The document provides information on the special senses and anatomy of the human eye. It discusses the eye as the dominant sense and its role in vision. The three layers of the eye - fibrous, vascular and sensory layers - are described. In particular, it outlines the structures of the retina such as the rods and cones, and how visual signals are transmitted via the optic nerve. Common vision conditions like myopia, hyperopia and cataracts that result from refractive errors are also summarized.
ocular anatomy fluid system glaucoma lens cataract phototransduction field visual acuity ocular movement errors of refraction light reflex accommodation corneal reflex visual pathway and its lesions
ocular anatomy fluid system glaucoma lens cataract phototransduction field visual acuity ocular movement errors of refraction light reflex accommodation corneal reflex visual pathway and its lesions
The visual pathway/visual system is the part of central nervous system which gives organisms the ability to process visual detail , as well as enabling the formation of several non-image photo response functions.
It detects interprets information from visible light to build a representation of the surrounding environment .
The visual system carries out a number of complex tasks , including the reception of light and the formation of monocular representations; the buildup of a nuclear binocular perception from a pair of two dimensional projections ; the identification and categorization of visual objects ; assessing distances to and between objects and guiding body movements in relation to the objects seen.
This ppt file belongs to Mr. Yonas Akalu one of my best instructors ...
Vision is by far the most used of the five senses and is one of the primary means that we use to gather information from our surroundings. More than 75% of the information we receive about the world around us consists of visual information.
The eye is often compared to a camera. Each gathers light and then transforms that light into a "picture." Both also have lenses to focus the incoming light. Just as a camera focuses light onto the film to create a picture, the eye focuses light onto a specialized layer of cells, called the retina.
The human eye is an organ which reacts to light and pressure. As a sense organ, the mammalian eye allows vision. Human eyes help to provide a three dimensional, moving image, normally coloured in daylight. Rod and cone cells in the retina allow conscious light perception and vision including color differentiation and the perception of depth. The human eye can differentiate between about 10 million colors[1] and is possibly capable of detecting a single photon.
The ear is the organ of hearing and, in mammals, balance. In mammals, the ear is usually described as having three parts—the outer ear, the middle ear, and the inner ear. The outer ear consists of the pinna and the ear canal.
structure of eye ball,eyeball is a specialized sense organ that helps us to understand our environment. It is a sensory unit composed of three parts: receptor, sensory pathway, and a brain center
The main parts of the human eye are The Conjunctiva,
Sclera,Choroid,
Cornea, Iris, Pupil,
Anterior Chamber,
Posterior Chamber, Aqueous humor, Lens, Vitreous humor, Retina,Macula and Optic nerve.
The visual pathway/visual system is the part of central nervous system which gives organisms the ability to process visual detail , as well as enabling the formation of several non-image photo response functions.
It detects interprets information from visible light to build a representation of the surrounding environment .
The visual system carries out a number of complex tasks , including the reception of light and the formation of monocular representations; the buildup of a nuclear binocular perception from a pair of two dimensional projections ; the identification and categorization of visual objects ; assessing distances to and between objects and guiding body movements in relation to the objects seen.
This ppt file belongs to Mr. Yonas Akalu one of my best instructors ...
Vision is by far the most used of the five senses and is one of the primary means that we use to gather information from our surroundings. More than 75% of the information we receive about the world around us consists of visual information.
The eye is often compared to a camera. Each gathers light and then transforms that light into a "picture." Both also have lenses to focus the incoming light. Just as a camera focuses light onto the film to create a picture, the eye focuses light onto a specialized layer of cells, called the retina.
The human eye is an organ which reacts to light and pressure. As a sense organ, the mammalian eye allows vision. Human eyes help to provide a three dimensional, moving image, normally coloured in daylight. Rod and cone cells in the retina allow conscious light perception and vision including color differentiation and the perception of depth. The human eye can differentiate between about 10 million colors[1] and is possibly capable of detecting a single photon.
The ear is the organ of hearing and, in mammals, balance. In mammals, the ear is usually described as having three parts—the outer ear, the middle ear, and the inner ear. The outer ear consists of the pinna and the ear canal.
structure of eye ball,eyeball is a specialized sense organ that helps us to understand our environment. It is a sensory unit composed of three parts: receptor, sensory pathway, and a brain center
The main parts of the human eye are The Conjunctiva,
Sclera,Choroid,
Cornea, Iris, Pupil,
Anterior Chamber,
Posterior Chamber, Aqueous humor, Lens, Vitreous humor, Retina,Macula and Optic nerve.
The eye is composed of a series of lenses and spaces that give focus to images, just as a camera does. It is composed of the vitreous humor, aqueous humor, the crystalline lens, and the cornea, and each of these has its own refraction index (the average being 1.34, because of the content of these tissues).Functions
Pupil. Opens and closes in order to regulate and control the amount of light.
Iris. Controls light level similar to the aperture of a camera.
Sclera. Protects the outer coat.
Cornea. A thin membrane which provides 67% of the eye's focusing power.
Crystalline lens. ...
Conjunctive. ...
Aqueous humour.
Vitreous humour.
The eye is composed of a series of lenses and spaces that give focus to images, just as a camera does. It is composed of the vitreous humor, aqueous humor, the crystalline lens, and the cornea, and each of these has its own refraction index (the average being 1.34, because of the content of these tissues)
he sense organs — eyes, ears, tongue, skin, and nose — help to protect the body. The human sense organs contain receptors that relay information through sensory neurons to the appropriate places within the nervous system.
Each sense organ contains different receptors.
General receptors are found throughout the body because they are present in skin, visceral organs (visceral meaning in the abdominal cavity), muscles, and joints.
Special receptors include chemoreceptors (chemical receptors) found in the mouth and nose, photoreceptors (light receptors) found in the eyes, and mechanoreceptors found in the ears.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
3. Vision
Dominant sense
70% of all sensory receptors are in the eyes
Converts the energy of light into electrical nerve
impulses that are interpreted by the brain as sight
Visual receptor cells (photoreceptors) sense and
encode patterns of light that enter the eye
Brain uses these signals to give us images
5. The Eye
Each eye has over a million nerve fibers
Protection for the eye
Most of the eye is enclosed in a bony orbit
A cushion of fat surrounds most of the eye
6. The Eye
Eye acts much like a camera
Lens of eye adjusts to bring object into clear
focus
Pupil of eye constricts to allow less light to
enter in bright setting or dilates to allow more
light to enter in darker setting
Through bending of light rays, image reaches
retina
7. Accessory Structures of the Eye
Eyelids and eyelashes
Conjunctiva
Lacrimal apparatus
Extrinsic eye muscles
9. Accessory Structures of the Eye
Eyelids
Eyelids (palpebrae)
Tarsal glands lubricate the eye
The tarsal glands (modified sebaceous gland) secrete a fluid
to keep the eye lids from adhering to each other.
The tarsal plate gives form and support to the eyelids.
Eyelashes
Eyelashes double/triple row of hairs.
Eyelashes are innervated by nerve ending – trigger blinking
Eyebrows
Shade
inhibit sweat
help protect the eyeballs from foreign objects, perspiration, and the
direct rays of the sun.
10.
11. Accessory Structures of the Eye
Conjunctiva
Membrane that lines the eyelids
Connects to the surface of the eye
Secretes mucus to lubricate the eye
Functions:
major
produce a lubricating mucus
prevents the eyes from drying out
other
protection
prevents foreign objects from penetrating beyond the confines of its sac
Conjunctivitis is inflammation, produces a pinkish
discoloration (pinkeye)
12. Accessory Structures of the Eye
Lacrimal apparatus
Lacrimal gland—produces lacrimal fluid
Lacrimal canals—drain lacrimal fluid from eyes
Lacrimal sac—provides passage of lacrimal fluid
towards nasal cavity
Nasolacrimal duct—empties lacrimal fluid into the
nasal cavity
13. FLOW OF TEARS
Lacrimal gland
Lacrimal ducts
Sup. or inf. lacrimal canal
Lacrimal sac
Nasolacrimal duct
Nasal cavity
14. Accessory Structures of the Eye
Function of the lacrimal apparatus
Protects, moistens, wash and lubricates the eye
Empties into the nasal cavity
Properties of lacrimal fluid
Dilute salt solution (tears)
Contains antibodies and lysozyme
15. Accessory Structures of the Eye
Muscles
Two types:
Extrinsic
Are skeletal muscles
Move the eye voluntarily
Intrinsic
Are smooth involuntary muscles
Located within the eye
Iris muscle
Ciliary muscle
16. Accessory Structures of the Eye
Extrinsic eye muscles
Six muscles attach to the outer surface of the eye
Produce eye movements
18. Structure of the Eye
Three Layers or coats or tunics forming the wall
of the eyeball
Fibrous layer
Outside layer
Vascular layer
Middle layer
Sensory layer
Inside layer
20. Structure of the Eye: The Fibrous Layer
Sclera
White connective tissue layer
Seen anteriorly as the “white of the eye”
Cornea
Transparent, central anterior portion
Allows for light to pass through
The only human tissue that can be transplanted
without fear of rejection
Both Composed of dense avascular connective tissue
21. Structure of the Eye: VascularLayer
Choroid
Is a blood-rich nutritive layer in the posterior of the eye
Pigment prevents light from scattering
Modified anteriorly into two structures
Ciliary body—smooth muscle attached to lens that change the
lense shape
Iris—regulates amount of light entering eye
• Pigmented layer that gives eye color
• Composed of circular and radial muscles
• Reflex contraction of circular muscle in bright light (small dia of
pupil)
• Reflex contraction of radial muscle in dim light (large dia of pupil)
Pupil—rounded opening in the iris
24. Structure of the Eye: Sensory Layer
Retina contains two
layers
Outer pigmented
layer
Inner neural layer
Contains receptor
cells
(photoreceptors)
Rods
Cones
25. Structure of the Eye: Sensory Layer
Three layers of neurons make up a major portion of the
retina. Named in the order in which the conduct impulses:
Photoreceptor neurons
Bipolar neurons
Ganglion neurons
Signals pass from photoreceptors via a two-neuron chain
Bipolar neurons
Ganglion cells
Signals leave the retina toward the brain through the optic
nerve
Optic disc (blind spot) is where the optic nerve leaves the
eyeball
Cannot see images focused on the optic disc
27. Structure of the Eye: Sensory Layer
Rods
Most are found towards the edges of the retina
Allow dim light vision and peripheral vision
Objects are seen in shades of gray not color
Contains pigment Rhodopsin
Rhodopsin is highly sensitive to light, light causes a
rapid breakdown of the pigment into its scotopsin and
retinal components
Cones
Allow for detailed color vision
Densest in the center of the retina
Fovea centralis—area of the retina with only cones
No photoreceptor cells are at the optic disc, or blind spot
28. Cone sensitivity
Three types of
cones red, green,
and blue
Different cones are
sensitive to different
wavelengths
Color blindness is
the result of the lack
of one cone type
29. Lens
Biconvex crystal-like structure, flexible
Held in place by a suspensory ligament attached to the
ciliary body
Focuses image onto retina
Changes lens thickness to allow light to be properly
focused onto retina
Cataracts result when the lens becomes hard and
opaque with age
Vision becomes hazy and distorted
Eventually causes blindness in affected eye
31. Watery fluid found between lens and cornea
Similar to blood plasma
Helps maintain intraocular pressure
Provides nutrients for the lens and cornea
Helps to maintain the shape of the eye
Prevent the eyeball from collapsing
Aqueous humor
32. Vitreous humor
Posterior to the lens
Gel-like substance with fine fibrils
Prevents the eye from collapsing
Helps maintain intraocular pressure
Transmits light
33. How do we see?
For vision to occur:
An image must be formed on the retina to stimulate
the rods and cones
Nerve impulses must be conducted to the visual
areas of the cerebral cortex
Interpretation occurs
34. Formation of a retinal image
Four processes focus light rays so that they form
clear images on the retina
Refraction of light rays
Accommodation of the lens
Constriction of the pupils
Convergence of the eyes
35. Process of image formation on the retina
1) Refraction:
bending of light as medium changes to focus light
2) Accommodation of lens for near/distance vision:
shape of lens changed by ciliary muscle to make light focus on retina
3) Dilation /Constriction of pupil:
ANS reflex to prevent scattering of light through edges of lens
4) Convergence of eyes:
to focus both eyes on same object and provide vision
Images are focused on the retina upside‑down and mirror‑image, and the
brain then translates this information.
36. Function of the Lens: Light Refraction
Bending of light
Occurs when light passes
at an angle from a
medium of one optical
density into a medium of
a different density
Convex surfaces cause
light to converge
Concave surfaces cause
light to diverge
38. Pathway of Light Through the Eye
Light must be focused to a point on the retina for
optimal vision
The eye is set for distance vision
Accommodation—the lens must change shape
to focus on closer objects
44. Visual Nerve Pathways
Ganglion cell axons leave the eye to form the
optic sensory nerve
The nerve fibers cross anterior to pituitary gland,
the optic chiasma.
Nerve fibers travel to the thalamus and to reflex
centers.
Optic radiations are nerve pathways that lead to
the visual association area in the occipital lobe.
48. Emmetropia—eye focuses images correctly
on the retina
Myopia (nearsighted)
Distant objects appear blurry
Light from those objects fails to reach the retina
and are focused in front of it
Results from an eyeball that is too long
Errors of Refraction
49. Errors of Refraction
Hyperopia (farsighted)
Near objects are blurry while distant objects are
clear
Distant objects are focused behind the retina
Results from an eyeball that is too short or from a
“lazy lens”
50.
51. Errors of Refraction
Astigmatism
Images are blurry
Results from light focusing as lines, not points, on
the retina due to unequal curvatures of the cornea
or lens
Correction
special lenses with uneven curvature
compensates for eye’s asymmetry
allows the image to focus evenly on retina
laser
52.
53.
54. Errors of Refraction
Cataracts
When lens becomes hard
and opaque, our vision
becomes hazy and distorted
Clouding of lens
Inadequate nutrient delivery
to deeper lens fibers
Causes: diabetes mellitus,
smoking, UV damage,
congenital, age-related
hardening, thickening of lens
55. Night blindness
Inhibited rod function that hinders the ability to see at
night
Hampers one’s ability to drive safely at night
most common cause-----prolonged vitamin A deficiency
leads to rod degeneration
treatment
vitamin A supplements
restore function
if administered before degenerative changes occur
56. Colorblindness
Genetic conditions that result in the inability to see certain
colors
Due to the lack of one type of cone (partial color blindness)
sex-linked
more common in males
most common type
red-green
deficit or absence of red or green cones
seen as same color
either red or green
57. Glaucoma
Can cause blindness due to increasing pressure
within the eye
Normally 15 (12-20) mm Hg
Above 25mm Hg an individual has glaucoma which
if untreated can lead to retinal damage and
blindness
Pressure can increase due to decreased drainage
or excess drainage of the aqueous humor which is
normally re-circulated via vessels into vitreous
humor