Sulfonamides are among the oldest antibacterial agents. They work by inhibiting the bacterial enzyme dihydropteroate synthetase, blocking the synthesis of folic acid and acting bacteriostatically. Gerhard Domagk discovered the first sulfonamide drug, Prontosil, in 1932, which was effective in treating streptococcal infections. Common sulfonamide drugs discussed in the document include sulfadiazine, sulfaguanidine, phthalylsulfathiazole, succinylsulfathiazole, sulfamethoxypyridazine, and cotrimoxazole.
Sulfonamide (also called sulphonamide, sulfa drugs or sulpha drugs) is the basis of several groups of drugs. The original antibacterial sulfonamides are synthetic antimicrobial agents that contain the sulfonamide group.
Sulfonamide (also called sulphonamide, sulfa drugs or sulpha drugs) is the basis of several groups of drugs. The original antibacterial sulfonamides are synthetic antimicrobial agents that contain the sulfonamide group.
THIS PRESENTATION ABOUT ANTIMALARIAL DRUGS DETAILING THE COMPLETE INFORMATION ABOUT THE DRUGS USED WITH ITS MECHANISM OF ACTION, STRUCTURAL ACTIVITY AND DOSES.
In 1935, Gerhard Domagk discovered the first sulphonamide--prontosil rubrum. Four years later he received the Noble Prize.
Developed mouse model of sepsis with Streptococcus hemolyticus infection
Lethal model with most mice dead in 24 hours
Tested azo-dyes directly in this model.
Others had shown some azo dyes to be active in vitro against a number of bacteria but not to have any in vivo activity
antiviral drugs medicinal chemistry by padala varaprasadVaraprasad Padala
medicinal chemistry of antiviral drugs by padala varaprasad
mainly includes structures, SAR , mechanism of action, uses and toxicity of antiviral drugs
THIS PRESENTATION ABOUT ANTIMALARIAL DRUGS DETAILING THE COMPLETE INFORMATION ABOUT THE DRUGS USED WITH ITS MECHANISM OF ACTION, STRUCTURAL ACTIVITY AND DOSES.
In 1935, Gerhard Domagk discovered the first sulphonamide--prontosil rubrum. Four years later he received the Noble Prize.
Developed mouse model of sepsis with Streptococcus hemolyticus infection
Lethal model with most mice dead in 24 hours
Tested azo-dyes directly in this model.
Others had shown some azo dyes to be active in vitro against a number of bacteria but not to have any in vivo activity
antiviral drugs medicinal chemistry by padala varaprasadVaraprasad Padala
medicinal chemistry of antiviral drugs by padala varaprasad
mainly includes structures, SAR , mechanism of action, uses and toxicity of antiviral drugs
Tuberculosis- causative agent
Anti-Tubercular Agents- definition, classification
[Study of the following category of medicinal compounds with respect classification, chemical name, chemical structure (compounds with * mark), uses, stability and storage conditions, different types of formulation & their popular brand names]
INH*,
Ethambutol,
Para Amino Salicylic Acid,
Pyrazinamide,
Rifampicin,
Bedaquiline,
Delamanid,
Pretomanid*
Anti-malarial agents include
Introduction
Classification
Sulphonamide and its classification
Mechanism of action of sulphonamide
Co-triomazole, its MOA
The sulfonylamide tragedy refers to a historical event that occurred in the 1930s, which resulted in the deaths of many patients who were treated with certain medications containing sulfa drugs.
Sulfa drugs were discovered in the early 20th century and were considered a revolutionary breakthrough in the treatment of bacterial infections. They were widely used during World War II and saved countless lives.
However, in the 1930s, the pharmaceutical industry was still in its infancy and drug safety regulations were not as stringent as they are today. This led to the production and distribution of poorly tested and inadequately regulated drugs.
One such drug was Elixir Sulfanilamide, which contained the sulfa drug sulfanilamide and diethylene glycol as a solvent. The drug was marketed as a safe and effective treatment for streptococcal infections.
Unfortunately, the solvent used in Elixir Sulfanilamide was highly toxic, causing severe liver and kidney damage. This led to the deaths of over 100 people, including many children.
The tragedy resulted in the passing of the Federal Food, Drug, and Cosmetic Act in 1938, which established new safety requirements for drugs and food additives. It also highlighted the need for thorough testing and regulation of pharmaceutical products before they are released to the market.
Today, sulfa drugs are still used in the treatment of bacterial infections, but they are much safer and undergo rigorous testing and regulation before being approved for use.
Sulphonamide and cotrimoxazole pptx-Dr.Jibachha SahDr. Jibachha Sah
Lecturer notes on veterinary pharmacology and toxicology for B.V.Sc & A.H Seventh semester student for educational purpose.This lecturer notes will be useful for all the veterinary students.Plesae send your comments,jibachhashah@gmail.com,mob.9845024121
Sulphonamides and their combination with trimethoprim - by Dr.Jibachha SahDr. Jibachha Sah
Sulphonamides and their combination with trimethoprim is lecturer notes on Veterinary Pharmacology & Toxicology(Chemotherapy) for B.V.Sc & A.H students of veterinary college.
Sulfonamides are synthetic antibacterial agents that contain the sulfonamide group. Classification, Chemistry and SAR, Mechanism of action, Side effects and Marketed preparations.....
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
2. DESCRIPTION
• One of the oldest antibacterial agents
used to combat infection
• Used for coccal infection in 1935
• They are bacteriostatic because it
inhibits bacterial synthesis of folic acid
• Clinical usefulness has decreased
because of the effectiveness of other
antibiotics and penicillin
3. Antimicrobial activity
1) Sulfonamides have a wide range of antimicrobial
activity.
G+,G- bacteria, Nocardia, Chlamydia trachomatis,
etc.
Enteric bacteria etc. less effective
2) Sulfonamides exert only bacteriostatic effect.
4. PRONTOSIL
Building on Ehrlichs early work, Gerhard
Domagk, a medical doctor employed by a
German dye manufacturer made a
breakthrough discovery by finding that a
dye known as prontosil, dosed orally, was
effective in curing life threatening
streptococci infections in humans. He
made the discovery in a desperate, but
successful attempt to save his daughter
who was dying of a streptococci infection.
German bacteriologist and pathologist who was awarded the
1939 Nobel Prize for Physiology or Medicine for his
discovery (announced in 1932) of the antibacterial effects of
Prontosil, the first of the sulfonamide drugs.
5. CHEMISTRY OF SULFONAMIDE
4- Recognized since 1932.
4- In clinical usage since 1935.
4- First compounds found to be effective antibacterial
agents in safe dose ranges.
4- Chemically, it is a molecule containing the sulfonamido
(sulfanilamide, SO ,NH2) functional group attached to an
aniline.
I Structurally related to p-amino benzoic acid (PABA).
4- This group is also present in other non-antibacterial
compounds like
-Sulphon ureas -Benzothiazids
-Furosemide They act as antimicrobial agents by inhibiting
-Acetazolamide bacterial growth and activity and commonly
called sulfa drugs.
6. MECHANISM OF SULFONAMIDE
4- Sulfonamide molecular structure is similar to p-Amino
benzoic acid (PABA) which is needed in bacteria organisms as
a substrate of the enzyme dihydric prorate synthetize for the
synthesis of Tetra Hydro Folic acid (THF).
4- Folic acid - synthesized from PABA, pteridine and
glutamate.
4- All sulfonamides are analogs of PABA.
4- All sulfa drugs are bacteriostatic.
7.
8. Mechanism of action
Structural analogs of para-amino benzoic acid
(PABA)
Inhibit dihydropteroate synthase - needed for
folic acid synthesis
Prevent normal bacterial utilization of
PABA for the synthesis of folic acid
Sulfanilamide
9. Mechanism of action
• Sulfonamides are a competitive inhibitors of
dihydropteroate synthetize which is a vital enzyme for the
synthesis of tetrahydrofolate ( Coenzyme F).
• Tetrahydrofolate is important for pyrimidine nucleic acid
synthesis so the bacteria can no longer grow and divide
which gives time for the host immune system to destroy the
bacterial cells.
• Sulfonamide is not recommended in patients with weak or
impaired immune system.
• This binding is reversible.
• Because of that sulfonamides have bacteriostatic effect not
bactericidal.
10. Mechanism of action
Sulfonamides mimic P-aminobenzoic acid (PABA) which is
the normal substrate for dihydropteroate synthetase. This
means that sulfonamide will bind in the same
manner as PABA:
PABA in the active site Sulfonamide in the active site
11. Mechanism of action
• Because sulfonamides are competitive inhibitors
for the enzyme, the bacteria can increase the
production of PABA to compete with sulfonamide
at the active site and become resistant to sulfa
drugs.
• In such case, the dose of sulfonamide agents
should be increased to overcome this resistant
mechanism. But this high dose is accompanied
with an increase in side effects especially the
crystalluria.
12. Mechanism of action
• In human, the cell synthesized tetrahydrofolate
from folic acid that obtained from food sources.
This folic acid is normally transported to inside
the cell by special transport system.
• Bacterial cell does not have such transport
system and they should synthesize
tetrahydrofolate using PABA.
• For that reason, human cells do not need
dihydropteroate synthetaze enzyme which means
sulfonamides have selective antibacterial activity.
17. Properties:
1. It is a white or whitish-yellowish crystalline powder.
2. It is having characteristic odour.
3. It is having bitter taste.
4. It is practically insoluble in water
5. It is soluble in solutions of alkali hydroxides &carbonates,& in
dilute solutions of mineral acids.
Storage:
It should be stored in well closed container at cool place away
from direct sunlight
N1- (pyrimidine-2yl) sulphanilamide
SULPHADIAZINE
18. Use:
1. It is as anti microbial agent.
2. It is used for treatment of Meningitis
3. It is used in the treatment of Urinary tract
infection.
4. It is in Toxoplasmosis.
5. It is used for the treatment Burn Therapy.
Official preparation:
Sulphadiazine I.P, B.P, U.S.P
Sulphadiazine tablet I.P, B.P
Sulphadiazine injection I.P
Sulphadiazine sodium I.P
Brand name:
Atrina, Cotrizine, Trimozin
19. SULPHAGUANIDINE
N-guanidyl sulphanilamide OR N-guanidyl sulphanilamide
Properties:
1. It is a white crystalline powder.
2. It is having characteristic odour.
3. It is sparingly soluble in water
4. It is dissolves in boiling water.
5. It is darken slowly on exposure to light.
20. Storage:
It should be stored in well closed light
resistant container at cool place away from
direct sunlight.
Use:
1. It is as anti microbial agent.
2. It is used for treatment of local GIT infection
3. It is is used in the treatment of bacillary
dysentery.
Official preparation:
Sulphaguanidine I.P
Sulphaguanidine tablet I.P
Brand name:
Ganidan, Gaunimycin,
Entrogen.
21. PHTHALYL SULPHATHIAZOLE
Properties:
1. It is a white powder.
2. It is having bitter taste.
3. It is insoluble in water.
4. It is slightly soluble in alcohol
5. It is soluble in aqueous solutions of alkali
hydroxides
and mineral acids.
6. It darkens slowly on exposure to light.
Storage:
It should be stored in well closed light resistant
container at cool place away from direct sunlight.
22. Use:
1. It is as anti microbial agent.
2. It is used for treatment of intestinal
infections.
3. It is used mainly in the preparation of
bowel surgery.
4. It is in chronic ulcerative colus.
5. It is used for the treatmentintestinal
amoebiasis.
Official preparation:
Phthalyl Sulphathiazole I.P, B.P
Phthalyl Sulphathiazole tablet I.P, B.P
Brand name:
Collicitina, Talidine
23. SUCCINYL SULPHATHIAZOLE
Properties:
1. It is a white to yellowish white crystalline powder.
2. It is having characteristic odour.
3. It is very slightly soluble in water.
4. It is soluble in aqueous solutions of alkali
hydroxides
and carbonates.
5. It is slowly darkens on exposure to light.
Storage:
It should be stored in well closed light resistant
container at cool place away from direct sunlight.
24. Use:
1. It is as anti microbial agent.
2. It is used for treatment of intestinal infections.
3. It is used mainly in the preparation of bowel surgery.
4. It is in chronic ulcerative colus.
5. It is used for the treatment intestinal amoebiasis.
Official preparation:
Succinyl Sulphathiazole I.P, B.P
Succinyl Sulphathiazole tablet I.P, B.P
Brand name:
SS Thiazole, Cremomycin, Cremostep, Sulphmycin.
25. SULPHADIMETHOXINE
Properties:
1. It is a creamy white crystalline powder.
2. It is having characteristic odour.
3. It is insoluble in water
4. It is moderately soluble in alcohol.
5. It is soluble in solutions of alkali hydroxides and
mineral acids.
Storage:
It should be stored in well closed container at cool
place away from direct sunlight.
26. Use:
1. It is as anti microbial agent.
2. It is used for treatment of systemic infection.
3. It is is used in the treatment of urinary tract
infections.
Official preparation:
Sulphadimethoxine I.P, B.P
Sulphadimethoxine tablet I.P, B.P
Brand name:
Bensulfa, Sulfadren, K-prim
27. SULPHAMETHOXYPYRIDAZINE
Properties:
1. It is a white to yellowish white crystalline powder.
2. It is having characteristic odor.
3. It is having bitter taste.
4. It is very slightly soluble in water and alcohol.
5. It is soluble solutions of alkali hydroxides and
mineral acids.
Storage:
It should be stored in well closed container at cool
place away from direct sunlight.
28. Use:
1. It is as anti microbial agent.
2. It is used for treatment of systemic infection
3. It is is used in the treatment of Conjunctivitis,
Trachoma.
4. It is in urinary tract infections.
5. It is topically used for the treatment of acne and
seborrhic
dermatitis.
Official preparation:
Sulphamethoxypyridazine I.P, B.P
Sulphamethoxypyridazine tablet I.P, B.P
Brand name:
Dyrasul, Confin
29. CO-TRIMOXAZOLE
Introduction:
Cotrimoxazole is the combination of two drugs i.e.
Sulphamethoxazole and Trimethoprim
Co-trimoxazole mixture contains 5 parts of sulphamethoxazole
and 1 part of trimethoprim.
These two drugs produce overtly similar effects; will sometimes
produce increased effects when used concurrently.
Sulphonamides block the biosynthesis of folic acid from p-
amino
benzoic acid.
Trimethoprim inhibits the enzyme folate reductase and blocks
the
conversion of folic acid to tetrahydofolic acid (THF).
THF is the form required for coenzyme synthesis.
Combination of Sulphamethoxazole and Trimethoprim by
synergism produces bactericidal effect.
30.
31. Use:
1. It is as anti microbial agent.
2. It is mainly used in treatment of;
Urinary tract infection
Upper and Lower respiratory infection (URTI and LRTI)
Skin and wound infection Septicemias
In systemic infection.
Official preparation:
Cotrimoxazole Tablets I.P., B.P.C.
Cotrimoxazole Mixture B.P.C.
Cotrimoxazole Injection B.P.C.
Cotrimoxazole Dispersible tablets B.P.C.
Pediatric Cotrimoxazole mixture B.P.C.
Cotrimoxazole Oral suspension I.P.
Brand name:
Bactrim, Bactrimel, Co-trimoxazole, Cotrim, Septra, Sulfatrim,
Biseptol, Trisul, Bactrom, Septram, Vactrim, Bibactin
32. SULPHACETAMIDE
N-acetyl sulphanilamide
or
N1-acetyl sulphanilamide
Properties:
1. It is a white crystalline powder.
2. It is having characteristic odor.
3. It is having bitter taste.
4. It is soluble in water and alcohol.
5. It is very soluble in hot water and solutions of
alkali
hydroxides and mineral acids.
Storage:
It should be stored in well closed container at
cool
place away from direct sunlight.
33. Use:
1. It is as anti microbial agent.
2. It is used for treatment of eye infection
3. It is is used in the treatment of Conjunctivitis, Trachoma.
4. It is in urinary tract infections.
5. It is topically used for the treatment of acne and seborrhic
dermatitis.
Official preparation:
Sulfacetamide I.P, B.P
Sulfacetamide sodium I.P, B.P
Sulfacetamide sodium eye ointment I.P, B.P
Brand name:
Albucid, Locula, Ne-Ba-sulf, Eycula, Cetamide, Isopto Cetamide,
Sodium Sulamyd, Sulf-10