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Webinar Slides by
NOVEL Health Strategies
2 Wisconsin Circle
Chevy Chase
Maryland, USA
Presenter
Saurabh (Rob) Aggarwal, PhD
Principal & Co-Founder
1-202-618-9365
sa2@novelhealthstrategies.com
Conducting Large
Systematic Reviews for
Meta-Analysis or
Mixed Treatment
Comparison
Contents
v  Concept of Systematic Reviews
v  Commonly Made Mistakes
v  NOVEL Process for Conducting
Reviews
Concept of Systematic Review
h"p://naviga+ngeffec+vetreatments.org.au/understanding_systema+c_reviews.html	
  
Concept of Systematic Review
h"p://naviga+ngeffec+vetreatments.org.au/understanding_systema+c_reviews.html	
  
Importance of Systematic Review
h"p://boringem.org/2013/01/27/a-­‐review-­‐of-­‐systema+c-­‐reviews/	
  
Common Mistakes Made While
Conducting Systematic Reviews
Not Clearly Defining Search
Strategy
Using Only One Database
Using Wrong Inclusion
Exclusion Criteria
Errors in Data Extraction and
Analysis
How NOVEL Health Strategies
can Help?
NOVEL Health Strategies Has Developed a New and
Efficient Methodology for Conducting Reviews
For Large Systematic Reviews It is Critical to be
Efficient and Accurate
We have Married Strategy, Automated Analytics
and Manual Screening to Save 50-80% Time and
Improve Accuracy
“This is very impressive. We
had missed so many
studies!”
Manager, HEOR, J&J
Client Comment for NOVEL
Health Strategies’ Review
“NOVEL’s methodology is
the most efficient and
accurate I have ever
seen”
Senior Director, Med Affairs
Client Comment for NOVEL
Health Strategies’ Review
NOVEL was Awarded Platinum and Bronze Medals by
Academy of Managed Care Pharmacy (AMCP) for
Market Access Studies
U.S.	
  Managed	
  Care	
  Pharmacy	
  Coverage	
  
Trends	
  for	
  New	
  Hepa;;s	
  C	
  Treatments	
  	
  
Impact	
  of	
  Essen;al	
  Health	
  Benefit	
  
Benchmark	
  Plans	
  on	
  Pharmacy	
  Coverage	
  	
  
Systema;c	
  Review	
  on	
  Cancer	
  Drugs	
  
Presented	
  at	
  ASCO	
  
Meta-­‐Analysis	
  and	
  Modeling	
  Study	
  
Presented	
  at	
  ISPOR	
  Montreal	
  
h"p://mee+nglibrary.asco.org/content/129362-­‐144	
  
RELATIONSHIPS	
  BETWEEN	
  FOOD	
  EFFECTS,	
  PATIENT	
  
ADHERENCE	
  TO	
  TREATMENT,	
  AND	
  
PHARMACOKINETICS	
  OF	
  ORAL	
  ANTICANCER	
  DRUGS.	
  
	
  
	
  
	
  
	
  
	
  
	
  
	
  
Millennium:	
  The	
  Takeda	
  Oncology	
  Company,	
  
Cambridge,	
  MA;	
  Takeda	
  Pharmaceu+cals	
  Interna+onal	
  
Co.,	
  Cambridge,	
  MA;	
  Novel	
  Health	
  Strategies,	
  
Bethesda,	
  MD	
  
	
  
META-ANALYSIS OF ANASTOMOTIC
LEAK RATES FOLLOWING HAND-SEWN
SUTURE VERSUS STAPLED
ANASTOMOSES DURING RIGHT COLON
SURGERY




Ethicon Surgical Care, Johnson & Johnson,
Somerville, NJ, USA, 2Ethicon Surgical
Care, Johnson & Johnson, Cincinnati, OH,
USA,3Novel Health Strategies, Bethesda,
MD, USA	
  
h"p://www.ispor.org/Event/ProgramList/43?type=Poster&sess=II&acode=PCN	
  
14	
  
Examples of NOVEL’s Systematic Reviews in Public
Domain
For Demo or to Learn More About our
Capabilities Please Contact Us at:
Saurabh (Rob) Aggarwal, PhD
Principal & Co-Founder
1-202-618-9365
sa2@novelhealthstrategies.com
www.NOVELHEALTHSTRATEGIES.COM	
  

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Conducting Large Systematic Reviews for Meta-Analysis and Mixed Treatment Comparison: Webinar by NOVEL Health Strategies

  • 1. Webinar Slides by NOVEL Health Strategies 2 Wisconsin Circle Chevy Chase Maryland, USA Presenter Saurabh (Rob) Aggarwal, PhD Principal & Co-Founder 1-202-618-9365 sa2@novelhealthstrategies.com Conducting Large Systematic Reviews for Meta-Analysis or Mixed Treatment Comparison
  • 2. Contents v  Concept of Systematic Reviews v  Commonly Made Mistakes v  NOVEL Process for Conducting Reviews
  • 3. Concept of Systematic Review h"p://naviga+ngeffec+vetreatments.org.au/understanding_systema+c_reviews.html  
  • 4. Concept of Systematic Review h"p://naviga+ngeffec+vetreatments.org.au/understanding_systema+c_reviews.html  
  • 5. Importance of Systematic Review h"p://boringem.org/2013/01/27/a-­‐review-­‐of-­‐systema+c-­‐reviews/  
  • 6. Common Mistakes Made While Conducting Systematic Reviews
  • 7. Not Clearly Defining Search Strategy Using Only One Database Using Wrong Inclusion Exclusion Criteria Errors in Data Extraction and Analysis
  • 8. How NOVEL Health Strategies can Help?
  • 9. NOVEL Health Strategies Has Developed a New and Efficient Methodology for Conducting Reviews
  • 10. For Large Systematic Reviews It is Critical to be Efficient and Accurate We have Married Strategy, Automated Analytics and Manual Screening to Save 50-80% Time and Improve Accuracy
  • 11. “This is very impressive. We had missed so many studies!” Manager, HEOR, J&J Client Comment for NOVEL Health Strategies’ Review
  • 12. “NOVEL’s methodology is the most efficient and accurate I have ever seen” Senior Director, Med Affairs Client Comment for NOVEL Health Strategies’ Review
  • 13. NOVEL was Awarded Platinum and Bronze Medals by Academy of Managed Care Pharmacy (AMCP) for Market Access Studies U.S.  Managed  Care  Pharmacy  Coverage   Trends  for  New  Hepa;;s  C  Treatments     Impact  of  Essen;al  Health  Benefit   Benchmark  Plans  on  Pharmacy  Coverage    
  • 14. Systema;c  Review  on  Cancer  Drugs   Presented  at  ASCO   Meta-­‐Analysis  and  Modeling  Study   Presented  at  ISPOR  Montreal   h"p://mee+nglibrary.asco.org/content/129362-­‐144   RELATIONSHIPS  BETWEEN  FOOD  EFFECTS,  PATIENT   ADHERENCE  TO  TREATMENT,  AND   PHARMACOKINETICS  OF  ORAL  ANTICANCER  DRUGS.                 Millennium:  The  Takeda  Oncology  Company,   Cambridge,  MA;  Takeda  Pharmaceu+cals  Interna+onal   Co.,  Cambridge,  MA;  Novel  Health  Strategies,   Bethesda,  MD     META-ANALYSIS OF ANASTOMOTIC LEAK RATES FOLLOWING HAND-SEWN SUTURE VERSUS STAPLED ANASTOMOSES DURING RIGHT COLON SURGERY Ethicon Surgical Care, Johnson & Johnson, Somerville, NJ, USA, 2Ethicon Surgical Care, Johnson & Johnson, Cincinnati, OH, USA,3Novel Health Strategies, Bethesda, MD, USA   h"p://www.ispor.org/Event/ProgramList/43?type=Poster&sess=II&acode=PCN   14   Examples of NOVEL’s Systematic Reviews in Public Domain
  • 15. For Demo or to Learn More About our Capabilities Please Contact Us at: Saurabh (Rob) Aggarwal, PhD Principal & Co-Founder 1-202-618-9365 sa2@novelhealthstrategies.com www.NOVELHEALTHSTRATEGIES.COM