (Boyd et al., 1994).

•   Calophyllum lanigerum, yielded calanolide A which showed
    significant anti-HIV activity (Kashman et al., 1992)

•   Prostratin from Homalanthus nutans (Gustafson et al., 1992)
    determined that prostratin is a potent activator of HIV
    expression in latently infected T-cell lines

•   Extracts of the Smokebush (Conospermum incurvum) yielded
    conocurvone as the active agent (Decosterd et al., 1993)
Therapeutics values of plant derived compounds
Introduction
•   Aim of the study:
         To study the production of cinnamyl alcohol glycosides by
          biotransformation


•   Rhodiola rosea is only the species that produce he
    cinamyl alcohol glycosides

•   Various secondary metabolites are the cinnamyl
    alcohol glycosides (rosin, rosavin, rosarinand) &
    tyrosol and its glycoside salidroside

•   Field cultivation takes several year so cell and
    tissues cultures give a satisfactory results

•   Apart other compounds 337, 481, 483, and 321 are
    also reported (Tolonen et al., 2004)
Biosynthetic pathway of salidroside and cinnamyl
               alcohol glycosides




                   (A)                                   (B)
    Biosynthetic pathway of A) rosin, rosavin, rosarin and B) salidroside.
Materials and methods
      Experimental material

      Experiment with the precursors

      Fresh and dry weight measurements

      Chemical analyses
         high performance liquid chromatography
          with mass spectrometric detection
Results and discussion
•   Growth of the cultures
•   Production of the cinnamyl alcohol glycosides
       Addition of glucose was beneficial concerning
         the production
       Rosin production increased
       Rosavin was not produced in the original
         medium
•   Production of salidroside
•   Addition of glucose to the medium show any
    positive effect
•   Accumulation pattern was same in both cases
Contd…




     The content of rosin and rosavin in the callus cultivated with 2 mM cinnamyl alcohol in the original MS-Rh
             medium (containing only sucrose) or in the glucose containing medium, during 14 days.




         The content of salidroside in the callus cultivated with 2 mM tyrosol in the original MS-Rh medium
                 (containing only sucrose) or in the glucose containing medium, during 14 days.
                                                                                            (Gyorgy et al., 2005)
Pharmacological effects of the alcohol-aqueous extract of Rhodiola rosea
                                                         (Gyorgy et al., 2006)
Conclusion

• Production of rosin and rosavin can be increased by
    biotransformation

• Ultimately leads to satisfactory content of the
  pharmacologically interesting compounds
Therapeutics values of plant derived compounds
Introduction

• Aim of study
    To study the anti-ulcer and ulcer-healing activity of OS.


• OC leaves 0.7% volatile oil comprising about 71%
  eugenol and 20% methyl eugenol.

• Additional components are carvacrol, sesquiterpine
  hydrocarbon caryophyllene, apigenin,
  luteolin,apigenin-7-O-glucuronide, orientin,
  molludistin and ursolic acid (Gupta et al., 2002)
Materials and methods
           •      Animals (rats/guinea pigs)
                –    Anti-ulcer study(6 rats6
                     guinea pigs)
                –    Ulcer healing study (20 rats/
                     20 guinea pigs)-acetic acid-
                     induced ulcer model.

           •     Treatment schedule

Control:                                   Treatment:
  OS extract and standard anti-               OS extract and OMZ
  ulcer drug Omeprazole (OMZ)                                3 days

                                                     Ulcerogens
                                           •   Cold restraint stress induced
                                               ulcers (CRU)
                                           •   Aspirin-induced ulcers (ASP)
                                           •   Alcohol-induced ulcers (AL)
                                           •   Histamine- induced ulcers (HST)
                                           •   Pylorus ligation-induced ulcers
                                               (PL)
• Evaluation of ulcer-healing activity- acetic acid- induced ulcer model
Results
   Effect of ethanolic extract of Ocimum sanctum and
omeprazole at doses of 50, 100 and 10 mg/kg body weight,
                respectively, on percentage
  protection of ulcer index in different anti-ulcer models.




                                                        Effect of ethanolic extract of Ocimum sanctum and
                                                      omeprazole at doses of 100 and 10 mg/kg body weight
                                                               per day, respectively, on percentage
                                                       protection of ulcer index in acetic acid-induced ulcer
                                                         model in rats after 5, 10, 15 and 20 days of drug
                                                                             treatment.
                                                                                     (Dharmani et al., 2004)
Histopathology of acetic acid-induced ulcers
      C                       T

                                                  Sections of ulcerated stomach obtained from
                                                 rats of control groups and treated with Ocimum
                                                  sanctum in acetic acid-induced ulcer model in
                                                                        rats
                                                             after 5 days of treatment



                                                           C                      T


 Sections of ulcerated stomach obtained from
rats of control groups and treated with Ocimum
 sanctum in acetic acid-induced ulcer model in
                       rats
           after 10 days of treatment


       C                       T


                                              Sections of ulcerated stomach obtained from
                                             rats of control groups and treated with Ocimum
                                              sanctum in acetic acid-induced ulcer model in
                                                                    rats
                                                        after 15 days of treatment
                                                                      (Dharmani et al., 2004)
Discussion and conclusion

•   Report suggests that anti-stress and anti-oxidant activity of OS
    which suggests the free radical scavenging effect of OS (Sen et
    al., 1992).

•   Ethanol induced ulcers are due to direct necrotizing effect of
    ethanol on gastric mucosa (Miller and Henagan, 1984) so OS
    increases mucus secretion.

•   In PL, ulcers are developed due to accumulation of gastric acid
    and pepsin which leads to auto-digestion of gastric mucosa
    (Goel and Bhattacharya, 1991).
Conclusion
Doubts please !!!
Thank you

More Related Content

What's hot

Phytomedicine
PhytomedicinePhytomedicine
Phytomedicine
Kunal Kumar
 
Production of-secondary-metabolites
Production of-secondary-metabolitesProduction of-secondary-metabolites
Production of-secondary-metabolites
Bahauddin Zakariya University lahore
 
A review on home yard medicinal plants ppt.
A review on home yard medicinal plants ppt.A review on home yard medicinal plants ppt.
A review on home yard medicinal plants ppt.
Gauhati University, Avra Pratim Chowdhury
 
Hairy root culture
Hairy root culture Hairy root culture
Hairy root culture
Dr Suresh Solleti
 
An Ethino-botanical Survey With Special Emphasis On Medicinal Plant Used By E...
An Ethino-botanical Survey With Special Emphasis On Medicinal Plant Used By E...An Ethino-botanical Survey With Special Emphasis On Medicinal Plant Used By E...
An Ethino-botanical Survey With Special Emphasis On Medicinal Plant Used By E...
Ramakrishna Mission Vivekananda Educational and Research Institute
 
Ethnopharmacology
EthnopharmacologyEthnopharmacology
Ethnopharmacology
Shreya Gupta
 
2. azadriachata indica(neem)
2. azadriachata indica(neem)2. azadriachata indica(neem)
2. azadriachata indica(neem)
Shailendra Shah
 
Antimicrobial plants
Antimicrobial plants  Antimicrobial plants
Antimicrobial plants
Ashish Agrawal
 
Tinospora cordifolia
Tinospora cordifoliaTinospora cordifolia
Tinospora cordifolia
Fragrence James
 
Plant as a source of drugs
Plant as a source of drugsPlant as a source of drugs
Plant as a source of drugs
Nabiilah Naraino Majie
 
Herbal medicine
Herbal medicineHerbal medicine
Herbal medicine
Utai Sukviwatsirikul
 
Herbal medicine
Herbal medicineHerbal medicine
Herbal medicine
Gaurav Kr
 
Protoplast Fusion
Protoplast FusionProtoplast Fusion
Protoplast Fusion
Melika M.razzaz
 
Phytotherapy 1 2020
Phytotherapy 1 2020Phytotherapy 1 2020
Phytotherapy 1 2020
Marwa A.A. Fayed
 
Medicinal Species of the Genus Artemisia
Medicinal Species of the Genus ArtemisiaMedicinal Species of the Genus Artemisia
Medicinal Species of the Genus Artemisia
CrownCountry
 
Plant tissue culture
Plant tissue culturePlant tissue culture
Plant tissue culture
abhay joshi
 
Plant Tissue Culture
Plant Tissue CulturePlant Tissue Culture
Plant Tissue Culture
Shekhar Tidke
 
Immobilization of plant cells
Immobilization of plant cellsImmobilization of plant cells
Immobilization of plant cells
aachal jain
 
Phyto therapy for cancer, plants used in cancer, Phytotherapy
Phyto therapy for cancer, plants used in cancer, PhytotherapyPhyto therapy for cancer, plants used in cancer, Phytotherapy
Phyto therapy for cancer, plants used in cancer, Phytotherapy
manojjeya
 
Edible Vaccine
 Edible Vaccine Edible Vaccine
Edible Vaccine
Dh Sani
 

What's hot (20)

Phytomedicine
PhytomedicinePhytomedicine
Phytomedicine
 
Production of-secondary-metabolites
Production of-secondary-metabolitesProduction of-secondary-metabolites
Production of-secondary-metabolites
 
A review on home yard medicinal plants ppt.
A review on home yard medicinal plants ppt.A review on home yard medicinal plants ppt.
A review on home yard medicinal plants ppt.
 
Hairy root culture
Hairy root culture Hairy root culture
Hairy root culture
 
An Ethino-botanical Survey With Special Emphasis On Medicinal Plant Used By E...
An Ethino-botanical Survey With Special Emphasis On Medicinal Plant Used By E...An Ethino-botanical Survey With Special Emphasis On Medicinal Plant Used By E...
An Ethino-botanical Survey With Special Emphasis On Medicinal Plant Used By E...
 
Ethnopharmacology
EthnopharmacologyEthnopharmacology
Ethnopharmacology
 
2. azadriachata indica(neem)
2. azadriachata indica(neem)2. azadriachata indica(neem)
2. azadriachata indica(neem)
 
Antimicrobial plants
Antimicrobial plants  Antimicrobial plants
Antimicrobial plants
 
Tinospora cordifolia
Tinospora cordifoliaTinospora cordifolia
Tinospora cordifolia
 
Plant as a source of drugs
Plant as a source of drugsPlant as a source of drugs
Plant as a source of drugs
 
Herbal medicine
Herbal medicineHerbal medicine
Herbal medicine
 
Herbal medicine
Herbal medicineHerbal medicine
Herbal medicine
 
Protoplast Fusion
Protoplast FusionProtoplast Fusion
Protoplast Fusion
 
Phytotherapy 1 2020
Phytotherapy 1 2020Phytotherapy 1 2020
Phytotherapy 1 2020
 
Medicinal Species of the Genus Artemisia
Medicinal Species of the Genus ArtemisiaMedicinal Species of the Genus Artemisia
Medicinal Species of the Genus Artemisia
 
Plant tissue culture
Plant tissue culturePlant tissue culture
Plant tissue culture
 
Plant Tissue Culture
Plant Tissue CulturePlant Tissue Culture
Plant Tissue Culture
 
Immobilization of plant cells
Immobilization of plant cellsImmobilization of plant cells
Immobilization of plant cells
 
Phyto therapy for cancer, plants used in cancer, Phytotherapy
Phyto therapy for cancer, plants used in cancer, PhytotherapyPhyto therapy for cancer, plants used in cancer, Phytotherapy
Phyto therapy for cancer, plants used in cancer, Phytotherapy
 
Edible Vaccine
 Edible Vaccine Edible Vaccine
Edible Vaccine
 

Viewers also liked

Popherbsppt(2)
Popherbsppt(2)Popherbsppt(2)
Popherbsppt(2)
guest754bc7
 
Chromatographic technique
Chromatographic techniqueChromatographic technique
Chromatographic technique
Senthil Natesan
 
TRV6
TRV6TRV6
Avila
AvilaAvila
Avila
3sanagus
 
National Phase .
 National Phase . National Phase .
National Phase .
Gayani Lasantha
 
Idbi federal life insurance co ltd.
Idbi federal life insurance co ltd.Idbi federal life insurance co ltd.
Idbi federal life insurance co ltd.
ani261090
 
Transcriptional factors in stress tolerance
Transcriptional factors in stress toleranceTranscriptional factors in stress tolerance
Transcriptional factors in stress tolerance
Senthil Natesan
 
Cancer - II
Cancer - IICancer - II
Cancer - II
PPRC AYUR
 
Ionomics
IonomicsIonomics
Ionomics
Senthil Natesan
 
Silybum marianum as a hepatoprotective agent
Silybum marianum as a hepatoprotective agentSilybum marianum as a hepatoprotective agent
Silybum marianum as a hepatoprotective agent
Hawkar Qadir
 
Biotransformation in Plant Tissue Culture and Animal Cell Culture
Biotransformation in Plant Tissue Culture and Animal Cell CultureBiotransformation in Plant Tissue Culture and Animal Cell Culture
Biotransformation in Plant Tissue Culture and Animal Cell Culture
Khushbkht R. Khan
 
Beyond Western Medicine powerpoint final
Beyond Western Medicine powerpoint finalBeyond Western Medicine powerpoint final
Beyond Western Medicine powerpoint final
Amref Health Africa in Canada
 
Engineering fatty acid biosynthesis
Engineering fatty acid biosynthesisEngineering fatty acid biosynthesis
Engineering fatty acid biosynthesis
Senthil Natesan
 
DNA Markers Techniques for Plant Varietal Identification
DNA Markers Techniques for Plant Varietal Identification DNA Markers Techniques for Plant Varietal Identification
DNA Markers Techniques for Plant Varietal Identification
Senthil Natesan
 
Ethical Issues in Traditional and Alternative Medicine (TAM) , By Dr. Pathir...
Ethical Issues in Traditional and Alternative Medicine (TAM) ,  By Dr. Pathir...Ethical Issues in Traditional and Alternative Medicine (TAM) ,  By Dr. Pathir...
Ethical Issues in Traditional and Alternative Medicine (TAM) , By Dr. Pathir...
Kamal Perera
 
Conventional and non conventional methods of crop improvement
Conventional and non conventional methods of crop improvementConventional and non conventional methods of crop improvement
Conventional and non conventional methods of crop improvement
Sachin Ekatpure
 
Study on Intellectual Property Rights (IPRs) and Trade in Traditional Medicin...
Study on Intellectual Property Rights (IPRs) and Trade in Traditional Medicin...Study on Intellectual Property Rights (IPRs) and Trade in Traditional Medicin...
Study on Intellectual Property Rights (IPRs) and Trade in Traditional Medicin...
Kamal Perera
 
Traditional and Alternative medicine
Traditional and Alternative medicineTraditional and Alternative medicine
Traditional and Alternative medicine
Justine Claire Daet
 
Ginger
GingerGinger
Ginger
PPRC AYUR
 

Viewers also liked (20)

Popherbsppt(2)
Popherbsppt(2)Popherbsppt(2)
Popherbsppt(2)
 
Aa minipptguia
Aa   minipptguiaAa   minipptguia
Aa minipptguia
 
Chromatographic technique
Chromatographic techniqueChromatographic technique
Chromatographic technique
 
TRV6
TRV6TRV6
TRV6
 
Avila
AvilaAvila
Avila
 
National Phase .
 National Phase . National Phase .
National Phase .
 
Idbi federal life insurance co ltd.
Idbi federal life insurance co ltd.Idbi federal life insurance co ltd.
Idbi federal life insurance co ltd.
 
Transcriptional factors in stress tolerance
Transcriptional factors in stress toleranceTranscriptional factors in stress tolerance
Transcriptional factors in stress tolerance
 
Cancer - II
Cancer - IICancer - II
Cancer - II
 
Ionomics
IonomicsIonomics
Ionomics
 
Silybum marianum as a hepatoprotective agent
Silybum marianum as a hepatoprotective agentSilybum marianum as a hepatoprotective agent
Silybum marianum as a hepatoprotective agent
 
Biotransformation in Plant Tissue Culture and Animal Cell Culture
Biotransformation in Plant Tissue Culture and Animal Cell CultureBiotransformation in Plant Tissue Culture and Animal Cell Culture
Biotransformation in Plant Tissue Culture and Animal Cell Culture
 
Beyond Western Medicine powerpoint final
Beyond Western Medicine powerpoint finalBeyond Western Medicine powerpoint final
Beyond Western Medicine powerpoint final
 
Engineering fatty acid biosynthesis
Engineering fatty acid biosynthesisEngineering fatty acid biosynthesis
Engineering fatty acid biosynthesis
 
DNA Markers Techniques for Plant Varietal Identification
DNA Markers Techniques for Plant Varietal Identification DNA Markers Techniques for Plant Varietal Identification
DNA Markers Techniques for Plant Varietal Identification
 
Ethical Issues in Traditional and Alternative Medicine (TAM) , By Dr. Pathir...
Ethical Issues in Traditional and Alternative Medicine (TAM) ,  By Dr. Pathir...Ethical Issues in Traditional and Alternative Medicine (TAM) ,  By Dr. Pathir...
Ethical Issues in Traditional and Alternative Medicine (TAM) , By Dr. Pathir...
 
Conventional and non conventional methods of crop improvement
Conventional and non conventional methods of crop improvementConventional and non conventional methods of crop improvement
Conventional and non conventional methods of crop improvement
 
Study on Intellectual Property Rights (IPRs) and Trade in Traditional Medicin...
Study on Intellectual Property Rights (IPRs) and Trade in Traditional Medicin...Study on Intellectual Property Rights (IPRs) and Trade in Traditional Medicin...
Study on Intellectual Property Rights (IPRs) and Trade in Traditional Medicin...
 
Traditional and Alternative medicine
Traditional and Alternative medicineTraditional and Alternative medicine
Traditional and Alternative medicine
 
Ginger
GingerGinger
Ginger
 

Similar to Therapeutics values of plant derived compounds

The herbal treatment of diseases
The herbal treatment of diseasesThe herbal treatment of diseases
The herbal treatment of diseases
Robinson Roy
 
The herbal treatment of diseases
The herbal treatment of diseasesThe herbal treatment of diseases
The herbal treatment of diseases
Robinson Roy
 
medicinal plants natural products and phytotheraphy
medicinal plants natural products and phytotheraphymedicinal plants natural products and phytotheraphy
medicinal plants natural products and phytotheraphy
safuraqazi
 
Medicinal planr diversity of india
Medicinal planr diversity of indiaMedicinal planr diversity of india
Medicinal planr diversity of india
keshav pai
 
Drug Yielding Plants.pptx
Drug Yielding Plants.pptxDrug Yielding Plants.pptx
Drug Yielding Plants.pptx
SeemaGaikwad15
 
Plants that heal (BY SEEMA BHARDWAJ KVVP)
Plants that heal (BY SEEMA BHARDWAJ KVVP)Plants that heal (BY SEEMA BHARDWAJ KVVP)
Plants that heal (BY SEEMA BHARDWAJ KVVP)
seemabtea
 
Labiateae
LabiateaeLabiateae
Labiateae
Dr. Samia
 
Herbal plants
Herbal plantsHerbal plants
Herbal plants
rohit3234
 
melissa
  melissa  melissa
FGID_Healing Herbs: Empowering Your Gut with Phytotherapy_@Abbas
FGID_Healing Herbs: Empowering Your Gut with Phytotherapy_@Abbas FGID_Healing Herbs: Empowering Your Gut with Phytotherapy_@Abbas
FGID_Healing Herbs: Empowering Your Gut with Phytotherapy_@Abbas
MOHAMMADABBAS547231
 
Phytochemical and Antioxidant Screening of major Herbs
Phytochemical and Antioxidant Screening of major HerbsPhytochemical and Antioxidant Screening of major Herbs
Phytochemical and Antioxidant Screening of major Herbs
Ali Raza Hameed
 
Herbal Medicines
Herbal MedicinesHerbal Medicines
Drugs Acting on Central Nervous System.
Drugs Acting on  Central Nervous System.Drugs Acting on  Central Nervous System.
Drugs Acting on Central Nervous System.
Nagpur College of Pharmacy,Nagpur
 
Global Market For Herbal Products In India
Global Market For Herbal Products In IndiaGlobal Market For Herbal Products In India
Global Market For Herbal Products In India
ANKITA MANKAR
 
Alternative medicine-1
Alternative medicine-1Alternative medicine-1
Alternative medicine-1
Mahedi Hassan Tusher
 
MEDICAL HERBALISM handout.pdf
MEDICAL HERBALISM handout.pdfMEDICAL HERBALISM handout.pdf
MEDICAL HERBALISM handout.pdf
SamuelTemesgenAmeno
 
Week 2 TRADITIONAL HEALTH CARE 2.ppt.pptx
Week 2 TRADITIONAL HEALTH CARE 2.ppt.pptxWeek 2 TRADITIONAL HEALTH CARE 2.ppt.pptx
Week 2 TRADITIONAL HEALTH CARE 2.ppt.pptx
TinguChantal
 
NOTES OF DRUGS ACTING ON NERVOUS SYSTEM .pdf
NOTES OF DRUGS ACTING ON NERVOUS SYSTEM .pdfNOTES OF DRUGS ACTING ON NERVOUS SYSTEM .pdf
NOTES OF DRUGS ACTING ON NERVOUS SYSTEM .pdf
Sumit Tiwari
 
Botany session 9
Botany session 9Botany session 9
Botany session 9
Fluke Fox
 
Role of plants in economy
Role of plants in economyRole of plants in economy
Role of plants in economy
Gopal Sitafale
 

Similar to Therapeutics values of plant derived compounds (20)

The herbal treatment of diseases
The herbal treatment of diseasesThe herbal treatment of diseases
The herbal treatment of diseases
 
The herbal treatment of diseases
The herbal treatment of diseasesThe herbal treatment of diseases
The herbal treatment of diseases
 
medicinal plants natural products and phytotheraphy
medicinal plants natural products and phytotheraphymedicinal plants natural products and phytotheraphy
medicinal plants natural products and phytotheraphy
 
Medicinal planr diversity of india
Medicinal planr diversity of indiaMedicinal planr diversity of india
Medicinal planr diversity of india
 
Drug Yielding Plants.pptx
Drug Yielding Plants.pptxDrug Yielding Plants.pptx
Drug Yielding Plants.pptx
 
Plants that heal (BY SEEMA BHARDWAJ KVVP)
Plants that heal (BY SEEMA BHARDWAJ KVVP)Plants that heal (BY SEEMA BHARDWAJ KVVP)
Plants that heal (BY SEEMA BHARDWAJ KVVP)
 
Labiateae
LabiateaeLabiateae
Labiateae
 
Herbal plants
Herbal plantsHerbal plants
Herbal plants
 
melissa
  melissa  melissa
melissa
 
FGID_Healing Herbs: Empowering Your Gut with Phytotherapy_@Abbas
FGID_Healing Herbs: Empowering Your Gut with Phytotherapy_@Abbas FGID_Healing Herbs: Empowering Your Gut with Phytotherapy_@Abbas
FGID_Healing Herbs: Empowering Your Gut with Phytotherapy_@Abbas
 
Phytochemical and Antioxidant Screening of major Herbs
Phytochemical and Antioxidant Screening of major HerbsPhytochemical and Antioxidant Screening of major Herbs
Phytochemical and Antioxidant Screening of major Herbs
 
Herbal Medicines
Herbal MedicinesHerbal Medicines
Herbal Medicines
 
Drugs Acting on Central Nervous System.
Drugs Acting on  Central Nervous System.Drugs Acting on  Central Nervous System.
Drugs Acting on Central Nervous System.
 
Global Market For Herbal Products In India
Global Market For Herbal Products In IndiaGlobal Market For Herbal Products In India
Global Market For Herbal Products In India
 
Alternative medicine-1
Alternative medicine-1Alternative medicine-1
Alternative medicine-1
 
MEDICAL HERBALISM handout.pdf
MEDICAL HERBALISM handout.pdfMEDICAL HERBALISM handout.pdf
MEDICAL HERBALISM handout.pdf
 
Week 2 TRADITIONAL HEALTH CARE 2.ppt.pptx
Week 2 TRADITIONAL HEALTH CARE 2.ppt.pptxWeek 2 TRADITIONAL HEALTH CARE 2.ppt.pptx
Week 2 TRADITIONAL HEALTH CARE 2.ppt.pptx
 
NOTES OF DRUGS ACTING ON NERVOUS SYSTEM .pdf
NOTES OF DRUGS ACTING ON NERVOUS SYSTEM .pdfNOTES OF DRUGS ACTING ON NERVOUS SYSTEM .pdf
NOTES OF DRUGS ACTING ON NERVOUS SYSTEM .pdf
 
Botany session 9
Botany session 9Botany session 9
Botany session 9
 
Role of plants in economy
Role of plants in economyRole of plants in economy
Role of plants in economy
 

More from Senthil Natesan

Centre of innovation, Agricultural College and Research Institute,Madurai
Centre of innovation, Agricultural College and Research Institute,MaduraiCentre of innovation, Agricultural College and Research Institute,Madurai
Centre of innovation, Agricultural College and Research Institute,Madurai
Senthil Natesan
 
Indian agriculture
Indian agriculture Indian agriculture
Indian agriculture
Senthil Natesan
 
wheat association mapping LTN
wheat association mapping LTNwheat association mapping LTN
wheat association mapping LTN
Senthil Natesan
 
Paradigm shift in breeding for Sugarcane to Energycane – An exclusive biofuel...
Paradigm shift in breeding for Sugarcane to Energycane – An exclusive biofuel...Paradigm shift in breeding for Sugarcane to Energycane – An exclusive biofuel...
Paradigm shift in breeding for Sugarcane to Energycane – An exclusive biofuel...
Senthil Natesan
 
The need for nutrient efficient rice varieties Status and prospects
The need for nutrient efficient rice varieties Status and prospectsThe need for nutrient efficient rice varieties Status and prospects
The need for nutrient efficient rice varieties Status and prospects
Senthil Natesan
 
Deployment of rust resistance genes in wheat varieties
Deployment of rust resistance genes in wheat varietiesDeployment of rust resistance genes in wheat varieties
Deployment of rust resistance genes in wheat varieties
Senthil Natesan
 
Caster pollination
Caster pollination Caster pollination
Caster pollination
Senthil Natesan
 
Genomics Assisted Breeding for Resilient Rice: Progress and Prospects
Genomics Assisted Breeding for Resilient Rice: Progress and ProspectsGenomics Assisted Breeding for Resilient Rice: Progress and Prospects
Genomics Assisted Breeding for Resilient Rice: Progress and Prospects
Senthil Natesan
 
COCONUT GENETIC RESOURCES CONSERVATION & UTILIZATION IN INDIA
COCONUT GENETIC RESOURCES CONSERVATION & UTILIZATION IN INDIACOCONUT GENETIC RESOURCES CONSERVATION & UTILIZATION IN INDIA
COCONUT GENETIC RESOURCES CONSERVATION & UTILIZATION IN INDIA
Senthil Natesan
 
Germplasm conservation in Oil Palm
Germplasm conservation in  Oil PalmGermplasm conservation in  Oil Palm
Germplasm conservation in Oil Palm
Senthil Natesan
 
Improvement of Medicinal Plants: Challenges and Innovative Approaches
Improvement of Medicinal Plants: Challenges and Innovative ApproachesImprovement of Medicinal Plants: Challenges and Innovative Approaches
Improvement of Medicinal Plants: Challenges and Innovative Approaches
Senthil Natesan
 
Role of induced mutations in legume improvement-Dr.Souframanien
Role of induced mutations in legume improvement-Dr.SouframanienRole of induced mutations in legume improvement-Dr.Souframanien
Role of induced mutations in legume improvement-Dr.Souframanien
Senthil Natesan
 
Towards improvement of oil content in safflower (Carthamus tinctorius L.)
Towards improvement of oil content in safflower (Carthamus tinctorius L.)Towards improvement of oil content in safflower (Carthamus tinctorius L.)
Towards improvement of oil content in safflower (Carthamus tinctorius L.)
Senthil Natesan
 
New paradigm in Seed industry
New paradigm in Seed industryNew paradigm in Seed industry
New paradigm in Seed industry
Senthil Natesan
 
Genomics platform for agriculture-CAT lecture
Genomics platform for agriculture-CAT lectureGenomics platform for agriculture-CAT lecture
Genomics platform for agriculture-CAT lecture
Senthil Natesan
 
Castor database ; Casterdp
Castor database ; Casterdp Castor database ; Casterdp
Castor database ; Casterdp
Senthil Natesan
 
Edible vaccine
Edible vaccineEdible vaccine
Edible vaccine
Senthil Natesan
 
Cellular signal transduction pathways under abiotic stress
Cellular signal transduction pathways under abiotic stressCellular signal transduction pathways under abiotic stress
Cellular signal transduction pathways under abiotic stress
Senthil Natesan
 
Genotyping by Sequencing
Genotyping by SequencingGenotyping by Sequencing
Genotyping by Sequencing
Senthil Natesan
 
TNAU CRMD - A Customer Relationship Management datahouse for TNAU
TNAU CRMD - A Customer Relationship Management datahouse for TNAUTNAU CRMD - A Customer Relationship Management datahouse for TNAU
TNAU CRMD - A Customer Relationship Management datahouse for TNAU
Senthil Natesan
 

More from Senthil Natesan (20)

Centre of innovation, Agricultural College and Research Institute,Madurai
Centre of innovation, Agricultural College and Research Institute,MaduraiCentre of innovation, Agricultural College and Research Institute,Madurai
Centre of innovation, Agricultural College and Research Institute,Madurai
 
Indian agriculture
Indian agriculture Indian agriculture
Indian agriculture
 
wheat association mapping LTN
wheat association mapping LTNwheat association mapping LTN
wheat association mapping LTN
 
Paradigm shift in breeding for Sugarcane to Energycane – An exclusive biofuel...
Paradigm shift in breeding for Sugarcane to Energycane – An exclusive biofuel...Paradigm shift in breeding for Sugarcane to Energycane – An exclusive biofuel...
Paradigm shift in breeding for Sugarcane to Energycane – An exclusive biofuel...
 
The need for nutrient efficient rice varieties Status and prospects
The need for nutrient efficient rice varieties Status and prospectsThe need for nutrient efficient rice varieties Status and prospects
The need for nutrient efficient rice varieties Status and prospects
 
Deployment of rust resistance genes in wheat varieties
Deployment of rust resistance genes in wheat varietiesDeployment of rust resistance genes in wheat varieties
Deployment of rust resistance genes in wheat varieties
 
Caster pollination
Caster pollination Caster pollination
Caster pollination
 
Genomics Assisted Breeding for Resilient Rice: Progress and Prospects
Genomics Assisted Breeding for Resilient Rice: Progress and ProspectsGenomics Assisted Breeding for Resilient Rice: Progress and Prospects
Genomics Assisted Breeding for Resilient Rice: Progress and Prospects
 
COCONUT GENETIC RESOURCES CONSERVATION & UTILIZATION IN INDIA
COCONUT GENETIC RESOURCES CONSERVATION & UTILIZATION IN INDIACOCONUT GENETIC RESOURCES CONSERVATION & UTILIZATION IN INDIA
COCONUT GENETIC RESOURCES CONSERVATION & UTILIZATION IN INDIA
 
Germplasm conservation in Oil Palm
Germplasm conservation in  Oil PalmGermplasm conservation in  Oil Palm
Germplasm conservation in Oil Palm
 
Improvement of Medicinal Plants: Challenges and Innovative Approaches
Improvement of Medicinal Plants: Challenges and Innovative ApproachesImprovement of Medicinal Plants: Challenges and Innovative Approaches
Improvement of Medicinal Plants: Challenges and Innovative Approaches
 
Role of induced mutations in legume improvement-Dr.Souframanien
Role of induced mutations in legume improvement-Dr.SouframanienRole of induced mutations in legume improvement-Dr.Souframanien
Role of induced mutations in legume improvement-Dr.Souframanien
 
Towards improvement of oil content in safflower (Carthamus tinctorius L.)
Towards improvement of oil content in safflower (Carthamus tinctorius L.)Towards improvement of oil content in safflower (Carthamus tinctorius L.)
Towards improvement of oil content in safflower (Carthamus tinctorius L.)
 
New paradigm in Seed industry
New paradigm in Seed industryNew paradigm in Seed industry
New paradigm in Seed industry
 
Genomics platform for agriculture-CAT lecture
Genomics platform for agriculture-CAT lectureGenomics platform for agriculture-CAT lecture
Genomics platform for agriculture-CAT lecture
 
Castor database ; Casterdp
Castor database ; Casterdp Castor database ; Casterdp
Castor database ; Casterdp
 
Edible vaccine
Edible vaccineEdible vaccine
Edible vaccine
 
Cellular signal transduction pathways under abiotic stress
Cellular signal transduction pathways under abiotic stressCellular signal transduction pathways under abiotic stress
Cellular signal transduction pathways under abiotic stress
 
Genotyping by Sequencing
Genotyping by SequencingGenotyping by Sequencing
Genotyping by Sequencing
 
TNAU CRMD - A Customer Relationship Management datahouse for TNAU
TNAU CRMD - A Customer Relationship Management datahouse for TNAUTNAU CRMD - A Customer Relationship Management datahouse for TNAU
TNAU CRMD - A Customer Relationship Management datahouse for TNAU
 

Recently uploaded

E-learning Odoo 17 New features - Odoo 17 Slides
E-learning Odoo 17  New features - Odoo 17 SlidesE-learning Odoo 17  New features - Odoo 17 Slides
E-learning Odoo 17 New features - Odoo 17 Slides
Celine George
 
Brigada Eskwela 2024 PowerPoint Update for SY 2024-2025
Brigada Eskwela 2024 PowerPoint Update for SY 2024-2025Brigada Eskwela 2024 PowerPoint Update for SY 2024-2025
Brigada Eskwela 2024 PowerPoint Update for SY 2024-2025
ALBERTHISOLER1
 
React Interview Question PDF By ScholarHat
React Interview Question PDF By ScholarHatReact Interview Question PDF By ScholarHat
React Interview Question PDF By ScholarHat
Scholarhat
 
Java MCQ Questions and Answers PDF By ScholarHat
Java MCQ Questions and Answers PDF By ScholarHatJava MCQ Questions and Answers PDF By ScholarHat
Java MCQ Questions and Answers PDF By ScholarHat
Scholarhat
 
MathematicsGrade7-Presentation-July-12024.pptx
MathematicsGrade7-Presentation-July-12024.pptxMathematicsGrade7-Presentation-July-12024.pptx
MathematicsGrade7-Presentation-July-12024.pptx
nolicaliso1
 
Dr. Nasir Mustafa CERTIFICATE OF APPRECIATION "NEUROANATOMY"
Dr. Nasir Mustafa CERTIFICATE OF APPRECIATION "NEUROANATOMY"Dr. Nasir Mustafa CERTIFICATE OF APPRECIATION "NEUROANATOMY"
Dr. Nasir Mustafa CERTIFICATE OF APPRECIATION "NEUROANATOMY"
Dr. Nasir Mustafa
 
SQL Server Interview Questions PDF By ScholarHat
SQL Server Interview Questions PDF By ScholarHatSQL Server Interview Questions PDF By ScholarHat
SQL Server Interview Questions PDF By ScholarHat
Scholarhat
 
Node JS Interview Question PDF By ScholarHat
Node JS Interview Question PDF By ScholarHatNode JS Interview Question PDF By ScholarHat
Node JS Interview Question PDF By ScholarHat
Scholarhat
 
11. Post harvest quality, Quality criteria and Judgement.pptx
11. Post harvest quality, Quality criteria and Judgement.pptx11. Post harvest quality, Quality criteria and Judgement.pptx
11. Post harvest quality, Quality criteria and Judgement.pptx
UmeshTimilsina1
 
QCE – Unpacking the syllabus Implications for Senior School practices and ass...
QCE – Unpacking the syllabus Implications for Senior School practices and ass...QCE – Unpacking the syllabus Implications for Senior School practices and ass...
QCE – Unpacking the syllabus Implications for Senior School practices and ass...
mansk2
 
Odoo 17 Events - Attendees List Scanning
Odoo 17 Events - Attendees List ScanningOdoo 17 Events - Attendees List Scanning
Odoo 17 Events - Attendees List Scanning
Celine George
 
DepEd School Calendar 2024-2025 DO_s2024_008
DepEd School Calendar 2024-2025 DO_s2024_008DepEd School Calendar 2024-2025 DO_s2024_008
DepEd School Calendar 2024-2025 DO_s2024_008
Glenn Rivera
 
BỘ ĐỀ THI HỌC SINH GIỎI CÁC TỈNH MÔN TIẾNG ANH LỚP 9 NĂM HỌC 2023-2024 (CÓ FI...
BỘ ĐỀ THI HỌC SINH GIỎI CÁC TỈNH MÔN TIẾNG ANH LỚP 9 NĂM HỌC 2023-2024 (CÓ FI...BỘ ĐỀ THI HỌC SINH GIỎI CÁC TỈNH MÔN TIẾNG ANH LỚP 9 NĂM HỌC 2023-2024 (CÓ FI...
BỘ ĐỀ THI HỌC SINH GIỎI CÁC TỈNH MÔN TIẾNG ANH LỚP 9 NĂM HỌC 2023-2024 (CÓ FI...
Nguyen Thanh Tu Collection
 
View Inheritance in Odoo 17 - Odoo 17 Slides
View Inheritance in Odoo 17 - Odoo 17  SlidesView Inheritance in Odoo 17 - Odoo 17  Slides
View Inheritance in Odoo 17 - Odoo 17 Slides
Celine George
 
C# Interview Questions PDF By ScholarHat.pdf
C# Interview Questions PDF By ScholarHat.pdfC# Interview Questions PDF By ScholarHat.pdf
C# Interview Questions PDF By ScholarHat.pdf
Scholarhat
 
JavaScript Interview Questions PDF By ScholarHat
JavaScript Interview  Questions PDF By ScholarHatJavaScript Interview  Questions PDF By ScholarHat
JavaScript Interview Questions PDF By ScholarHat
Scholarhat
 
C Interview Questions PDF By Scholarhat.pdf
C Interview Questions PDF By Scholarhat.pdfC Interview Questions PDF By Scholarhat.pdf
C Interview Questions PDF By Scholarhat.pdf
Scholarhat
 
FIRST AID PRESENTATION ON INDUSTRIAL SAFETY by dr lal.ppt
FIRST AID PRESENTATION ON INDUSTRIAL SAFETY by dr lal.pptFIRST AID PRESENTATION ON INDUSTRIAL SAFETY by dr lal.ppt
FIRST AID PRESENTATION ON INDUSTRIAL SAFETY by dr lal.ppt
ashutoshklal29
 
MVC Interview Questions PDF By ScholarHat
MVC Interview Questions PDF By ScholarHatMVC Interview Questions PDF By ScholarHat
MVC Interview Questions PDF By ScholarHat
Scholarhat
 
MATATAG CURRICULUM sample lesson exemplar.docx
MATATAG CURRICULUM sample lesson exemplar.docxMATATAG CURRICULUM sample lesson exemplar.docx
MATATAG CURRICULUM sample lesson exemplar.docx
yardenmendoza
 

Recently uploaded (20)

E-learning Odoo 17 New features - Odoo 17 Slides
E-learning Odoo 17  New features - Odoo 17 SlidesE-learning Odoo 17  New features - Odoo 17 Slides
E-learning Odoo 17 New features - Odoo 17 Slides
 
Brigada Eskwela 2024 PowerPoint Update for SY 2024-2025
Brigada Eskwela 2024 PowerPoint Update for SY 2024-2025Brigada Eskwela 2024 PowerPoint Update for SY 2024-2025
Brigada Eskwela 2024 PowerPoint Update for SY 2024-2025
 
React Interview Question PDF By ScholarHat
React Interview Question PDF By ScholarHatReact Interview Question PDF By ScholarHat
React Interview Question PDF By ScholarHat
 
Java MCQ Questions and Answers PDF By ScholarHat
Java MCQ Questions and Answers PDF By ScholarHatJava MCQ Questions and Answers PDF By ScholarHat
Java MCQ Questions and Answers PDF By ScholarHat
 
MathematicsGrade7-Presentation-July-12024.pptx
MathematicsGrade7-Presentation-July-12024.pptxMathematicsGrade7-Presentation-July-12024.pptx
MathematicsGrade7-Presentation-July-12024.pptx
 
Dr. Nasir Mustafa CERTIFICATE OF APPRECIATION "NEUROANATOMY"
Dr. Nasir Mustafa CERTIFICATE OF APPRECIATION "NEUROANATOMY"Dr. Nasir Mustafa CERTIFICATE OF APPRECIATION "NEUROANATOMY"
Dr. Nasir Mustafa CERTIFICATE OF APPRECIATION "NEUROANATOMY"
 
SQL Server Interview Questions PDF By ScholarHat
SQL Server Interview Questions PDF By ScholarHatSQL Server Interview Questions PDF By ScholarHat
SQL Server Interview Questions PDF By ScholarHat
 
Node JS Interview Question PDF By ScholarHat
Node JS Interview Question PDF By ScholarHatNode JS Interview Question PDF By ScholarHat
Node JS Interview Question PDF By ScholarHat
 
11. Post harvest quality, Quality criteria and Judgement.pptx
11. Post harvest quality, Quality criteria and Judgement.pptx11. Post harvest quality, Quality criteria and Judgement.pptx
11. Post harvest quality, Quality criteria and Judgement.pptx
 
QCE – Unpacking the syllabus Implications for Senior School practices and ass...
QCE – Unpacking the syllabus Implications for Senior School practices and ass...QCE – Unpacking the syllabus Implications for Senior School practices and ass...
QCE – Unpacking the syllabus Implications for Senior School practices and ass...
 
Odoo 17 Events - Attendees List Scanning
Odoo 17 Events - Attendees List ScanningOdoo 17 Events - Attendees List Scanning
Odoo 17 Events - Attendees List Scanning
 
DepEd School Calendar 2024-2025 DO_s2024_008
DepEd School Calendar 2024-2025 DO_s2024_008DepEd School Calendar 2024-2025 DO_s2024_008
DepEd School Calendar 2024-2025 DO_s2024_008
 
BỘ ĐỀ THI HỌC SINH GIỎI CÁC TỈNH MÔN TIẾNG ANH LỚP 9 NĂM HỌC 2023-2024 (CÓ FI...
BỘ ĐỀ THI HỌC SINH GIỎI CÁC TỈNH MÔN TIẾNG ANH LỚP 9 NĂM HỌC 2023-2024 (CÓ FI...BỘ ĐỀ THI HỌC SINH GIỎI CÁC TỈNH MÔN TIẾNG ANH LỚP 9 NĂM HỌC 2023-2024 (CÓ FI...
BỘ ĐỀ THI HỌC SINH GIỎI CÁC TỈNH MÔN TIẾNG ANH LỚP 9 NĂM HỌC 2023-2024 (CÓ FI...
 
View Inheritance in Odoo 17 - Odoo 17 Slides
View Inheritance in Odoo 17 - Odoo 17  SlidesView Inheritance in Odoo 17 - Odoo 17  Slides
View Inheritance in Odoo 17 - Odoo 17 Slides
 
C# Interview Questions PDF By ScholarHat.pdf
C# Interview Questions PDF By ScholarHat.pdfC# Interview Questions PDF By ScholarHat.pdf
C# Interview Questions PDF By ScholarHat.pdf
 
JavaScript Interview Questions PDF By ScholarHat
JavaScript Interview  Questions PDF By ScholarHatJavaScript Interview  Questions PDF By ScholarHat
JavaScript Interview Questions PDF By ScholarHat
 
C Interview Questions PDF By Scholarhat.pdf
C Interview Questions PDF By Scholarhat.pdfC Interview Questions PDF By Scholarhat.pdf
C Interview Questions PDF By Scholarhat.pdf
 
FIRST AID PRESENTATION ON INDUSTRIAL SAFETY by dr lal.ppt
FIRST AID PRESENTATION ON INDUSTRIAL SAFETY by dr lal.pptFIRST AID PRESENTATION ON INDUSTRIAL SAFETY by dr lal.ppt
FIRST AID PRESENTATION ON INDUSTRIAL SAFETY by dr lal.ppt
 
MVC Interview Questions PDF By ScholarHat
MVC Interview Questions PDF By ScholarHatMVC Interview Questions PDF By ScholarHat
MVC Interview Questions PDF By ScholarHat
 
MATATAG CURRICULUM sample lesson exemplar.docx
MATATAG CURRICULUM sample lesson exemplar.docxMATATAG CURRICULUM sample lesson exemplar.docx
MATATAG CURRICULUM sample lesson exemplar.docx
 

Therapeutics values of plant derived compounds

  • 1. Therapeutics values of plant derived compounds Punyakishore Maibam
  • 2. Quotation “Within the infant rind of this small flower Poison hath residence and medicine power: For this, being smelt, with that part cheers each part; Being tasted, slays all senses with the heart….” (Romeo & Juliet Act II Scene III.)
  • 3. Introduction • Powerful ingredients. • Only 15% of estimated plant species on earth have been investigated for possible Medicinal uses. • No magic, diets high in fruits, grains, legumes reduce the risk of a various number of diseases • More than 95 % of the population in the least developing countries use herbs for health and other purposes.
  • 4. History • History of traditional medicine in eastern culture – Ayurveda medicine – Chinese medicine • History of traditional medicine in western culture – European history  The Greco-Roman Period  The Dark ages  19th Century  The 20th Century – American history • Breakthrough in pharmaceutical chemistry came when Serturner isolated morphine from opium poppy in 1806
  • 6. Ayurveda The aim of Ayurveda is proper maintenance of metabolic equilibrium of the human psychosomatic material and the restoration of the same to the normal when disturbed
  • 7. Contd… • Ayurveda utilizes herbs and product from natural resources for healing • Herbs like Neem , Aloe vera, Turmeric, Tulsi ( Holy basil), Babool, Garlic etc.
  • 8. Chinese • The Chinese believe that all things in creation possess the qualities of yin and yang, the opposing forces of nature • When the balance between these two is lost, disease is manifest. • Diagnosis is performed primarily through the pulse and tongue.
  • 9. Unani • Unani tibb meaning ‘Ionian’ or ‘Greek’ medicine • based on the Greek tradition of four humours – blood, phlegm, black and yellow bile
  • 10. Japanese • Ancient Japanese medical practices involved exorcism, ritual bathing and herbal therapy • kampo, using fewer and smaller quantities of herbs, often ground into granules to be taken in tea.
  • 11. Aromatherapy • It is the art of using the pure essence extract to promote the health and well-being of body and mind. • Relies primarily on the use of essential oils • Common oils- lavender, eucalyptus, tea tree oil, neem, tulsi and cinnamon etc
  • 12. Common plants used with its derived products
  • 13. Neem (Azadirachta indica) Plant family: Meliaceae Plant used: Entire plant Origin culture: Native to East India and Burma Common uses: Antiviral, antifungal, antibacterial, antimalarial, antifertility, antiulcerogenic, antihypersensitive and antihyperglycaemic, antidermatophytic, orodontal, hepatoprotective and anticancer activity. Active constituents: Diterpenoids, triterpenoids (Azadirachtin), vilasinin type of compounds, limonoids and its derivatives.
  • 14. Jungli amla (Phyllanthus amarus) Plant Family: Euphorbiaceae Parts used: Entire plant Origin: South India Common uses: Hepatitis, Gonorrhea, frequent menstruation, and Diabetes, anti-viral effect, skin for sores, swelling, and itchiness. Active constituents: Phyllanthin D, hypophyllanthine and five flavonaoids viz. quercertin, astralgin, quercertrin, isoquercitrin and rutin.
  • 15. Aloe vera Plant family: Asphodelaceae Part used: Leaf pulp Origin culture: Sub-Saharan African and Coptic traditional medicine Common uses: Treatment of burns, skin blemishes, topical irritations, antibacterial, digestive aid. Active constituents: Anthroquinones, anthrols, anthrones, chrysophanic acid.
  • 16. Garlic (Allium sativum) Plant family: Alliaceae Part used: Leaves & stem (together . called the bulb) Origin culture: Chinese, Coptic, Farsi, Mediterranean, and Semitic traditional medicine Common uses: Immunostimulation and augmented circulation, triglyceride and cholesterol level reduction, hypertension control. Active constituents: Allicin, and allyl sulfides.
  • 17. Ginger (Zingiber officinale) Plant family: Zingiberaceae Part used: Rhizome . Origin culture: Chinese and Indian traditional medicine. Common uses: Digestive aid, carminative, nausea/vomiting remedy, anti-inflammatory. Active constituents: Zingiberene, gingerols/shogoals (volatile oils).
  • 18. Ginseng (Panax ginseng) Plant family: Araliaceae . Part used: Roots/rhizomes Origin culture: Chinese, Korean, and Siberian traditional medicine. Common uses: Taken internally for fatigue/endurance/stress, control high and low blood pressure. Active constituents: Ginsenosides
  • 19. Feverfew (Tanacetum parthenium) Plant family: Asteraceae Part used: Leaves Origin culture: Mediterranean traditional medicine. Common uses: Migraine headaches, fevers. Active constituents: Parthenolide (a sesquiterpene lactose), tanetin.
  • 20. Ginkgo (Ginkgo biloba) Plant family: Ginkgoaceae . Part used: Leaves Origin culture: Chinese traditional medicine Common uses: Improved memory, Alzheimer’s disease, Parkinson’s disease, improved circulation, post stroke recovery. Active constituents: Ginkgolides/ bilobalide and flavonoids
  • 21. Milk Thistle (Silybum marianum) Plant family: Asteraceae . Part used: Seeds Origin culture: Mediterranean traditional medicine. Common uses: Hepatitis, liver diseases. Active constituents: Silymarin, silibinin, flavonoids.
  • 22. St. Johns Wort (Hypericum perforatum) Plant family: Clusiaceae Part used: Flowers & upper stems/leaves Origin culture: Greek traditional medicine. Common uses: Antidepressant, Antiviral. Active constituents: Volatile oil, carotenes, taninnin, flavanoids (inc. hypericin)
  • 23. To make it more effective and commercialized… Principal concepts of research on new medicines (Kuo-Hsiung Lee, 2005)
  • 24. New approach • Biotransformation: The chemical conversion of an exogenously supplied substance by living cell cultures, permeabilzed cells or entrapped enzymes derived from cell culture.( Yeoman et al., 1990) • Single step or multiple step • A method used to improve the product yield.
  • 25. Production of digitoxin • Cardiac glycosides from Digitalis species for heart diseases • Yeild from D. lanuta & D. purpurea were low. • Progesterone added for yield Biotransformation of β-methyldigoxin by D. lanata cells in 201 bioreactor over a period of 17 days g% β-Methyldigitoxin added 17.24 (100) Unconverted β-methyldigitoxin 2.0 (11.8) β-Methyldigoxin formed 14.36 (81.7) By-product 0.28 (1.4) Yield (94.90) (Misawa, 1994)
  • 26. Drawbacks • Toxicities are not well defined in herbal medicine • Risk of overdose is higher • Too much believe in herbal therapy • Herbs and other alternatives therapies are more likely to abandon potentially beneficial conventional therapy when faced with an illness.
  • 27. Reported Adverse Effects of Some Common Herbs (Winslow et al., 1998)
  • 30. Introduction • Two most dreadful diseases • Plants have formed the basis of sophisticated traditional medicine systems that have been in existence for thousands of years in countries, such as China (Chang & But, 1986) and India (Kapoor, 1990). • Plant-derived compounds have played an important role in the development of several clinically useful anti-cancer and anti-aids agents.
  • 31. Plant- Derived Anti Cancer agents First agents, vinca alkaloids (vinblastine and vincristine) from the Madagascar periwinkle, Catharanthus roseus (Cragg et al., 1994) • Epipodophyllotoxin used as the active anti -tumour agent from the genus Podophyllum (Cragg et al., 1994) • Most recent additions are Paclitaxel (Taxus brevifolia), campothecin (Camptotheca acuminata) homoharringtonine (Cephalotaxus harringtonia var. Drupacea), elliptinium, a derivative of ellipticine (Bleekeria vitensis), combretastatins, (Combretum caffrum)
  • 32. Contd… • The leaves of T. baccata are used in the traditional Asiatic Indian (Ayurvedic) medicine system (Kapoor, 1990), with one reported use in the treatment of .cancer. (Hartwell, 1982) • Homoharringtonine against various leukemias while elliptinium for the treatment of breast cancer (Cragg et al., 1993b). • The combretastatins (Combretum caffrum) which act as anti- angiogenic agents, causing vascular shutdown in tumours (Holwell et al., 2002).
  • 33. Anti- HIV agents • Michellamine B isolated from the leaves of the liana, Ancistrocladus korupensis, (Boyd et al., 1994). • Calophyllum lanigerum, yielded calanolide A which showed significant anti-HIV activity (Kashman et al., 1992) • Prostratin from Homalanthus nutans (Gustafson et al., 1992) determined that prostratin is a potent activator of HIV expression in latently infected T-cell lines • Extracts of the Smokebush (Conospermum incurvum) yielded conocurvone as the active agent (Decosterd et al., 1993)
  • 35. Introduction • Aim of the study:  To study the production of cinnamyl alcohol glycosides by biotransformation • Rhodiola rosea is only the species that produce he cinamyl alcohol glycosides • Various secondary metabolites are the cinnamyl alcohol glycosides (rosin, rosavin, rosarinand) & tyrosol and its glycoside salidroside • Field cultivation takes several year so cell and tissues cultures give a satisfactory results • Apart other compounds 337, 481, 483, and 321 are also reported (Tolonen et al., 2004)
  • 36. Biosynthetic pathway of salidroside and cinnamyl alcohol glycosides (A) (B) Biosynthetic pathway of A) rosin, rosavin, rosarin and B) salidroside.
  • 37. Materials and methods  Experimental material  Experiment with the precursors  Fresh and dry weight measurements  Chemical analyses  high performance liquid chromatography with mass spectrometric detection
  • 38. Results and discussion • Growth of the cultures • Production of the cinnamyl alcohol glycosides  Addition of glucose was beneficial concerning the production  Rosin production increased  Rosavin was not produced in the original medium • Production of salidroside • Addition of glucose to the medium show any positive effect • Accumulation pattern was same in both cases
  • 39. Contd… The content of rosin and rosavin in the callus cultivated with 2 mM cinnamyl alcohol in the original MS-Rh medium (containing only sucrose) or in the glucose containing medium, during 14 days. The content of salidroside in the callus cultivated with 2 mM tyrosol in the original MS-Rh medium (containing only sucrose) or in the glucose containing medium, during 14 days. (Gyorgy et al., 2005)
  • 40. Pharmacological effects of the alcohol-aqueous extract of Rhodiola rosea (Gyorgy et al., 2006)
  • 41. Conclusion • Production of rosin and rosavin can be increased by biotransformation • Ultimately leads to satisfactory content of the pharmacologically interesting compounds
  • 43. Introduction • Aim of study  To study the anti-ulcer and ulcer-healing activity of OS. • OC leaves 0.7% volatile oil comprising about 71% eugenol and 20% methyl eugenol. • Additional components are carvacrol, sesquiterpine hydrocarbon caryophyllene, apigenin, luteolin,apigenin-7-O-glucuronide, orientin, molludistin and ursolic acid (Gupta et al., 2002)
  • 44. Materials and methods • Animals (rats/guinea pigs) – Anti-ulcer study(6 rats6 guinea pigs) – Ulcer healing study (20 rats/ 20 guinea pigs)-acetic acid- induced ulcer model. • Treatment schedule Control: Treatment: OS extract and standard anti- OS extract and OMZ ulcer drug Omeprazole (OMZ) 3 days Ulcerogens • Cold restraint stress induced ulcers (CRU) • Aspirin-induced ulcers (ASP) • Alcohol-induced ulcers (AL) • Histamine- induced ulcers (HST) • Pylorus ligation-induced ulcers (PL) • Evaluation of ulcer-healing activity- acetic acid- induced ulcer model
  • 45. Results Effect of ethanolic extract of Ocimum sanctum and omeprazole at doses of 50, 100 and 10 mg/kg body weight, respectively, on percentage protection of ulcer index in different anti-ulcer models. Effect of ethanolic extract of Ocimum sanctum and omeprazole at doses of 100 and 10 mg/kg body weight per day, respectively, on percentage protection of ulcer index in acetic acid-induced ulcer model in rats after 5, 10, 15 and 20 days of drug treatment. (Dharmani et al., 2004)
  • 46. Histopathology of acetic acid-induced ulcers C T Sections of ulcerated stomach obtained from rats of control groups and treated with Ocimum sanctum in acetic acid-induced ulcer model in rats after 5 days of treatment C T Sections of ulcerated stomach obtained from rats of control groups and treated with Ocimum sanctum in acetic acid-induced ulcer model in rats after 10 days of treatment C T Sections of ulcerated stomach obtained from rats of control groups and treated with Ocimum sanctum in acetic acid-induced ulcer model in rats after 15 days of treatment (Dharmani et al., 2004)
  • 47. Discussion and conclusion • Report suggests that anti-stress and anti-oxidant activity of OS which suggests the free radical scavenging effect of OS (Sen et al., 1992). • Ethanol induced ulcers are due to direct necrotizing effect of ethanol on gastric mucosa (Miller and Henagan, 1984) so OS increases mucus secretion. • In PL, ulcers are developed due to accumulation of gastric acid and pepsin which leads to auto-digestion of gastric mucosa (Goel and Bhattacharya, 1991).