The document discusses the application of the supercritical antisolvent (SAS) method for drug encapsulation using biodegradable polymers. It describes how SAS works by dissolving a polymer and drug in an organic solvent, then spraying the solution into a vessel containing supercritical CO2 which acts as an antisolvent, precipitating the drug and polymer into particles. The document outlines the ideal properties of drug delivery methods and notes SAS achieves many of these using biodegradable polymers. It also discusses factors that influence particle size produced by SAS like temperature, pressure, chemical compositions and flow rates.
a substance can absorb any visible light or external radiation and then again emit it. this called fluorescence and the process of reduction in fluorescence intensity is called quenching. this presentation is all about quenching of fluorescence.
In this ppt ,i have covered the introduction of microspheres,various preparation methods of microspheres, advantages and disadvantage of microspheres,types and evaluation parameters of the microspheres.
a substance can absorb any visible light or external radiation and then again emit it. this called fluorescence and the process of reduction in fluorescence intensity is called quenching. this presentation is all about quenching of fluorescence.
In this ppt ,i have covered the introduction of microspheres,various preparation methods of microspheres, advantages and disadvantage of microspheres,types and evaluation parameters of the microspheres.
Microemulsion is an isotropic mixture of oil, surfactant, Cosurfactant and drug.
Upon mild agitation followed by dilution in aqueous media, such as gastrointestinal (GI) fluids, the systems can form fine oil in water (O/W) Microemulsions which usually have a droplet size less than 100 nm.
Microemulsion have been successfully used to improve the solubility, chemical stability, and oral bioavailability of many poorly water soluble drugs.
They have characteristic properties such as a low interfacial tension, large interfacial area and capacity to solubilize both aqueous and oil-soluble compounds.
Microemulsion is an isotropic mixture of oil, surfactant, Cosurfactant and drug.
Upon mild agitation followed by dilution in aqueous media, such as gastrointestinal (GI) fluids, the systems can form fine oil in water (O/W) Microemulsions which usually have a droplet size less than 100 nm.
Microemulsion have been successfully used to improve the solubility, chemical stability, and oral bioavailability of many poorly water soluble drugs.
They have characteristic properties such as a low interfacial tension, large interfacial area and capacity to solubilize both aqueous and oil-soluble compounds.
A short series of slides I put together to show what we could be doing in regards to our B2B presentations. Typically our sales team has a massive amount of data and info they want to share on each slide. My personal philosophy on slide design is to keep it minimal, show graphics when needed, make it somewhat animated to keep the attention of your viewers, and chose colors and fonts that work well within the respects of each project. Although this does not show all of that work you can see the groundwork for this philosophy.
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CRISIS MIGRATION: A NEW ROLE TRADE UNION?
BY NICOLAS GIANNAKOPOULOS
- 11/21/2015
Originally published in French from Switzerland at Sept.info - http://www.sept.info/club/crise-migratoire-un-nouveau-role-syndical/
Global migration waves
Europe wakes up in full migration crisis. The publication of the lifeless body images of a small Kurdish boy on the tourist beaches of Turkey, whose "picture silenced the world" according to Le Parisien, made the "one" of all European media and beyond. So we expected a real "awareness" among European leaders. A "shock" that did not happen, and did not forget an international reality that has accelerated since more than 10 years.
Datasheet Fluke 1750. Hubungi PT. Siwali Swantika 021-45850618PT. Siwali Swantika
Datasheet fluke Three-Phase Power Recorder. Informasi lebih detail hubungi PT. Siwali Swantika, Jakarta Office : 021-45850618 atau Surabaya Office : 031-8421264
Deck I created for a local auto dealership. The copy was dictated by my sales crew (otherwise I would have done far less info on each slide). I was responsible for the overall style, graphic mockups, and so on.
Keep in mind not all elements translate properly to Slideshare.
Business pitch deck I designed a couple years back. Went for a textural feel with some simple and clean typography.
Keep in mind the copy was dictated by sales, and therefore is much heavier than I would have chose.
Datasheet Fluke 8508A. Hubungi PT. Siwali Swantika 021-45850618PT. Siwali Swantika
Datasheet Fluke 8508A Reference Multimeter. Informasi lebih detail hubungi PT. Siwali Swantika, Jakarta Office : 021-45850618 atau Surabaya Office : 031-8421264
This presentation provides an detailed information about dissolution study. Furthermore, it provides various dissolution theories, application , various dissolution apparatus etc.
Dissolution apparatus, invivo-invitro corelation, factor affecting,BCS classification ..
Complete dissolution topic in this slide & easy way to write..
Cheak it now and give feedback
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
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New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
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2. In the name of God
Application of supercritical
antisolvent method in
drug encapsulation
Maryam kazemi
Ph.D student of pharmaceutics
Shiraz university of medical sciences
3. The ideal drug delivery method:
Safe
Inert
Comfortable for patient
Biocompatible
Easily administered or removable
High drug loading
Using biodegradable polymers for drug encapsul
ation is one of the best ways to achieved this ide
al method .
4. Supercritical fluid properties:
• SCF is a solvent
• Tempreture & pressure are greater than its
critical T , P.
• It remains as a single phase
5.
6. The best SCF is CO2:
• Non toxic
• Inert
• Low critical T=304 k & low critical P =7.38 MPa.
• Poor solubility for many polymers & drugs /rapid mixing
with the solvent.
• Low viscosity like a gas , Its density similar to the liquid
• Its ability to provide a non degrading and nonoxidizing
environment for sensitive compounds.
7. Limitation of SCF:
Non biocompatibility or toxicity of the
polymers.
Unwanted by product of degradation .
Higher cost
8.
9. The anti solvent application
Bleich and coworkers firstly discovered .
CO2= anti solvent percipitation of the solute
from an organic solvent.
10. The base of this technique is:
• Dissolving a large volume of a SCF by a
n organic solvent .
• Reciprocal miscibility of the SCF CO2 &
an organic solvent
• The low afinity of SCF for solute.
11. Mechanism of SAS
• SC Co2 is pumped in to the high pressure vessel to a
specific pressure .
• Solution (drug+biodegredable polymer+organic solv
ent ) is sprayed in the reactor via a suitable nozzle.
• CO2 diffused in the solvent evaporated in the ga
s phase & the solvent diffuses rapidly from the solut
ion droplet in to the bulk SCF percipitation th
e solute.
12.
13.
14. • Formed particles are collected on a filter
Washed with SCF to remove the resitual solvent
SCF dissolving into the liquid droplet
Evaporation of the organic solvent in the SCF phase
Later percipitate
15. Disadvantages of this method
• Long washing period aggregation particles
To minimize :intensivly mixing SAS & solution
Method : Using Ultra sonic nozzles 10-100 kHZ
Increase mass transfer between SCF & solution
Smaller droplet
16.
17. Effects of the process parameters on the particle size in
the supercritical antisolvent (SAS) process
Effects of pressure:
At higher pressure, obtained smaller particle size. At higher pressu
re, the deforming pressure forces must be increased to break the
droplets into smaller particles. Moreover, particle nucleation and it
s growth are other important factors affecting particle size. Rapid
mass transfer of antisolvent and solvent causes high supersaturati
ons for the solute. High supersaturation results in rapid nucleation
and growth of more than one particle per primary droplet.
At lower pressure, obtained smaller particle size. In a situation abo
ve the critical condition, reduction in pressure is observed to decr
ease the solubility which then results in higher maximum supersat
uration in the reactor; therefore, smaller particles are produced.
Pressure variations have no significant effect on particle size beca
use the free intermolecular volume of the polymer will be occupie
d at the saturation pressure.
18. Effects of temperature
At higher temperature
smaller size and more spherical particles obtained
. But the temperature must be lower than the Tg of
the polymer.
At lower temperature
smaller particle size,obtained due to higher
volatility.
19. Effects of chemical composition of the organic solvent
Particle size decreases with increase in volatility of
the solvent.
Particle size decreased by using a stronger solvent.
Solubility of the biodegradable polymer in the orga
nic solvent must be higher than the solubility of its
drug Contents.
20. Effects of chemical composition of the drug
Lower solubility of the drug in a supercritical
fluid enhances rapid precipitation.
Enhancement of drug lipophilicity reduces the
loading drug efficiency in the SAS process
21. Effects of chemical composition of the biodegr
adable polymer
The crystalline polymer forms smaller particle
size with narrower particle size distribution.
Drug stability in amorphous polymers is higher
than in crystalline polymers
22. Effects of the nozzle geometry
A smaller nozzle diameter reduces the particle size
and produces more spherical-shaped particles.
The effect of the nozzle diameter is not highly
significant.
Co-axial nozzle, is especially designed for
improvement of the morphology.
23. Effects of flow rates of CO2 and liquid phase
Increasing the ratio of CO2 flow rate over the
organic solution flow rate reduces particle size.
24. • References:
• M. Kalani, R. Yunus, Application of supercritical antisolvent
method in drug encapsulation: a review, International Journal of n
anomedicine 6 (2011) 1429‐1442.