Autism refers to a neurological condition that negatively affects the brain development and is characterized by abnormalities in communication and social interactions.
Currently, treatment involves counseling, rehabilitation, and medication. However, these can result in improvement of symptoms instead of treating the disease from the core.
In this situation, stem cell therapy plays a major role and serves as a repair system.
Stem cells in regenerative biology and medicinePasteur_Tunis
Présentation réalisée par Shahragim Tajbakhsh durant le cours du réseau international des instituts Pasteur de "Médecine Génomique: du diagnostic à la thérapie " (17-21 octobre 2016)
Autism refers to a neurological condition that negatively affects the brain development and is characterized by abnormalities in communication and social interactions.
Currently, treatment involves counseling, rehabilitation, and medication. However, these can result in improvement of symptoms instead of treating the disease from the core.
In this situation, stem cell therapy plays a major role and serves as a repair system.
Stem cells in regenerative biology and medicinePasteur_Tunis
Présentation réalisée par Shahragim Tajbakhsh durant le cours du réseau international des instituts Pasteur de "Médecine Génomique: du diagnostic à la thérapie " (17-21 octobre 2016)
This presentation describes in detail the various types and sources of stem cells. it also describes the stem cell therapies used to treat various diseases.
This presentation describes in detail the various types and sources of stem cells. it also describes the stem cell therapies used to treat various diseases.
Fun games to keep your kids active and outdoors this winterEmily Mark
Winters come with the added necessity of keeping kids warm and often indoors to keep them safe from the cold. This could mean that their activity reduces and they become more prone to getting lazy. This is not only harmful for their physical health but can also lead to them getting overweight over time.
Nine things know about stem cells treatmentpallaviparmar9
Many clinics offering stem cell treatments make claims that are not supported by a current understanding of science Stem cells have tremendous promise to help us understand and treat a range of diseases, injuries and other health-related conditions.
Webinar about stem cell therapies for spinal cord injury_Oct2014Jennifer French
Consumer oriented webinar presentation about stem cell therapies for spinal cord injury/disorder. Original broadcast with the United Spinal Association on Oct 23, 2014
Everything you need to know about stem cells.pptxpallaviparmar9
Adult stem cells (also known as Somatic stem cells) are undifferentiated cells found throughout your body.
In some adult tissues, such as bone marrow, muscle, and brain, discrete populations of adult stem cells generate replacements for other cells that are lost through normal wear and tear, injury, or disease.
Eukaryotic cells have their genetic material in the nucleus, in the other side, prokaryotes have it dispersed in the cytoplasm.
From this DNA will be synthesized RNA, which will act as an intermediary, carrying genetic information from the nucleus to the ribosomes located in the cytoplasm to carry out protein synthesis.
genetic code consists of 64 triplets (codons) of nucleotides, each codon encodes for one of the 20 amino-acids used in the synthesis of proteins.
The study of the genetic code, allow s us identify mutations in specific genes, to detect diseases or predispositions to some pathologies such as those proposed by the articles, and with tan information, implement a PREVENTIVE MEDICINE.
Knowing the sequence of genes that cause certain genetic diseases, is essential for GENE THERAPY branch. In brief it consist in introduce a correct copy of the defective gene that was visualized into the cells, by some vectors, previously studied.
With the knowledge of genetic information, can be provided counseling before and after pregnancy to future parents (Give information about the diseases to which it is susceptible and existing treatments), having always instilled an ethical principle: THE HUMAN LIFE RESPECT.
Promote investigation in medicine basic areas, such as cell biology, molecular biology, biochemistry and pharmacology, with the aim of implement humanity solutions .
The leaflet aims at providing general objective information on genetic tests, including their nature and the potential implications of their results. It presents the different types of tests available, their applications in the medical field and the extent and limit of the significance of the information resulting from these tests.
More information - www.coe.int/bioethics
Stem cell therapies also known as regenerative medicine needs to be chosen and desinged carefully according to pateint needs. Scientists and Physicians at DiponEd work closely with health-care providers to arrive at the best and safe stem cell therapy options available around the world and in India. We thereby help our patients to reach to an informed decision on what would be the best option for them.
For better view, press F5.
As we go through our lives each of us will have very different needs for our own healthcare.
Scientist's are constantly researching to make medical care treatment more personalized.
One way they are doing this is by-
Stem Cells therapy
Stem-cell therapy is the use of stem cells to treat or prevent a disease or condition.
It is also known as regenerative medicine, promotes the reparative response of diseased, dysfunctional or injured tissue using stem cells or their derivatives.
It is the next chapter of organ transplantation and uses cells instead of donor organs, which are limited in supply.
What are Stem cells?
Stem cells are called “master cells”
Stem cells are cells that are undifferentiated.
What are Stem cells?
Steam cells have the potential to become all other kinds of cells in our body.
What are Stem cells?
Types of Stem cells
How stem cell therapy works?
Disease cured by stem cell therapy.
Spinal Cord Injuries
Stem cell treatment of Diabetes mellitus type 1 & 2
Stem cell treatment of Stroke
Cancer treatment
Heart damage
Baldness
Tooth implanting
Deafness and blindness
Have stem cells already been used to treat diseases?
Ethical Consideration of Stem Cell Therapy
As the research method mainly focused on Embryonic Stem Cells, which involves taking tissue from an aborted embryo to get proper material to study. This is typically done just days after conception or between the 5th and 9th week.
Since then, researchers have moved on to more ethical study methods, such as Induced Pluripotent Stem Cells (iPS). iPS is artificially derived from a non-pluripotent cell, such as adult somatic cells.
Nowadays stem cell treatment has been spreaded throughout the world. It has also been grown commercially in developed countries.
It is thought that one day it may be the major key to treat various diseases.
Using stem cells to conduct medical research and treat disease is acceptable?
Don’t know
No
Yes
Do you approve of the extraction of stem cells from human embryos for medical research?
Don’t know
No
Yes
Neurodegenerative diseases are a group of disorders characterized by the gradual loss of structure or function of neurons in the brain or spinal cord. Some common neurodegenerative diseases include Alzheimer's disease, Parkinson's disease, and Huntington's disease.
GENETIC TESTING: Introduction, definition, methods: molecular, chromosomal and biochemical, indications, types: preimplantation, forensic, newborn, carrier, prenatal, ethical, social and legal issues, interpretation of tests, risks and limitations, role of nurse
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
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2. Licensing
Please attribute Dr. Ernesto Gutiérrez, M.D. with
a link to http://asd.worldstemcellsclinic.com
This work is licensed under the Creative Commons Attribution-NonCommercial-
NoDerivatives 4.0 International License. To view a copy of this license, visit
http://creativecommons.org/licenses/by-nc-nd/4.0/.
2
3. Disclaimer
The purpose of this lecture is to provide education
about stem cell therapies in general. Given Dr.
Gutierrez’s experience, it focuses mostly on autologous
stem cell therapies, their potential benefits and current
limitations in the treatment of autism.
The information in these slides is designed to
complement Dr. Gutierrez’s lecture and should not be
interpreted out of context or taken as medical advice.
The information provided here DOES NOT substitute
your medical doctor’s advice.
3
4. “Behind the child that makes the most
progress is an actively involved parent”
5. Dr. Ernesto Gutiérrez, M.D.
• President of World Stem Cells, LLC
• President and Medical Director of
World Stem Cells Clinic.
• Professor of Physiology and
Anatomy premed course at Anáhuac
University School of Medicine
• info@worldstemcellsclinic.com
• 1.866.290.9722
5
6. What you’ll learn
• What are stem cells.
• How stem cell therapy works
in Autism.
• What is involved in stem cell
therapy.
• What to look for in stem cell
clinics.
6
11. Allogeneic Autologous
Genetically different
from the intended
recipient.
Belong to the same
species.
Most commonly from
cord blood donors.
Easily control the
number of cells to be
used.
Harvested from the
same patient.
No chance of rejection.
Common sources are:
bone marrow, adipose
(fat), teeth, peripheral
blood.
Number of cells to be
utilized depends on
patient yield.
11
14. Stem Cell Activity
• Stem cells do not cure; they heal.
• Stem cells recognize damaged tissues and
differentiate into the specific cellular populations
required.
• This process happens every day in our bodies.
14
15. SCT in Autism
• Stem Cell Therapy (SCT) is a medical treatment that
uses stem cells to replace or repair a patient’s cells
or tissues that are damaged.
• In patients with Autism, SCT is geared towards
addressing the following systems:
• Neurologic
• Gastrointestinal
• Immunologic
15
16. Gastrointestinal Regulation
• Patients with autism have a varying degree of
gastrointestinal affliction.
• SCT is believed to assist in repairing the intestinal
wall and regulate function.
16
17. Gastrointestinal Regulation
• Mucosal lesions have been described uniquely to
children with autism but not healthy controls.
• This inflammatory condition is associated not only
with lesions on the intestinal wall, but also in the
upper GI tract.
Ichim TE, Solano F, Glenn E, Morales F, et.al. Stem Cell Therapy for Autism. Journal of
Translational Medicine 2007 June 27; 5:30
17
18.
19.
20. Immune Regulation
• Researchers have demonstrated active
neuroinflammatory processes in the cerebral cortex,
white matter, and notably in the cerebellum of
autistic patients.
20
Vargas DL, Nascimbene C, Krishnan C, Zimmerman AW, Pardo CA: Neuroglial activation
and neuroinflammation in the brain of patients with autism. Ann Neurol 2005, 57:67-81.
21. Immune Regulation
• IFN-gamma has been detected at elevated levels in
the plasma of children with autism.
• IFN-gamma is a cytokine which has been implicated
in dementias associated with chronic inflammatory
states.
21
Huang D, Han Y, Rani MR, Glabinski A, Trebst C, Sorensen T, Tani M, Wang J, Chien P,
O'Bryan S, et al.: Chemokines and chemokine receptors in inflammation of the nervous
system: manifold roles and exquisite regulation. Immunol Rev 2000, 177:52-67.
22. Immune Regulation
• Treatment of immune deregulation in autism
ameliorates intestinal and systemic symptoms as
well as neurologic function.
22
Ichim TE, Solano F, Glenn E, Morales F, et.al. Stem Cell Therapy for Autism. Journal of
Translational Medicine 2007 June 27; 5:30
23. Immunomodulatory Effects of SCT
in ASD Treatment
Siniscalco D, Sapone A, Cirillo A, Giordano C, Maione S, Antonucci N: Autism Spectrum
Disorders: Is Mesenchymal Stem Cell Personalized Therapy for the Future? Journal of
Biomedicine and Biotechnology Vol 2012, Article ID 480289.
23
24. Brain Hypoperfusion
• Children with autism have been consistently shown
to have impaired, or subnormal CNS circulation, as
well as resulting hypoxia.
• In these children, specific temporal lobe areas
associated with face recognition, social interaction
and language comprehension have been
demonstrated to be hypoperfused.
24
Ichim TE, Solano F, Glenn E, Morales F, et.al. Stem Cell Therapy for Autism. Journal of
Translational Medicine 2007 June 27; 5:30
29. Stimulation
• Full medical history and exam.
• Baseline laboratory studies.
• Stimulation in one or two
doses.
29
30. Harvesting
• Bone marrow aspirate.
• Outpatient procedure under inhalatory sedation.
NOT GENERAL ANESTHESIA.
• Harvesting of stem cells in sterile and low particle
laboratory.
30
31.
32. Expansion
• Under strict sterile conditions.
• Cells are placed in a CO2
incubator to exponentially
increase their numbers.
32
35. Therapy
• It is very important to start stimulating the new
stem cells as soon as possible.
• New, different stimuli are in order.
• Depends on the needs of each patient.
35
38. What to look for?
• Stem cell harvesting and infusion are medical
procedures and as such, should be provided by
medical professionals (M.D. or equivalent).
• Source of stem cells to be utilized.
• In our experience, SCT for autism MUST include
intrathecal infusion performed by qualified and
experienced physician.
38
39. What to look for?
• If autologous: where are the cells harvested? Do they
have to be transported to different locations between
aspirate -> harvest -> infusion.
• If allogeneic: what tests were done on the donors? Where
are the cells brought in from? Under what conditions?
• Valid operational licenses with the local health
authorities.
• Credentials of the physicians who will be involved in
providing care for your child.
39
40. What to look for?
• Make sure that there are inclusion and exclusion
criteria set in place for accepting a patient.
• Treatment to be addressed by a medical team made
up of different specialists; it can’t be a one man show.
• Ability to speak directly to at least one of the
physicians who will be personally involved with the
therapy.
• Having all your questions answered according to
your child’s needs and your concerns.
40
41. What to look for?
• If traveling to a foreign country:
• Are translation services provided?
• Will the documentation, reports, results and
forms be given in English?
• Who is responsible for emergency medical care
should something happen?
41
42. What to avoid
• Claims based exclusively on patient testimonials.
• Evading questions about stem cell sources.
• Claims there is no risk.
• Hidden costs.
• Requirement to commit to several repeat
treatments.
42
43. What to avoid
• Being asked for payment before speaking to a
physician or before having your child’s case
evaluated.
• Physicians treating in countries or states they are
not licensed in.
• Treatments performed by non-medical personnel.
43