Describe the major available electronic resources
Describe how to build a search strategy
Describe some alternate sources for finding trials
Describe what to do once you get your search results
Researcher KnowHow session presented by Judith Carr, Research Data Manager and co-ordinated by Gary Jeffers, Research Data Officer at University of Liverpool Library.
A systematic review uses systematic and explicit methods to identify, select, critically appraise, and extract and analyze data from relevant research [Higgins & Green 2011].
EAHIL CPD Pilot Program: Search filters - what are they good for?maria gp
In this one hour webinar, Julie reviewed how to find filters, how to assess the quality of filters and occasions when filters may or not be helpful. This webinar is part of the EAHIL CPD pilot program. Visit http://eahil.eu
eahil cpd pilot program. Webinar 50 shades of reviewmaria gp
Dr. Andrew Booth share his expertise in this webinar to help medical librarians better support their users when facing the task of literature review.
This webinar is part of a CPD pilot program for the EAHIL.
EAHIL CPD Pilot Program: 10 things you may not know about Cochrane Library - ...maria gp
This one-hour webinar was intended for healthcare librarians who are familiar with the Cochrane Library as well as those who are less well acquainted with it. Carol Lefebvre was our Presenter in this webinar, part of the EAHIL CPD Pilot Program. Juanuary 2017.
Researcher KnowHow session presented by Judith Carr, Research Data Manager and co-ordinated by Gary Jeffers, Research Data Officer at University of Liverpool Library.
A systematic review uses systematic and explicit methods to identify, select, critically appraise, and extract and analyze data from relevant research [Higgins & Green 2011].
EAHIL CPD Pilot Program: Search filters - what are they good for?maria gp
In this one hour webinar, Julie reviewed how to find filters, how to assess the quality of filters and occasions when filters may or not be helpful. This webinar is part of the EAHIL CPD pilot program. Visit http://eahil.eu
eahil cpd pilot program. Webinar 50 shades of reviewmaria gp
Dr. Andrew Booth share his expertise in this webinar to help medical librarians better support their users when facing the task of literature review.
This webinar is part of a CPD pilot program for the EAHIL.
EAHIL CPD Pilot Program: 10 things you may not know about Cochrane Library - ...maria gp
This one-hour webinar was intended for healthcare librarians who are familiar with the Cochrane Library as well as those who are less well acquainted with it. Carol Lefebvre was our Presenter in this webinar, part of the EAHIL CPD Pilot Program. Juanuary 2017.
Systematic review guidance. Systematic Review support from tutor.
Dissertation Help, Literature review help.
http://www.dissertationmanageronline.com/
UK based tutor, coach. Retired UK University senior lecturer, dissertation marker, examiner.
Developing a search strategy for your systematic reviewSarah Young
This presentation was made to researchers in public health and nutrition at the Summer Institute for Systematic Reviews in Nutrition for Global Policy Making, a collaboration of WHO, Cochrane Collaboration and Cornell University's Division of Nutritional Sciences.
embase.com webinar presented on 25th february 2015, on systematic searching for medical librarians. How to search systematically for instance for a systematic review. How can you check for completeness of the terms used.
The original presentation contained a live demonstration, but here screenshots are shown within the presentation.
A recording of the webinar can be found at: https://attendee.gotowebinar.com/recording/293088383310057474
For a School of Information class on medical librarianship, this presentation was created to provide a very basic introduction and overview of the concepts, expectations, and experience of the librarian portion of working in a systematic review team.
A session for the Dent 610 course at the University of Michigan, on research methods and processes. Specific focus of this session on systematic review methods and processes, especially through database searching.
This presentation was given as part of a searching workshop in the 6th GCC Evidence-Based Healthcare & Knowledge Translation in Riyadh, December 11-12, 2010. Organized by Sheikh Abdullah S Bahamdan Research Chair, at King Saud University. The presentation assumes prior knowledge of EBM principles. It goes over the hierarchy of information sources & how to get the information effectively & efficiently.
Construct a EMBASE Search that complements your MEDLINE search
Discuss other databases to consider for searching
Understand the role of GreyLit in systematic reviews
Searching for clinical trials
Download and manage results
Discuss the importance of search in the systematic review methodology
Select where to search for studies for a systematic review
Determine the availability and overlap of published studies
Construct a MEDLINE Search that will be sensitive to pick up all available and published studies
Download and manage results
June 3, 2024 Anti-Semitism Letter Sent to MIT President Kornbluth and MIT Cor...Levi Shapiro
Letter from the Congress of the United States regarding Anti-Semitism sent June 3rd to MIT President Sally Kornbluth, MIT Corp Chair, Mark Gorenberg
Dear Dr. Kornbluth and Mr. Gorenberg,
The US House of Representatives is deeply concerned by ongoing and pervasive acts of antisemitic
harassment and intimidation at the Massachusetts Institute of Technology (MIT). Failing to act decisively to ensure a safe learning environment for all students would be a grave dereliction of your responsibilities as President of MIT and Chair of the MIT Corporation.
This Congress will not stand idly by and allow an environment hostile to Jewish students to persist. The House believes that your institution is in violation of Title VI of the Civil Rights Act, and the inability or
unwillingness to rectify this violation through action requires accountability.
Postsecondary education is a unique opportunity for students to learn and have their ideas and beliefs challenged. However, universities receiving hundreds of millions of federal funds annually have denied
students that opportunity and have been hijacked to become venues for the promotion of terrorism, antisemitic harassment and intimidation, unlawful encampments, and in some cases, assaults and riots.
The House of Representatives will not countenance the use of federal funds to indoctrinate students into hateful, antisemitic, anti-American supporters of terrorism. Investigations into campus antisemitism by the Committee on Education and the Workforce and the Committee on Ways and Means have been expanded into a Congress-wide probe across all relevant jurisdictions to address this national crisis. The undersigned Committees will conduct oversight into the use of federal funds at MIT and its learning environment under authorities granted to each Committee.
• The Committee on Education and the Workforce has been investigating your institution since December 7, 2023. The Committee has broad jurisdiction over postsecondary education, including its compliance with Title VI of the Civil Rights Act, campus safety concerns over disruptions to the learning environment, and the awarding of federal student aid under the Higher Education Act.
• The Committee on Oversight and Accountability is investigating the sources of funding and other support flowing to groups espousing pro-Hamas propaganda and engaged in antisemitic harassment and intimidation of students. The Committee on Oversight and Accountability is the principal oversight committee of the US House of Representatives and has broad authority to investigate “any matter” at “any time” under House Rule X.
• The Committee on Ways and Means has been investigating several universities since November 15, 2023, when the Committee held a hearing entitled From Ivory Towers to Dark Corners: Investigating the Nexus Between Antisemitism, Tax-Exempt Universities, and Terror Financing. The Committee followed the hearing with letters to those institutions on January 10, 202
Synthetic Fiber Construction in lab .pptxPavel ( NSTU)
Synthetic fiber production is a fascinating and complex field that blends chemistry, engineering, and environmental science. By understanding these aspects, students can gain a comprehensive view of synthetic fiber production, its impact on society and the environment, and the potential for future innovations. Synthetic fibers play a crucial role in modern society, impacting various aspects of daily life, industry, and the environment. ynthetic fibers are integral to modern life, offering a range of benefits from cost-effectiveness and versatility to innovative applications and performance characteristics. While they pose environmental challenges, ongoing research and development aim to create more sustainable and eco-friendly alternatives. Understanding the importance of synthetic fibers helps in appreciating their role in the economy, industry, and daily life, while also emphasizing the need for sustainable practices and innovation.
How to Make a Field invisible in Odoo 17Celine George
It is possible to hide or invisible some fields in odoo. Commonly using “invisible” attribute in the field definition to invisible the fields. This slide will show how to make a field invisible in odoo 17.
The Roman Empire A Historical Colossus.pdfkaushalkr1407
The Roman Empire, a vast and enduring power, stands as one of history's most remarkable civilizations, leaving an indelible imprint on the world. It emerged from the Roman Republic, transitioning into an imperial powerhouse under the leadership of Augustus Caesar in 27 BCE. This transformation marked the beginning of an era defined by unprecedented territorial expansion, architectural marvels, and profound cultural influence.
The empire's roots lie in the city of Rome, founded, according to legend, by Romulus in 753 BCE. Over centuries, Rome evolved from a small settlement to a formidable republic, characterized by a complex political system with elected officials and checks on power. However, internal strife, class conflicts, and military ambitions paved the way for the end of the Republic. Julius Caesar’s dictatorship and subsequent assassination in 44 BCE created a power vacuum, leading to a civil war. Octavian, later Augustus, emerged victorious, heralding the Roman Empire’s birth.
Under Augustus, the empire experienced the Pax Romana, a 200-year period of relative peace and stability. Augustus reformed the military, established efficient administrative systems, and initiated grand construction projects. The empire's borders expanded, encompassing territories from Britain to Egypt and from Spain to the Euphrates. Roman legions, renowned for their discipline and engineering prowess, secured and maintained these vast territories, building roads, fortifications, and cities that facilitated control and integration.
The Roman Empire’s society was hierarchical, with a rigid class system. At the top were the patricians, wealthy elites who held significant political power. Below them were the plebeians, free citizens with limited political influence, and the vast numbers of slaves who formed the backbone of the economy. The family unit was central, governed by the paterfamilias, the male head who held absolute authority.
Culturally, the Romans were eclectic, absorbing and adapting elements from the civilizations they encountered, particularly the Greeks. Roman art, literature, and philosophy reflected this synthesis, creating a rich cultural tapestry. Latin, the Roman language, became the lingua franca of the Western world, influencing numerous modern languages.
Roman architecture and engineering achievements were monumental. They perfected the arch, vault, and dome, constructing enduring structures like the Colosseum, Pantheon, and aqueducts. These engineering marvels not only showcased Roman ingenuity but also served practical purposes, from public entertainment to water supply.
Operation “Blue Star” is the only event in the history of Independent India where the state went into war with its own people. Even after about 40 years it is not clear if it was culmination of states anger over people of the region, a political game of power or start of dictatorial chapter in the democratic setup.
The people of Punjab felt alienated from main stream due to denial of their just demands during a long democratic struggle since independence. As it happen all over the word, it led to militant struggle with great loss of lives of military, police and civilian personnel. Killing of Indira Gandhi and massacre of innocent Sikhs in Delhi and other India cities was also associated with this movement.
Unit 8 - Information and Communication Technology (Paper I).pdfThiyagu K
This slides describes the basic concepts of ICT, basics of Email, Emerging Technology and Digital Initiatives in Education. This presentations aligns with the UGC Paper I syllabus.
Unit 8 - Information and Communication Technology (Paper I).pdf
Searching for Trials for a Systematic Review
1. Searching for Trials for a
Systematic Review
US Cochrane Eyes and Vision Group
Completing a Cochrane Systematic Review Workshop
July 18, 2013
2. Describe the major available electronic
resources
Describe how to build a search strategy
Describe some alternate sources for finding
trials
Describe what to do once you get your
search results
Objectives
3. OK, I Have a Title-
What next?
If you are doing a Cochrane review, work with the
Trials Search Coordinator for the relevant Cochrane
review group.
Work with an information specialist trained in searching
for systematic reviews
Use Chapter 6 in the Cochrane Handbook as a guide
Include the search protocol in your protocol (strategy
and sources)
Document everything you do and when you do it!!!!
4. Identification of evidence
Develop your protocol for conducting the search:
What sources
• Databases
• Hand searching
How – search strategies
How to make decisions (duplicate screening?)
How to document – dates, numbers included,
excluded
5. Cochrane Central Register of Controlled Trials
(CENTRAL) (www.thecochranelibrary.com)
Includes about 650,000 citations
Includes MEDLINE and EMBASE searches
Includes Cochrane group specialized registers
MEDLINE/PubMED (www.ncbi.nlm.nih.gov/sites/entrez)
Includes 22 million citations; > 5,600 journals in 39 languages
Citations fully indexed from 1966 forward
PubMed has most recent – but non-indexed articles
EMBASE (www.embase.com)
Includes 25 million citations > 7,600 journals
Includes MEDLINE
Includes > 6 million conference abstracts
Major electronic databases used to
search for clinical trials
6. Other important databases
National and regional databases (often local language)
LILACS (bases.bireme.br)
Subject-specific databases
CINAHL (www.cinahl.com)
PsycINFO (www.apa.org/psycinfo/)
OTSeeker (www.otseeker.com)
Citation databases
Web of Science (www.thomsonreuters.com)
Scopus (www.scopus.com)
Dissertations, thesis databases
ProQuest (www.Proquest.com)
Grey literature databases
Opengrey (www.opengrey.eu) – formerly SIGLE
7. Will review be limited to RCTs or will it include other
study designs?
Will adverse events be included?
Is there any geographic consideration?
Is there a limited time period when the intervention
was used?
Other issues to consider
8. Add to search strategy
Plurals - (acuity, acuities)
Abbreviations - (e.g., CNV for choroidal neovascularization)
Synonyms -
Lucentis, ranibiuzumab
Avastin, bevacizumab
Spelling variations - (randomized/randomised)
Truncation – (antibod* for antibody or antibodies)
9. Medical Subject Headings (MeSH)
- Descriptors (with thesaurus)
- Most specific term used
Textword searching
- titles for all records, abstracts since 1975
- truncation useful
Publication type
Sensitivity (recall) vs Specificity (precision)
- no gold standard available
Searching trials on PubMed
10. 1. Start with simple search strategy
2. Run search and retrieve reports
3. Analyze MeSH and text words of studies
fitting your criteria
4. Re-run search with revised strategy
5. Repeat steps 2 – 4 if necessary
6. Run optimal search strategy
7. Retrieve reports identified with optimal
search strategy
Development of
MEDLINE search strategy
11. To develop simple search strategy,
start with your question
Population
Intervention(s)
Comparison(s)
Outcome
12. P
I
C
O
For patients with choroidal neovascularization
associated with age-related macular degeneration,
do intravitreal injections of Lucentis, when compared
with Avastin, prevent vision loss?
Individuals with choroidal neovascularization
associated with age-related macular degeneration
Lucentis, ranibizumab
Avastin, bevacizumab
Change in visual acuity or visual field
13. Searching PubMED
Start with the general format:
(Population OR synonym# 1 OR synonym #2) AND
(Intervention OR synonym # 1 OR synonym#2) AND
(Comparator OR synonym#1 OR synonym#2) AND
(Outcome OR synonym# 1 OR synonym # 2) AND
Add study type filter terms
14. How do we find the
terms to use in the
search strategy?
28. Completed search strategy
(this is added to the Cochrane “highly sensitive search strategy”)
#1 exp macular degeneration/
#2 exp retinal degeneration/
#3 exp retinal neovascularization/
#4 exp choroidal neovascularization/
#5 exp macula lutea/
#6 maculopath$.tw.
#7 ((macul$ or retina$ or choroid$*) adj3 degener$).tw.)
#8 ((macul$ or retina$ or choroid$*) adj3 neovasc$).tw.)
#9 ((macula$ adj2 lutea.tw
#10 or/1-9
#11 exp angiogenesis inhibitors/
#12 exp angiogenesis inducing agents/
#13 exp vascular endothelial growth factors/
#14 (lucentis$ or avastin$ or ranibizumab$ or bevacizumab$).tw
#15 (anti adj2 VEGF$).tw.
#16 (endothelial adj2 growth adj2 factor$).tw.
#17 or/ 11-16
#18 10 AND 17
P
I,
C
Add study filter terms to identify study type
29. Common errors in search
strategies
Spelling errors
Missed spelling variant (randomized instead of random)
Truncation error (methods* instead of method*)
Logical operator error (using NOT instead of AND)
Wrong line number (when combining lines)
MeSH and free text terms on same line
Irrelevant MeSH term
Missed MeSH term
Unwarranted explosion of MeSH terms
Redundancy without rationale
Search strategy not tailored for other databases
Sampson et al, J Clin Epi 2006
30. Use of all databases may be necessary to identify all reports
Lawrence et al Inj Prev 2008
31. Registers of ongoing or completed trials
www.clinicaltrials.govwww.clinicaltrials.gov
www.controlled-trials.comwww.controlled-trials.com
www.who.int/ictrp/enwww.who.int/ictrp/en (WHO portal)
Clinical Trial registers
32. Google Scholar vs PubMed
Search engine No citations
Mean (SD) Median (IQR)
Google scholar 2211 (3999) 1040 (339,1958)
PubMed 44 (47) 35 (20,53)
Identified 22 Drug Information Rounds review articles
Searched PubMed or Google Scholar with 2 keywords
(MeSH) or text
Google presented “older” literature first compared with
PubMed - Freeman et al Pharmacotherapy 2009
Similar results reported using clinical query (PubMed)
and advanced scholar search (Google scholar)
- Anders et al (Resp. Care 2010)
33. Journals in topic area
Conference proceedings in area
Bibliographies of related systematic reviews
More efficient and more accurate to use SCOPUS to
download all references in a review than to review them
manually - Chapman et al, Health Information and Libraries J 2010)
Handsearching
34. Other sources of trial results
FDA
Pharmaceutical company registers
Communication with experts in the field
www.clinicaltrials.gov
35. Systematic Snowballing
Use included articles as a source to identify missing
studies:
Reference lists - check cited articles = backward
searching
Web of Science, SCOPUS - check citing articles =
forward searching
(“Related articles”/ “Find Similar”) in MEDLINE,
EMBASE) – also could use to find new terms to
expand your search strategy
36. Use of all sources may be necessary
to identify all reports
Sources of studies for a systematic review for studies
promoting a shift from use of cars to walking or cycling
Source Total No. No. in review %
Health databases 4 3 14
Citation databases 8 3 14
Other databases 8 2 9
Transport database 33 9 41
Internet search 10 3 14
Handsearch abstracts 6 2 9
Total 69 22 100
Ogilvie et al JECH 2005
37. Screening search results
Full record citations downloaded from electronic
databases into an electronic file – either a text file or a
reference manager file
Files distributed to two team members for screening
Yes, Maybe, No
Systematic reviews - obtain full copy for review of references
Disagreements resolved by consensus or by third team
member
Electronic documentation
Reference manager – use new field to enter yes/no/maybe/ref
Word – identify using highlighted text, comment box, copy/paste
to new file
Excel – possible, but difficult to manage
38. Screening full text articles
Develop and use a data collection form (paper or
electronic)
Query inclusion/exclusion criteria
Duplicate screening - Yes, no, unclear
Disagreements resolved by consensus or by third team member
Responses for excluded studies provide “reason for
exclusion” in RevMan
Articles with unclear designation usually need author
contact –go into “awaiting assessment” in RevMan
Start to identify multiple articles from same trial
Authors
Numbers of randomized participants
Interventions
39. Document your findings
When you searched (month/year)
Where you searched
Electronic databases
Handsearches
Trial registers
Communications with experts, industry
Bibliographies, etc.
Internet
How you searched
Search strategies
What you found
PRISMA flow diagram
40. PRISMA Flow of Information
No. records identified
through database searching
No. additional records identified
through other sources
No. records
screened
No. studies included
in qualitative synthesis
No. full-length articles
assessed for eligibility
No. records after
duplicates removed
No. records excluded
No. full-length articles
excluded, with reasons
No. studies included
in quantitative synthesis
41. Conclusions
Develop a search strategy for electronic database
searching using an iterative approach, starting with
your question
Make sure to perform searches from all additional
sources (adapting strategy as necessary)
Document when, where, and how you searched and
what you found
Editor's Notes
When creating a complex search strategy as done by a Trials Search Co-ordinator (TSC) or medical librarian, the following is used (similar to when formulating a clinical question). TSCs tend to use population, intervention(s) and condition in their searches but not specific outcomes as this might lead to the search being too narrow. In CENTRAL you do not need to use any terminology for trials as it is made up mainly of RCTs and CCTs. However, RCT filters can be obtained from your Review Group for searching MEDLINE and EMBASE.
Here is the completed strategy, using both MeSH and text words. Please note that truncation has been used on the text words ie macula* with and without the r. Text words are in lower caps, MeSH in upper caps. We have put in lines to split the condition and interventions. Explain that it was decided to leave out the population as well as names for other treatments. Joyce – you can now run the search in CENTRAL.
The Science Citation Index provides access to current and retrospective bibliographic information, author abstracts, and cited references. Amongst other things you can do cited reference searching on it.
Manual searching includes handsearching, whereby you identify a journal in your field of interest and you literally search from cover to cover. Conference proceedings are also a good source of finding trials that may never make it to journal publication. (May want to mention Roberta Scherer’s study regarding ARVO abstracts and how many trials in abstract form never made it to publication in a journal). A good reference point is also the bibliographies of included studies, or other reviews on the subject.