1.solid dispersion 1 st sem
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This document summarizes a seminar presentation on solid dispersion techniques. It defines solid dispersion as dispersing one or more active ingredients in an inert matrix in the solid state. The goals of solid dispersion include improving drug solubility, stability, dissolution rate and bioavailability. Various preparation methods are discussed, including melting, solvent evaporation, melt extrusion, supercritical fluid technology and spray drying. Characterization techniques involve assessing drug-carrier interactions and miscibility, as well as physical structure and stability. Applications include increasing solubility, dissolution and bioavailability of poorly soluble drugs. Advantages are improved properties like wettability and porosity, while disadvantages include potential instability issues.
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mouth dissolving tablet
This document provides details on the development of a mouth dissolving tablet formulation of meloxicam. It begins with an introduction on the benefits of mouth dissolving tablets and ideal properties. The document then outlines the aim to develop a solid dispersion technique to enhance the solubility of meloxicam and prepare mouth dissolving tablets. The plan of work, materials, and methods are described for characterizing the drug and excipients, preparing the solid dispersions using a kneading method, and evaluating the tablets. The evaluation would include hardness, thickness, friability, disintegration time, wetting time, drug content, and in vitro dissolution testing. References are also provided.
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This document discusses fast dissolution disintegrating dosage forms (FDDFs). It begins with an introduction to FDDFs, noting they dissolve or disintegrate quickly without water. The needs and advantages of FDDFs are then outlined, including ease of administration for those who have trouble swallowing. Various formulation methods, ingredients, and patented technologies are described. Several example formulations are provided. Clinical studies on bioavailability and pregastric absorption are mentioned. Popular commercial FDDF products are listed before concluding FDDFs can improve compliance by dissolving rapidly in the mouth.
Review On Mouth Dissolving Tablet
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The concept of mouth dissolving drug delivery systems (MDDDS) or fast dissolving tablets emerged with an objective to improve patient’s compliance.
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Formulation Development and Evaluation of Oral Fast Dissolving Films of Metac...
Metaclopromide HCl is an Anti emetic used to treat nausea, vomiting and to increase gastric motility. The present work aimed at preparing oral fast dissolving films of Metaclopromide HCl with the purpose of developing a dosage form for a very quick onset of action, which is very convenient for administration, without the problem of swallowing and using water. Oral fast dissolving films of Metaclopromide HCl were prepared using HPMC E5, E15 polymers as film forming agents and polyethylene glycol 400 as plasticizer by solvent casting method. FTIR showed that there is no interaction between drug and excipients. Dissolution of prepared fast dissolving oral films of Metaclopromide HCl was performed using USP type II apparatus in pH 6.8 phosphate buffer medium at 50 rpm with temperature being maintained at 37 0.5º C. The films prepared were evaluated for various parameters like thickness, drug content uniformity, weight variation, disintegration time, folding endurance and in vitro drug release and were showed satisfactory results. In conclusion, development of oral fast dissolving oral films using HPMC polymer gives rapid drug delivery and rapid onset of action. Zeenath Ruhy "Formulation Development and Evaluation of Oral Fast Dissolving Films of Metaclopromide HCL" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-4 | Issue-1 , December 2019, URL: https://www.ijtsrd.com/papers/ijtsrd29702.pdf Paper URL: https://www.ijtsrd.com/pharmacy/novel-drug-delivery-sys/29702/formulation-development-and-evaluation-of-oral-fast-dissolving-films-of-metaclopromide-hcl/zeenath-ruhy
pellets final
Pharmaceutical pellets are small spherical units prepared by agglomerating fine powders. They range in size from 0.5-1.5mm. Pellets can be used for both oral and injectable drug delivery and offer benefits like taste masking, immediate or sustained release, and delivery of chemically incompatible products in a single dose. Various methods are used to produce pellets including extrusion-spheronization, hot melt extrusion, fluid bed granulation, spray drying, and layering techniques. Pellets can be further processed into tablets, capsules, or other dosage forms and coated to provide modified release of drugs over an extended period.
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mouth dissolving tablet
This document provides details on the development of a mouth dissolving tablet formulation of meloxicam. It begins with an introduction on the benefits of mouth dissolving tablets and ideal properties. The document then outlines the aim to develop a solid dispersion technique to enhance the solubility of meloxicam and prepare mouth dissolving tablets. The plan of work, materials, and methods are described for characterizing the drug and excipients, preparing the solid dispersions using a kneading method, and evaluating the tablets. The evaluation would include hardness, thickness, friability, disintegration time, wetting time, drug content, and in vitro dissolution testing. References are also provided.
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This document discusses fast dissolution disintegrating dosage forms (FDDFs). It begins with an introduction to FDDFs, noting they dissolve or disintegrate quickly without water. The needs and advantages of FDDFs are then outlined, including ease of administration for those who have trouble swallowing. Various formulation methods, ingredients, and patented technologies are described. Several example formulations are provided. Clinical studies on bioavailability and pregastric absorption are mentioned. Popular commercial FDDF products are listed before concluding FDDFs can improve compliance by dissolving rapidly in the mouth.
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Formulation and evaluation of fast dissolving tablets
The concept of mouth dissolving drug delivery systems (MDDDS) or fast dissolving tablets emerged with an objective to improve patient’s compliance.
These dosage forms rapidly disintegrate and/or dissolve to release the drug as soon as they come in contact with saliva, thus obviating the need for water during administration, an attribute that makes them highly attractive for pediatric and geriatric patients.
Formulation Development and Evaluation of Oral Fast Dissolving Films of Metac...
Metaclopromide HCl is an Anti emetic used to treat nausea, vomiting and to increase gastric motility. The present work aimed at preparing oral fast dissolving films of Metaclopromide HCl with the purpose of developing a dosage form for a very quick onset of action, which is very convenient for administration, without the problem of swallowing and using water. Oral fast dissolving films of Metaclopromide HCl were prepared using HPMC E5, E15 polymers as film forming agents and polyethylene glycol 400 as plasticizer by solvent casting method. FTIR showed that there is no interaction between drug and excipients. Dissolution of prepared fast dissolving oral films of Metaclopromide HCl was performed using USP type II apparatus in pH 6.8 phosphate buffer medium at 50 rpm with temperature being maintained at 37 0.5º C. The films prepared were evaluated for various parameters like thickness, drug content uniformity, weight variation, disintegration time, folding endurance and in vitro drug release and were showed satisfactory results. In conclusion, development of oral fast dissolving oral films using HPMC polymer gives rapid drug delivery and rapid onset of action. Zeenath Ruhy "Formulation Development and Evaluation of Oral Fast Dissolving Films of Metaclopromide HCL" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-4 | Issue-1 , December 2019, URL: https://www.ijtsrd.com/papers/ijtsrd29702.pdf Paper URL: https://www.ijtsrd.com/pharmacy/novel-drug-delivery-sys/29702/formulation-development-and-evaluation-of-oral-fast-dissolving-films-of-metaclopromide-hcl/zeenath-ruhy
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1. Orally disintegrating tablets (ODTs) are solid dosage forms that disintegrate rapidly, usually within seconds, when placed on the tongue without the need for water.
2. ODTs are appropriate for patients who have difficulty swallowing tablets or capsules, such as elderly patients, children, and bedridden patients. They can improve medication compliance and therapeutic effects.
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SSDN SACHIN LPU GUIDE MR. NARENDRA PANDEY
This document provides an overview of mouth dissolving tablets (MDT), including promising drug candidates, popular disintegrants used, formulation techniques, marketed products, and evaluation methods. MDTs are designed to dissolve rapidly in the mouth within 3 minutes before swallowing for improved patient compliance. Common techniques for MDT formulation include lyophilization, moulding, direct compression, and sublimation. Evaluation of MDTs involves testing of granules, tablets, and dissolution properties. Future research aims to identify suitable drug candidates and excipients while improving dissolution times and patient acceptability.
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Granules are aggregations of fine powder particles that are roughly spherical in shape. They are produced to improve powder flowability, enhance compressibility, reduce toxicity, and prevent caking. There are three main granulation methods: wet granulation, dry granulation, and granulation by crystallization. Wet granulation is most common and involves mixing powder with a liquid to form a paste, then granulating and drying the paste. Granules are sieved after drying to achieve a uniform size distribution suitable for their intended use as a final or intermediate pharmaceutical product. Quality tests such as dissolution and friability are performed to ensure granule properties are suitable.
Development and Characterisation of Fast Dissolving Oral Films
For My review article on Fast Dissolving Oral Films, click on this link http://www.ijupbs.com/Uploads/2.%20RPA13140283015.pdf or copy paste this link in browser.
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The concept of mouth dissolving tablets known as MDTs has emerged with an objective to improve patient’s compliance. Methods to improve patient’s compliance have always attracted scientists towards the development of fancy oral drug delivery systems. Among them, mouth dissolving drug delivery systems (MDDDS) have obtained an important position in the market by overcoming previously encountered administration problems and contributing to extension of patent life. These dosage forms rapidly disintegrate in contact with saliva even within <60 seconds, an attribute that makes them highly attractive for paediatric, geriatric, bedridden patients and for active patients who are busy and in travelling may not have access to water. This special dosage form has some prerequisite criteria for formulation and this also involves the use of special techniques for large scale industrial production. The aim of this article is to review the advantages and disadvantages of MDTs, common excipients used in the formulation especially highlighting the use of superdisintegrating agents and taste masking agents in formulation and finally the popular methods used to produce large scale tablets for commercial purpose.
Formulation and evaluation of fast-disintegrating tablets of Flupirtine
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Recent developments in fast-dissolving or disintegrating tablets have brought convenience in dosing to elderly and children who have trouble in swallowing tablets. The main objective of the present study was to prepare the orally disintegrating tablets of Flupirtine, a non-steroidal anti-inflammatory drug (NSAID) using different superdisintegrants by direct compression method. Different concentrations (4%, 8%, and 10%) of super disintegrants such as Primogel, Kollidon Cl, Lycoat were used in the formulation. Mannitol was used as a bulking agent and to enhance the mouth feel and taste. The formulated tablets were evaluated for pre-formulation and post-formulation parameters and they were found to be satisfactory and within the official limits. All the tablets shown hardness 3-4.5kg/cm2, friability of all the formulations was less than 1%, weight variation and drug content were found to be within official limits. Amongst all formulations, the optimized formulation F9 was prepared with Lycoat as a super disintegrant showed least disintegration time and faster dissolution.
Key words: Flupirtine, fast-disintegrating tablet, direct compression method, superdisintegrants.
Formulation and Evaluation of Risperidone Fast Dissolving Tablets
The document discusses the formulation and evaluation of risperidone fast dissolving tablets. Four formulations of risperidone FDTs were developed using different concentrations and combinations of crospovidone and croscarmellose sodium as superdisintegrants. The tablets were prepared by direct compression method and evaluated for characteristics like hardness, friability, thickness, drug content, wetting time, disintegration time and in-vitro drug release. Formulation F2 showed the most promising results with no drug-excipient interactions. Stability studies on F2 for one month also showed acceptable results, making it the optimized risperidone FDT formulation.
Mouth dissolving tablet seminar
MDT is fast dissolving tablet in mouth only ,give quick action ,with pleasant test mainly used in journey without use of water.
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Granulation process may be defined as a process wherein small particles adhere together by forming bonds between them , resulting in the formation of large aggregates called granules.
Shashank Jain
The document discusses oral disintegrating tablets (ODTs), which are oral solid dosage forms that dissolve or disintegrate rapidly in the mouth without water. ODTs offer advantages over traditional tablets like improved patient compliance and bioavailability. Key attributes of ODTs include rapid disintegration (within 30 seconds), good taste masking, and the use of superdisintegrants, sugars, and other excipients to facilitate quick dissolution. Common technologies for producing ODTs involve freeze-drying, direct compression, spray drying, and mass extrusion. Preformulation studies and tests of disintegration time and dissolution profile are important for developing an effective ODT formulation.
PREPARATION AND EVALUATION OF FAST DISSOLVING LEVOCITRAZINE TABLETS1
This document summarizes a student research project on developing fast dissolving tablets of Levocetirizine dihydrochloride. It lists the students and supervisor involved. It then provides background information on fast dissolving tablets, including definitions, advantages, techniques for preparation, and mechanisms of mouth dissolving. The objectives and methodology of the study are described. Formulations of fast dissolving tablets containing Levocetirizine were developed and evaluated for pre-compression and post-compression parameters such as drug content and in vitro drug release. The optimized formulation showed 99.81% drug release within 10 minutes and disintegrated within 14 seconds.
Formulation and Evaluation of Fast Dissolving Tablets of Carbamazepine Using ...
Formulation and Evaluation of Fast Dissolving Tablets of Carbamazepine Using ...International journal of pharmacy research and science (IJPRSONLINE)
Abstract:
The purpose of present research work was to
optimize the formulation of fast dissolving tablet
of carbamazepine. Carbamazepine is one the most
prescribed antiepileptic drug. Fast dissolving
tablets of carbamazepine were prepared by using
different types of superdisintegrants like
croscarmellose sodium and sodium starch
glycolate. Fast dissolving tablet is prepared by
direct compression method. The formulations
were evaluated for wetting time, hardness,
friability, content uniformity, invitro
disintegration time, release profile. The result
revealed that the formulation F5 which containing
the 5% croscarmellose sodium as a
superdisintegrant have good dissolution profile
with shortest Disintegration time. It can be
concluded that the tablet of carbamazepine with
better pharmaceutical properties than conventional
tablets could be obtained using formulation F5.
Oral Dispersible Tablets - A Review
This document provides a review of oral dispersible tablets. It begins with an introduction that defines oral dispersible tablets as solid dosages that disintegrate rapidly, usually within seconds, when placed on the tongue. It describes the advantages of these tablets for patients who have difficulty swallowing conventional tablets. The document then reviews various technologies used to manufacture oral dispersible tablets, including lyophilization, molding, cotton candy process, and spray drying. It also discusses commonly used excipients and superdisintegrants and their mechanisms of action in rapidly disintegrating tablets.
Powder and grannules
Powders are mixtures of finely divided drugs and chemicals that may be intended for internal or external use. They offer advantages like rapid onset of action and ease of administration to infants. However, they can be difficult to formulate when drugs are hygroscopic, deliquescent, or efflorescent. Powder production involves size reduction, mixing, and packaging. Size reduction methods include cutting, compression, impact, and attrition. Mixing ensures uniform drug distribution and appearance. Hygroscopic powders require formulations like granules or packets to reduce moisture absorption.
Solid dispersion
SOLID DISPERSION
Definition: The technology is the science of dispersing one or more active ingredients in an inert matrix in the solid stage.
Need of solid dispersion:
Increases Oral bioavailability of a drug
Increased dissolution rate.
Enhanced release of drugs from ointment.
Improved the solubility & stability.
The concept of solid dispersion was originally proposed by Sekiguchi & obi.
Increasing the dissolution, absorption & therapeutic efficacy of drugs in dosage forms.
Increasing solubility in water.
Improving the oral absorption and bioavailability of BCS Class II drugs.
solid dispersion by shubhangi
The term solid dispersion refers to a group of solid products consisting of a hydrophilic matrix and a hydrophobic drug frequently prepared by fusion solvent method. The matrix can be amorphous or crystalline in nature .
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1. Orally disintegrating tablets (ODTs) are solid dosage forms that disintegrate rapidly, usually within seconds, when placed on the tongue without the need for water.
2. ODTs are appropriate for patients who have difficulty swallowing tablets or capsules, such as elderly patients, children, and bedridden patients. They can improve medication compliance and therapeutic effects.
3. Key factors in developing ODTs include selecting drugs that have appropriate properties, using superdisintegrants and other excipients to enable rapid disintegration, and employing manufacturing techniques like direct compression that avoid moisture.
Fast dissolving tablets
This document defines and discusses fast dissolving tablets (FDTs). FDTs disintegrate rapidly in the mouth without water. Their history dates back to the 1970s when scientists developed Zydis, an early FDT formulation. FDTs provide advantages like accurate dosing, easy administration for patients who can't swallow, and a faster onset of action compared to normal tablets. They are made through freeze drying or spray drying which creates a highly porous structure for rapid dissolution. While FDTs offer benefits, their use is limited by formulation challenges like bitter tasting drugs and large doses. The future of FDTs depends on overcoming these difficulties.
SSDN SACHIN LPU GUIDE MR. NARENDRA PANDEY
This document provides an overview of mouth dissolving tablets (MDT), including promising drug candidates, popular disintegrants used, formulation techniques, marketed products, and evaluation methods. MDTs are designed to dissolve rapidly in the mouth within 3 minutes before swallowing for improved patient compliance. Common techniques for MDT formulation include lyophilization, moulding, direct compression, and sublimation. Evaluation of MDTs involves testing of granules, tablets, and dissolution properties. Future research aims to identify suitable drug candidates and excipients while improving dissolution times and patient acceptability.
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Granules are aggregations of fine powder particles that are roughly spherical in shape. They are produced to improve powder flowability, enhance compressibility, reduce toxicity, and prevent caking. There are three main granulation methods: wet granulation, dry granulation, and granulation by crystallization. Wet granulation is most common and involves mixing powder with a liquid to form a paste, then granulating and drying the paste. Granules are sieved after drying to achieve a uniform size distribution suitable for their intended use as a final or intermediate pharmaceutical product. Quality tests such as dissolution and friability are performed to ensure granule properties are suitable.
Development and Characterisation of Fast Dissolving Oral Films
For My review article on Fast Dissolving Oral Films, click on this link http://www.ijupbs.com/Uploads/2.%20RPA13140283015.pdf or copy paste this link in browser.
Pardeep Kumar Jangra
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Orally disintegrating tablets (ODTs) are solid dosage forms that disintegrate rapidly in the mouth. The first FDA-approved ODT was a Zydis formulation of Claritin in 1996. ODTs are suitable for patients who have difficulty swallowing pills like pediatric and geriatric patients. They have advantages like convenience of administration without water and faster onset of action. ODTs contain active ingredients, disintegrants, binders, flavors and other excipients. Common disintegrants include starches, crospovidone and celluloses. Formulation methods include freeze drying, moulding, sublimation and direct compression. Many drug classes have been formulated into ODTs for improved patient
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Stroks law
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Precipitation method:
Dispersion method
Comparision of partical setteling in Defloculated Suspension and Floculated Suspension
Characteristics of an Ideal Suspensions
Formulation of Flocculated and Defloculated Suspensions
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formulation and evalution of effervescent tablet
Effervescent tablets dissolve quickly upon contact with water, releasing carbon dioxide bubbles through a chemical reaction between a carbonate or bicarbonate salt (e.g. sodium bicarbonate) and a weak organic acid (e.g. citric or tartaric acid). This reaction facilitates rapid disintegration without needing additional disintegrants. Effervescent tablets offer benefits like fast onset of action, improved palatability and absorption, but are more expensive to produce than regular tablets due to additional excipients required and specialized manufacturing processes. They are commonly used to formulate medicines that are difficult to digest or cause irritation when swallowed.
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The concept of mouth dissolving tablets known as MDTs has emerged with an objective to improve patient’s compliance. Methods to improve patient’s compliance have always attracted scientists towards the development of fancy oral drug delivery systems. Among them, mouth dissolving drug delivery systems (MDDDS) have obtained an important position in the market by overcoming previously encountered administration problems and contributing to extension of patent life. These dosage forms rapidly disintegrate in contact with saliva even within <60 seconds, an attribute that makes them highly attractive for paediatric, geriatric, bedridden patients and for active patients who are busy and in travelling may not have access to water. This special dosage form has some prerequisite criteria for formulation and this also involves the use of special techniques for large scale industrial production. The aim of this article is to review the advantages and disadvantages of MDTs, common excipients used in the formulation especially highlighting the use of superdisintegrating agents and taste masking agents in formulation and finally the popular methods used to produce large scale tablets for commercial purpose.
Formulation and evaluation of fast-disintegrating tablets of Flupirtine
ABSTRACT
Recent developments in fast-dissolving or disintegrating tablets have brought convenience in dosing to elderly and children who have trouble in swallowing tablets. The main objective of the present study was to prepare the orally disintegrating tablets of Flupirtine, a non-steroidal anti-inflammatory drug (NSAID) using different superdisintegrants by direct compression method. Different concentrations (4%, 8%, and 10%) of super disintegrants such as Primogel, Kollidon Cl, Lycoat were used in the formulation. Mannitol was used as a bulking agent and to enhance the mouth feel and taste. The formulated tablets were evaluated for pre-formulation and post-formulation parameters and they were found to be satisfactory and within the official limits. All the tablets shown hardness 3-4.5kg/cm2, friability of all the formulations was less than 1%, weight variation and drug content were found to be within official limits. Amongst all formulations, the optimized formulation F9 was prepared with Lycoat as a super disintegrant showed least disintegration time and faster dissolution.
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Formulation and Evaluation of Risperidone Fast Dissolving Tablets
The document discusses the formulation and evaluation of risperidone fast dissolving tablets. Four formulations of risperidone FDTs were developed using different concentrations and combinations of crospovidone and croscarmellose sodium as superdisintegrants. The tablets were prepared by direct compression method and evaluated for characteristics like hardness, friability, thickness, drug content, wetting time, disintegration time and in-vitro drug release. Formulation F2 showed the most promising results with no drug-excipient interactions. Stability studies on F2 for one month also showed acceptable results, making it the optimized risperidone FDT formulation.
Mouth dissolving tablet seminar
MDT is fast dissolving tablet in mouth only ,give quick action ,with pleasant test mainly used in journey without use of water.
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Granulation process may be defined as a process wherein small particles adhere together by forming bonds between them , resulting in the formation of large aggregates called granules.
Shashank Jain
The document discusses oral disintegrating tablets (ODTs), which are oral solid dosage forms that dissolve or disintegrate rapidly in the mouth without water. ODTs offer advantages over traditional tablets like improved patient compliance and bioavailability. Key attributes of ODTs include rapid disintegration (within 30 seconds), good taste masking, and the use of superdisintegrants, sugars, and other excipients to facilitate quick dissolution. Common technologies for producing ODTs involve freeze-drying, direct compression, spray drying, and mass extrusion. Preformulation studies and tests of disintegration time and dissolution profile are important for developing an effective ODT formulation.
PREPARATION AND EVALUATION OF FAST DISSOLVING LEVOCITRAZINE TABLETS1
This document summarizes a student research project on developing fast dissolving tablets of Levocetirizine dihydrochloride. It lists the students and supervisor involved. It then provides background information on fast dissolving tablets, including definitions, advantages, techniques for preparation, and mechanisms of mouth dissolving. The objectives and methodology of the study are described. Formulations of fast dissolving tablets containing Levocetirizine were developed and evaluated for pre-compression and post-compression parameters such as drug content and in vitro drug release. The optimized formulation showed 99.81% drug release within 10 minutes and disintegrated within 14 seconds.
Formulation and Evaluation of Fast Dissolving Tablets of Carbamazepine Using ...
Formulation and Evaluation of Fast Dissolving Tablets of Carbamazepine Using ...International journal of pharmacy research and science (IJPRSONLINE)
Abstract:
The purpose of present research work was to
optimize the formulation of fast dissolving tablet
of carbamazepine. Carbamazepine is one the most
prescribed antiepileptic drug. Fast dissolving
tablets of carbamazepine were prepared by using
different types of superdisintegrants like
croscarmellose sodium and sodium starch
glycolate. Fast dissolving tablet is prepared by
direct compression method. The formulations
were evaluated for wetting time, hardness,
friability, content uniformity, invitro
disintegration time, release profile. The result
revealed that the formulation F5 which containing
the 5% croscarmellose sodium as a
superdisintegrant have good dissolution profile
with shortest Disintegration time. It can be
concluded that the tablet of carbamazepine with
better pharmaceutical properties than conventional
tablets could be obtained using formulation F5.
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This document provides a review of oral dispersible tablets. It begins with an introduction that defines oral dispersible tablets as solid dosages that disintegrate rapidly, usually within seconds, when placed on the tongue. It describes the advantages of these tablets for patients who have difficulty swallowing conventional tablets. The document then reviews various technologies used to manufacture oral dispersible tablets, including lyophilization, molding, cotton candy process, and spray drying. It also discusses commonly used excipients and superdisintegrants and their mechanisms of action in rapidly disintegrating tablets.
Powder and grannules
Powders are mixtures of finely divided drugs and chemicals that may be intended for internal or external use. They offer advantages like rapid onset of action and ease of administration to infants. However, they can be difficult to formulate when drugs are hygroscopic, deliquescent, or efflorescent. Powder production involves size reduction, mixing, and packaging. Size reduction methods include cutting, compression, impact, and attrition. Mixing ensures uniform drug distribution and appearance. Hygroscopic powders require formulations like granules or packets to reduce moisture absorption.
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Similar to 1.solid dispersion 1 st sem
Solid dispersion
SOLID DISPERSION
Definition: The technology is the science of dispersing one or more active ingredients in an inert matrix in the solid stage.
Need of solid dispersion:
Increases Oral bioavailability of a drug
Increased dissolution rate.
Enhanced release of drugs from ointment.
Improved the solubility & stability.
The concept of solid dispersion was originally proposed by Sekiguchi & obi.
Increasing the dissolution, absorption & therapeutic efficacy of drugs in dosage forms.
Increasing solubility in water.
Improving the oral absorption and bioavailability of BCS Class II drugs.
solid dispersion by shubhangi
The term solid dispersion refers to a group of solid products consisting of a hydrophilic matrix and a hydrophobic drug frequently prepared by fusion solvent method. The matrix can be amorphous or crystalline in nature .
Solid dispersion
Solid dispersion techniques can increase the dissolution and bioavailability of poorly water soluble drugs. This is done by improving the drug's solubility in water and enhancing oral absorption. There are various types of solid dispersions categorized by their miscibility and how drug molecules are distributed. Common preparation methods include melting, solvent evaporation, and melting solvent techniques. Solid dispersions produce colloidal drug particles that have higher dissolution rates and absorption compared to conventional dosage forms. Characterization methods include thermal analysis, X-ray diffraction, spectroscopy, and dissolution testing. Solid dispersions can improve drug stability, taste masking, and release from semisolid dosage forms.
Dissolution enhancement of drugs. technologies and effect of carries
The document discusses various techniques for enhancing the dissolution of poorly water soluble drugs, including the use of carriers. It begins with an introduction to dissolution and factors affecting drug dissolution rates. Several techniques are then described such as solid dispersions, inclusion complexation, melt granulation, and use of carriers like polymers, superdisintegrants, and surfactants. Specific examples of drugs and carriers/techniques used to increase dissolution are also provided, along with the proposed mechanisms of enhancement. The conclusion reiterates that improving a drug's physicochemical properties through these methods can increase its dissolution rate.
Solubility enhancement technique
This presentation brifely explains about importants of solubility ,techniques to improve solubility
Methods of solubility enhancements
This document discusses various methods for enhancing the solubility of poorly soluble drugs, which is important for improving their bioavailability. It describes solubility and defines it qualitatively and quantitatively. It then explains the need for and categories of solubility enhancement techniques, including physical modifications, chemical modifications, and miscellaneous methods. Some key physical modification techniques discussed are particle size reduction through micronization and nanosuspensions, modifying the crystal habit through polymorphism, and using drug carriers like solid dispersions and cryogenic techniques. Chemical modification techniques include changing the pH, complexation, salt formation, and neutralization. Miscellaneous methods include microemulsions, use of adjuvants like surfactants, and cosolvency.
Solubility of drugs
Solubility is an important factor in achieving the desired drug concentration in systemic circulation for a pharmacological response. Over 40% of new chemical entities have poor water solubility, posing challenges for formulation. Various techniques can be used to enhance drug solubility, including reducing particle size, modifying crystal forms, forming solid dispersions or nanosuspensions, changing pH, and using adjuvants like surfactants. The selection of a solubility enhancement method depends on drug properties, absorption site, and dosage form characteristics.
Compaction profile & solubility enhancement techniques Naveen Balaji
This document discusses techniques to enhance the solubility and dissolution rate of poorly soluble drugs. It begins with an overview of compaction profiles when forming tablets. The bulk of the document focuses on solubility enhancement techniques, including physical modifications like particle size reduction and solid dispersions, chemical modifications like changing pH and derivatization, and other methods like co-solvency. A variety of specific techniques are described within each category to improve a drug's solubility such as micronization, nanosuspensions, cyclodextrin complexation, and use of surfactants, buffers, or co-solvents. The document provides details on the mechanisms and examples of various solubility enhancement methods.
mehods to enhance the solubility of poorly soluble drugs
Mr. Praveen Halagali presented on different techniques to enhance drug solubility to Dr. D.V. Gowda. The presentation covered the importance of solubility for drug bioavailability and listed various physical, chemical, and technological methods to improve solubility. These included reducing particle size, modifying crystal forms, complexation, and use of surfactants, cosolvents, and nanotechnology approaches like nanocrystals and nanomorphs. The mechanisms and specific techniques involved in each method were described in detail.
Solid dispersion as a technique for enhancement of
This document discusses solid dispersion as a technique to enhance the solubility of poorly water soluble drugs. It defines solid dispersion as the dispersion of an active ingredient in an inert carrier in the solid state, prepared through melting, solvent evaporation, or other techniques. The document outlines several mechanisms by which solid dispersions can increase drug solubility, such as reducing particle size and forming soluble complexes. It then describes various techniques for producing solid dispersions, including melting, solvent evaporation, kneading, and hot melt extrusion. Advantages are improved drug solubility and bioavailability, while disadvantages include potential instability over time.
Solid Dispersion - Solubility enhancing tool
The document discusses solid dispersions as a promising approach for improving the solubility and bioavailability of poorly soluble drugs. Solid dispersions involve dispersing a drug in an inert hydrophilic carrier through melting, solvent, or melting-solvent methods. This produces a high surface area drug particles that dissolve faster. Characterization techniques like particle size analysis, dissolution testing, infrared spectroscopy, and X-ray diffraction are used to analyze the interactions between drug and carrier and the state of the drug in the solid dispersion. The advantages of solid dispersions include reduced particle size, improved wettability, increased porosity, and transforming crystalline drugs into amorphous states with higher solubility. Alternative preparation techniques like lyophilization and spraying on
solubility enancement tecnique.pptx
The document provides an overview of various solubility enhancement techniques including particle size reduction through micronization and nanosuspension, hydrotropy, cosolvency, solubilization by surfactants, solid dispersions, pH adjustment, high pressure homogenization, supercritical fluid recrystallization, sonocrystallization, complexation, spray drying, inclusion complex formation, liquisolid technique, microemulsion, self-emulsifying drug delivery systems, neutralization, and cryogenic methods. Specific techniques like kneading, co-precipitation, and dropping methods for complexation and solid dispersions are also described along with the principles and processes involved in solubility enhancement.
Theories of solubulisation
This document discusses various techniques for enhancing the solubility of poorly soluble drugs. It begins by defining solubility and factors that affect solubility such as particle size, temperature, and pressure. It then describes techniques like particle size reduction through micronization and nanosuspensions, modifying crystal habits through polymorphism, drug dispersion in carriers like solid dispersions and solid solutions, complexation using agents like cyclodextrins, and solubilization using surfactants to form microemulsions. Other approaches discussed include co-crystallization, cosolvency, hydrotrophy, and nanotechnology methods like producing nanocrystals. The conclusion emphasizes that solubility is a key factor in oral drug bioavailability and various
Solubility of poorly soluble drugs by using solid ppt
Three sentence summary:
Solid dispersion techniques can be used to improve the solubility and bioavailability of poorly soluble drugs. Various methods can be used to prepare solid dispersions, including solvent evaporation, melting, and spray drying. Characterization of the solid dispersions is important and can be done using methods like thermal analysis, spectroscopy, and dissolution testing to understand the physical properties and drug release behavior.
Solubility enhancement techniques
This document discusses various techniques for enhancing the solubility of poorly soluble drugs, which is an important consideration in drug development and formulation. It begins by defining solubility and explaining the importance of solubility for drug bioavailability. Some key techniques discussed include particle size reduction through micronization or supercritical fluid processing, modifying the drug's crystal structure through polymorphism or amorphization, forming solid dispersions or complexes with carriers like cyclodextrins, and chemical modifications like salt formation or prodrugs. The document provides an overview of the various physical, chemical, and other approaches to improving a drug's solubility.
Shivaoo1
The document discusses various techniques for enhancing the solubility of poorly soluble drugs. It begins by explaining the importance of drug solubility for bioavailability and effectiveness. The main techniques discussed include reducing particle size through methods like micronization and nanosuspensions. It also covers modifying the crystal structure of drugs through polymorphism, amorphism, and changing hydration states. The document provides details on methods like sonocrystallization and supercritical fluid processing for size reduction.
Shivaoo1
The document discusses various techniques for enhancing the solubility of poorly soluble drugs. It begins by explaining the importance of drug solubility for bioavailability and outlines several techniques, including physical modifications like reducing particle size and modifying crystal forms, chemical modifications like changing pH, and forming complexes with agents. A key technique is using surfactants to create microemulsions that can solubilize drugs and enhance permeability across biological membranes. Overall, the techniques aim to increase surface area, modify crystal energy states, or alter a drug's chemistry to improve its solubility.
Preformulation shuaib
This document discusses various preformulation techniques used to improve the solubility and dissolution rate of poorly soluble drugs. It describes solubilization methods like surfactants, pH adjustment, cosolvency and solid dispersions using carriers like β-cyclodextrin. Key factors that influence dissolution like temperature, surface area, and hydrodynamics based on the Noyes-Whitney equation are also covered. The importance of preformulation properties like pKa, solubility and polymorphism on drug development are highlighted. References on industrial pharmacy and pharmaceutical dosage forms are listed for further reading.
Rapid Release Granulation Technology ppt
The document discusses rapid release granulation technology for improving the dissolution and bioavailability of poorly water-soluble drug compounds. It describes how formulation factors like the drug form, particle size, polymorphism, and additives as well as granulation factors like liquid binder quantity and equipment can be manipulated to produce rapid release granules. The goal is to enhance dissolution by increasing surface area, solubilization, wettability and disintegration. Rapid dissolution leads to higher absorption and bioavailability for Class II drugs with high permeability but low solubility.
Rate limiting steps in drug absorption [autosaved]
Rate limiting steps in drug absorption 1.Disintegration time
2.Dissolution and solubility
3.Physical and chemical nature of active drug substance
4.Nature of excipients
5.Method of granulation
6.Dissolution test conditions
7.Gastric emptying
Similar to 1.solid dispersion 1 st sem (20)
Dissolution enhancement of drugs. technologies and effect of carries
Dissolution enhancement of drugs. technologies and effect of carries
Compaction profile & solubility enhancement techniques Naveen Balaji
Compaction profile & solubility enhancement techniques Naveen Balaji
mehods to enhance the solubility of poorly soluble drugs
mehods to enhance the solubility of poorly soluble drugs
Solid dispersion as a technique for enhancement of
Solid dispersion as a technique for enhancement of
Solubility of poorly soluble drugs by using solid ppt
Solubility of poorly soluble drugs by using solid ppt
Rate limiting steps in drug absorption [autosaved]
Rate limiting steps in drug absorption [autosaved]
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1.solid dispersion 1 st sem
- 2. SOLID DISPERSION A Seminar By Mr.Hanmant A.Galande. Under the Guidance of Dr. P.K. Pawar Head of Pharmaceutics Department Gourishankar Institute of Pharmaceutical Education & Research Limb, Satara. (2016-17)
- 3. Introduction of Solid Dispersion Definition & Need Selection of The Carrier Types of Solid Dispersion Preparation Techniques Characterization of Solid Dispersion Advantages of Solid Dispersion Disadvantages of Solid Dispersion Application of Solid Dispersion References CONTENTS
- 4. INTRODUCTION The concept of solid dispersion was originally proposed by Sekiguchi & obi. Increasing solubility in water. Increasing the dissolution, absorption & therapeutic efficacy of drugs in dosage forms. Improving the oral absorption and bioavailability of BCS Class II drugs.
- 5. Definition & Need Definition: The technology is the science of dispersing one or more active ingredients in an inert matrix in the solid stage. Need of solid dispersion: Improved the solubility & stability. Enhanced release of drugs from ointment. Increased dissolution rate. Increases Oral bioavailability of a drug
- 6. SELECTION OF A CARRIER Freely water-soluble. Non-toxic and pharmacologically inert. Thermal stability Soluble in a variety of solvents. Enhances solubility of drug Chemically compatible with drugs. Eg.PVP,PEG,HPMC,CMC,CMEC,Urea
- 7. TYPES OF SOLID DISPERSION
- 8. PREPARATION TECHNIQUES Melting method Solvent evaporation method Melt extrusion method Super Critical Fluid (SCF) Technology Melting solvent method Spray drying Lyophilization technique Kneading method
- 9. 1) Melting method Physical mixture of a drug & water soluble carrier heat directly until it get melted cooled & solidified rapidly-ice bath-vigorous stirring. solid mass was crushed, pulverized & sieved.
- 10. 2) Solvent evaporation method Drug + matrix ( both dissolve in solvent) Solution Evaporate The Solvent Solid Mass is Sieved & Dried Solid Dispersion E.g..Atrovastatin + Neem gum Temperatures used for solvent evaporation generally lie in the range 23- 65°C. The solvent evaporation can be done by spray drying or freeze drying.
- 11. High rotating speed Drug + carrier mix small period of time using co-rotating twin- screw extruder. Simultaneously melted & homogenized extruded and shaped as tablets, granules, pellets 3) Melt extrusion method
- 12. 4) Supercritical fluid technology These process involves the spaying of the solution of solute and organic solvent into continuous Supercritical phase flowing concurrently Eg. Carbon dioxide ,Nitrogen etc.
- 13. 5) Melting solvent method Drug dissolve in suitable solvent Add melt of PEG Evaporation of solvent left clear film Drying of film to get const.wt
- 14. 6) Spray Drying polymeric fluid stream solution or melt delivered through a millimeter-scale nozzle Rapid drying Produces fine dust free powder with specific size & shape
- 15. SOLID DISPERSION-CHARACTERIZATION 1.Drug -carrier miscibility • Hot stage microscopy • Differential scanning calorimetry • Powder X-ray diffraction • NMR 1H Spin lattice relaxation time 2.Drug carrier interactions • FT-IR spectroscopy • Raman spectroscopy • Solid state NMR
- 16. Physical Structure • Scanning electron microscopy • Surface area analysis • Surface properties • Dynamic vapor sorption • Inverse gas chromatography • Atomic force microscopy • Raman microscopy Amorphous content • Polarized light optical microscopy • Hot stage microscopy • Humidity stage microscopy • DSC (MTDSC) • Powder X-ray diffraction
- 17. Stability • Humidity studies • Isothermal Calorimetry • DSC (Tg, Temperature recrystallization) • Dynamic vapor sorption • Saturated solubility studies Dissolution enhancement • Dissolution • Intrinsic dissolution • Dynamic solubility • Dissolution in bio-relevant media
- 18. APPLICATIONS To increase the solubility, dissolution rate , absorption and bioavailability. Improved the solubility & stability. To formulate a fast released dosage form. To reduce side effect of certain drugs. Masking of unpleasant taste and smell of drugs Improvement of drug release from ointment, creams .
- 19. ADVANTAGES To reduced particle size. To improve wettability. To improve porosity of drug. To decrease the crystalline structure of drug in to amorphous form. To improve dissolution in water of a poorly water- soluble drug.
- 20. DISADVANTAGES Instability Not easy handling because of tackiness. The scale up of manufacturing processes.
- 21. REFERENCES 1. Singh Sameer, Raviraj Singh Baghel., Yadav Lalit, 2011.A review on solid dispersion. International Journal of pharmacy & life sciences. 2. Rajni Sharma, Rupa Mazumder, Archana Sharma and Praveen Verma A review on: Solid dispersion International Journal Of Pharmacy & Life Sciences. 3. L.Nikghalb1 ,G. Singh ,Gaurav Singh, and K.Kahkeshan Solid Dispersion: Methods and Polymers to increase the solubility of poorly soluble drugs Journal of Applied Pharmaceutical Science Vol. 2 (10), pp. 170-175.