Sciatica is pain that radiates from the lower back down the back of the thigh and leg. It is caused by irritation or compression of the sciatic nerve, which can occur due to herniated discs, spinal stenosis, spondylolisthesis, or other causes like tumors or infections. Symptoms include pain that is worsened by certain movements and activities, numbness, and difficulty walking. Diagnosis involves physical examination including straight leg raise testing and neurological evaluation, as well as imaging like MRI or CT scan. Treatment options include medications, physiotherapy, surgery such as laminectomy or removal of bone compressing the nerve.