This PowerPoint presentation summarizes information about psoriasis for a medical student presentation. It defines psoriasis as a chronic inflammatory skin disease causing rapid skin cell production, buildup, and flaking. The presentation covers the types of psoriasis including plaque, guttate, inverse, pustular, and erythrodermic psoriasis. It discusses the genetic and environmental factors involved in psoriasis development and outlines management approaches like topical treatments, phototherapy, and systemic drugs. The presentation concludes by summarizing results from an Italian study finding high rates of depressive symptoms in psoriasis patients, particularly younger men and those with less education.

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Peer Group Presentation
Subject – Medical Surgical Nursing
Topic – Psoriasis
Presented by
Mr. Hari Singh Nagar
M.Sc Nursing 1st year

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Psoriasis
It is one of the most common skin disease.
It is thought that this chronic disease stems
from a hereditary effect that causes
overproduction of keratin.
Incidence - It affect approximately 2% of
the population. It occurs in any age, most
commonly occurs in people between 15-35
years of age.

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Definition
It is a chronic, non-infectious skin inflammation
involving keratin synthesis that results in psoriatic
patches.
It is an inflammatory skin disease in which the skin
cell replicate at an extremely rapid rate. New cells
are produced 8 times faster then normal but the rate
at which old cells sloughed off is unchanged, this
cause the cell build up on skin surface, forming thick
patches or plaque of red sores, covered with flaky,
silvery white dead skin cells (scale).

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Etiology
• Unknown
• Genetic
Some factor may aggravate the condition such as: -
• Stress
• Smoking, alcohol
• Trauma
• Obesity
• Hormonal changes
• Climate
• Autoimmune disease
• Medication – lithium salt, beta blockers

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Types of psoriasis
Plaque psoriasis – also known
as psoriasis vulgaris.
It appear as raised, inflamed
red skin, covered by silvery
patches or scales.
Site are: - elbow, knee,
sacrum, scalp, hands, feet's
& lower back.

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Guttate psoriasis
Eruption of small papule
over the upper trunk and
proximal extremities.

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Inverse psoriasis
It is found in the skin
folds such as inguinal,
axilla and sweating
areas. Scaling is minimal
or absent and lesion
appears glossy, smooth
and bright red.

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Pustular psoriasis
It is an pus filled lesion
surrounded by a red
skin. It appears at hands
and feet.

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Erythrodermic psoriasis
it is a superficial scaling/
peeling that may appear
like burning. It affect all
the body sites. Causes is
sunburn, allergic
reaction and strong coal
product use.

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Nail psoriasis
It appear as small nail,
yellow brown nail with
chalk like debris build
up under nails.

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Psoriatic arthritis
This condition involve
both psoriasis and joint
inflammation.

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Pathophysiology
Due to E/F
Hyperactivity of T-cells
Epidermis infiltration & keratinocyte proliferation
Deregulated inflammatory response
Large production of various cytokines
Superficial blood vessels dilated and vascular engorgement
Epidermal hyperplasia & improper cell maturation
Fails to release adequate lipid which lead to flaking,
scaling presentation of psoriasis lesion
Silvery scale of the skin

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Clinical manifestation
• The first sign is ‘red spot’ on body.
• Patches of the skin is dry, swollen and inflamed covered
with silvery flakes.
• Raised and thick skin.
• Pain, itching and burning.
• Yellow discolouration, pitting and thickening of the nails
are noted if they are affected.
• Cracked and bleeding points, if the scale are scraped
away.
• Koebner phenomenon – it is develop at the site of injury
such as scratch or sunburn.

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Diagnostic evaluation
• History
• Physical examination
• Skin biopsy
• Blood and radiography to rule out psoriatic arthritis.

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Management
1. Topical treatment – it slow overactive epidermis.
I. Topical corticosteroids – they slow the turnover by
suppressing the immune system which reduce
inflammation & relieve itching.
II. Topical steroids
III. Vitamin D analogues – e.g.. – calcipotriene, it
suppress epidermopoiesis (development of epidermal
cells) causing sloughing of growing epidermal cells.
IV. Coal tar – dry distillation product of organic matter
heated in the absence of oxygen, combination of
creams, ointments and pastes.

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V. Tazarotene – it reduce mainly scaling & plaque
Thickness, normalize the DNA activity.
VI. Topical Calcineurin Inhibitors – tracolimus, they
inhibit activation of the cells which reduce
inflammation and plaque build up.
VII. Emollients – to avoid dryness. It reduce scaling and
limit pain.
2. Phototherapy
I. Sunlight – activated T-cells in skin are destroy lead to
reduce scaling and inflammation.
II. UV broadband phototherapy – artificial light

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sources. It used to treat single patches.
IV. Photo chemotherapy Plus UVA – light sensitizing
medication taken before exposure to UV light.
V. Eximer laser – control beam of UVB light directed to
psoriatic plaque to control scaling.
VI. Pulse dye laser – it destroy the tiny blood vessels that
contribute psoriasis.
3. Systemic therapy – e.g. Cyclosporine, methotraxate,
acitretin.
Complication
• Psoriatic arthritis
• Erythrodermic psoriasis

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Nursing management
1. Nursing diagnosis – Impaired skin integrity related to
lesion & inflammatory response as evidence by itching
all over the body.
Nursing goal – To maintain skin integrity
Intervention
• To advice the patient not to scratch the affected areas.
• Too frequent washing produce more soreness & scaling
water should be warm, not hot and the skin should be
dry by patting a towel rather then rubbing. .
• Apply a thin film of emollients after washing the area.
• Provide a calorie and high protein diet.

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2. Nursing diagnosis – risk of infection related to
hyponatremia as evidence by loss of protein and fluid
from lesion.
Nursing goal – To prevent from infection
Intervention
• Monitor vital sign.
• Examine for sign of infection.
• Keep the lesion clean.
• Motivate the patient to improve the nutrition.
• To provide the antibiotics.

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3. Nursing diagnosis – acute pain related to inflammation
as evidence by patient verbalization.
Nursing goal – to reduce the pain
Intervention
• Provide the emollients after washing the area it will
relieve the soreness.
• To provide the comfort measures.
• To provide the pain medication which relieves pain.

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Recent studies on psoriasis
An Italian Study on Psoriasis and Depression
The aim of this study was to investigate the prevalence
of depressive symptomatology among Italian patients
with psoriasis vulgaris,
Depression Scale (CES-D) questionnaire, a 20-item
instrument developed to perform epidemiological
studies of depressive symptomatology in the general
population.

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Recent studies on psoriasis
Results:
• We received evaluable questionnaires from 2,391
patients, including 1,528 men (63.9%) and 863 women
(36.1%).
• Depressive symptomatology was observed in 1,482/2,391
patients (62% overall; females, 63%; males, 61%).
• Men <40 years of age were significantly more likely to
report depressive symptoms than were men ≧40 years of
age.
• Depressive symptomatology was more prevalent in
psoriatic patients with only primary or secondary
education than in psoriatic patients with higher education.

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