This document provides an overview of proteomics, including protein modification and sequencing. It defines the proteome and proteomics, giving a brief history. It describes the main types of proteomics including expression and interaction proteomics. It also outlines some of the key tools and methods used in proteomics, including protein structure databases and the main methods for protein sequencing like N-terminal sequencing. The document concludes by defining and describing different types of protein modification like trimming and covalent attachments. It also lists some related proteomics tools.