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Nine Things
To Know About
Stem Cell Treatments
Many clinics offering stem cell treatments make claims that are not
supported by a current understanding of science
• Stem cells have tremendous promise to help us understand and treat a range of diseases, injuries and other health-related
conditions.
• Their potential is evident in the use of blood stem cells to treat diseases of the blood, a therapy that has saved the lives of
thousands of children with leukemia; and can be seen in the use of stem cells for tissue grafts to treat diseases or injury to
the bone, skin and surface of the eye.
• Important clinical trials involving stem cells are underway for many other conditions and researchers continue to explore
new avenues using stem cells in medicine.
• The information on this page is intended to help you understand both the potential and the limitations of stem cells at this
point in time, and to help you spot some of the misinformation that is widely circulated by clinics offering unproven
treatments.
• It is important to discuss these Nine Things to Know and any research or information you gather
with your primary care physician and other trusted members of your healthcare team in deciding
what is right for you.
Nine things to know about stem cells treatment
Currently, very few stem cell treatments have been proven safe and effective
There is something to lose when you try an unproven treatment
Different types of stem cells serve different purposes in the body
The same stem cell treatment is unlikely to work for different diseases or conditions
The science behind a disease should match the science behind the treatment
Cells from your own body are not automatically safe when used in treatments
Patient testimonials and other marketing provided by clinics may be misleading
An experimental treatment offered for sale is not the same as a clinical trial
The process by which science becomes medicine is designed to minimize harm and maximize effectiveness
Let’s Discuss All
Points
Currently, very few stem cell treatments have been proven safe and effective
• The list of diseases for which stem cell treatments have been shown to be beneficial is still very short.
• The best-defined and most extensively used stem cell treatment is hematopoietic (or blood) stem cell transplantation, for
example, bone marrow transplantation, to treat certain blood and immune system disorders or to rebuild the blood
system after treatments for some kinds of cancer.
• Some bone, skin and corneal (eye) injuries and diseases can be treated by grafting or implanting tissues, and the healing
process relies on stem cells within this implanted tissue.
• These procedures are widely accepted as safe and effective by the medical community.
• All other applications of stem cells are yet to be proven in clinical trials and should be considered highly experimental.
• Beware of stem cell treatments offered without regulatory approval or outside
the confines of a legitimate and registered clinical trial.
There is something to lose when you try an unproven treatment
When there is no existing or effective treatment for a disease or condition, it is easy to understand why you may feel there is
nothing to lose from trying something new, even if it isn’t proven. Unfortunately, most of the unproven stem cell treatments
for sale throughout the world carry very little promise of actual benefit and very real risks:
 Complications may create new short- and long-term health problems, and/or may make your condition or symptoms more
difficult to manage
 Receipt of one unproven or experimental treatment may make you ineligible for future clinical trials or treatment options
 Out-of-pocket expenses could be enormous. In addition to treatment costs, there may be accommodation charges or
other fees. In most cases, insurance companies and government health programs do not cover the cost of experimental
treatments
 If travel is involved, there are additional considerations, including time away from friends and family
Different types of stem cells serve different purposes in the body
• Different types of stem cells come from different places in your body and have different functions. Learn more about
various types of stem cells here.
• Scientists are exploring the different roles tissue-specific stem cells might play in healing, with the understanding that
these stem cells have specific and limited capabilities.
• Without manipulation in the lab, tissue-specific stem cells can only generate the other cell types found in the tissues
where they live.
The same stem cell treatment is unlikely to work for different diseases or conditions
• Because stem cells that are specific to certain tissues cannot make cells found in other tissues without careful
manipulation in the lab, it is very unlikely that the same stem cell treatment will work for diseases affecting different
tissues and organs within the body.
• Scientists have learned to make certain specialized cell types through a multi-step processes using pluripotent stem cells,
that is embryonic stem cells or induced pluripotent stem (iPS) cells.
• These cells have the potential to form all the different cell types in the body and offer an exciting opportunity to develop
new treatment strategies.
The science behind a disease should match the science behind the treatment
• The more you know about the causes and effects of your disease, the better armed you are to identify your best
treatment options.
• If you have a certain type of blood cancer, for example, transplantation with blood-forming stem cells makes sense, as the
treatment requires those specific cells to do exactly what they are designed to do.
• If you have diabetes, receiving a blood-forming stem cell treatment doesn’t make sense, because the problem is in the
pancreas rather than in the blood itself.
• Without significant and careful manipulation in the lab, tissue-specific stem cells do not generate cell types found outside
of their home tissues.
Cells from your own body are not automatically safe when used in treatments
• In theory, your immune system would not attack your own cells if they were used in a transplant. The use of a patient’s
own cells is called an autologous transplant. However, the processes by which the cells were acquired, grown and then
reintroduced into the body would carry risks. Here are just a few known risks of autologous stem cell treatments:
 Any time cells are removed from your body, there is a risk they may be contaminated with viruses, bacteria or other
pathogens that could cause disease when reintroduced
 Manipulation of cells by a clinic may interfere with their normal function, including those that control cell growth
 How and where the cells are put back into your body matters, and some clinics inject cells into places where they are not
normally present and do not belong
Patient testimonials and other marketing provided by clinics may be misleading
• It can be hard to tell the difference between doctors conducting responsible clinical trials and clinics selling unproven
treatments.
• One common differentiator is the way a treatment is marketed.
• Most specialized doctors receive patient referrals, while clinics selling stem cell treatments tend to market directly to
patients, often through persuasive language on the Internet, Facebook and in newspaper advertisements.
• Clinics peddling unproven stem cell treatments frequently overstate the benefits of their offerings and use patient
testimonials to support their claims.
An experimental treatment offered for sale is not the same as a clinical trial
The fact that a procedure is experimental does not automatically mean that it is part of a research study or clinical trial.
Responsible clinical trials share several important features:
 They build upon their own preclinical data, lab-based research on cells, tissues and animals, that indicates the treatment
being tested is likely to be safe and effective
 Oversight by an independent medical ethics committee to protect participant's rights
 Conformity to regulatory requirements, including a listing in a recognized clinical trial registry
 A structure designed to answer specific questions about a new treatment or a new way of using current treatments
(results are usually compared with a control group of patients who do not receive the experimental treatment)
 The cost of the new treatment and monitoring is not covered by the participant
The process by which science becomes medicine is designed to minimize harm and
maximize effectiveness
• There is a lengthy, multi-step process involved in responsibly translating science into safe and effective medical
treatments.
• During this process, scientists may discover that an approach that seemed promising in the lab, does not work in animals,
or that an approach that worked in animals, does not work in humans.
• They may discover that a treatment effectively addresses symptoms of a disease or injury in humans, but that it carries
unacceptable risks.
References:
• https://www.closerlookatstemcells.org/stem-cells-medicine/nine-
things-to-know-about-stem-cell-treatments/

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Nine things know about stem cells treatment

  • 1. Nine Things To Know About Stem Cell Treatments
  • 2. Many clinics offering stem cell treatments make claims that are not supported by a current understanding of science • Stem cells have tremendous promise to help us understand and treat a range of diseases, injuries and other health-related conditions. • Their potential is evident in the use of blood stem cells to treat diseases of the blood, a therapy that has saved the lives of thousands of children with leukemia; and can be seen in the use of stem cells for tissue grafts to treat diseases or injury to the bone, skin and surface of the eye. • Important clinical trials involving stem cells are underway for many other conditions and researchers continue to explore new avenues using stem cells in medicine. • The information on this page is intended to help you understand both the potential and the limitations of stem cells at this point in time, and to help you spot some of the misinformation that is widely circulated by clinics offering unproven treatments. • It is important to discuss these Nine Things to Know and any research or information you gather with your primary care physician and other trusted members of your healthcare team in deciding what is right for you.
  • 3. Nine things to know about stem cells treatment Currently, very few stem cell treatments have been proven safe and effective There is something to lose when you try an unproven treatment Different types of stem cells serve different purposes in the body The same stem cell treatment is unlikely to work for different diseases or conditions The science behind a disease should match the science behind the treatment Cells from your own body are not automatically safe when used in treatments Patient testimonials and other marketing provided by clinics may be misleading An experimental treatment offered for sale is not the same as a clinical trial The process by which science becomes medicine is designed to minimize harm and maximize effectiveness
  • 5. Currently, very few stem cell treatments have been proven safe and effective • The list of diseases for which stem cell treatments have been shown to be beneficial is still very short. • The best-defined and most extensively used stem cell treatment is hematopoietic (or blood) stem cell transplantation, for example, bone marrow transplantation, to treat certain blood and immune system disorders or to rebuild the blood system after treatments for some kinds of cancer. • Some bone, skin and corneal (eye) injuries and diseases can be treated by grafting or implanting tissues, and the healing process relies on stem cells within this implanted tissue. • These procedures are widely accepted as safe and effective by the medical community. • All other applications of stem cells are yet to be proven in clinical trials and should be considered highly experimental. • Beware of stem cell treatments offered without regulatory approval or outside the confines of a legitimate and registered clinical trial.
  • 6. There is something to lose when you try an unproven treatment When there is no existing or effective treatment for a disease or condition, it is easy to understand why you may feel there is nothing to lose from trying something new, even if it isn’t proven. Unfortunately, most of the unproven stem cell treatments for sale throughout the world carry very little promise of actual benefit and very real risks:  Complications may create new short- and long-term health problems, and/or may make your condition or symptoms more difficult to manage  Receipt of one unproven or experimental treatment may make you ineligible for future clinical trials or treatment options  Out-of-pocket expenses could be enormous. In addition to treatment costs, there may be accommodation charges or other fees. In most cases, insurance companies and government health programs do not cover the cost of experimental treatments  If travel is involved, there are additional considerations, including time away from friends and family
  • 7. Different types of stem cells serve different purposes in the body • Different types of stem cells come from different places in your body and have different functions. Learn more about various types of stem cells here. • Scientists are exploring the different roles tissue-specific stem cells might play in healing, with the understanding that these stem cells have specific and limited capabilities. • Without manipulation in the lab, tissue-specific stem cells can only generate the other cell types found in the tissues where they live.
  • 8. The same stem cell treatment is unlikely to work for different diseases or conditions • Because stem cells that are specific to certain tissues cannot make cells found in other tissues without careful manipulation in the lab, it is very unlikely that the same stem cell treatment will work for diseases affecting different tissues and organs within the body. • Scientists have learned to make certain specialized cell types through a multi-step processes using pluripotent stem cells, that is embryonic stem cells or induced pluripotent stem (iPS) cells. • These cells have the potential to form all the different cell types in the body and offer an exciting opportunity to develop new treatment strategies.
  • 9. The science behind a disease should match the science behind the treatment • The more you know about the causes and effects of your disease, the better armed you are to identify your best treatment options. • If you have a certain type of blood cancer, for example, transplantation with blood-forming stem cells makes sense, as the treatment requires those specific cells to do exactly what they are designed to do. • If you have diabetes, receiving a blood-forming stem cell treatment doesn’t make sense, because the problem is in the pancreas rather than in the blood itself. • Without significant and careful manipulation in the lab, tissue-specific stem cells do not generate cell types found outside of their home tissues.
  • 10. Cells from your own body are not automatically safe when used in treatments • In theory, your immune system would not attack your own cells if they were used in a transplant. The use of a patient’s own cells is called an autologous transplant. However, the processes by which the cells were acquired, grown and then reintroduced into the body would carry risks. Here are just a few known risks of autologous stem cell treatments:  Any time cells are removed from your body, there is a risk they may be contaminated with viruses, bacteria or other pathogens that could cause disease when reintroduced  Manipulation of cells by a clinic may interfere with their normal function, including those that control cell growth  How and where the cells are put back into your body matters, and some clinics inject cells into places where they are not normally present and do not belong
  • 11. Patient testimonials and other marketing provided by clinics may be misleading • It can be hard to tell the difference between doctors conducting responsible clinical trials and clinics selling unproven treatments. • One common differentiator is the way a treatment is marketed. • Most specialized doctors receive patient referrals, while clinics selling stem cell treatments tend to market directly to patients, often through persuasive language on the Internet, Facebook and in newspaper advertisements. • Clinics peddling unproven stem cell treatments frequently overstate the benefits of their offerings and use patient testimonials to support their claims.
  • 12. An experimental treatment offered for sale is not the same as a clinical trial The fact that a procedure is experimental does not automatically mean that it is part of a research study or clinical trial. Responsible clinical trials share several important features:  They build upon their own preclinical data, lab-based research on cells, tissues and animals, that indicates the treatment being tested is likely to be safe and effective  Oversight by an independent medical ethics committee to protect participant's rights  Conformity to regulatory requirements, including a listing in a recognized clinical trial registry  A structure designed to answer specific questions about a new treatment or a new way of using current treatments (results are usually compared with a control group of patients who do not receive the experimental treatment)  The cost of the new treatment and monitoring is not covered by the participant
  • 13. The process by which science becomes medicine is designed to minimize harm and maximize effectiveness • There is a lengthy, multi-step process involved in responsibly translating science into safe and effective medical treatments. • During this process, scientists may discover that an approach that seemed promising in the lab, does not work in animals, or that an approach that worked in animals, does not work in humans. • They may discover that a treatment effectively addresses symptoms of a disease or injury in humans, but that it carries unacceptable risks.