Scabies is caused by tiny burrowing mites that infest the skin and lay eggs, causing intense itching. It spreads through direct, prolonged skin-to-skin contact. The mites burrow beneath the skin and lay eggs, causing a rash and itching that is usually worse at night. Scabies is diagnosed through examination of burrows and microscopic identification of mites. Treatment involves applying prescription creams or lotions to kill the mites. Multiple treatments and treating all contacts is usually needed to prevent reinfestation.