Scabies is a skin infection caused by the Sarcoptes scabiei mite. It causes an itchy rash and affects nearly 130 million people worldwide, with prevalence rates in India ranging from 13-59% in rural and urban areas respectively. Scabies presents as itchy papules and vesicles located typically on hands, wrists, feet, and genitalia. It can develop into more severe forms like nodular or crusted scabies in immunocompromised individuals. Treatment involves topical scabicides like permethrin or oral ivermectin. Proper hygiene and avoiding shared items can help prevent transmission.
dermatological disease caused by bacterial infection (Staphylococcus aureus & Streptococcus pyrogen) contagious disease but it is easy to cure by taking oral antibiotics and topical antibiotic cream
dermatological disease caused by bacterial infection (Staphylococcus aureus & Streptococcus pyrogen) contagious disease but it is easy to cure by taking oral antibiotics and topical antibiotic cream
Scabies is a superficial epidermal infestation by the mite Sarcoptes scabiei var. hominis.
Etiologic Agent:
S. scabiei var. hominis. Thrive and multiply only on human skin, i.e., obligate human parasite.
Transmission
Skin-to-skin contact
Fomites: Mites can remain alive for >2 days on clothing or in bedding; hence, scabies can be acquired without skin-to-skin contact.
intimate personal contact, such as having sexual intercourse
Scabietic (Scabious) Nodule: Inflammatory papule or nodule ;burrow sometimes seen on the surface of a very early lesion. • Distribution : Areola, axillae, scrotum, penis.
This is a seminar conducted by 4th year medical student under supervision of a lecturer. Sorry for not attaching the references.
Information were from few textbooks, google and also from previous dermatology posting group's seminar.
Pathophysiology of scabies
Clinical presentation,
Principles of treatment.
Antiscabietic drugs: permethrin, benzyl benzoate, crotamiton,lindane and Ivermectin.
Instruction to patien,t
Clinical problem and
Causes of persistent itching
Scabies
Causative organism: Sarcoptes scabiei var. hominis (Itch mite).
Highly contagious disease
spreads in households and environments where there is intimate personal contact
Transmitted through infected clothes, linens and sexual contacts.
PATHOGENESIS
CLASSIFICATION
Classical
Nodular scabies
Crusted (Norwegian) scabies
Bullous scabies
PREDISPOSING FACTORS
Lack of hygiene
Low socioeconomic conditions
Close physical contacts
Immunocompromisation
Vagabond
Old age
Hospital stay
Down syndrome, Organ transplant, Leukemia, AIDS patients
CLINICAL FEATURES
Pathognomonic lesion:
Burrow which is slightly elevated, greyish and tortuous lines. Vesicle or pustule containing the mite may be found found at the end of the burrow
(Definition: a linear or curvilinear papule, caused by a burrowing scabies mite)
Papules, excoriations, bulla, crust and lichenification occurs.
Pruritus is prominent symptom which is severe and usually more intense in the night.
Even after successful treatment, itch can continue and occasionally nodular lesions persist.
SITES
Finger webs
Wrists
Axilla
Nipple and Areola
Umbilicus
Lower abdomen
Genitalia
Buttock
Scrotum and penis
Face and scalp in infant
Around and underneath nails
Involvement of the genitals in males and of the nipples in females are pathognomic.
COMPLICATIONS
Local:
Secondary bacterial infections – impetigo, folliculitis, furunculosis.
Eczematization
systemic: acute glomerulonephritis
INVESTIAGATIONS
The diagnosis is made by identifying the scabietic burrow and visualizing the mite (by extracting with a needle under microscope or using a dermatoscope).
Burrow is detected with gentian violet and then the organism is isolated with needle or scalpel and visualized under microscope.
TREATMENT
General measures
Counselling and reassurance
Maintenance of personal hygiene
Treatment of family members and close contacts at a time.
Washing of clothes and beddings.
Specific measures
Topical therapy
1.5% permethrin cream – 2 applications 1 week apart., Apply all over the body (except head and face in adults) and keep it for 8 to 12 hours. Then wash off .
All family members and physical contacts need to apply in the same way at same time.
2.25% Benzyl benzoate
3.Crotamiton 10% cream
4.10% precipitated sulphur
5.Malathion
6.Lindane
7.Monosulfirum
Systemic therapy
Ivermectin: single dose in case of severe infestation and in immunosuppressed patients.
Scabies is a superficial epidermal infestation by the mite Sarcoptes scabiei var. hominis.
Etiologic Agent:
S. scabiei var. hominis. Thrive and multiply only on human skin, i.e., obligate human parasite.
Transmission
Skin-to-skin contact
Fomites: Mites can remain alive for >2 days on clothing or in bedding; hence, scabies can be acquired without skin-to-skin contact.
intimate personal contact, such as having sexual intercourse
Scabietic (Scabious) Nodule: Inflammatory papule or nodule ;burrow sometimes seen on the surface of a very early lesion. • Distribution : Areola, axillae, scrotum, penis.
This is a seminar conducted by 4th year medical student under supervision of a lecturer. Sorry for not attaching the references.
Information were from few textbooks, google and also from previous dermatology posting group's seminar.
Pathophysiology of scabies
Clinical presentation,
Principles of treatment.
Antiscabietic drugs: permethrin, benzyl benzoate, crotamiton,lindane and Ivermectin.
Instruction to patien,t
Clinical problem and
Causes of persistent itching
Scabies
Causative organism: Sarcoptes scabiei var. hominis (Itch mite).
Highly contagious disease
spreads in households and environments where there is intimate personal contact
Transmitted through infected clothes, linens and sexual contacts.
PATHOGENESIS
CLASSIFICATION
Classical
Nodular scabies
Crusted (Norwegian) scabies
Bullous scabies
PREDISPOSING FACTORS
Lack of hygiene
Low socioeconomic conditions
Close physical contacts
Immunocompromisation
Vagabond
Old age
Hospital stay
Down syndrome, Organ transplant, Leukemia, AIDS patients
CLINICAL FEATURES
Pathognomonic lesion:
Burrow which is slightly elevated, greyish and tortuous lines. Vesicle or pustule containing the mite may be found found at the end of the burrow
(Definition: a linear or curvilinear papule, caused by a burrowing scabies mite)
Papules, excoriations, bulla, crust and lichenification occurs.
Pruritus is prominent symptom which is severe and usually more intense in the night.
Even after successful treatment, itch can continue and occasionally nodular lesions persist.
SITES
Finger webs
Wrists
Axilla
Nipple and Areola
Umbilicus
Lower abdomen
Genitalia
Buttock
Scrotum and penis
Face and scalp in infant
Around and underneath nails
Involvement of the genitals in males and of the nipples in females are pathognomic.
COMPLICATIONS
Local:
Secondary bacterial infections – impetigo, folliculitis, furunculosis.
Eczematization
systemic: acute glomerulonephritis
INVESTIAGATIONS
The diagnosis is made by identifying the scabietic burrow and visualizing the mite (by extracting with a needle under microscope or using a dermatoscope).
Burrow is detected with gentian violet and then the organism is isolated with needle or scalpel and visualized under microscope.
TREATMENT
General measures
Counselling and reassurance
Maintenance of personal hygiene
Treatment of family members and close contacts at a time.
Washing of clothes and beddings.
Specific measures
Topical therapy
1.5% permethrin cream – 2 applications 1 week apart., Apply all over the body (except head and face in adults) and keep it for 8 to 12 hours. Then wash off .
All family members and physical contacts need to apply in the same way at same time.
2.25% Benzyl benzoate
3.Crotamiton 10% cream
4.10% precipitated sulphur
5.Malathion
6.Lindane
7.Monosulfirum
Systemic therapy
Ivermectin: single dose in case of severe infestation and in immunosuppressed patients.
It is an immune system condition that causes the rapid buildup of skin cells.
It is a long term (chronic) disease.
It is most commonly seen the knees, elbows, trunk, and scalp.
It is a chronic inflammatory disease of the sebaceous glands.
It may be occur on areas of the body that have sebaceous glands such as face, neck, back and shoulders.
It is associated with high rail of sebum secretion.
It has two types of acne such as inflammatory, in which the hair follicle is blocked by sebum that may be cause by bacteria and eventually rupture the follicle and second non inflammatory, in which the follicle doesn't rupture but remains dilated.
Acne is a disease that involves the oil glands of the skin.
It is not dangerous.
Acne occurs most commonly during adolescence, and often continues into adulthood. In adolescence, acne is usually caused by an increase in testosterone, which people of both genders during puberty.
There are various types of pimples
Whiteheads - remain under the skin and are very small.
Blackheads - clearly visible, they are black and appear on the surface of the skin.
Papules - visible on the surface of the skin. They are small bumps, usually pink.
Pustules - clearly visible on the surface of the skin. They are red at their base and have pus at the top.
Nodules - clearly visible on the surface of the skin. They are large, solid pimples. They are painful and are embedded deep in the skin.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
6. CRUSTED SCABIES/ NORWEGIAN SCABIES
• More severe and extremely contagious type of Scabies
• People develop thick crusts of skin that contain thousands of mites and eggs
• It develops in people with weak immune system
15. DRUGS USED IN TREATMENT OF SCABIES
Drug Category Mode of action Dose Adverse affects
Permethrin Topical
Scabicidal
Kills parasite by
affecting their
nerve cells
5% cream-BD for 7 days Burning
Stinging
Pruritis
Hypersensitivity
Crotamiton Topical
antipruritic
agent
Counter irritant
effect by cooling
the skin
10% lotion-OD for 7 days Allergic contact dermatitis
Rash
Pruritis
Hypersensitivity
Warm sensation
Sulfur Topical anti
acne agent
It shows
keratolytic action
and also have
Scabicidal action
5-10% -HS-for 3 days Erythema
Excessive desquamation
Skin irritation
Skin inflammation
Hypersensitivity
16. Lindane Topical
Scabicidal
Kills parasite by
affecting their
nerve cells
1% lotion-BD Local irritation
Contact dermatitis
Alopecia
Conjunctivitis
Rash
Ivermectin Anti helmenthic
agent
Kills parasite by
affecting their
nerve cells
200mcg/kg/day for 3 days like
1,2, and 8 th day-PO
Asthenia
Hypotension
Peripheral oedema
Transient
tachycardia
Insomnia
Benzyl
benzoate
Topical
Scabicidal
Kills parasite by
affecting their
nerve cells
5% lotion-BD for 7 days Application site
irritation
Pruritis
Erythema
Ocular irritation
Dandruff
17. Salicylic acid Topical
keratolytic
agent
Dissolves the
intracellular
cement and
helps in
desquamation
of hard skin
5% cream-BD for 7 days Stinging
Peeling
Scaling
Dizziness
Head ache
Cetrizine Anti histamine Competes with
histamine on
effector cells
and blocks
histamine
actions
10mg-HS -PO Somnolence
Head ache
Fatigue
Dry mouth
Malaise
