antileprotic drugs

1. ANTILEPROTIC
DRUGS
UTTARAJOSHI
1

3. DAPSONE(DDS)
• Dapsone is derivative from diphenylsulphone
and is actually
bis(4-aminophenyl) sulphone
• PHYSICAL PROPERTIES :-
• It is white or creamy white crystalline powder .
• Slightly soluble in water
• It is freely soluble in ethanol.
• It is soluble in mineral acids.
• It melts at 175-176*c.

4. CHEMICAL PROPERTIES:-
• Since it contains two aromatic primary amino
groups .
• It can be diazotised by treatment with HCL and
sodium nitrate and the resulting compound
coupled with b-naphthol to give an orange red
azo dye.

5. STABILITY AND STORAGE:-
• Since it is affected by light, store it in well closed
light resistant
container
• Use: -
• Antileprotic drugs
• It is also used in combination with
pyrimethamine in the
treatment of chloroquine resistant malaria.

6. OFFICIALPREPRATIONS:-
• Dapsone, I.P., B.P.
• Dapsone tablets ,I.P. ,B.P.
• Brand names –
• Dapsone , DDS , novophone ,
diphenasone.

7. SOLAPSONE
• Solapsone Is The Tetrasodium Sulphonate
Derivative Of
Dapsone.
• It Is Also Used In The Treatment of Leprosy But
It Is Consider As Less Potent.
• Physical Properties :-
• It Is White Powder.
• Soluble In Water
• Insoluble In Alcohol

8. • Acid Catalysed Hydrolysis Decomposes Solapsone
Giving Cinnamaldehyde , Sulphurous Acid And A
Dapsone Salt. Due To Presence Of Cinnamaldehyde
And Sulpharous Acid , The Resulting Solutions
Answers The Reactions Of Unsaturated
Compounds.
• Stability And Storage :-
• Stored In Well Closed Container.
• Uses : -
• Antileprotic Drugs . It I less Potent Than Dapsone And
Is Used When There Is A Gastric Intolerance To
Dapsone.
• Brand Names –
• Sulphetrone , Solusulfone ,Salapsone Etc.

9. CLOFAZIMINE
• This is iminophenazine dye which is used as an
antileprotic
agent.
• BRAND NAMES : -
• Lamprine , Clofozine , Hansepran.
• PHYSICAL PROPERTIES : -
• Dark Red Crystal Or Reddish Brown
• It Is Fine Powder Without Odour.
• It Is Practically Insoluble In Water But Soluble In
Chloroform , Dioxan , And Dimethylformamide.
• It is slightly soluble in ethanol (95%) and very
slightly soluble
in ether.

10. CHEMICALPROPERTIES:--
• When it is dissolve in water and hydrochloric acid is
added , an intense violet colour is produced . if the
sodium hydroxide solution is added to this , the colour
changes to orange red.
• STABILITY AND STORAGE :--
• Store in well closed container.
• USE:-
• Antileprotic drug . it is orally active and is used
as a component of multidrug therapy of
leprosy.
• It is also used as a second line drugs in dapsone resistant
cases
• It has inflammatory action also.

11. THIAMBUTOSINE
• Thiambutosine is a thiourea derivative
• It is also a phenolic ether and a tertiary
aromatic amine.
• PROPERTIES :--
• White powder
• Insoluble in water
• Soluble in chloroform , and ether
• Odourless
• Bitter taste
• STORAGE :-- Store in well closed container
USES :--
Antileprotic drug.

12. THANK YOU