Stem Cell




By Lalit Mahajan
Definition
• A cell that has the ability to continuously
  divide and differentiate (develop) into
  various other kinds of cells/tissues.




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Introduction

• “Células madre” is a Spanish word for stem
  cell.
• Stem cells are “mother” cells that give rise to
  all other cells in the body.
• They are cells found in all multicellular
  organisms that can undergo mitosis to give
  rise to specialized cells, or more stem cells.


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Special Characteristics of all
            Stem Cells

• Self-renewal (proliferation)- the ability of a stem
  cell to clone itself indefinitely by cell division.
• Asymmetric cell division.
• Relocation and Differentiation are abilities of
  stem cells to “migrate” to where they’re needed
  in the body and specialize into a particular type
  of mature cell.

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Cell division of stem cell




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Kinds of Stem Cells
Stem cell
  type    Description                   Examples
                                    Cells from early
              Each cell can develop
Totipotent                          (1-3 days)
              into a new individual
                                    embryos
                                      Some cells of
              Cells can form any
Pluripotent                           blastocyst (5 to
              (over 200) cell types
                                      14 days)
              Cells differentiated, Fetal tissue, cord
Multipotent   but can form a number blood, and adult
              of other tissues      stem cells
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Types of stem cell


• Embryonic stem cells

• Somatic/ adult stem cells




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Embryonic stem cells

• come from embryos
   • This stage embryo is called a Blastocyst.
   (4-5 days old embryo)
• can self-renew forever.
• are pluripotent – they can differentiate to
  become almost every cell in the body.
• Can be used for treatments for Paralysis,
  Diabetes, Alzheimer’s.

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Generates every cell in the body
                         including the placenta and extra-
 Can form the entire     embryonic tissues
   human being


                         Can generate every cell in the
Cannot form the entire
                         body except placenta and extra-
    human being
                         embryonic tissues




                                         Become specific
                                         cell types are less
                                         flexible than above


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Somatic/ adult stem cells

• found in adult tissue.
• can self-renew many times.
• are multipotent – they can differentiate to
  become only the types of cells in the tissue
  they come from.




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Potential uses of stem cells

•   Replacing damaged tissue
•   Studying human development
•   Testing new drugs
•   Screening toxins
•   Testing gene therapy methods



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Thank you




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Stem cell

  • 1.
  • 2.
    Definition • A cellthat has the ability to continuously divide and differentiate (develop) into various other kinds of cells/tissues. #
  • 3.
    Introduction • “Células madre”is a Spanish word for stem cell. • Stem cells are “mother” cells that give rise to all other cells in the body. • They are cells found in all multicellular organisms that can undergo mitosis to give rise to specialized cells, or more stem cells. #
  • 4.
    Special Characteristics ofall Stem Cells • Self-renewal (proliferation)- the ability of a stem cell to clone itself indefinitely by cell division. • Asymmetric cell division. • Relocation and Differentiation are abilities of stem cells to “migrate” to where they’re needed in the body and specialize into a particular type of mature cell. #
  • 5.
    Cell division ofstem cell #
  • 6.
    Kinds of StemCells Stem cell type Description Examples Cells from early Each cell can develop Totipotent (1-3 days) into a new individual embryos Some cells of Cells can form any Pluripotent blastocyst (5 to (over 200) cell types 14 days) Cells differentiated, Fetal tissue, cord Multipotent but can form a number blood, and adult of other tissues stem cells #
  • 7.
    Types of stemcell • Embryonic stem cells • Somatic/ adult stem cells #
  • 8.
  • 9.
    Embryonic stem cells •come from embryos • This stage embryo is called a Blastocyst. (4-5 days old embryo) • can self-renew forever. • are pluripotent – they can differentiate to become almost every cell in the body. • Can be used for treatments for Paralysis, Diabetes, Alzheimer’s. #
  • 10.
    Generates every cellin the body including the placenta and extra- Can form the entire embryonic tissues human being Can generate every cell in the Cannot form the entire body except placenta and extra- human being embryonic tissues Become specific cell types are less flexible than above #
  • 11.
    Somatic/ adult stemcells • found in adult tissue. • can self-renew many times. • are multipotent – they can differentiate to become only the types of cells in the tissue they come from. #
  • 12.
  • 13.
    Potential uses ofstem cells • Replacing damaged tissue • Studying human development • Testing new drugs • Screening toxins • Testing gene therapy methods #
  • 14.

Editor's Notes

  • #5 How are stem cells different than all other cells? “ Células madre,” Spanish for “stem cells,” reveals that these “mother” cells are responsible for certain cell lineages In culture, a stem cell will reproduce itself forever if given the right environment. Non-stem cells stop dividing after a certain number of divisions. (Draw on board) Stem cell divides into two daughter cells; one remains a stem cell, while the other turns into a more specialized cell Stem cells can travel around the body and turn into tissues that the body needs. (example get a cut, cells migrate over and replace damaged tissue) Now Laurel will talk more about differentiation.