- The ECG detects the mean vector, which is the average of all instantaneous vectors representing the direction of electrical flow in the heart. This mean vector direction is called the mean electrical axis.
- The QRS axis represents the average of all vectors during ventricular depolarization. It normally points downward and leftward but can deviate right or left.
- The limb leads are used to determine if the QRS axis is normal or deviated by examining the orientations of the QRS complex in leads I and aVF.
Vector Analysis at Undergraduate in Science (Math, Physics, Engineering) level. The presentation gives a general description of the subject.
Please send comments and suggestions to solo.hermelin@gmail.com, thanks. For more presentations, please visit my website at
http://www.solohermelin.com .
Vector Analysis at Undergraduate in Science (Math, Physics, Engineering) level. The presentation gives a general description of the subject.
Please send comments and suggestions to solo.hermelin@gmail.com, thanks. For more presentations, please visit my website at
http://www.solohermelin.com .
definition of conductive system of heart brief explanation of components of conductive system
ECG interpretations major waves of ECG ,intervals of ECG ,
segments of ECG brief explanation
Presentation on basic principles of pediatric ecg with important examples: BY Dr. Nivedita Mishra (PGY2 PEDIATRICS, TRIBHUVAN UNIVERSITY TEACHING HOSPITAL,KATHMANDU,NEPAL)
This presentation will enable the fresh medical/nursing and other health professionals to understand basics of ECG along with they can able to interpret in beginning.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
2. Electrical Axis
• 12-lead ECG can measure the axis of the
electrical flow of energy during the cardiac
cycle
3. Instantaneous Vectors
• Cardiac cell
depolarization and
repolarization
produces many small
electrical currents
– Sum of these currents
called instantaneous
vectors
– Average of
instantaneous vectors
called the mean vector
I
4. Mean Electrical Axis
• Direction of the mean
vector called the
mean electrical axis
• Axis is defined in the
frontal plane only
6. QRS Axis
• The most important
most frequently
determined axis
7. Ventricular Depolarization
and Mean QRS Axis
• Interventricular septum depolarization represents
the first cardiac vector associated with
ventricular depolarization
• A sequence of vectors is produced as the
Purkinje fibers carry the impulse from the
endocardial lining of the RV and LV through the
ventricular wall toward the epicardium
8. Ventricular Depolarization
and Mean QRS Axis
• Completion of right
ventricular activation
occurs first
• The thinner wall of the
RV transmits impulse
quicker than the
thicker wall of LV
9. Mean QRS Axis
• The small
depolarization vectors
of the thicker LV are
larger
• Therefore, the mean
QRS axis points more
to the left
I
10. Position of the Mean QRS Axis
• Limb leads provide information about the
frontal plane and are used to determine
the position of the mean QRS axis
• Described in degrees within an imaginary
circle drawn over the patient’s chest
I
11. Position of the Mean QRS Axis
• AV node is center of circle
• Intersection of all lines divides circle into equal,
30-degree segments
• Lead I starts at +0 degrees and is located at the
three o’clock position
• Lead aVF starts at +90 degrees and is located at
the six o’clock position
12.
13. Position of the Mean QRS Axis
• Mean QRS axis normally points downward and
to patient’s left (between 0 and +90 degrees)
14. Determining Electrical Axis
• Use leads I and aVF
– The two leads that can best detect variations
in the heart’s electrical axis
I
15. • If the mean QRS vector directed anywhere between -90º
and +90º, positive QRS complex in lead I
I
Determining Electrical Axis
16. • If mean QRS vector directed between 0º and +180º,
positive QRS complex in lead aVF
I
Determining Electrical Axis
19. Determining Electrical Axis
• Location of axis
influenced by:
– Heart’s position in the
chest
– Heart size
– Patient’s body size
– Conduction pathways
– Force of electrical
impulses being
generated
24. Summary
• The mean or average of all the instantaneous vectors
which the ECG detects is called the mean vector.
• The direction of the mean vector is called the mean
electrical axis.
• When the electrical current traveling through the heart is
moving toward a positive ECG electrode on a person’s
chest or extremity the ECG machine records it as a
positive or upright waveform.
25. Summary
• The mean of all vectors that result from ventricular
depolarization is called the QRS axis.
• Completion of right ventricle activation occurs first as the
thinner wall of the right ventricle transmits the impulse in
a fraction of the time it takes the impulse to travel
through the thick lateral wall of the left ventricle.
• Sum of all the small vectors of ventricular depolarization
is called the mean QRS vector.
26. Summary
• Because the small depolarization vectors of the thicker
left ventricle are larger, the mean QRS axis points more
to the left.
• The limb leads are used to determine the position (axis)
of the mean QRS vector which is described in degrees
within an imaginary circle drawn over the patient’s chest.
• Lead I starts at +0 degrees and is located at the three
o’clock position.
• Lead aVF starts at +90 degrees and is located at the six
o’clock position.
27. Summary
• The mean QRS axis normally points downward and to
the patient’s left, between 0 and +90 degrees.
• An axis between +90 and +180 degrees indicates right
axis deviation, and one between 0 and -90 degrees
indicates left axis deviation.
• An axis deviation between -180 and -90 degrees
indicates extreme axis deviation and is called an
indeterminate axis.
28. Summary
• Leads I and aVF can be used to quickly determine
whether the mean QRS axis on any ECG is normal.
• If the QRS complex is positive in leads I and aVF, the
QRS axis must be normal.
29. Summary
• If the QRS complex is upright in lead I and negative in
lead aVF then left axis deviation exists.
• If the QRS complex is negative in lead I and positive in
lead aVF then right axis deviation exists.
• If the QRS complex is negative in both leads extreme
right axis deviation exists.