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International Research Journal of Engineering and Technology (IRJET) e-ISSN: 2395 -0056
Volume: 04 Issue: 06 | June -2017 www.irjet.net p-ISSN: 2395-0072
© 2017, IRJET | Impact Factor value: 5.181 | ISO 9001:2008 Certified Journal | Page 1383
Real Time Implementation of Ede Detection Technique for Angiogram
Images on FPGA
SAJANA UMMER1, SREEKUMAR R.2
1Mtech Student, Dept. Of Ece, Gec Idukki
2 Asst. Professor, Dept. Of Ece,Gec Idukki, Kerala,India
---------------------------------------------------------------------***---------------------------------------------------------------------
Abstract - An X-ray test that takes pictures of the blood
flow in blood vessels is termed as angiography. An angiogram
can look at the arteries near the heart, lungs, brain, head,
arms, legs and the aorta. An angiogram is prepared to detect
problems with veins and arteries that affect blood flow.
Examples of such problems include a tear in a blood vessel,
pattern of blood flow to a tumor, check how bad
atherosclerosis is in the coronary arteries, or check for blocks
in coronary arteries etc. Analysis of the angiogram images
uses different image processing techniques such as image
enhancement, segmentation etc. Also such a high end analysis
requires high speed and a large amount of accuracy. This
paper detects edges of vessels in an angiogram image, by
means of a new algorithm on FPGA and compares the results
with existing classical image processing algorithms. Steps
involved are Histogram equalization technique, a new
algorithm for Canny edge Detector. Exploiting the parallelism
in algorithms yields considerable speedup in running times.
The proposed design is coded in Verilog HDL and synthesized
using ISE design suite14.2andimplementedonARTIX-7FPGA.
Key Words: Angiography, Image segmentation, Image
enhancement, Canny edge detector, Histogram
Equalization, FPGA
1. INTRODUCTION
Detection and analysis of blood vessels in an angiogram
image depends upon segmentation. One of the important
image segmentation processes is the edge detection. An
image processing technique for finding the boundaries of
objects within images is termed as edge detection. It works
by detecting discontinuities in brightness. Edge detection
has prime importance in digital image processing. Edge
detection removes worthless data, noise, and frequencies
while extracting vascular regions from other background
regions in an image. It is a process of partitioning an image
into several non- overlapping regions. Based on the results
obtained, surfaces of vasculaturescanbeextracted,andused
in the detection of vascular diseases.Developinga consistent
and accurate image segmentation method is therefore
important for making angiography useful and proficient.
Various edge detection techniques Are availablefor
image extraction etc. Each technique is constructed to be
shrewd for firm types of edges. Among them Prewitt, Sobel,
Robert, Canny are the foremost techniques. Canny edge
detector is one which is commonly used due to its superior
performance and accurate edge detection. Even though the
accuracy of conventional canny edge detector is high, it is
computationally very complex and very susceptibletonoise.
If the edge detection step is successful, the subsequent task
of interpreting the information contents in the original
image may, therefore, be substantially simplified. Our aim is
to reduce the latency and computational complexity without
sacrificing the edge detection performance. Existing Canny
algorithms fails to detect accurate edges for a less contrast
images [1,9]. In such situations theproposedalgorithmhasa
wide application. The new algorithm has reduced
computational complexity and reduced delay and a good
edge detection performance
2. Literature Survey
Many implementations of theCannyalgorithmwasproposed
on a widelist of hardware platforms. Thereisasetofworkon
Deriche filters that have been derived using Canny’s criteria
and implemented on ASIC-based platforms. A highlyefficient
algorithm which uses a recursive filter for edge detection is
presented [2].
The cost is still toohighforrealtimeimplementation
on FPGA circuits. A design which is optimized both
algorithmic and architectural aspects of the original Deriche
filter. A new organization of the filter is proposed at the 2D
and 1D levels which reduce the memory size and the
computation cost by a factor of two for both software and
hardware implementations [3].
The canny edge detection is able to significantly
outperform existing edge detection techniques due to its
superior performance. Unfortunately,theimplementationof
the systems in real time is computationally complex, high
hardware cost with increased latency. The algorithm in this
paper uses approximation methods to replace the complex
operations; the pipelining is employed to reduce the latency
[4].
In this paper edge detection on a Real Time Image
Capture is implemented. The video is captured and then
interfaced with FPGA kit and the edge detected image is
shown in VGA display. In addition, Canny Edge Detection
algorithm is used to obtain the edge detected version of the
RGB image captured by the interfaced camera [5].
An edge detection method for vascular angiogram
tree, which is an important step in computeraideddiagnosis
on vascular diseases. It combines classical edge detection
algorithms except canny to detect edge points and uses the
connection for edge points based on the shortest path [6].
International Research Journal of Engineering and Technology (IRJET) e-ISSN: 2395 -0056
Volume: 04 Issue: 06 | June -2017 www.irjet.net p-ISSN: 2395-0072
© 2017, IRJET | Impact Factor value: 5.181 | ISO 9001:2008 Certified Journal | Page 1384
We propose a completely computerized method to
enhance the angiogram images and detect the arteries. The
method contains three steps which are Hessian filter
enhancement, feature extraction andvessel regiondetection
[7].
An image processing technique to detect calcified
plaques hampering to diagnose vessel lumen from CCTA
(Coronary Computed Tomography Angiography) image
using MSCT (Multi-Slice Computed Tomography) is
presented [8].
3. Proposed System
The beginning stages of image processing identify
the features in images that are significant in estimating the
structure and properties of objects. Edges are important
features for analyzing images. It occurs on the boundary
between two different regions in an image. Edge pixels are
defined as the pixels at which the intensity profile in an
image function changes abruptly. Edges are the set of
connected edge pixels. Edge detection is probably the first
step in recovering information from images. The
methodology used in this paper as follows:
Fig -1: flow chart of propose system
Proposed algorithm:
Step 1: Read the given angiogram image, and convert it into
gray scale image.
Step2: Apply HE to enhance the image.
Step3: Apply Sobel operator to find gradients in X and Y
direction and calculate gradient magnitude and direction.
Step4: Apply Non maximum suppression to preserve the
local maxima and discard the local minima.
Step5: Apply double thresholding to find out which are all
the edge points in the final output .
Step6: Obtain the hysteresis to get final edge map of the
angiogram image.
Fig -1 shows the flow chart of the propose system. First the
image is converted to gray scale the apply pre processing
steps and finally apply the edge detection algorithm to find
the edge map.
3.1 Histogram Equalization
The principal objective of image enhancement is to
process a given image so that the result ismoresuitablethan
the original image for a specific application. It accentuates
image features such as edges, boundaries, or contrast to
make a graphic display more helpful fordisplayandanalysis.
The enhancement doesn't increase the inherentinformation
content of the data, but it increases the dynamic range of the
selected features so that they can be detected easily. HE is a
contrast adjustmenttechnique.Ahistogramistheestimation
of the probability distribution of a particular type of data.
Fig-2 histogram equalization
3.1 Edge Detection
Edge detection algorithm relies on block level
statistics instead of frame level statistics. The direct
application of original Canny to block leads to a wrong
detection because the statistics of blocks are different from
that of the entire image. The proposed edge detection
algorithm has mainly five steps like conventional Canny’s
algorithm. The difference is that the former one uses an
adaptive threshold selections scheme for threshold
calculation.
International Research Journal of Engineering and Technology (IRJET) e-ISSN: 2395 -0056
Volume: 04 Issue: 06 | June -2017 www.irjet.net p-ISSN: 2395-0072
© 2017, IRJET | Impact Factor value: 5.181 | ISO 9001:2008 Certified Journal | Page 1385
(i)Pixel and block classification
First, the mean and variance are calculated.
According to the value of variance, each pixel is classified as
uniform, texture or edge pixels. There are two threshold
values Tu (for uniform pixels) and Te (for edge pixels). Here
Tu=900 and Te=100.
Table -1 Block classification
(ii) Gradient magnitude and direction calculation
We have defined edges as abrupt changes in
intensity, to detect edges all we need is to find edge pixels;
the physical derivative gives rate change functions. So,
derivative can be used to detect edge pixels. The first
derivate sometimes called the gradient of the pixels is
calculated. We use Sobel operator for gradient calculationof
each pixel in X and Y directions.
The gradient magnitudes (also known asthe edgestrengths)
and direction can then be determined as:
|G| =|Gx|+|Gy|
(iii) Directional Non Maximum Suppression
The edges are made slender by converting the
blurred edges of the imagegradientsintopointed edges.This
can be accomplished by suppressing the local minima and
preserving the local maxima in the gradient image.
Horizontal and vertical gradient stored in the memory are
the input to the NMS unit. Depending upon the directionand
magnitude of four neighbourhood pixels, two intermediate
magnitude values (M1(x,y), M2(x,y))arecalculatedaccording
to the equation.
M1(x,y) =(1-d)*M(x+1,y-1)+d* M(x+1,y-1)
M2(x,y) =(1-d)*M(x-1,y-1)+d* M(x-1,y)
iv)Threshold calculation:
Threshold calculation is the decisive steps in the
edge detection algorithm. The performance of Canny edge
detector depend upon threshold values and so these values
should be calculated with high accuracy. The input to the
threshold calculation unit is the output of NMS unit. The
median value of the gradient magnitude helps to find the
value of thresholds and is based on the histogram of the
gradient magnitude. Th=0.66*median value and low
threshold Tl=42% of Th.
(v)Thresholding with Hysteresis
Non-maximum suppression technique finds the physically
powerful edges and they may be affected by noise and
lighting conditions. If the gradient magnitude isgreaterthan
the high threshold, then it is the strong edge pixel and those
edges are conserved. If gradient magnitude is lowerthanthe
low threshold, those edges are discarded. If the gradient
magnitude value lies between low and high threshold then
further investigation is done. The currentpixel isconsidered
as a strong edge pixel if any of the neighbours of the current
pixel is strong edge pixel; otherwise, it is suppressed ie,
those who lie between these two thresholds are classified
edges or non-edges based on their connectivity.
This algorithm is computationally less complex but
gives accurate results if the image is corrupted by noise and
for less contrast images. Also this has reduced latency and
increased speed by the incorporating pipelining and
parallelism in the algorithm.
Fig-3: Parallel execution
International Research Journal of Engineering and Technology (IRJET) e-ISSN: 2395 -0056
Volume: 04 Issue: 06 | June -2017 www.irjet.net p-ISSN: 2395-0072
© 2017, IRJET | Impact Factor value: 5.181 | ISO 9001:2008 Certified Journal | Page 1386
4. Experimental Results
TheproposedFPGA-basedarchitecturecanmaintain
multiple image sizes and block sizes. To show the
performance of the proposed system, a Xilinx Artix-7 FPGA
was used to process grayscale images with a block size of
64 × 64. The angiogram image is considered as the input for
applying the edge detection techniques. Following figures
shows the experimental results. Fig 5 shows the RTL
schematic of the system.TheproposedFPGAimplementation
takes only 0.562ms for execution.
(a) (b)
(c) (d) (e)
Fig-4: Results obtained (a) original image (b)
Enhanced image(c) canny edge detection (d)
distributed canny (e) proposed system.
Fig-5: RTL schematic of the system
5. CONCLUSIONS
The proposed algorithm detects edges of blood
vessels from an angiogram image by image processing
techniques. It is observed that edges thus segmented are
both precise and lucid. Steps involved in this algorithm are
easy and straightforward for implementation. Resultsprove
that detection of algorithms is proficient and useful in
determining edges. The work has compared different edge
detecting techniques. Also, the proposed FPGA
implementation takes only 0.562ms for execution.
REFERENCES
[1] Qian Xu, Srenivas Varadarajan, Chaitali Chakrabartiand
Lina J. Karam, (JULY 2014), “A Distributed Canny Edge
Detector: Algorithm and FPGA Implementation”, IEEE
Transactions On Image Processing, VOL. 23, NO. 7, pp.
2944-2960.
[2] R. Deriche, “Using canny criteria to derive a recursively
implemented optimal edge detector,” Int.J.Comput.Vis.,
vol. 1, no. 2, pp. 167–187, 1987.
[3] F. G. Lorca, L. Kessal, and D. Demigny, (Oct. 1997),
“Efficient ASIC and FPGA implementation of IIR filters
for real time edge detection,” Proc. IEEE ICIP, vol. 2, pp.
406–409.
[4] Sangeetha, D. and Deepa, P., (2016, January) “An
Efficient Hardware Implementation of Canny Edge
Detection Algorithm” VLSI Design and 2016 15th
International Conferenceon EmbeddedSystems(VLSID)
IEEE, pp. 457-462.
[5] Jeyakumar, R., Prakash, M., Sivanantham, S. and
Sivasankaran, K, (2015, November) “FPGA
implementation of edge detection using Canny
algorithm” Green Engineering and Technologies (IC-
GET) IEEE, pp. 1-4.
[6] Hu, Haijiang, et al. "Simple edge detection method for
vascular tree angiogram." Advanced Information
Technology, Electronic and Automation Control
Conference (IAEAC), 2015 IEEE. IEEE, 2015.
[7] Fazlali, H. R., et al. "Vessel region detection in coronary
X-ray angiograms." Image Processing (ICIP), 2015 IEEE
International Conference on. IEEE, 2015.
[8] Yoshida, Yuki, et al. "Semi-automatic detection of
calcified plaque in coronary CT angiograms with 320-
MSCT." Signal Processing Conference (EUSIPCO), 2016
24th European. IEEE, 2016.
[9] J. F. Canny, (Nov. 1986), “A computation approach to
edge detection,” IEEE Trans. Pattern Anal. Mach. Intell.,
vol. 8, no. 6, pp. 769–798.

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  • 1. International Research Journal of Engineering and Technology (IRJET) e-ISSN: 2395 -0056 Volume: 04 Issue: 06 | June -2017 www.irjet.net p-ISSN: 2395-0072 © 2017, IRJET | Impact Factor value: 5.181 | ISO 9001:2008 Certified Journal | Page 1383 Real Time Implementation of Ede Detection Technique for Angiogram Images on FPGA SAJANA UMMER1, SREEKUMAR R.2 1Mtech Student, Dept. Of Ece, Gec Idukki 2 Asst. Professor, Dept. Of Ece,Gec Idukki, Kerala,India ---------------------------------------------------------------------***--------------------------------------------------------------------- Abstract - An X-ray test that takes pictures of the blood flow in blood vessels is termed as angiography. An angiogram can look at the arteries near the heart, lungs, brain, head, arms, legs and the aorta. An angiogram is prepared to detect problems with veins and arteries that affect blood flow. Examples of such problems include a tear in a blood vessel, pattern of blood flow to a tumor, check how bad atherosclerosis is in the coronary arteries, or check for blocks in coronary arteries etc. Analysis of the angiogram images uses different image processing techniques such as image enhancement, segmentation etc. Also such a high end analysis requires high speed and a large amount of accuracy. This paper detects edges of vessels in an angiogram image, by means of a new algorithm on FPGA and compares the results with existing classical image processing algorithms. Steps involved are Histogram equalization technique, a new algorithm for Canny edge Detector. Exploiting the parallelism in algorithms yields considerable speedup in running times. The proposed design is coded in Verilog HDL and synthesized using ISE design suite14.2andimplementedonARTIX-7FPGA. Key Words: Angiography, Image segmentation, Image enhancement, Canny edge detector, Histogram Equalization, FPGA 1. INTRODUCTION Detection and analysis of blood vessels in an angiogram image depends upon segmentation. One of the important image segmentation processes is the edge detection. An image processing technique for finding the boundaries of objects within images is termed as edge detection. It works by detecting discontinuities in brightness. Edge detection has prime importance in digital image processing. Edge detection removes worthless data, noise, and frequencies while extracting vascular regions from other background regions in an image. It is a process of partitioning an image into several non- overlapping regions. Based on the results obtained, surfaces of vasculaturescanbeextracted,andused in the detection of vascular diseases.Developinga consistent and accurate image segmentation method is therefore important for making angiography useful and proficient. Various edge detection techniques Are availablefor image extraction etc. Each technique is constructed to be shrewd for firm types of edges. Among them Prewitt, Sobel, Robert, Canny are the foremost techniques. Canny edge detector is one which is commonly used due to its superior performance and accurate edge detection. Even though the accuracy of conventional canny edge detector is high, it is computationally very complex and very susceptibletonoise. If the edge detection step is successful, the subsequent task of interpreting the information contents in the original image may, therefore, be substantially simplified. Our aim is to reduce the latency and computational complexity without sacrificing the edge detection performance. Existing Canny algorithms fails to detect accurate edges for a less contrast images [1,9]. In such situations theproposedalgorithmhasa wide application. The new algorithm has reduced computational complexity and reduced delay and a good edge detection performance 2. Literature Survey Many implementations of theCannyalgorithmwasproposed on a widelist of hardware platforms. Thereisasetofworkon Deriche filters that have been derived using Canny’s criteria and implemented on ASIC-based platforms. A highlyefficient algorithm which uses a recursive filter for edge detection is presented [2]. The cost is still toohighforrealtimeimplementation on FPGA circuits. A design which is optimized both algorithmic and architectural aspects of the original Deriche filter. A new organization of the filter is proposed at the 2D and 1D levels which reduce the memory size and the computation cost by a factor of two for both software and hardware implementations [3]. The canny edge detection is able to significantly outperform existing edge detection techniques due to its superior performance. Unfortunately,theimplementationof the systems in real time is computationally complex, high hardware cost with increased latency. The algorithm in this paper uses approximation methods to replace the complex operations; the pipelining is employed to reduce the latency [4]. In this paper edge detection on a Real Time Image Capture is implemented. The video is captured and then interfaced with FPGA kit and the edge detected image is shown in VGA display. In addition, Canny Edge Detection algorithm is used to obtain the edge detected version of the RGB image captured by the interfaced camera [5]. An edge detection method for vascular angiogram tree, which is an important step in computeraideddiagnosis on vascular diseases. It combines classical edge detection algorithms except canny to detect edge points and uses the connection for edge points based on the shortest path [6].
  • 2. International Research Journal of Engineering and Technology (IRJET) e-ISSN: 2395 -0056 Volume: 04 Issue: 06 | June -2017 www.irjet.net p-ISSN: 2395-0072 © 2017, IRJET | Impact Factor value: 5.181 | ISO 9001:2008 Certified Journal | Page 1384 We propose a completely computerized method to enhance the angiogram images and detect the arteries. The method contains three steps which are Hessian filter enhancement, feature extraction andvessel regiondetection [7]. An image processing technique to detect calcified plaques hampering to diagnose vessel lumen from CCTA (Coronary Computed Tomography Angiography) image using MSCT (Multi-Slice Computed Tomography) is presented [8]. 3. Proposed System The beginning stages of image processing identify the features in images that are significant in estimating the structure and properties of objects. Edges are important features for analyzing images. It occurs on the boundary between two different regions in an image. Edge pixels are defined as the pixels at which the intensity profile in an image function changes abruptly. Edges are the set of connected edge pixels. Edge detection is probably the first step in recovering information from images. The methodology used in this paper as follows: Fig -1: flow chart of propose system Proposed algorithm: Step 1: Read the given angiogram image, and convert it into gray scale image. Step2: Apply HE to enhance the image. Step3: Apply Sobel operator to find gradients in X and Y direction and calculate gradient magnitude and direction. Step4: Apply Non maximum suppression to preserve the local maxima and discard the local minima. Step5: Apply double thresholding to find out which are all the edge points in the final output . Step6: Obtain the hysteresis to get final edge map of the angiogram image. Fig -1 shows the flow chart of the propose system. First the image is converted to gray scale the apply pre processing steps and finally apply the edge detection algorithm to find the edge map. 3.1 Histogram Equalization The principal objective of image enhancement is to process a given image so that the result ismoresuitablethan the original image for a specific application. It accentuates image features such as edges, boundaries, or contrast to make a graphic display more helpful fordisplayandanalysis. The enhancement doesn't increase the inherentinformation content of the data, but it increases the dynamic range of the selected features so that they can be detected easily. HE is a contrast adjustmenttechnique.Ahistogramistheestimation of the probability distribution of a particular type of data. Fig-2 histogram equalization 3.1 Edge Detection Edge detection algorithm relies on block level statistics instead of frame level statistics. The direct application of original Canny to block leads to a wrong detection because the statistics of blocks are different from that of the entire image. The proposed edge detection algorithm has mainly five steps like conventional Canny’s algorithm. The difference is that the former one uses an adaptive threshold selections scheme for threshold calculation.
  • 3. International Research Journal of Engineering and Technology (IRJET) e-ISSN: 2395 -0056 Volume: 04 Issue: 06 | June -2017 www.irjet.net p-ISSN: 2395-0072 © 2017, IRJET | Impact Factor value: 5.181 | ISO 9001:2008 Certified Journal | Page 1385 (i)Pixel and block classification First, the mean and variance are calculated. According to the value of variance, each pixel is classified as uniform, texture or edge pixels. There are two threshold values Tu (for uniform pixels) and Te (for edge pixels). Here Tu=900 and Te=100. Table -1 Block classification (ii) Gradient magnitude and direction calculation We have defined edges as abrupt changes in intensity, to detect edges all we need is to find edge pixels; the physical derivative gives rate change functions. So, derivative can be used to detect edge pixels. The first derivate sometimes called the gradient of the pixels is calculated. We use Sobel operator for gradient calculationof each pixel in X and Y directions. The gradient magnitudes (also known asthe edgestrengths) and direction can then be determined as: |G| =|Gx|+|Gy| (iii) Directional Non Maximum Suppression The edges are made slender by converting the blurred edges of the imagegradientsintopointed edges.This can be accomplished by suppressing the local minima and preserving the local maxima in the gradient image. Horizontal and vertical gradient stored in the memory are the input to the NMS unit. Depending upon the directionand magnitude of four neighbourhood pixels, two intermediate magnitude values (M1(x,y), M2(x,y))arecalculatedaccording to the equation. M1(x,y) =(1-d)*M(x+1,y-1)+d* M(x+1,y-1) M2(x,y) =(1-d)*M(x-1,y-1)+d* M(x-1,y) iv)Threshold calculation: Threshold calculation is the decisive steps in the edge detection algorithm. The performance of Canny edge detector depend upon threshold values and so these values should be calculated with high accuracy. The input to the threshold calculation unit is the output of NMS unit. The median value of the gradient magnitude helps to find the value of thresholds and is based on the histogram of the gradient magnitude. Th=0.66*median value and low threshold Tl=42% of Th. (v)Thresholding with Hysteresis Non-maximum suppression technique finds the physically powerful edges and they may be affected by noise and lighting conditions. If the gradient magnitude isgreaterthan the high threshold, then it is the strong edge pixel and those edges are conserved. If gradient magnitude is lowerthanthe low threshold, those edges are discarded. If the gradient magnitude value lies between low and high threshold then further investigation is done. The currentpixel isconsidered as a strong edge pixel if any of the neighbours of the current pixel is strong edge pixel; otherwise, it is suppressed ie, those who lie between these two thresholds are classified edges or non-edges based on their connectivity. This algorithm is computationally less complex but gives accurate results if the image is corrupted by noise and for less contrast images. Also this has reduced latency and increased speed by the incorporating pipelining and parallelism in the algorithm. Fig-3: Parallel execution
  • 4. International Research Journal of Engineering and Technology (IRJET) e-ISSN: 2395 -0056 Volume: 04 Issue: 06 | June -2017 www.irjet.net p-ISSN: 2395-0072 © 2017, IRJET | Impact Factor value: 5.181 | ISO 9001:2008 Certified Journal | Page 1386 4. Experimental Results TheproposedFPGA-basedarchitecturecanmaintain multiple image sizes and block sizes. To show the performance of the proposed system, a Xilinx Artix-7 FPGA was used to process grayscale images with a block size of 64 × 64. The angiogram image is considered as the input for applying the edge detection techniques. Following figures shows the experimental results. Fig 5 shows the RTL schematic of the system.TheproposedFPGAimplementation takes only 0.562ms for execution. (a) (b) (c) (d) (e) Fig-4: Results obtained (a) original image (b) Enhanced image(c) canny edge detection (d) distributed canny (e) proposed system. Fig-5: RTL schematic of the system 5. CONCLUSIONS The proposed algorithm detects edges of blood vessels from an angiogram image by image processing techniques. It is observed that edges thus segmented are both precise and lucid. Steps involved in this algorithm are easy and straightforward for implementation. Resultsprove that detection of algorithms is proficient and useful in determining edges. The work has compared different edge detecting techniques. Also, the proposed FPGA implementation takes only 0.562ms for execution. REFERENCES [1] Qian Xu, Srenivas Varadarajan, Chaitali Chakrabartiand Lina J. Karam, (JULY 2014), “A Distributed Canny Edge Detector: Algorithm and FPGA Implementation”, IEEE Transactions On Image Processing, VOL. 23, NO. 7, pp. 2944-2960. [2] R. Deriche, “Using canny criteria to derive a recursively implemented optimal edge detector,” Int.J.Comput.Vis., vol. 1, no. 2, pp. 167–187, 1987. [3] F. G. Lorca, L. Kessal, and D. Demigny, (Oct. 1997), “Efficient ASIC and FPGA implementation of IIR filters for real time edge detection,” Proc. IEEE ICIP, vol. 2, pp. 406–409. [4] Sangeetha, D. and Deepa, P., (2016, January) “An Efficient Hardware Implementation of Canny Edge Detection Algorithm” VLSI Design and 2016 15th International Conferenceon EmbeddedSystems(VLSID) IEEE, pp. 457-462. [5] Jeyakumar, R., Prakash, M., Sivanantham, S. and Sivasankaran, K, (2015, November) “FPGA implementation of edge detection using Canny algorithm” Green Engineering and Technologies (IC- GET) IEEE, pp. 1-4. [6] Hu, Haijiang, et al. "Simple edge detection method for vascular tree angiogram." Advanced Information Technology, Electronic and Automation Control Conference (IAEAC), 2015 IEEE. IEEE, 2015. [7] Fazlali, H. R., et al. "Vessel region detection in coronary X-ray angiograms." Image Processing (ICIP), 2015 IEEE International Conference on. IEEE, 2015. [8] Yoshida, Yuki, et al. "Semi-automatic detection of calcified plaque in coronary CT angiograms with 320- MSCT." Signal Processing Conference (EUSIPCO), 2016 24th European. IEEE, 2016. [9] J. F. Canny, (Nov. 1986), “A computation approach to edge detection,” IEEE Trans. Pattern Anal. Mach. Intell., vol. 8, no. 6, pp. 769–798.