stem cells, stem cell ppt, biology slideshow , presentations

1. Stem Cells Keith Channon Department of Cardiovascular Medicine University of Oxford John Radcliffe Hospital, Oxford For more slides click here DOWNLOAD THIS SLIDE

3. Stem Cells

4. N Engl J Med 2003;349:570-82. Phenotypically Characterised Adult Stem Cells

5. Why are Stem Cells Relevant to Interventional Cardiology? Understanding stem cell biology challenges and informs our understanding of cardiovascular disease Stem cells may offer new therapeutic approaches in cardiovascular disease

8. Red=Cardiac Myosin a Green=Cell Nuclei c-kit neg c-kit pos

11. Engraftment does not occur in absence of MI……..

16. Bone Marrow Derived Stem Cells : Vascular Injury

17. Bone Marrow Derived Stem Cells : Atherosclerosis

18. Bone Marrow Derived Stem Cells : Transplant Vasculopathy

19. Stem Cells in Human Restenosis ? smc-actin c-kit+ Hibbert et al. Am J Physiol 2004

20. Stem Cells in Human Restenosis ? smc-actin c-kit+ Hibbert et al. Am J Physiol 2004

22. Endothelial Progenitor Cells- Role in Endothelial Maintenance Jonathan Hill, 2004 high blood pressure high cholesterol / triglycerides smoking diabetes infections other RISK FACTORS Cytokines e.g. G-CSF STATINS EXERCISE

23. J. Hill et al. NEJM 2003; 348:593-600

26. Mean ~ CK 800 U/L

28. TOPCARE-AMI: Late MRI follow up

29. TOPCARE-AMI: Late MRI follow up

32. Saline GM-CSF Saline GM-CSF

34. EPC Colony-Forming Capacity Following G-CSF J. Hill et al. JACC 2005; in press

36. Shirota et al. Biomaterials 2003 vWF Flk-1 LDL-Uptake Isolation of EPCs for Stent Delivery

39. Stem Cells in Interventional Cardiology vascular disease risk, biology, drug therapy cell therapy for post-MI repair cell therapy in PCI