SlideShare a Scribd company logo
SHIV KUMAR
M.PHARM(2ND
SEM)
DEPARTMENT OF PHARMACEUTICAL
SCIENCES AND TECHNOLOGY
MRSPTU,BHATINDA
1. INTRODUCTION
2. WHAT IS PHYTOSOMES?
3. MERITS OF PHYTOSOMES COMPLEX USES
4. DIFFERENCE BETWEEN PHYTOSOMES AND LIPOSOMES
5. METHOD OF PREPARATION
6. CHARACTERIZATION OF PHYTOSOMES
7. FORMULATION OF PHYTOSOMES
8. COMMERCIALLY AVAILABLE PHYTOSOMES
2
 Polyphenolics and terpenes are ubiquitous in plants, but their poor
solubility in water and organic solvents make the bioavailability of several
botanical extracts erratic and poor.
 The limited solubility , both in water and in lipophilic phases, as well as
hydrolytical instability at physiological pH values make several botanical
extracts containing polyphenolics and terpenes very poorly absorbed both
orally and topically.
 Bioavailability can be improved by using new delivery systems which can
enhance the rate and the extent of solubilization into aqueous intestinal fluids
and the capacity to cross biomembranes.
Department of pharmacognosy/LMCP/Mrugesh
Patel 3
 Polyphenolics exhibit a marked affinity for phospholipids via hydrogen
bondings and dipolar interactions with the charged phosphates groups of
phospholipids.
 By complexing the polyphenolic phytoconstituents in a definite ratio with
phosphatidylcholine,
 Indena has developed a delivery system named “Phytosome®”.
 First phytosomal preparation-Flavonognan Silybin(silymarin)obtained from
Milk thistle fruit having properties of antioxidant,liver detoxification,anti-
inflamatory.
Department of pharmacognosy/LMCP/Mrugesh
Patel 4
 Phytosomes are novel drug delivery system containing hydrophilic
bioactive phytoconstituents of herbs surround and bound by
phospholipids.
 The term “phyto” means plant while “some” means cell-like.
 Phytosomes are little cell like structure.
 This is advanced forms of herbal formulations which contains the bioactive
phytoconsituents of herb extract surrounds and bound by a lipid. Most of the
bioactive constituents of phytomedicines are water-soluble compounds like
flavonoids, glycosides.
Department of pharmacognosy/LMCP/Mrugesh
Patel 5
 Phospholipid:
a) Phosphotidylcholine
b) Phosphotidylethanolamine
c) Phosphotidylserine
 Phospholipid : drug(2:1 or 1:1)
Department of pharmacognosy/LMCP/Mrugesh
Patel 6
 There is a dramatic enhancement of the bioavailability of botanical extract
due to their complexation with phospholipid and improved absorption in
the intestinal tract.
 They permit the non-lipophilic botanical extract to allow better absorption
from the intestinal lumen, which is otherwise not possible.
 Phytosome process produces a little cell whereby the valuable component of
the herbal extracts are protected from destruction by digestive secretions
and gut bacteria.
 The formulation of phytosomes is safe and the components have all been
approved for pharmaceuticals and cosmetic use.
 Phytosomes shows better stability profile because chemical bond are
formed between phosphotidylcholine molecules and phytoconstituents.
Department of pharmacognosy/LMCP/Mrugesh
Patel 7
 They have been used to deliver liver protecting flavonoids because
they can be made easily bioavailable by phytosomes.
 Entrapment efficiency is high and more over predetermined because
drug itself in conjugation with lipids is forming vesicles.
 Phosphotidylcholine used in the phytosomes process besides acting as a
carrier also nourishes the skin because it is a essential part of cell
membrane.
 They can be also used for enhanced permeation of drug through skin
for transdermal and dermal delivery.
 Their low solubility in the aqueous media allows the formation of
stable emulsions or creams.
 Phytosomes are also superior to liposomes in the skin care products.
Department of pharmacognosy/LMCP/Mrugesh
Patel 8
PHYTOSOMES LIPOSOMES
Active chemical
constituents(phytoconstituents)
are anchored through
chemical bonds to the polar
head of the phospholipids.
Active chemical constituents is
dissolved in the medium of the
cavity or in the layer of the
membrane.
No chemical bonds are
formed.
Ratio of phosphatidylcholine
to phytoconstituents is 1:1
or 2:1 , depending on the
phytoconstituents.
Thousand of
phosphatidylcholine
molecules surrounds the water
soluble molecules.
Department of pharmacognosy/LMCP/Mrugesh
Patel 9
 The most significant dietary source of the essential nutrient choline, is an
orthomolecule ubiquitous in known life form.
 Besides being an important emulsifier in the lungs,gastrointestinal tract,bile.
 PC is the principal molecular building block for circulating lipoproteins and
for cell membrane. They are making up the matrix into which fit a large
variety of proteins that are enzymes, transport proteins, receptors and
other biological energy converters.
 Manage the vast majority of life processes.
 As a carrier for both fat-miscible and water-miscible nutrient.
Department of pharmacognosy/LMCP/Mrugesh
Patel 10
 Phytosomes are prepared by reacting natural or synthetic phospholipids with active
components like bioflavonoid, flavolignan and polyphenolic constituents.
 Solvent Evaporation method is the most common technique used for the
preparation of phytosomes.(Refluxed at 50-60C for 2hr). Phytosomes of
ginsenoside, puerarin and kushenin are prepared in this manner.
 Mechanical Dispersion method is used for the preparation of marsupsin-
phospholipid complexes.
 Phospholipids is dissolved in a suitable solvent and active ingredient is added drop
by drop while sonicating the solution .Phospholipid complex is sometimes prepared
under reflux and stirring conditions to effect complete interaction.
 Prepared complex called phytosome can be isolated by precipitation with
nonsolvent,lyophilization,spray drying or vacuum drying.
11
 Visualization of particle size
 Transmission electron microscopy(TEM)
 Scanning electron microscopy(SEM)
 Spectroscopic evaluation
 1
H-NMR
 13
C-NMR
 FTIR(Chemical stability)
 Entrapment efficiency(Ultracentifugation)
 Spreadibility
 Percentage yield
 DSC
Department of pharmacognosy/LMCP/Mrugesh
Patel 12
 Can be formulated :
(a)Orally
(b)Topically
 The formulation tips here shown is indicated by the Indena for
(a) Soft gelatin capsules
(b) Hard gelatin capsules
(c) Tablets
(d) Topical dosage form
Department of pharmacognosy/LMCP/Mrugesh
Patel 13
Ingredients Quantity
Ginkgoselect ®
Phytosome®
180 mg
Soy bean oil 250 mg
Soy lecithin q.S
Glycerylmonostearate q.S
Department of pharmacognosy/LMCP/Mrugesh
Patel 14
Ingredients Quantity
Ginkgoselect ®
Phytosome®
180 mg
Dicalcium phosphate dihydrate 196 mg
Silicified microcrystalline cellulose 47 mg
Croscarmellose sodium 23 mg
Talc 2 mg
Magnesium stearate 2 mg
Department of pharmacognosy/LMCP/Mrugesh
Patel 15
Ingredients Quantity
Leucoselect ®
Phytosome®
100 mg
Soy polysaccharides 138 mg
Corn starch 100 mg
Silicon dioxide 6 mg
Talc 3 mg
Magnesium stearate 3 mg
Department of pharmacognosy/LMCP/Mrugesh
Patel 16
Phytosome Herbal drug Indication
Ginkgoselect ®
ginkgobiloba Improve memory,
Brain function,
Anti inflammatory agent
Silybin®
Silybum marianum Anti oxidant,
Anti aging,
Hepatoprotective
Hawthore®
Crataegus oxyacantha Help to strengthen heart
and cardiovascular
system
Ginselect®
Panax ginseng Promote adaptogenic
functions and resistance
to stress
Curcumin Curcuma longa Chemoprotective agent
Grapseed Grapseed Natural antioxidant
protectantDepartment of pharmacognosy/LMCP/Mrugesh
Patel 17
Phytosome Herbal drug Indication
Greenselect®
Camellia sinensis Antioxidant,
Cardioprotective,
Food product
Mirtoselect®
Vaccinium myrtillus Antioxidant
Leucoselect®
Vitis vinifera Cardiovascular protectant,
Anti-inflammatory,
Antioxidant
Sabalselect®
Serenoa repens Non-cancerous prostate
enlargement
Lymphaselect®
Melilotus officinalis Effective in hemorrhoids,
thrombophlebitis, post-
surgical edema formation,
lymphedema
OleaselectTM
Olea europaea Antioxidant, inhibit harmful
oxidation of LDL
PolinaceaTM
Echinacea angostifolia Enhance immune function
in response to toxic
challenge
Department of pharmacognosy/LMCP/Mrugesh
Patel 18
1. Shalini Sharma,"Phytosomes : AN EMERGING TECHNOLOGY”,
JPRD/2010/PUB/ARTI/VOV-2/ISSUE-5/JULY/2014,ISSN 0974 – 9446.
2. Sanjat Saha,Phytomes:a brief overview,2013:2(1):12-20.
3. Asit R Sahu, Formulation and Evaluation of Phytosome Drug Delivery
System of Boswellia Serrata Extract, Int J Res Med. 2015; 4(2);94-99.
4. Sushila Rathee, Optimization and development of Antidiabetic phytosomes
by box-benhken design, ISSN: 0898-2104 (Print) 1532-2394.
5. http://ijpsr.com/bft-article/phytosomes-a-novel-drug-delivery-for-herbal-
extracts/?view=fulltext
6. https://www.pharmatutor.org/articles/phytosomes-is-a-novel-drug-delivery-
system-based-herbal-formulation-an-review
19

More Related Content

What's hot

Regulatory provision related to manufacture of cosmetic
Regulatory provision related to manufacture of cosmeticRegulatory provision related to manufacture of cosmetic
Regulatory provision related to manufacture of cosmetic
Manish Rajput
 
Microcapsules: types, preparation and evaluation
Microcapsules: types, preparation and evaluationMicrocapsules: types, preparation and evaluation
Microcapsules: types, preparation and evaluation
MOHAMMAD ASIM
 
Microspheres
MicrospheresMicrospheres
Microspheres
Thilak Chandra
 
Phytosome
PhytosomePhytosome
Phytosome
surya singh
 
Formulation and evaluation of aerosals
Formulation and evaluation of aerosalsFormulation and evaluation of aerosals
Formulation and evaluation of aerosals
Siddu K M
 
Microcapsules and microspheres
Microcapsules and microspheresMicrocapsules and microspheres
Microcapsules and microspheres
SNJBs SSDJ College of Pharmacy, Chandwad
 
Targeted drug delivery systems
Targeted drug delivery systemsTargeted drug delivery systems
Targeted drug delivery systems
Dr Subodh Satheesh
 
Pulmonary Drug Delivery System (PDDS)
Pulmonary Drug Delivery System (PDDS)Pulmonary Drug Delivery System (PDDS)
Pulmonary Drug Delivery System (PDDS)
PRABU12345678
 
Application Of Polymer In Controlled Release Formulation
Application Of Polymer In Controlled Release FormulationApplication Of Polymer In Controlled Release Formulation
Application Of Polymer In Controlled Release Formulation
Anindya Jana
 
Micro capsules or microspheres
Micro capsules or microspheresMicro capsules or microspheres
Micro capsules or microspheres
PV. Viji
 
Preparation and application of Niosomes
Preparation and application of  Niosomes Preparation and application of  Niosomes
Preparation and application of Niosomes
PV. Viji
 
Phytosomes
PhytosomesPhytosomes
Phytosomes
Sujit1225
 
microspheres types , preparation and evaluation
microspheres types , preparation and evaluationmicrospheres types , preparation and evaluation
microspheres types , preparation and evaluation
Sowjanya
 
Niosomes
NiosomesNiosomes
Niosomes
Sagar Savale
 
Microspheres and microcapsules
Microspheres and microcapsulesMicrospheres and microcapsules
Microspheres and microcapsules
JayBhavsar41
 
Nano particle Preparation and Evaluation
Nano particle Preparation and EvaluationNano particle Preparation and Evaluation
Nano particle Preparation and Evaluation
Navaneethakrishnan Palaniappan
 
polymer in pharmacy and application of polymers
polymer in pharmacy and application of polymerspolymer in pharmacy and application of polymers
polymer in pharmacy and application of polymers
Roshan Bodhe
 
Review of guidelines for herbal cosmetics by private bodies like cosmos
Review of guidelines for herbal cosmetics by private bodies like cosmosReview of guidelines for herbal cosmetics by private bodies like cosmos
Review of guidelines for herbal cosmetics by private bodies like cosmos
NimmiRoy
 
Misbranded and spurious cosmetics
Misbranded and spurious cosmeticsMisbranded and spurious cosmetics
Misbranded and spurious cosmetics
Foram Machhar
 

What's hot (20)

Formulation and evaluation of microspheres
Formulation and evaluation of microspheresFormulation and evaluation of microspheres
Formulation and evaluation of microspheres
 
Regulatory provision related to manufacture of cosmetic
Regulatory provision related to manufacture of cosmeticRegulatory provision related to manufacture of cosmetic
Regulatory provision related to manufacture of cosmetic
 
Microcapsules: types, preparation and evaluation
Microcapsules: types, preparation and evaluationMicrocapsules: types, preparation and evaluation
Microcapsules: types, preparation and evaluation
 
Microspheres
MicrospheresMicrospheres
Microspheres
 
Phytosome
PhytosomePhytosome
Phytosome
 
Formulation and evaluation of aerosals
Formulation and evaluation of aerosalsFormulation and evaluation of aerosals
Formulation and evaluation of aerosals
 
Microcapsules and microspheres
Microcapsules and microspheresMicrocapsules and microspheres
Microcapsules and microspheres
 
Targeted drug delivery systems
Targeted drug delivery systemsTargeted drug delivery systems
Targeted drug delivery systems
 
Pulmonary Drug Delivery System (PDDS)
Pulmonary Drug Delivery System (PDDS)Pulmonary Drug Delivery System (PDDS)
Pulmonary Drug Delivery System (PDDS)
 
Application Of Polymer In Controlled Release Formulation
Application Of Polymer In Controlled Release FormulationApplication Of Polymer In Controlled Release Formulation
Application Of Polymer In Controlled Release Formulation
 
Micro capsules or microspheres
Micro capsules or microspheresMicro capsules or microspheres
Micro capsules or microspheres
 
Preparation and application of Niosomes
Preparation and application of  Niosomes Preparation and application of  Niosomes
Preparation and application of Niosomes
 
Phytosomes
PhytosomesPhytosomes
Phytosomes
 
microspheres types , preparation and evaluation
microspheres types , preparation and evaluationmicrospheres types , preparation and evaluation
microspheres types , preparation and evaluation
 
Niosomes
NiosomesNiosomes
Niosomes
 
Microspheres and microcapsules
Microspheres and microcapsulesMicrospheres and microcapsules
Microspheres and microcapsules
 
Nano particle Preparation and Evaluation
Nano particle Preparation and EvaluationNano particle Preparation and Evaluation
Nano particle Preparation and Evaluation
 
polymer in pharmacy and application of polymers
polymer in pharmacy and application of polymerspolymer in pharmacy and application of polymers
polymer in pharmacy and application of polymers
 
Review of guidelines for herbal cosmetics by private bodies like cosmos
Review of guidelines for herbal cosmetics by private bodies like cosmosReview of guidelines for herbal cosmetics by private bodies like cosmos
Review of guidelines for herbal cosmetics by private bodies like cosmos
 
Misbranded and spurious cosmetics
Misbranded and spurious cosmeticsMisbranded and spurious cosmetics
Misbranded and spurious cosmetics
 

Similar to Seminar on Phytosomes

Isf college of pharmacy (moga,142001,pb)
Isf  college of pharmacy  (moga,142001,pb)Isf  college of pharmacy  (moga,142001,pb)
Isf college of pharmacy (moga,142001,pb)
sumel ashique
 
Phytosomes
PhytosomesPhytosomes
Phytosomes
Ashish Agrawal
 
Pharma supplements recombinant proteins as excipients
Pharma supplements recombinant proteins as excipients Pharma supplements recombinant proteins as excipients
Pharma supplements recombinant proteins as excipients
Stephen Berezenko
 
PHYTOSOMES.pptx
PHYTOSOMES.pptxPHYTOSOMES.pptx
PHYTOSOMES.pptx
Mayankpandey626786
 
Protein and peptides drug delivery systems
Protein and peptides drug delivery systemsProtein and peptides drug delivery systems
Protein and peptides drug delivery systems
VINOTH R
 
Cell culture, Different type of cell culture media, types of media
Cell culture, Different type of cell culture media, types of mediaCell culture, Different type of cell culture media, types of media
Cell culture, Different type of cell culture media, types of media
Rajashekar Baldhu
 
Cell culture media
Cell culture mediaCell culture media
Cell culture media
Pharmacy Slides
 
Phytosome, preaparation
Phytosome, preaparationPhytosome, preaparation
Phytosome, preaparation
Tushar Chavan
 
phytosomes.pptx NDDS and herbal drugs. Recent advances
phytosomes.pptx NDDS and herbal drugs. Recent advancesphytosomes.pptx NDDS and herbal drugs. Recent advances
phytosomes.pptx NDDS and herbal drugs. Recent advances
Rakesh Barik
 
2011 enteric microdphere formultions of papain
2011 enteric microdphere formultions of papain2011 enteric microdphere formultions of papain
2011 enteric microdphere formultions of papain
RocioChong
 
Vesicular drug delivery system
Vesicular drug delivery systemVesicular drug delivery system
Vesicular drug delivery system
Vijaykumar Chavan
 
Liposomes & Iontophoresis
Liposomes & IontophoresisLiposomes & Iontophoresis
Liposomes & Iontophoresis
Pramod Ghule
 
Pro-Drug and Active Drug In Medicinal Chemistry.ppt
Pro-Drug and Active Drug In Medicinal Chemistry.pptPro-Drug and Active Drug In Medicinal Chemistry.ppt
Pro-Drug and Active Drug In Medicinal Chemistry.ppt
Prachi Pandey
 
Pro-Drug In MedChem..pptx
Pro-Drug In MedChem..pptxPro-Drug In MedChem..pptx
Pro-Drug In MedChem..pptx
RAHUL PAL
 
Phytosomes.pptx
Phytosomes.pptxPhytosomes.pptx
Phytosomes.pptx
SaurabhNikam22
 
Healing Effects of Hydroalcoholic Extract of Guava (Psidium guajava) Leaf on ...
Healing Effects of Hydroalcoholic Extract of Guava (Psidium guajava) Leaf on ...Healing Effects of Hydroalcoholic Extract of Guava (Psidium guajava) Leaf on ...
Healing Effects of Hydroalcoholic Extract of Guava (Psidium guajava) Leaf on ...
Dr. Anuj S Parihar
 
Protein and Peptide Drug Delivery Oral Approaches.pptx
Protein and Peptide Drug Delivery Oral Approaches.pptxProtein and Peptide Drug Delivery Oral Approaches.pptx
Protein and Peptide Drug Delivery Oral Approaches.pptx
jacksgamer
 
Presentation of phytosomes
Presentation of phytosomesPresentation of phytosomes
Presentation of phytosomes
Tanayapalit1
 
Phytosomes ppt
Phytosomes pptPhytosomes ppt
Phytosomes ppt
yogita rayate
 

Similar to Seminar on Phytosomes (20)

Isf college of pharmacy (moga,142001,pb)
Isf  college of pharmacy  (moga,142001,pb)Isf  college of pharmacy  (moga,142001,pb)
Isf college of pharmacy (moga,142001,pb)
 
Phytosomes
PhytosomesPhytosomes
Phytosomes
 
Pharma supplements recombinant proteins as excipients
Pharma supplements recombinant proteins as excipients Pharma supplements recombinant proteins as excipients
Pharma supplements recombinant proteins as excipients
 
PHYTOSOMES.pptx
PHYTOSOMES.pptxPHYTOSOMES.pptx
PHYTOSOMES.pptx
 
Protein and peptides drug delivery systems
Protein and peptides drug delivery systemsProtein and peptides drug delivery systems
Protein and peptides drug delivery systems
 
Cell culture, Different type of cell culture media, types of media
Cell culture, Different type of cell culture media, types of mediaCell culture, Different type of cell culture media, types of media
Cell culture, Different type of cell culture media, types of media
 
Cell culture media
Cell culture mediaCell culture media
Cell culture media
 
Phytosome, preaparation
Phytosome, preaparationPhytosome, preaparation
Phytosome, preaparation
 
phytosomes.pptx NDDS and herbal drugs. Recent advances
phytosomes.pptx NDDS and herbal drugs. Recent advancesphytosomes.pptx NDDS and herbal drugs. Recent advances
phytosomes.pptx NDDS and herbal drugs. Recent advances
 
2011 enteric microdphere formultions of papain
2011 enteric microdphere formultions of papain2011 enteric microdphere formultions of papain
2011 enteric microdphere formultions of papain
 
Vesicular drug delivery system
Vesicular drug delivery systemVesicular drug delivery system
Vesicular drug delivery system
 
Formulation biotherapeutics
Formulation biotherapeuticsFormulation biotherapeutics
Formulation biotherapeutics
 
Liposomes & Iontophoresis
Liposomes & IontophoresisLiposomes & Iontophoresis
Liposomes & Iontophoresis
 
Pro-Drug and Active Drug In Medicinal Chemistry.ppt
Pro-Drug and Active Drug In Medicinal Chemistry.pptPro-Drug and Active Drug In Medicinal Chemistry.ppt
Pro-Drug and Active Drug In Medicinal Chemistry.ppt
 
Pro-Drug In MedChem..pptx
Pro-Drug In MedChem..pptxPro-Drug In MedChem..pptx
Pro-Drug In MedChem..pptx
 
Phytosomes.pptx
Phytosomes.pptxPhytosomes.pptx
Phytosomes.pptx
 
Healing Effects of Hydroalcoholic Extract of Guava (Psidium guajava) Leaf on ...
Healing Effects of Hydroalcoholic Extract of Guava (Psidium guajava) Leaf on ...Healing Effects of Hydroalcoholic Extract of Guava (Psidium guajava) Leaf on ...
Healing Effects of Hydroalcoholic Extract of Guava (Psidium guajava) Leaf on ...
 
Protein and Peptide Drug Delivery Oral Approaches.pptx
Protein and Peptide Drug Delivery Oral Approaches.pptxProtein and Peptide Drug Delivery Oral Approaches.pptx
Protein and Peptide Drug Delivery Oral Approaches.pptx
 
Presentation of phytosomes
Presentation of phytosomesPresentation of phytosomes
Presentation of phytosomes
 
Phytosomes ppt
Phytosomes pptPhytosomes ppt
Phytosomes ppt
 

Recently uploaded

Knee anatomy and clinical tests 2024.pdf
Knee anatomy and clinical tests 2024.pdfKnee anatomy and clinical tests 2024.pdf
Knee anatomy and clinical tests 2024.pdf
vimalpl1234
 
263778731218 Abortion Clinic /Pills In Harare ,
263778731218 Abortion Clinic /Pills In Harare ,263778731218 Abortion Clinic /Pills In Harare ,
263778731218 Abortion Clinic /Pills In Harare ,
sisternakatoto
 
Basavarajeeyam - Ayurvedic heritage book of Andhra pradesh
Basavarajeeyam - Ayurvedic heritage book of Andhra pradeshBasavarajeeyam - Ayurvedic heritage book of Andhra pradesh
Basavarajeeyam - Ayurvedic heritage book of Andhra pradesh
Dr. Madduru Muni Haritha
 
Top 10 Best Ayurvedic Kidney Stone Syrups in India
Top 10 Best Ayurvedic Kidney Stone Syrups in IndiaTop 10 Best Ayurvedic Kidney Stone Syrups in India
Top 10 Best Ayurvedic Kidney Stone Syrups in India
Swastik Ayurveda
 
Integrating Ayurveda into Parkinson’s Management: A Holistic Approach
Integrating Ayurveda into Parkinson’s Management: A Holistic ApproachIntegrating Ayurveda into Parkinson’s Management: A Holistic Approach
Integrating Ayurveda into Parkinson’s Management: A Holistic Approach
Ayurveda ForAll
 
Journal Article Review on Rasamanikya
Journal Article Review on RasamanikyaJournal Article Review on Rasamanikya
Journal Article Review on Rasamanikya
Dr. Jyothirmai Paindla
 
Light House Retreats: Plant Medicine Retreat Europe
Light House Retreats: Plant Medicine Retreat EuropeLight House Retreats: Plant Medicine Retreat Europe
Light House Retreats: Plant Medicine Retreat Europe
Lighthouse Retreat
 
ARTHROLOGY PPT NCISM SYLLABUS AYURVEDA STUDENTS
ARTHROLOGY PPT NCISM SYLLABUS AYURVEDA STUDENTSARTHROLOGY PPT NCISM SYLLABUS AYURVEDA STUDENTS
ARTHROLOGY PPT NCISM SYLLABUS AYURVEDA STUDENTS
Dr. Vinay Pareek
 
Role of Mukta Pishti in the Management of Hyperthyroidism
Role of Mukta Pishti in the Management of HyperthyroidismRole of Mukta Pishti in the Management of Hyperthyroidism
Role of Mukta Pishti in the Management of Hyperthyroidism
Dr. Jyothirmai Paindla
 
micro teaching on communication m.sc nursing.pdf
micro teaching on communication m.sc nursing.pdfmicro teaching on communication m.sc nursing.pdf
micro teaching on communication m.sc nursing.pdf
Anurag Sharma
 
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAdv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS
AkankshaAshtankar
 
ABDOMINAL TRAUMA in pediatrics part one.
ABDOMINAL TRAUMA in pediatrics part one.ABDOMINAL TRAUMA in pediatrics part one.
ABDOMINAL TRAUMA in pediatrics part one.
drhasanrajab
 
Chapter 11 Nutrition and Chronic Diseases.pptx
Chapter 11 Nutrition and Chronic Diseases.pptxChapter 11 Nutrition and Chronic Diseases.pptx
Chapter 11 Nutrition and Chronic Diseases.pptx
Earlene McNair
 
Identification and nursing management of congenital malformations .pptx
Identification and nursing management of congenital malformations .pptxIdentification and nursing management of congenital malformations .pptx
Identification and nursing management of congenital malformations .pptx
MGM SCHOOL/COLLEGE OF NURSING
 
Aortic Association CBL Pilot April 19 – 20 Bern
Aortic Association CBL Pilot April 19 – 20 BernAortic Association CBL Pilot April 19 – 20 Bern
Aortic Association CBL Pilot April 19 – 20 Bern
suvadeepdas911
 
BRACHYTHERAPY OVERVIEW AND APPLICATORS
BRACHYTHERAPY OVERVIEW  AND  APPLICATORSBRACHYTHERAPY OVERVIEW  AND  APPLICATORS
BRACHYTHERAPY OVERVIEW AND APPLICATORS
Krishan Murari
 
Cervical & Brachial Plexus By Dr. RIG.pptx
Cervical & Brachial Plexus By Dr. RIG.pptxCervical & Brachial Plexus By Dr. RIG.pptx
Cervical & Brachial Plexus By Dr. RIG.pptx
Dr. Rabia Inam Gandapore
 
Temporomandibular Joint By RABIA INAM GANDAPORE.pptx
Temporomandibular Joint By RABIA INAM GANDAPORE.pptxTemporomandibular Joint By RABIA INAM GANDAPORE.pptx
Temporomandibular Joint By RABIA INAM GANDAPORE.pptx
Dr. Rabia Inam Gandapore
 
Best Ayurvedic medicine for Gas and Indigestion
Best Ayurvedic medicine for Gas and IndigestionBest Ayurvedic medicine for Gas and Indigestion
Best Ayurvedic medicine for Gas and Indigestion
Swastik Ayurveda
 
Vision-1.pptx, Eye structure, basics of optics
Vision-1.pptx, Eye structure, basics of opticsVision-1.pptx, Eye structure, basics of optics
Vision-1.pptx, Eye structure, basics of optics
Sai Sailesh Kumar Goothy
 

Recently uploaded (20)

Knee anatomy and clinical tests 2024.pdf
Knee anatomy and clinical tests 2024.pdfKnee anatomy and clinical tests 2024.pdf
Knee anatomy and clinical tests 2024.pdf
 
263778731218 Abortion Clinic /Pills In Harare ,
263778731218 Abortion Clinic /Pills In Harare ,263778731218 Abortion Clinic /Pills In Harare ,
263778731218 Abortion Clinic /Pills In Harare ,
 
Basavarajeeyam - Ayurvedic heritage book of Andhra pradesh
Basavarajeeyam - Ayurvedic heritage book of Andhra pradeshBasavarajeeyam - Ayurvedic heritage book of Andhra pradesh
Basavarajeeyam - Ayurvedic heritage book of Andhra pradesh
 
Top 10 Best Ayurvedic Kidney Stone Syrups in India
Top 10 Best Ayurvedic Kidney Stone Syrups in IndiaTop 10 Best Ayurvedic Kidney Stone Syrups in India
Top 10 Best Ayurvedic Kidney Stone Syrups in India
 
Integrating Ayurveda into Parkinson’s Management: A Holistic Approach
Integrating Ayurveda into Parkinson’s Management: A Holistic ApproachIntegrating Ayurveda into Parkinson’s Management: A Holistic Approach
Integrating Ayurveda into Parkinson’s Management: A Holistic Approach
 
Journal Article Review on Rasamanikya
Journal Article Review on RasamanikyaJournal Article Review on Rasamanikya
Journal Article Review on Rasamanikya
 
Light House Retreats: Plant Medicine Retreat Europe
Light House Retreats: Plant Medicine Retreat EuropeLight House Retreats: Plant Medicine Retreat Europe
Light House Retreats: Plant Medicine Retreat Europe
 
ARTHROLOGY PPT NCISM SYLLABUS AYURVEDA STUDENTS
ARTHROLOGY PPT NCISM SYLLABUS AYURVEDA STUDENTSARTHROLOGY PPT NCISM SYLLABUS AYURVEDA STUDENTS
ARTHROLOGY PPT NCISM SYLLABUS AYURVEDA STUDENTS
 
Role of Mukta Pishti in the Management of Hyperthyroidism
Role of Mukta Pishti in the Management of HyperthyroidismRole of Mukta Pishti in the Management of Hyperthyroidism
Role of Mukta Pishti in the Management of Hyperthyroidism
 
micro teaching on communication m.sc nursing.pdf
micro teaching on communication m.sc nursing.pdfmicro teaching on communication m.sc nursing.pdf
micro teaching on communication m.sc nursing.pdf
 
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAdv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS
 
ABDOMINAL TRAUMA in pediatrics part one.
ABDOMINAL TRAUMA in pediatrics part one.ABDOMINAL TRAUMA in pediatrics part one.
ABDOMINAL TRAUMA in pediatrics part one.
 
Chapter 11 Nutrition and Chronic Diseases.pptx
Chapter 11 Nutrition and Chronic Diseases.pptxChapter 11 Nutrition and Chronic Diseases.pptx
Chapter 11 Nutrition and Chronic Diseases.pptx
 
Identification and nursing management of congenital malformations .pptx
Identification and nursing management of congenital malformations .pptxIdentification and nursing management of congenital malformations .pptx
Identification and nursing management of congenital malformations .pptx
 
Aortic Association CBL Pilot April 19 – 20 Bern
Aortic Association CBL Pilot April 19 – 20 BernAortic Association CBL Pilot April 19 – 20 Bern
Aortic Association CBL Pilot April 19 – 20 Bern
 
BRACHYTHERAPY OVERVIEW AND APPLICATORS
BRACHYTHERAPY OVERVIEW  AND  APPLICATORSBRACHYTHERAPY OVERVIEW  AND  APPLICATORS
BRACHYTHERAPY OVERVIEW AND APPLICATORS
 
Cervical & Brachial Plexus By Dr. RIG.pptx
Cervical & Brachial Plexus By Dr. RIG.pptxCervical & Brachial Plexus By Dr. RIG.pptx
Cervical & Brachial Plexus By Dr. RIG.pptx
 
Temporomandibular Joint By RABIA INAM GANDAPORE.pptx
Temporomandibular Joint By RABIA INAM GANDAPORE.pptxTemporomandibular Joint By RABIA INAM GANDAPORE.pptx
Temporomandibular Joint By RABIA INAM GANDAPORE.pptx
 
Best Ayurvedic medicine for Gas and Indigestion
Best Ayurvedic medicine for Gas and IndigestionBest Ayurvedic medicine for Gas and Indigestion
Best Ayurvedic medicine for Gas and Indigestion
 
Vision-1.pptx, Eye structure, basics of optics
Vision-1.pptx, Eye structure, basics of opticsVision-1.pptx, Eye structure, basics of optics
Vision-1.pptx, Eye structure, basics of optics
 

Seminar on Phytosomes

  • 1. SHIV KUMAR M.PHARM(2ND SEM) DEPARTMENT OF PHARMACEUTICAL SCIENCES AND TECHNOLOGY MRSPTU,BHATINDA
  • 2. 1. INTRODUCTION 2. WHAT IS PHYTOSOMES? 3. MERITS OF PHYTOSOMES COMPLEX USES 4. DIFFERENCE BETWEEN PHYTOSOMES AND LIPOSOMES 5. METHOD OF PREPARATION 6. CHARACTERIZATION OF PHYTOSOMES 7. FORMULATION OF PHYTOSOMES 8. COMMERCIALLY AVAILABLE PHYTOSOMES 2
  • 3.  Polyphenolics and terpenes are ubiquitous in plants, but their poor solubility in water and organic solvents make the bioavailability of several botanical extracts erratic and poor.  The limited solubility , both in water and in lipophilic phases, as well as hydrolytical instability at physiological pH values make several botanical extracts containing polyphenolics and terpenes very poorly absorbed both orally and topically.  Bioavailability can be improved by using new delivery systems which can enhance the rate and the extent of solubilization into aqueous intestinal fluids and the capacity to cross biomembranes. Department of pharmacognosy/LMCP/Mrugesh Patel 3
  • 4.  Polyphenolics exhibit a marked affinity for phospholipids via hydrogen bondings and dipolar interactions with the charged phosphates groups of phospholipids.  By complexing the polyphenolic phytoconstituents in a definite ratio with phosphatidylcholine,  Indena has developed a delivery system named “Phytosome®”.  First phytosomal preparation-Flavonognan Silybin(silymarin)obtained from Milk thistle fruit having properties of antioxidant,liver detoxification,anti- inflamatory. Department of pharmacognosy/LMCP/Mrugesh Patel 4
  • 5.  Phytosomes are novel drug delivery system containing hydrophilic bioactive phytoconstituents of herbs surround and bound by phospholipids.  The term “phyto” means plant while “some” means cell-like.  Phytosomes are little cell like structure.  This is advanced forms of herbal formulations which contains the bioactive phytoconsituents of herb extract surrounds and bound by a lipid. Most of the bioactive constituents of phytomedicines are water-soluble compounds like flavonoids, glycosides. Department of pharmacognosy/LMCP/Mrugesh Patel 5
  • 6.  Phospholipid: a) Phosphotidylcholine b) Phosphotidylethanolamine c) Phosphotidylserine  Phospholipid : drug(2:1 or 1:1) Department of pharmacognosy/LMCP/Mrugesh Patel 6
  • 7.  There is a dramatic enhancement of the bioavailability of botanical extract due to their complexation with phospholipid and improved absorption in the intestinal tract.  They permit the non-lipophilic botanical extract to allow better absorption from the intestinal lumen, which is otherwise not possible.  Phytosome process produces a little cell whereby the valuable component of the herbal extracts are protected from destruction by digestive secretions and gut bacteria.  The formulation of phytosomes is safe and the components have all been approved for pharmaceuticals and cosmetic use.  Phytosomes shows better stability profile because chemical bond are formed between phosphotidylcholine molecules and phytoconstituents. Department of pharmacognosy/LMCP/Mrugesh Patel 7
  • 8.  They have been used to deliver liver protecting flavonoids because they can be made easily bioavailable by phytosomes.  Entrapment efficiency is high and more over predetermined because drug itself in conjugation with lipids is forming vesicles.  Phosphotidylcholine used in the phytosomes process besides acting as a carrier also nourishes the skin because it is a essential part of cell membrane.  They can be also used for enhanced permeation of drug through skin for transdermal and dermal delivery.  Their low solubility in the aqueous media allows the formation of stable emulsions or creams.  Phytosomes are also superior to liposomes in the skin care products. Department of pharmacognosy/LMCP/Mrugesh Patel 8
  • 9. PHYTOSOMES LIPOSOMES Active chemical constituents(phytoconstituents) are anchored through chemical bonds to the polar head of the phospholipids. Active chemical constituents is dissolved in the medium of the cavity or in the layer of the membrane. No chemical bonds are formed. Ratio of phosphatidylcholine to phytoconstituents is 1:1 or 2:1 , depending on the phytoconstituents. Thousand of phosphatidylcholine molecules surrounds the water soluble molecules. Department of pharmacognosy/LMCP/Mrugesh Patel 9
  • 10.  The most significant dietary source of the essential nutrient choline, is an orthomolecule ubiquitous in known life form.  Besides being an important emulsifier in the lungs,gastrointestinal tract,bile.  PC is the principal molecular building block for circulating lipoproteins and for cell membrane. They are making up the matrix into which fit a large variety of proteins that are enzymes, transport proteins, receptors and other biological energy converters.  Manage the vast majority of life processes.  As a carrier for both fat-miscible and water-miscible nutrient. Department of pharmacognosy/LMCP/Mrugesh Patel 10
  • 11.  Phytosomes are prepared by reacting natural or synthetic phospholipids with active components like bioflavonoid, flavolignan and polyphenolic constituents.  Solvent Evaporation method is the most common technique used for the preparation of phytosomes.(Refluxed at 50-60C for 2hr). Phytosomes of ginsenoside, puerarin and kushenin are prepared in this manner.  Mechanical Dispersion method is used for the preparation of marsupsin- phospholipid complexes.  Phospholipids is dissolved in a suitable solvent and active ingredient is added drop by drop while sonicating the solution .Phospholipid complex is sometimes prepared under reflux and stirring conditions to effect complete interaction.  Prepared complex called phytosome can be isolated by precipitation with nonsolvent,lyophilization,spray drying or vacuum drying. 11
  • 12.  Visualization of particle size  Transmission electron microscopy(TEM)  Scanning electron microscopy(SEM)  Spectroscopic evaluation  1 H-NMR  13 C-NMR  FTIR(Chemical stability)  Entrapment efficiency(Ultracentifugation)  Spreadibility  Percentage yield  DSC Department of pharmacognosy/LMCP/Mrugesh Patel 12
  • 13.  Can be formulated : (a)Orally (b)Topically  The formulation tips here shown is indicated by the Indena for (a) Soft gelatin capsules (b) Hard gelatin capsules (c) Tablets (d) Topical dosage form Department of pharmacognosy/LMCP/Mrugesh Patel 13
  • 14. Ingredients Quantity Ginkgoselect ® Phytosome® 180 mg Soy bean oil 250 mg Soy lecithin q.S Glycerylmonostearate q.S Department of pharmacognosy/LMCP/Mrugesh Patel 14
  • 15. Ingredients Quantity Ginkgoselect ® Phytosome® 180 mg Dicalcium phosphate dihydrate 196 mg Silicified microcrystalline cellulose 47 mg Croscarmellose sodium 23 mg Talc 2 mg Magnesium stearate 2 mg Department of pharmacognosy/LMCP/Mrugesh Patel 15
  • 16. Ingredients Quantity Leucoselect ® Phytosome® 100 mg Soy polysaccharides 138 mg Corn starch 100 mg Silicon dioxide 6 mg Talc 3 mg Magnesium stearate 3 mg Department of pharmacognosy/LMCP/Mrugesh Patel 16
  • 17. Phytosome Herbal drug Indication Ginkgoselect ® ginkgobiloba Improve memory, Brain function, Anti inflammatory agent Silybin® Silybum marianum Anti oxidant, Anti aging, Hepatoprotective Hawthore® Crataegus oxyacantha Help to strengthen heart and cardiovascular system Ginselect® Panax ginseng Promote adaptogenic functions and resistance to stress Curcumin Curcuma longa Chemoprotective agent Grapseed Grapseed Natural antioxidant protectantDepartment of pharmacognosy/LMCP/Mrugesh Patel 17
  • 18. Phytosome Herbal drug Indication Greenselect® Camellia sinensis Antioxidant, Cardioprotective, Food product Mirtoselect® Vaccinium myrtillus Antioxidant Leucoselect® Vitis vinifera Cardiovascular protectant, Anti-inflammatory, Antioxidant Sabalselect® Serenoa repens Non-cancerous prostate enlargement Lymphaselect® Melilotus officinalis Effective in hemorrhoids, thrombophlebitis, post- surgical edema formation, lymphedema OleaselectTM Olea europaea Antioxidant, inhibit harmful oxidation of LDL PolinaceaTM Echinacea angostifolia Enhance immune function in response to toxic challenge Department of pharmacognosy/LMCP/Mrugesh Patel 18
  • 19. 1. Shalini Sharma,"Phytosomes : AN EMERGING TECHNOLOGY”, JPRD/2010/PUB/ARTI/VOV-2/ISSUE-5/JULY/2014,ISSN 0974 – 9446. 2. Sanjat Saha,Phytomes:a brief overview,2013:2(1):12-20. 3. Asit R Sahu, Formulation and Evaluation of Phytosome Drug Delivery System of Boswellia Serrata Extract, Int J Res Med. 2015; 4(2);94-99. 4. Sushila Rathee, Optimization and development of Antidiabetic phytosomes by box-benhken design, ISSN: 0898-2104 (Print) 1532-2394. 5. http://ijpsr.com/bft-article/phytosomes-a-novel-drug-delivery-for-herbal- extracts/?view=fulltext 6. https://www.pharmatutor.org/articles/phytosomes-is-a-novel-drug-delivery- system-based-herbal-formulation-an-review 19