This study investigated the potential of bone marrow (BM) stem cells to contribute to the pool of cardiac stem cells (CSCs) in the heart. The researchers found that over 50% of CSCs are derived from BM. BM-derived CSCs displayed similar characteristics to host CSCs and differentiated into cardiomyocytes after transplantation into heart ischemia models. Therefore, BM stem cells could serve as a backup source of CSCs to restore heart function after injury or maintain CSC homeostasis.

1. Bone Marrow Is a Reservoir for Cardiac Resident Stem Cells
Na Liu, Xin Qi, Zhibo Han, Lu Liang, Deling Kong, Zhongchao Han.
Nature; international weekly journal of science, 2016
Abstract:
Cardiac stem cells (CSCs) represent a responsive stem cell
reservoir within the adult myocardium and have a significant
function in myocardial homeostasis and injury. However, the
distribution, origin, homing and possible therapeutic benefits
of CSCs are still under discussion. In this research potential of
bone marrow (BM) stem cells in contributing to repopulating
the pool of CSCs in heart is
investigated. clarified that more than 50% CSCs are derived
from BM and confirmed that BM-derived CSCs have similar
characteristics with the host CSCs. Furthermore, we
transplanted BM-derived CSCs into heart ischemia models and
presented evidence for the first time that BM-derived CSCs
can differentiate into cardiomyocytes in vivo. In conclusions,
BM stem cells could be a potential back-up source of CSCs for
restoring heart function after injury or maintaining homeostasis
of CSCs.
Background:
Figure no:1 : trafficking of BM stem cells into blood
circulation and heart [3]
BM stem cells could be a potential back-up source of
CSCs for restoring the function of ischemia heart disease
or maintaining the homeostasis of CSCs. [3]
Methodology:
References:
Results:
Conclusion:
Presented By:
• BM-derived CSCs have similar characteristics with host
CSCs
• BM-derived CSCs can differentiate into cardiomyocytes in
vivo in heart ischemia models.
• BM stem cells could be a potential back-up source of CSCs
for restoring heart function after injury or maintaining the
homeostasis of CSCs
• CSCs represent a responsive stem cell reservoir within the
adult myocardium and recent studies have revealed that
CSCs have a significant function in myocardial homeostasis
and after injury
Cardiovascular disease (CVD) refers to a group of illnesses
that have to do with the heart and the blood vessels that carry
blood around the body. Some of these illnesses include: High
blood pressure (hypertension), Heart disease (known generally
as coronary heart disease, which includes heart attacks),
Stroke.
Heart stem or progenitor cells are multipotent cells residing in
the adult mammalian heart that are capable of self-renewing
and generating coronary vessels and heart muscle cells called
cardiomyocytes. These cardiac stem cells have potential to
repair the heart after mycocardial infaraction.
Khadija Khawar
Roll no: 10
Neelam Basharat
Roll no:50
Amna Munir
Roll no:54
Asifa Zafar
Roll no. 69
Presented To: Ma’am Usmara Sajid
Course: Health Biotechnology
Department: Biotechnology
Semester: 6th
University of Gujrat
Introduction:
Heart failure is still a major cause of hospitalization and
mortality in developed countries. Many clinical trials and
researches have tested the use of multipotent stem cells as a
cardiac regenerative medicine. The benefit for the patients of
this therapeutic intervention has remained limited. [1]The
majority of studies indicate that CMs renewal rate is very low,
less than 1% per year, and the rate declines with age . The
mechanism for cardiomyocyte homeostasis in normal
mammalian myocardium is potentially different from
regeneration after injury, which could trigger a cascade of
signals that result in activation of dormant progenitor cells or
proliferation of existing cardiomyocytes .[2] Previous works
have demonstrated that CSCs can contribute to new CMs and
vascular lineages after injury4 and also improve cardiac function
after CSCs injected into the infarct zone.[3]
[1]. The new York times, 29 july, 2017. Coronary Heart
Disease
[2] Clinical Methods: The History, Physical, and
Laboratory Examinations. 3rd edition, chapter no 14
History of Cardiovascular Disease
[3]Na Liu, Xin Qi, Zhibo Han, Lu Liang, Deling Kong ,
( 27 june 2016) Bone Marrow Is a Reservoir for Cardiac
Resident Stem Cells
Figure no.3 : schematic diagram of procedure[3]
Figure no. 2: flow sheet explanation of
experiment steps
Figure no.4: Engraftment of BM stem cells[3]
Figure no.5: Bioluminace of BM stem
cells[3]
Figure no. 6: Quantitative analysis of CSCs in BMT mice
[3]