This document provides information about the sciatic nerve and muscles it innervates. It originates from the ischial tuberosity and inserts into the tibia and fibula bones of the leg. It is supplied by the tibial division of the sciatic nerve. The muscles it innervates allow for flexion of the knee and extension of the hip. These muscles include the semitendinosus, semimembranosus, and biceps femoris. Compression of the sciatic nerve can occur against the femur or from conditions like lumbar disc prolapse and can result in shooting pain along the nerve's cutaneous distribution.