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If oxygen is available, pyruvic acid can continue through aerobic
respiration inside the mitochondria

Pyruvic Acid
(3 Carbon)

Aerobic Pathways Includes
1. Citric Acid Cycle
2. Electron Transport Chain (ETC)

Mitochondrion
mitochondria
Mitochondria are the powerhouse of cell.
Most ATP are synthesized within mitochondria

Mitochondria consists of two layers
Outer Membrane
Inner Membrane – the inner membrane is highly
folded into cristae. Cristae greatly
increase the surface area for the ETC
Priming Pyruvic Acid for the Citric Acid Cycle
Before pyruvic acid can enter the CAC it
must first be converted into acetyl CoA

For each pyruvic acid, this reaction produces
1 CO2 molecule
1 NADH molecule
1 Acetyl CoA

pyruvic acid

1 molecule of
CO2 is released

Acetyl CoA is the substrate
for the citric acid cycle.

NAD+

NADH

Coenzyme A

acetyl CoA
Citric Acid Cycle
The citric acid cycle occurs in the
matrix of the mitochondrion.
pyruvic acid

Citric Acid Cycle

Conenzyme A released

Acetyl CoA combines with
oxaloacetic acid to form citric acid.

acetyl coA
Citric acid is converted back to
oxaloacetic acid

+
oxaloacetic acid

acetic acid

citric acid
FADH2

Citric Acid Cycle

3 NAD+

FAD
3 NADH

2CO2
ATP

ADP + P
Products of the citric acid cycle include:
1 ATP
3 NADH = transports electrons to ETC
1 FADH2 = transports electrons to ETC
2 CO2
electron transport chain (ETC)
The ETC is located on the inner membrane of mitochondria
An enzyme called ATP synthase forms ATP by attaching a phosphate to ADP
ATP synthase is powered by the transfer of e- along a chain protein complexes that
form the ETC.
The ETC produces 32-34 ATP per glucose
Oxygen removes electrons from the final complex protein, so it is the final e- acceptor

ETC
Electron Transport Chain

1. NADH (and FADH2) transfer
their electrons to the first
complex protein.

2. e- are transported along the
protein complexes of the ETC.

Products of Electron Transport Chain
include 32-34 ATP and Water.

5. The H+ gradient established by the
ETC is used to power ATP Synthase.

3. Energy from the etransfer is used to pump
H+ into the inner
membrane space.

4. Oxygen removes efrom the last complex
protein. Water is formed
in this reaction.

6. ATP Synthase generates new ATP by
adding a phosphate to ADP.
catabolism of proteins, fats, & carbohydrates
Lipids & Proteins can also be broken
down and used for ATP synthesis

Most organic molecules are converted
into acetyl CoA and enter the citric acid
cycle as acetyl coA

End of Section 3, Chapter 4

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section 3, chapter 4

  • 1.
  • 2. If oxygen is available, pyruvic acid can continue through aerobic respiration inside the mitochondria Pyruvic Acid (3 Carbon) Aerobic Pathways Includes 1. Citric Acid Cycle 2. Electron Transport Chain (ETC) Mitochondrion
  • 3. mitochondria Mitochondria are the powerhouse of cell. Most ATP are synthesized within mitochondria Mitochondria consists of two layers Outer Membrane Inner Membrane – the inner membrane is highly folded into cristae. Cristae greatly increase the surface area for the ETC
  • 4. Priming Pyruvic Acid for the Citric Acid Cycle Before pyruvic acid can enter the CAC it must first be converted into acetyl CoA For each pyruvic acid, this reaction produces 1 CO2 molecule 1 NADH molecule 1 Acetyl CoA pyruvic acid 1 molecule of CO2 is released Acetyl CoA is the substrate for the citric acid cycle. NAD+ NADH Coenzyme A acetyl CoA
  • 5. Citric Acid Cycle The citric acid cycle occurs in the matrix of the mitochondrion.
  • 6. pyruvic acid Citric Acid Cycle Conenzyme A released Acetyl CoA combines with oxaloacetic acid to form citric acid. acetyl coA Citric acid is converted back to oxaloacetic acid + oxaloacetic acid acetic acid citric acid FADH2 Citric Acid Cycle 3 NAD+ FAD 3 NADH 2CO2 ATP ADP + P
  • 7. Products of the citric acid cycle include: 1 ATP 3 NADH = transports electrons to ETC 1 FADH2 = transports electrons to ETC 2 CO2
  • 8. electron transport chain (ETC) The ETC is located on the inner membrane of mitochondria An enzyme called ATP synthase forms ATP by attaching a phosphate to ADP ATP synthase is powered by the transfer of e- along a chain protein complexes that form the ETC. The ETC produces 32-34 ATP per glucose Oxygen removes electrons from the final complex protein, so it is the final e- acceptor ETC
  • 9. Electron Transport Chain 1. NADH (and FADH2) transfer their electrons to the first complex protein. 2. e- are transported along the protein complexes of the ETC. Products of Electron Transport Chain include 32-34 ATP and Water. 5. The H+ gradient established by the ETC is used to power ATP Synthase. 3. Energy from the etransfer is used to pump H+ into the inner membrane space. 4. Oxygen removes efrom the last complex protein. Water is formed in this reaction. 6. ATP Synthase generates new ATP by adding a phosphate to ADP.
  • 10. catabolism of proteins, fats, & carbohydrates Lipids & Proteins can also be broken down and used for ATP synthesis Most organic molecules are converted into acetyl CoA and enter the citric acid cycle as acetyl coA End of Section 3, Chapter 4