my physical medicine and rehabilitation seminar 2013.... kindly leave feedback as comments...

1. Stem cell therapy for spinal
cord injuries
VISHNU AMBAREESH

7. japanese scientist Shinya Yamanaka

8. British scientist
John B. Gurdon

12. Spinal cord injury became the first condition
targeted in a human clinical trial using cells
made from embryonic stem cells
begun by Geron in 2010
later cancelled for financial reasons.

21. Doug Brutlag 2011
Geron Stem Cell Therapy
Tom Okarma - Geron

22. GRNOPC1 Improves Locomotor Behavior
Doug Brutlag 2011
after Spinal Cord Injury
Tom Okarma - Geron

25. GRNOPC1 – contains oligodendrocyte progenitor cells.
Which turn into oligodendrocytes,
If GRNOPC1 works, the progenitor cells will produce
new oligodendrocytes in the injured area of the
patient's spine, potentially allowing for new
movement.

37. Treatment of chronic spinal cord injured
patients with autologous bone marrow-derived
hematopoietic stem cell
transplantation
• Cairo University conducted human trial of
hematopoietic progenitor stem cells in SCI
Patients
• Results: Improved functions
• Not FDA approved
• MRI showed no tumors
• Awaiting 1 year follow up

39. Human Embryonic Stem Cell (hESC)
Doug Brutlag 2011
Based Therapy
Tom Okarma - Geron

41. Doug Brutlag 2011
GRNOP1 Phase 1 Multi-Center
Spinal Cord Injury Trial
Tom Okarma - Geron

42. • injected into the patients' spines 1-2weeks
after injury between their third and 10th
thoracic vertebrae, or roughly the middle to
upper back. Later trials would include patients
with less severe spinal injuries and damage to
other parts of the spine.
In lab animals, the results were dramatic -
paralyzed rodents moved again.

44. Science is discovering the
unknown
• Stem cell field is still in its infancy
• Human embryonic stem cell research is a decade
old, adult stem cell research has 30-year head
start
• Holds hope for curing or improving treatments
for
70+ diseases

45. SHOULD WE DO IT???

46. Traditional Chinese herbal medicines
an ancient medicinal practice, called Ji-Sui-Kang
(JSK), can improve locomotor function in rats
withspinal cord injuries.

48. “Stay clear of stem cell treatment for Spinal Cord Injury (SCI),” Professor Alan Mackay-Sim

49. AJIT JOGI