This document discusses gastric proton pump inhibitors (PPIs), which are irreversible inhibitors of the gastric parietal cell proton pump that reduce acid production in the stomach. It details four specific PPIs: omeprazole, lansoprazole, rabeprazole, and pantoprazole, describing their chemical properties, mechanisms of action, and therapeutic uses for conditions like GERD and peptic ulcer disease. The document emphasizes their importance in treating acid-related disorders and preventing complications such as esophageal cancer.

1. Gastric Proton pump inhibitors (PPIs)
Presented by-
Gautam Kumar
B. Pharm,5 semester
School of Pharmacy

2. Gastric Proton pump inhibitors (PPIs)
• Proton Pump Inhibitors (PPIs) are irreversible
inhibitors of gastric parietal cell proton pump.
• This enzyme promotes the exchange of H + or K+ ions, which are required
for mediating HCl secretion. PPIs induce 80 -90% inhibition of basal,
nocturnal, and food stimulated acid levels after single administration.
• PPIs reduce the acid production by blocking the enzyme present in the
stomach wall.
• Reduction in the production of acid by stomach prevents the occurrence of ulcers
and also facilitates the healing of ulcers already existing in the oesophagus,
stomach, and duodenum.

3. Study of Drugs
1)Omeprazole,
2) Lansoprazole
3) Rabeprazole
4) Pantoprazole.

4. Omeparazole
5-methoxy-2-(((4-methoxy-3,5-dimethyl-2-pyridinyl)methyl)-
1Hbenzimidazole
Omeprazole inhibits the proton pump and decreases the amount of acid produced in the
stomach
Belongs to the class of organic compounds known as sulfinylbenzimidazoles.
Stop gastric acid secretion by selective inhibition of the H+/K+ATPase enzyme system.
It is used for t reating GERD and other conditions caused by excessive production of
stomach acid.
It is used to promote the healing of erosive oesophagitis (damage caused to oesophagus
by the stomach acid).

5. It is used to relieve heartburn, difficulty in swallowing, and
persistent cough.
It is used to prevent oesophageal cancer.
It is used along with antibiotics to treat gastric ulcer caused
by H. pylori.
This Photo by Unknown
Author is licensed under CC
BY-SA
This Photo by Unknown Author is licensed under
CC BY-SA
This Photo by Unknown Author is licensed under CC BY

6. Lansoprazole
2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]-1H-
benzimidazole
• Lansoprazole is a substituted benzimidazole prodrug having the selective
and irreversible proton pump inhibitor activity
• It prevents the production of acid in the stomach.
• Belongs to the class of organic compounds known as sufinylbenzimidazoles.
• Lansoprazole is a prodrug and requires protonation via an acidic
environment to become activated.
• It is used for treating acid -reflux disorders ( like GERD) and peptic ulcer disease.
• It is used for H. pylori eradication.
• It is used in combination with NSAIDs for preventing gastrointestinal bleeding.
This Photo by Unknown Author is licensed under CC
BY-SA-NC

7. Rabeprazole
2[[[4-(3-methoxypropoxy)-3-methyl-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole
• Rabeprazole is an antiulcer drug that blocks the H + -K + -ATPase of the coating
gastric cells
• It also inhibits the dose -dependent oppresses basal and stimulated gastric acid secretion.
• Belongs to the class of organic compounds known as sulfinylbenzimidazoles.
• It is used in the treatment of Gastroes ophageal reflux disease (GERD) and poorly responsive
systemic GERD.

8. • It is used in severe erosive esophagitis.
• It is used in pathol ogic hypersecretory conditions, like Zollinger-Ellison
syndrome, systemic mastocytosis, and multiple endocrine adenomas
• It is used for treating duodenal ulcers with or without anti -infectives for
Helicobacter pylori.
• It is also used for curing the daytime or night time heartburn.
• When studied in vitro,rabeprazole is chemically activated at pH 1.2 with a half –
life of 78 second.
This Photo by Unknown Author is licensed under
CC BY-SA
This Photo by Unknown Author is licensed under CC BY-SA

9. • Pantoprazole
5-(difluoromethoxy)-2-[[3,4-dimethoxy-2-pyridinyl)methyl]-1H-benzimidazole
Pantoprazole is a first generation PPI. It is also used for treating other disorders
wherein gastric acid secretion needs to be reduced .
Pantoprazole is available in many forms , such as a delayed -release oral capsule,
oral suspension, and intravenous injection.
Belongs to the class of organic compounds known as sulfinylbenzimidazoles.
Pantoprazole injection is given t o patients having GERD and history of erosive
esophagitis for short -term treatment (7 -10 days) . It is given as an alternate to
pantoprazole delayed-release tablets in patients who are not able to swallow the
tablets.

10. • It is used in the treatment of pathological hypersecretory conditions related
to Zollinger-Ellison syndrome or other neoplastic conditions.
• Pantoprazole delayed-release oral suspension is used for short-term
treatment of erosive esophagitis related to GERD.
• It is also used to promote the healing of erosive esophagitis and decrease the
relapse rates of daytime and night time heartburn symptoms in adult patients
of GERD.
• Due to their good safety profile and as several PPIs are available over the
counter without a prescription.
This Photo by Unknown Author is licensed under CC BY-SA

11. Medicinal Chemistry-
2,Dr.SelvaKumar.S,Dr.SachinJ.Dighade,Dr.R.Srin
ivasan Thakur Publication Pvt.Ltd. Gastric
Proton pump inhibitors.
Omeprazole,Lansoprazole,Rabeprazole,Pantopr
azole. Page45-46,45-49.
References

12. THANK YOU!