1) Therapeutic hypothermia for neonatal hypoxic-ischemic encephalopathy has been shown to reduce mortality and morbidity when initiated before 6 hours of life. 2) Studies have found hypothermia reduces brain injury as seen on MRI and lowers rates of cerebral palsy, cognitive impairment, and death when compared to normothermia. 3) While mid-term outcomes up to age 7 show benefits of hypothermia, long-term follow up is still needed to fully understand impacts on neurocognitive, behavioral, and social development into childhood. Combining hypothermia with neuroprotective drugs is a promising area for further research.