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Procedural sedation in
Emergency Medicine
Dr . Venugopalan. P.P
DA,DNB,MNAMS,MEM[GWU]
Director Emergency Medicine
PG Teacher in EM , NBE
Founder & Executive director ,ANGELS
Aster DM Health care
India
Objectives
What does it mean
What needs to be
considered.
What do we normally
use it for.
Review commonly
used agents
Briefly discuss
alternatives to PSA
Overview
DISCLAIMER….
This is a very simplified overview of a
complex topic.
It is not a substitute for in-depth research,
background knowledge and training.
Acknowledgement
Presentations by
Deon Stoltz ,
Dr Garry Clearwater and
Barnes-Jewish Hospital
What is
Procedural
Sedation?
To reduce patient anxiety
and awareness
To facilitate a painful
medical procedure
Patient maintains their
airway & breathing
“Conscious sedation”
“Deep sedation”
What is Procedural Sedation?
• Procedure (n) A series
of steps taken to
accomplish an end.
Examples: EGD,
bronchoscopy,
fracture/dislocation
reduction, cardiac
catheterization
• Sedation (n)
Reduction of anxiety,
stress, irritability, or
excitement by
administration of a
sedative agent or
drug.Procedural Sedation (n) Reducing anxiety or stress
with medications in order to perform a procedure.
These medications may include, but are not limited to
Opiates (e.g., morphine, fentanyl) and
Benzodiazepines (e.g., midazolam, lorazepam).
The goals of PS
Patient safety &
welfare the first
priority.
Adequate
analgesia,
anxiolysis,
sedation and
amnesia during the
performance of
painful diagnostic or
therapeutic
procedures in the
ED.
Minimize the
adverse
psychological
responses
Control motor
behaviour that
inhibits the provision
of necessary medical
care.
Return the patient to
a state in which safe
discharge is
Procedural
Sedation Positives
Avoids the discomfort
associated with local or
regional anaesthetic
techniques.
Doesn’t affect anatomy
Relatively simple
technique
Negatives
Consumes resources
General anaesthesia in
the
ED
is frowned upon…
How low should you go?
Depth of Procedural Sedation
Minimal Sedation (Anxiolysis)
Moderate Sedation/Analgesia
Deep Sedation/Analgesia
General Anaesthesia
Normal LOC
Sedation Continuum Moving from one state of conscious to
another is a dose-related continuum that depends on patient
response NOT type, dose or route of medication, or any other
external factors..
MINIMAL
SEDATION
(ANXIOLYSIS)
MODERATE
SEDATION
DEEP
SEDATION
ANESTHESIA
Response Normal
response to
verbal
stimulation
Purposeful
response to
verbal or
tactile
stimulation
Purposeful
response
following
repeated or
painful
stimulation
Unarousable
even with
painful
stimulus
Airway Unaffected No
intervention
required
Intervention
may be
required
Intervention
often required
Spontaneous
Ventilation
Unaffected Adequate May be
inadequate
Frequently
inadequate
Cardiovascular
Function
Unaffected Usually
maintained
Usually
maintained
May be
impaired
Uses Reduction of
dislocations:
 Shoulder, elbow, hip,
patella, ankle
Reduction of fractures:
 Wrist, ankle
 Washout compound
fracture
Paediatric injuries:
 Wound inspection,
closure, suturing
Abscess I&D
Considerations for PS in the
ED
Environmen
tal
Patient Agent
Patient
Case – Mr. F. B.
Case
A 40 yo
man
presents
with a
painful,
swollen
right wrist
after a fall.
You do an
So what about our patient?
Allergies:
Eggs
Medications:
Enalapril
Salbutamol
Flovent
Past Medical History:
Asthma
Obstructive sleep apnea
Hypertension
DM II
• Last Meal:
– 30 minutes ago
• Events:
– Patient came immediately to the
hospital after falling.
AMPL
E
To sedate or not to sedate…
86 yo female with a dislocated hip
Allergies: NKDA
Meds:
Metoprolol
Nitroglycerin patch
Enalapril
Lasix
ASA
Last meal:
NPO for 4 hours
• PMHx:
– MI x 2 (multi-vessel
CAD)
– Angina with minimal
activity
– PVD
– HTN
– CVA
– CRF
• Events:
– Pt felt a pop while
trying to get up from
To sedate or not to sedate…
22 yo intoxicated male with an ankle fracture
Allergies: NKDA
Meds: unknown
PMHx: unknown
Last meal:
Smells like EtOH
Unknown
Events:
No one really knows
To sedate or not to sedate…
28 yo female with a fractured wrist
What risks
are
associated
with sedation
during
pregnancy?
Patient
Assessment
 The AMPLE
history
Allergies
Medications
Past medical
history
Last meal
Events before &

after the incident
 Physical Exam
Airway
assessment
Respiratory
exam
Cardiovascular
ASA Physical Status
Classification
I. Healthy Patient
II. Mild systemic disease – no
functional limitation
III. Severe systemic disease –
definite functional limitation
IV. Severe systemic disease that is a
constant threat to life
V. Moribund patient that is not
expected to survive with the
ASA PS (physical status) classification
Definition Details Examples
ASA
PS 1
A
normal
healthy
patient
Healthy individual with no
systemic disease, undergoing
elective surgery. Patient not at
extremes of age. (Note: Age
is often ignored as affecting
operative risk; however, in
practice, patients at either
extreme of age are thought to
represent increased risk.)
Fit patient with inguinal
hernia.
Fibroid uterus in an
otherwise healthy woman
ASA
PS 2
A
patient
with
mild
systemic
disease
Individual with one system,
well-controlled disease.
Disease does not affect daily
activities. Other anesthetic
risk factors, including mild
obesity, alcoholism, and
smoking can be incorporated
at this level.
Non-limiting or only
slightly limiting organic
heart disease.
Mild diabetes, essential
hypertension, or
anemia.
ASA PS (physical status) classification continued
Definition Details Examples
ASA
PS 3
A
patient
with
severe
systemic
disease
Individual with multiple
system disease or well
controlled major system
disease. Disease status
limits daily activity.
However, there is no
immediate danger of
death from any
individual disease.
Severely limiting organic heart
disease. Severe diabetes with
vascular complications.
Moderate to severe degrees of
pulmonary insufficiency.
Angina pectoris or healed
myocardial infarction.
ASA
PS 4
A patient
with
severe
systemic
disease
that is a
constant
threat to
life
Individual with severe,
incapacitating disease.
Normally, disease state
is poorly controlled or
end-stage. Danger of
death due to organ
failure is always present
Organic heart disease showing
marked signs of cardiac
insufficiency, Persistent
anginal syndrome, or active
myocarditis. Advanced
degrees of pulmonary, hepatic,
renal, or endocrine
insufficiency.
ASA PS (physical status) classification continued
Definition Details Examples
ASA PS 5 A
moribund
patient not
expected to
survive (24
hrs)
Patient who is in
imminent danger of death.
Operation deemed to be a
last resort attempt at
preserving life. Patient not
expected to live through
the next 24 hours. In some
cases, the patient may be
relatively healthy prior to
catastrophic event, which
led to the current medical
condition.
Burst abdominal
aneurysm with
profound
shock.
Major cerebral
trauma with rapidly
increasing
intracranial
pressure.
Massive pulmonary
embolus.
ASA PS 6 A declared
brain-dead
patient /
organ
donor
“It’s only a little chest pain”
ASA Scores & PSA
• The ASA classification is not validated
outside of the OR.
• Malviya et al showed an increased risk
of adverse sedation-related events in
paediatric patients with an ASA > 2.
“The patient’s ASA status should be
determined. For non-emergent
procedures, ED sedation and
analgesia should be limited to ASA
class 1 or 2 patients.”
Class B, Level III
Procedural sedation and analgesia in the emergency department
Canadian Consensus Guidelines
The Last Supper
Fasting & PSA
ANZCA recommendations for healthy
elective GA patients:
2 h NPO for liquids
6 h NPO for solids
The risk of aspiration during PSA is
extremely low.
There is no evidence that fasting
improves outcome during procedural
sedation and analgesia.
One large paediatric study of ED procedural sedation showed
no increase in the number of adverse events in patients that
Starved for how long…?
Controversial.
Probably not as rigid as anaesthetic guidelines
for GA...
Depends on degree and duration of sedation
Starship CED paediatric guideline:
 Clear fluids: at least 2 hours
 Non-clear fluids and solids: at least 4 hours
Oral Intake
Guidelines
Age does not matter – what they
took orally is the issue.
Ingested Material
Minimum Fasting Period
Clear Liquids 2
hours
Breast Milk 4
hours
Infant Formula
6hours
Non-clear Liquids 6
hours
Light Meal 6
hours
Options for the patient not within
these guidelines:
Cancel the Procedure
Emergent
Procedures
Emergent
Procedures :
life- or organ
(i.e., CNS)
saving
procedures
(consult
anesthesiolog
y)
Urgent procedure are those
which need to be done
in 2-4 hrs
•Document why it is
urgent;
•Assess the need for
sedation and
preferably administer
none
•Consider postponing
or consult
anesthesiology
•Monitor the patient's
airway closely
•Look for active or
silent regurgitation
and aspiration.
PATIENT SELECTION
Can you hold the fort if something goes wrong?
BREATHING & CIRCULATION:
 Lung disease?
 Stable cardiac status?
 BP stable?
Medications
Allergies (e.g. watch out for soy, eggs: Propofol)
Airway Assessment
Can you bag?
Can you
Intubate?
Predictors of Difficult BVM Ventilation
Beard
Obesity
Old (age > 55 yrs)
Toothless
Snores
Langeron O, Masso E, Huraux C, et al. Prediction of difficult
mask ventilation. Anesthesiology. 2000; 92:1229-36.
The LEMON Method of Airway
Assessment
• Look for external characteristics known to causes
problems with BVM or intubation.
• Evaluate the 3-3-1 Rule:
Mouth opening > 3 fingers
Hyoid – chin distance > 3 fingers
Anterior low jaw subluxation > 1 finger
• Mallampati Score
• Obstruction – any pathology within or surrounding the
upper airway
• Neck Mobility - full flexion & extension
Considerations for PS in the
ED
Environmen
tal
Patient
Agent
Choosing appropriate
medications
• Agents should be chosen
based on the desired
pharmacological
response. Depending on
the particular agent one,
two or all three of these
below effects can be
achieved:
Adverse effects -
The potential side
effects of any
medication in a
particular patient
must by
considered.
Many sedative
agents can
produce cardiac
or respiratory
depression.
Analgesi
a
Amnesi
a
Pharmacokineti
c
Considerations
When selecting a sedative,
the following pharmacokinetic
parameters should be
considered to optimize
response in a given situation.
* Onset and Duration
* Elimination Route
* Accumulation
* Drug interactions /
potentiations
* Cross-Tolerance
e.g. patients with prior
opiate use may require higher
doses of opiates; those with
prior ethanol exposure may
require larger doses or
benzodiazepines, etc.
-
The Perfect
Drug
Provides adequate
sedation and analgesia
for:
Patient comfort
Easy completion of the
procedure
Maintains airway
reflexes
Does not affect
hemodynamics
Does not affect
respiratory function
Commonly
Used Agents Propofol
Fentanyl
Ketamine
Midazola
m
Commonly Used
Agents
Propofol
Category
Sedative-Hypnotic
What is it?
2,6-diisopropofol, an
alkylphenol oil in an
emulsion
How does it work?
Potentiates GABA
activity
How much do you
need?
Starting dose of 0.5 -
1 mg/kg
Commonly Used
Agents
Propofol
What else does it do?
CNS: Mild analgesic
properties; euphoria
CVS: Myocardial
depressant;
vasodilation
Resp: Respiratory
depressant
GI: Antiemetic
MSK: Myoclonus
What does the body do
with it?
Rapid redistribution
Hepatic and
extrahepatic
metabolism
Commonly Used
Agents
Propofol
Pros
Shown to be safe for
ED PSA use
Rapid onset and
recovery
Cons
Must be combined with
an analgesic agent
May cause apnea &
loss of airway reflexes
Myocardial depressant
and vasodilator
Commonly Used
Agents
Fentanyl
Category
Analgesic agent
What is it?
Synthetic opioid
How does it work?
Decreases
conduction along
nociceptive
pathways and
increases activity in
pain control
pathways in the
brain.
How much do you
need?
Starting dose of 1-2
mcg/kg
Commonly Used
Agents
Fentanyl
What else does it do?
CNS: Euphoria (or
dysphoria)
Resp: Respiratory
depressant; chest wall
rigidity
CVS: May decrease
HR
GI: Decreased motility
What does the body do
with it?
Hepatic metabolism
(inactive metabolite)
Renal excretion
Commonly Used
Agents
Fentanyl
Pros
Good hemodynamic
stability
Rapid onset and
recovery
Cons
Must be combined with
an amnestic agent
May cause bradycardia
May cause chest wall
rigidity
May cause apnea &
loss of airway reflexes
Commonly Used
Agents
Midazolam
Category
Amnestic
What is it?
Benzodiazepine
How does it work?
Bind to
benzodiazepine
receptors which up-
regulate GABA
activity
How much do you
need?
0.02 – 0.1 mg/kg IV
Commonly Used
Agents
Midazolam
What else does it do?
CNS: Anxiolysis
CVS: Slight decrease in
PVR & decreased
contractility.
Resp: Respiratory
depression
What does the body do
with it?
Hepatic metabolism
(active metabolite)
Renal excretion
Commonly Used
Agents
Ketamine
Category
Dissociative Amnestic
What is it?
Derivative of
phencyclidine with
some opioid properties.
How does it work?
Stimulates the limbic
system while inhibiting
the thalamus & cortex
(dissociation)
Binds to NMDA and
opioid receptors
Commonly Used
Agents
Ketamine
What else does it do?
CNS: Emergence
reactions
CVS: Increased
contractility, HR and
PVR through
sympathetic stimulation.
Direct myocardial
depressant.
Resp: Laryngospasm,
bronchodilation,
increased secretions
What does the body do with
it?
Hepatic metabolism
• Frequency is reported to
be anywhere from <1% to
50% in adults.
• Treatment with
benzodiazepines is the
most effective way to
prevent emergence
reactions.
But won’t it give him nightmares?
Ketamine & Emergence Reactions
Commonly Used
Agents
Ketamine How much do you
need?
1 – 2 mg/kg IV
How much
midazolam?
0.7 mg/kg given at
the time of
ketamine injection.
Mix & Match
Commonly used combinations:
Propofol + Fentanyl
Fentanyl + Midazolam
Propofol + Midazolam + Fentanyl
Ketamine + Midazolam
Ketamine + Propofol
“Ketofol”
If respiratory depression and/or hemodynamic instability
occurs, consider use of reversal agents.
Naloxone
(Narcan®)  Opioid antagonist
 Dosing: 0.4–2 mg q 2-3
min, up to 10 mg
 Onset time: 1-2 min
 Duration of effect: 30-60
min
 Adverse effects:
precipitate withdrawal,
pulmonary edema
Flumazenil
(Romazicon®)  Benzodiazepine
antagonist
 Dosing: 0.2 mg q 1 min,
up to 1 mg
 Onset time: 1-2 min
 Duration of effect: 30-90
min
 Adverse effects: seizures
 Reversing BZD-induced
hypoventilation
How low should you go?
Depth of Procedural Sedation
Minimal Sedation (Anxiolysis)
Moderate Sedation/Analgesia
Deep Sedation/Analgesia
General Anaesthesia
Normal LOC
Considerations for PS in the
ED
Environmen
tal
Patient
Agent
Environmenta
l
PREPARATIO
N
Prepare for the worst….
What can go wrong?
 Unexpected drug
reaction or anaphylaxis
 Vomit and aspirate
 Obstructed airway (e.g.
laryngospasm, tongue)
 Apnoea, respiratory
arrest
 Profound hypotension
PREPARATIO
N
Not quite the worst …
What can go wrong?
 Disinhibition / agitation
 Terrors, nightmares
 Unexpected drug
reactions: dystonias
 Inadequate sedation
 Unsuccessful
procedure… still needs
GA
PREPARATIO
N
ACEM POLICY
DOCUMENT -
USE OF
INTRAVENOU
S SEDATION
FOR
PROCEDURE
S IN THE
EMERGENCY
DEPARTMENT
© ACEM. 5 December
PREPARATION
Environment
 Separate space
to perform the
procedure
 A recovery
space: ideally
quiet, available
for 1-2 hours,
easily observed.
PREPARATIO
N
ENVIRONMENT
The procedure must be
performed in a
suitable clinical area
with facilities for:
 Monitoring,
 Oxygen
 Suction
 Immediate access to
emergency
resuscitation
equipment, drugs and
PREPARATIO
N
ENVIRONMENT
Readily
available
equipment
must
include:
 Resuscitatio
n trolley
 Defibrillator
 Bag-Valve-
Mask device
for
PREPARATIO
N
MONITORING
Cardiac rhythm,Non-
invasive blood
pressure, Pulse
oximetry must be
monitored “throughout
the procedure and
recovery period”
PREPARATIO
N
PERSONNEL
The involvement of at least
two clinical staff is
required:
 PERSON PERFORMING
PROCEDURE
must understand the
procedure and its potential
complications.
 PERSON GIVING DRUGS
AND MONITORING PATIENT
- must have training and
experience of resuscitation,
emergency drugs and ….
(details of) the drugs used.
This person is not involved in
the performance of the
procedure but is dedicated to
PREPARATIO
N
PATIENT PREPARATION
Explanation
Consent
Secure IV access
is mandatory.
Informed Consent
* The person performing the procedure (clinician) is to review objectives,
risks, benefits and alternatives of Procedural Sedation (informed consent)
* This can be done at the same time as the procedure is explained
* Informed consent for the sedation does not require a patient signature.
Rather there is a check box on the Pre-Procedure/Pre-Sedation Assessment
form. If paper forms are not available, it is the responsibility of the clinician
to document this in the pre- procedure note.
* If the person who will monitor the patient (assistant) finds that the patient has
additional questions, the person performing the procedure (clinician) will be
contacted to answer these questions before sedation is given.
Assistant Responsibilities
– Patient assessment and
appropriate documentation
throughout the procedure
– Reassure patient and monitor
patient awareness.
– Provide comfort measures as
needed
– Notify clinician of changes /
concerns.
– Documentation of required
parameters.
The Assistant is not to leave patient bedside for any
reason during the procedure (although may assist
the clinician with short, interruptible tasks) The
assistant must be able to drop those tasks if the
patient needs attention)
Documentations
Don’t forget …..
Must ….
Pre-Procedure/Pre-Sedation Assessment form (required
for all procedural sedation) includes documentation of the
following:
Review of Systems:
*Can be completed by nursing or medical staff. If completed by nursing,
must
be reviewed by the clinician completing the pre-procedure
assessment.
Focused Assessment:
Must be completed by a licensed independent practitioner according
to
Medical Staff Bylaws. It includes procedure-specific parameters, and
addresses any new or pertinent data seen on the Review of Systems.
Airway Assessment:
* Aim is to plan for airway management if that would be necessary.
* Assessment parameters may include
* Assessing dentures, loose teeth, partials, etc.
* When the patient opens his/her mouth, how easily can the cords
and
pharynx be visualized should intubation be necessary.
* Are there physical limitations, which would impede proper
Pre-Procedure/Pre-Sedation Assessment form
(required for all procedural sedation) includes
documentation of the following:
Risk Assessment (ASA PS Score)
*To be completed by clinician, even if you’re not Anesthesia
personnel
Risks/Benefits/Alternatives for Sedation
*Required discussion with patient should be documented
either on outpatientforms, or in procedure note
Risks/Benefits/Alternatives for Procedure
*As above, with the addition of signature on procedural
consent
Sedation Plan:
*The level of sedation that was presented to, and accepted by
the patient. This must be documented before initiation of the
procedure.
Prevent wrong site / wrong patient / wrong
limb / wrong equipment
• Site Verification / Marking “YES” on the procedure site
– Must be completed before the procedure starts
– Is the responsibility of the person performing the procedure
(clinician)
– Should be a process which includes patient input / verification /
understanding
• TIME OUT!
– To be completed immediately before the first dose of sedation /
start of the procedure.
– Is the responsibility of the clinician, although may be
documented by the assistant
– Should be a group interaction (clinician, assistant, others
present in the room)
– Includes four questions:
1. Is this the Correct Patient?
2. Is this the Correct Procedure?
3. Is this the Correct Site?
4. Is this the Correct Equipment?
Intra-procedure Monitoring requirements
*BP, Pulse, Respiratory Rate, SpO2
Immediately before the procedure / first dose of sedation, monitored
frequently and documented every 10 minutes throughout the
procedure and recovery period.
*Mechanical noninvasive blood pressure is preferred, however may
use manual (cuff) method.
*Continuous Pulse Oximetry
*Sedation
*Assessed and documented with vital signs
*RASS Sedation Scale
Richmond Agitation Sedation Scale (RASS)
Score Term (not included
on documentation
forms)
Description
+4 Combative Overtly combative, violent, immediate danger to staff
+3 Very agitated Pulls or removes tube(s) or catheter(s), aggressive
+2 Agitated Frequent, non-purposeful movement. Fights ventilator
+1 Restless Anxious, but movements not aggressive, vigorous
0 Alert and Calm
-1 Drowsy Not fully alert, but has sustained awakening
(Eye-opening/eye-contact) to voice, ≥ 10 seconds
-2 Light sedation Briefly awakens with eye-contact to voice, <10 seconds
-3 Moderate sedation Movement or eye-opening to voice, (but no eye
contact)
-4 Deep sedation No response to voice, but movement or eye opening to
physical stimulation
-5 Unarousable No response to voice or physical stimulation
Intra-procedure Monitoring requirements
EKG monitor
*Assistants may not be able to perform rhythm
interpretation
*Identify when more in depth patient assessment
is required
1). For example: heart rate drops, assistant
may stimulate
patient, check BP, or other
2). Another example: heart rate accelerates,
assistant may ask patient about comfort level.
*Assistants should notify the clinician for any
noticeable changes in rhythm, rate, or other
concerns noted on monitor for further medical
Intra-procedure Monitoring
requirements
Capnography?
*Although not essential this indicates if
patient is ventilating
adequately.
*This will indicate hypoventilation
before pulse oximetry.
*Currently available to intubated
patients only
Responsible Individual
for discharge planning
• The person who will provide the patient’s ride home and be
available to the patient after the procedure will be identified
before the procedure begins.
• This person may be an adult, or someone in their late teens that
the patient feels comfortable with.
• If the patient is an outpatient, this person frequently
accompanies the patient to the hospital
• If the responsible individual is not present, hospital staff need to
verify the individual by telephone.
• If the patient is an inpatient, it may not be necessary to identify
this individual pre-procedure.
• If the inpatient is discharged within 24 hours of the
procedure, the patient must be discharged to a responsible
individual.
Responsible individual?
• For outpatients: If either the clinician (person performing
the procedure) or the assistant (person monitoring the
patient) feels the individual present would not be
appropriate in this role, or the patient has no one
identified, the clinician needs to determine:
– Can the procedure be cancelled (or postponed) until a
responsible individual is available?
– Should the procedure be completed and the patient
kept an additional 4 hours after discharge criteria are
reached, then released with appropriate
transportation?
Discharge to Responsible Person
Guidelines:
Best Practice: Patient accompanied by Responsible
Adult
If no responsible adult present at patient admission,
staff should
-Verify via phone the responsible adult who will be
present at discharge
-Or
-Identify a responsible individual to whom the patient
can be reasonably transported after the procedure
-Or
-Cancel the Procedure!
How do I know the
person is
responsible?
Use your
professional
judgment.
If no responsible adult present after the procedure is completed,
observe the patient for 4 hours after completion of the recovery
period, then discharge (patient must not drive for 24 hours after
sedation).
READY TO GO…
Explain
Pre-oxygenate
IV Access and IV fluid running
Splints or plaster or equipment all
ready to go
Hand over your phone or pager…
ALDRETE POST PROCEDURE RECOVERY SCORE
Aldrete Post Procedure Recovery Score Base
Line
Post
Procedure D/C
Activity Moves 4 Extremities voluntarily or on command
Moves 2 Extremities voluntarily or on command
Moves 0 Extremities voluntarily or on command
2
1
0
2
1
0
2
1
0
Circulation SBP ± 20 mmHg of Preprocedure Level
± 20-50 mmHg of Preprocedure Level
± 50 mmHg of Preprocedure Level
Preprocedure BP / .
2
1
0
2
1
0
2
1
0
Respirations Able to deep breath or cough freely
Dyspnea, shallow, or limited breathing
Apneic or Mechanical Vent
2
1
0
2
1
0
2
1
0
Consciousness Awake (oriented, answers questions approp.)
Arousable on calling (responds to voice)
Non-responsive
2
1
0
2
1
0
2
1
0
Color Normal
Pale, dusky, mottled, jaundiced, other
Cyanotic
2
1
0
2
1
0
2
1
0
Discharge score must be a minimum of pre-procedure score minus
one, with stable vital signs to meet discharge criteria.
TOTAL:
Baseline must be done before sedation initiated. This
is what post-procedure Aldretes are compared to.
Post Procedure is done at the end of the procedure, then every 10 minutes until patient
meets recovery criteria. A minimum of 3 aldrete scores must be completed before the
patient can be identified as “recovered” When recovery criteria are met, the last
(frequently the third) Aldrete can be the D/C score.
Recovery criteria
*A minimum of two consecutive Aldrete scores are baseline minus one
with stable vital signs
*The patient’s room air oxygen saturation must be back to baseline
*Sufficient time (i.e., a minimum of 1 hour) should have elapsed after the
last administration of reversal agents (naloxone, flumazenil) to ensure
that
the patient does not become resedated after reversal effects have
abated.
* Patients who will be discharged to home and receive IV
medications for relief of pain, nausea, vomiting etc. must be
observed no less than two consecutive Aldrete / vital sign
assessments following administration of such medication
Discharge criteria
Vital signs stable (Vital signs include BP, HR, R,& O2 Sat. The VS are
determined to be stable if they are consistent with the patient’s age and with the
patient’s pre-operative VS)
Swallow, cough present (patient demonstrates ability to swallow fluids and
is able to cough
Able to ambulate (patient demonstrates ability to ambulate at pre-procedure
level)
Nausea, vomiting, dizziness is minimal
Absence of respiratory distress (patient’s respiratory effort consistent
with pre-procedure status)
State of consciousness (patient is alert, oriented to time, place and person
consistent with pre-procedure level of consciousness).
Level of comfort (Pain controlled as per BJH pain policy)
Post-procedure (oral and written) discharge instructions are
given to the patient and/or significant other regarding the following: purpose and
expected effects of sedation, patient’s care, emergency phone number,
medications, dietary or activity restrictions, and necessary precautions (e.g., no
driving for 24 hours, avoid alcohol and use of power tools, etc.).
Phone a friend…
Consider sending the at-risk patient
to the OR.
Questions?
Key Points
Be
prepared
Know
your drugs
and your
drug
interactions
Consider
all your
options
Thank you so muc
Procedural Sedation Post Test
1. Which treatment is an example of procedural sedation?
A. Preventing anxiety prior to treatment without
altering the
patient’s level of consciousness.
B. Providing comfort measures to the patient.
C. Performing a simple dressing change.
D. Administering medication to alter the level of
consciousness prior to a procedure.
2. A Physician prescribes a one-time dose of Morphine and
Ativan to
reduce the patient’s pain and anxiety during a dressing
change.
This is considered procedural sedation.
Procedural Sedation Post Test
3. To prepare for procedural sedation, the RN must:
A. Obtain patient consent for both the procedure and the sedation.
B. Confirm auscultation of heart, lungs, and airway assessment was
performed by MD
C. Be aware of sedation plan
D. Perform patient identification and a “Time-Out”
E. Perform a baseline PASS assessment.
F. All of the above
4. To perform procedural sedation, the RN must:
A. Have age-specific resuscitative equipment.
B. Have a physician privileged in Procedural Sedation present in the
room.
C. Receive age specific advanced life support certification.
D. Provide a cardiac monitor, O2 monitoring, and ET CO2 monitoring.
Procedural Sedation Post Test
5. When performing procedural sedation, it is satisfactory to have the
physician be available by pager during the procedure.
A. True
B. False
6. The nurse providing moderate sedation should remain with the patient
at all times.
A. True
B. False
• 7. Before a procedural sedation patient can be discharged, they need to
be observed for a minimum of 30 minutes after the last dose of sedative
or analgesic was administered. Longer periods of observation are
required if reversal agents are used.
A. True
B. False
Procedural Sedation Post Test
8. To discharge a patient following procedural sedation, a post-procedural
assessment must be conducted (by a credentialed practitioner
privileged in this
procedure), the patient needs to receive written discharge instructions,
and a
responsible adult/driver must be identified.
A. True
B. False
9. A “time-out” is performed prior to the start of the procedure and
typically includes:
A. A description of the nature of the procedure, the patient’s condition,
details of any abnormal history or condition, and any special patient
needs.
B. Use of two patient identifiers – patient name and medical record on
arm band.
C. Verification of the site, both physically and verbally, and if required,
marking of the site.
D. A review of the expected course of the procedure and recovery.
E. All of the above
Procedural Sedation Post Test
10. Development of chest wall rigidity (“wooden chest”) may result in
serious respiratory compromise and is most often seen with the rapid
administration of:
A. Fentanyl (Sublimaze)
B. Morphine
C. Ketamine (Ketalar)
D. Flumazenil (Romazicon)
11. The reversal agent and initial dose preferred for a 300-pound 18
year-old who has had Diazepam, Midazolam, and Lorazepam
during a procedure is:
A. Flumazenil (Romazicon) 0.2 mg, repeat every 1-2 minutes as
needed
B. Naloxone (Narcan) 0.4 mg, repeat every 2-3 minutes as needed
C. Both a and b
Procedural Sedation Post Test
12. A 60 year-old male patient with coronary artery disease undergoes a
pacemaker implant under IV sedation. During the procedure, the
patient’s oxygen saturation decreases to 84%. The patient is snoring
and responds to vigorous stimulation. You should:
A. Lift the chin and jaw, attempt to provide a better airway, notify the
physician immediately after the change in the patient's condition,
increase oxygen delivery, call for assistance and consider reversal
agents.
B. Continue to monitor for further changes; reduce the next dose of
sedation medication by half.
C. Document the patient's status on the assessment form; notify the
MD at the conclusion of the procedure.

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Procedural sedation in emergency medicine

  • 1. Procedural sedation in Emergency Medicine Dr . Venugopalan. P.P DA,DNB,MNAMS,MEM[GWU] Director Emergency Medicine PG Teacher in EM , NBE Founder & Executive director ,ANGELS Aster DM Health care India
  • 2. Objectives What does it mean What needs to be considered. What do we normally use it for. Review commonly used agents Briefly discuss alternatives to PSA
  • 3. Overview DISCLAIMER…. This is a very simplified overview of a complex topic. It is not a substitute for in-depth research, background knowledge and training. Acknowledgement Presentations by Deon Stoltz , Dr Garry Clearwater and Barnes-Jewish Hospital
  • 4. What is Procedural Sedation? To reduce patient anxiety and awareness To facilitate a painful medical procedure Patient maintains their airway & breathing “Conscious sedation” “Deep sedation”
  • 5. What is Procedural Sedation? • Procedure (n) A series of steps taken to accomplish an end. Examples: EGD, bronchoscopy, fracture/dislocation reduction, cardiac catheterization • Sedation (n) Reduction of anxiety, stress, irritability, or excitement by administration of a sedative agent or drug.Procedural Sedation (n) Reducing anxiety or stress with medications in order to perform a procedure. These medications may include, but are not limited to Opiates (e.g., morphine, fentanyl) and Benzodiazepines (e.g., midazolam, lorazepam).
  • 6. The goals of PS Patient safety & welfare the first priority. Adequate analgesia, anxiolysis, sedation and amnesia during the performance of painful diagnostic or therapeutic procedures in the ED. Minimize the adverse psychological responses Control motor behaviour that inhibits the provision of necessary medical care. Return the patient to a state in which safe discharge is
  • 7. Procedural Sedation Positives Avoids the discomfort associated with local or regional anaesthetic techniques. Doesn’t affect anatomy Relatively simple technique Negatives Consumes resources General anaesthesia in the ED is frowned upon…
  • 8. How low should you go? Depth of Procedural Sedation Minimal Sedation (Anxiolysis) Moderate Sedation/Analgesia Deep Sedation/Analgesia General Anaesthesia Normal LOC
  • 9. Sedation Continuum Moving from one state of conscious to another is a dose-related continuum that depends on patient response NOT type, dose or route of medication, or any other external factors.. MINIMAL SEDATION (ANXIOLYSIS) MODERATE SEDATION DEEP SEDATION ANESTHESIA Response Normal response to verbal stimulation Purposeful response to verbal or tactile stimulation Purposeful response following repeated or painful stimulation Unarousable even with painful stimulus Airway Unaffected No intervention required Intervention may be required Intervention often required Spontaneous Ventilation Unaffected Adequate May be inadequate Frequently inadequate Cardiovascular Function Unaffected Usually maintained Usually maintained May be impaired
  • 10. Uses Reduction of dislocations:  Shoulder, elbow, hip, patella, ankle Reduction of fractures:  Wrist, ankle  Washout compound fracture Paediatric injuries:  Wound inspection, closure, suturing Abscess I&D
  • 11. Considerations for PS in the ED Environmen tal Patient Agent
  • 13. Case – Mr. F. B.
  • 14. Case A 40 yo man presents with a painful, swollen right wrist after a fall. You do an
  • 15. So what about our patient? Allergies: Eggs Medications: Enalapril Salbutamol Flovent Past Medical History: Asthma Obstructive sleep apnea Hypertension DM II • Last Meal: – 30 minutes ago • Events: – Patient came immediately to the hospital after falling. AMPL E
  • 16. To sedate or not to sedate… 86 yo female with a dislocated hip Allergies: NKDA Meds: Metoprolol Nitroglycerin patch Enalapril Lasix ASA Last meal: NPO for 4 hours • PMHx: – MI x 2 (multi-vessel CAD) – Angina with minimal activity – PVD – HTN – CVA – CRF • Events: – Pt felt a pop while trying to get up from
  • 17. To sedate or not to sedate… 22 yo intoxicated male with an ankle fracture Allergies: NKDA Meds: unknown PMHx: unknown Last meal: Smells like EtOH Unknown Events: No one really knows
  • 18. To sedate or not to sedate… 28 yo female with a fractured wrist What risks are associated with sedation during pregnancy?
  • 19. Patient Assessment  The AMPLE history Allergies Medications Past medical history Last meal Events before &  after the incident  Physical Exam Airway assessment Respiratory exam Cardiovascular
  • 20. ASA Physical Status Classification I. Healthy Patient II. Mild systemic disease – no functional limitation III. Severe systemic disease – definite functional limitation IV. Severe systemic disease that is a constant threat to life V. Moribund patient that is not expected to survive with the
  • 21. ASA PS (physical status) classification Definition Details Examples ASA PS 1 A normal healthy patient Healthy individual with no systemic disease, undergoing elective surgery. Patient not at extremes of age. (Note: Age is often ignored as affecting operative risk; however, in practice, patients at either extreme of age are thought to represent increased risk.) Fit patient with inguinal hernia. Fibroid uterus in an otherwise healthy woman ASA PS 2 A patient with mild systemic disease Individual with one system, well-controlled disease. Disease does not affect daily activities. Other anesthetic risk factors, including mild obesity, alcoholism, and smoking can be incorporated at this level. Non-limiting or only slightly limiting organic heart disease. Mild diabetes, essential hypertension, or anemia.
  • 22. ASA PS (physical status) classification continued Definition Details Examples ASA PS 3 A patient with severe systemic disease Individual with multiple system disease or well controlled major system disease. Disease status limits daily activity. However, there is no immediate danger of death from any individual disease. Severely limiting organic heart disease. Severe diabetes with vascular complications. Moderate to severe degrees of pulmonary insufficiency. Angina pectoris or healed myocardial infarction. ASA PS 4 A patient with severe systemic disease that is a constant threat to life Individual with severe, incapacitating disease. Normally, disease state is poorly controlled or end-stage. Danger of death due to organ failure is always present Organic heart disease showing marked signs of cardiac insufficiency, Persistent anginal syndrome, or active myocarditis. Advanced degrees of pulmonary, hepatic, renal, or endocrine insufficiency.
  • 23. ASA PS (physical status) classification continued Definition Details Examples ASA PS 5 A moribund patient not expected to survive (24 hrs) Patient who is in imminent danger of death. Operation deemed to be a last resort attempt at preserving life. Patient not expected to live through the next 24 hours. In some cases, the patient may be relatively healthy prior to catastrophic event, which led to the current medical condition. Burst abdominal aneurysm with profound shock. Major cerebral trauma with rapidly increasing intracranial pressure. Massive pulmonary embolus. ASA PS 6 A declared brain-dead patient / organ donor
  • 24. “It’s only a little chest pain” ASA Scores & PSA • The ASA classification is not validated outside of the OR. • Malviya et al showed an increased risk of adverse sedation-related events in paediatric patients with an ASA > 2.
  • 25. “The patient’s ASA status should be determined. For non-emergent procedures, ED sedation and analgesia should be limited to ASA class 1 or 2 patients.” Class B, Level III Procedural sedation and analgesia in the emergency department Canadian Consensus Guidelines
  • 26. The Last Supper Fasting & PSA ANZCA recommendations for healthy elective GA patients: 2 h NPO for liquids 6 h NPO for solids The risk of aspiration during PSA is extremely low. There is no evidence that fasting improves outcome during procedural sedation and analgesia. One large paediatric study of ED procedural sedation showed no increase in the number of adverse events in patients that
  • 27. Starved for how long…? Controversial. Probably not as rigid as anaesthetic guidelines for GA... Depends on degree and duration of sedation Starship CED paediatric guideline:  Clear fluids: at least 2 hours  Non-clear fluids and solids: at least 4 hours
  • 28. Oral Intake Guidelines Age does not matter – what they took orally is the issue. Ingested Material Minimum Fasting Period Clear Liquids 2 hours Breast Milk 4 hours Infant Formula 6hours Non-clear Liquids 6 hours Light Meal 6 hours Options for the patient not within these guidelines: Cancel the Procedure
  • 29. Emergent Procedures Emergent Procedures : life- or organ (i.e., CNS) saving procedures (consult anesthesiolog y) Urgent procedure are those which need to be done in 2-4 hrs •Document why it is urgent; •Assess the need for sedation and preferably administer none •Consider postponing or consult anesthesiology •Monitor the patient's airway closely •Look for active or silent regurgitation and aspiration.
  • 30. PATIENT SELECTION Can you hold the fort if something goes wrong? BREATHING & CIRCULATION:  Lung disease?  Stable cardiac status?  BP stable? Medications Allergies (e.g. watch out for soy, eggs: Propofol)
  • 31. Airway Assessment Can you bag? Can you Intubate?
  • 32. Predictors of Difficult BVM Ventilation Beard Obesity Old (age > 55 yrs) Toothless Snores Langeron O, Masso E, Huraux C, et al. Prediction of difficult mask ventilation. Anesthesiology. 2000; 92:1229-36.
  • 33. The LEMON Method of Airway Assessment • Look for external characteristics known to causes problems with BVM or intubation. • Evaluate the 3-3-1 Rule: Mouth opening > 3 fingers Hyoid – chin distance > 3 fingers Anterior low jaw subluxation > 1 finger • Mallampati Score • Obstruction – any pathology within or surrounding the upper airway • Neck Mobility - full flexion & extension
  • 34. Considerations for PS in the ED Environmen tal Patient Agent
  • 35.
  • 36. Choosing appropriate medications • Agents should be chosen based on the desired pharmacological response. Depending on the particular agent one, two or all three of these below effects can be achieved: Adverse effects - The potential side effects of any medication in a particular patient must by considered. Many sedative agents can produce cardiac or respiratory depression. Analgesi a Amnesi a
  • 37. Pharmacokineti c Considerations When selecting a sedative, the following pharmacokinetic parameters should be considered to optimize response in a given situation. * Onset and Duration * Elimination Route * Accumulation * Drug interactions / potentiations * Cross-Tolerance e.g. patients with prior opiate use may require higher doses of opiates; those with prior ethanol exposure may require larger doses or benzodiazepines, etc. -
  • 38. The Perfect Drug Provides adequate sedation and analgesia for: Patient comfort Easy completion of the procedure Maintains airway reflexes Does not affect hemodynamics Does not affect respiratory function
  • 40. Commonly Used Agents Propofol Category Sedative-Hypnotic What is it? 2,6-diisopropofol, an alkylphenol oil in an emulsion How does it work? Potentiates GABA activity How much do you need? Starting dose of 0.5 - 1 mg/kg
  • 41. Commonly Used Agents Propofol What else does it do? CNS: Mild analgesic properties; euphoria CVS: Myocardial depressant; vasodilation Resp: Respiratory depressant GI: Antiemetic MSK: Myoclonus What does the body do with it? Rapid redistribution Hepatic and extrahepatic metabolism
  • 42. Commonly Used Agents Propofol Pros Shown to be safe for ED PSA use Rapid onset and recovery Cons Must be combined with an analgesic agent May cause apnea & loss of airway reflexes Myocardial depressant and vasodilator
  • 43. Commonly Used Agents Fentanyl Category Analgesic agent What is it? Synthetic opioid How does it work? Decreases conduction along nociceptive pathways and increases activity in pain control pathways in the brain. How much do you need? Starting dose of 1-2 mcg/kg
  • 44. Commonly Used Agents Fentanyl What else does it do? CNS: Euphoria (or dysphoria) Resp: Respiratory depressant; chest wall rigidity CVS: May decrease HR GI: Decreased motility What does the body do with it? Hepatic metabolism (inactive metabolite) Renal excretion
  • 45. Commonly Used Agents Fentanyl Pros Good hemodynamic stability Rapid onset and recovery Cons Must be combined with an amnestic agent May cause bradycardia May cause chest wall rigidity May cause apnea & loss of airway reflexes
  • 46. Commonly Used Agents Midazolam Category Amnestic What is it? Benzodiazepine How does it work? Bind to benzodiazepine receptors which up- regulate GABA activity How much do you need? 0.02 – 0.1 mg/kg IV
  • 47. Commonly Used Agents Midazolam What else does it do? CNS: Anxiolysis CVS: Slight decrease in PVR & decreased contractility. Resp: Respiratory depression What does the body do with it? Hepatic metabolism (active metabolite) Renal excretion
  • 48. Commonly Used Agents Ketamine Category Dissociative Amnestic What is it? Derivative of phencyclidine with some opioid properties. How does it work? Stimulates the limbic system while inhibiting the thalamus & cortex (dissociation) Binds to NMDA and opioid receptors
  • 49. Commonly Used Agents Ketamine What else does it do? CNS: Emergence reactions CVS: Increased contractility, HR and PVR through sympathetic stimulation. Direct myocardial depressant. Resp: Laryngospasm, bronchodilation, increased secretions What does the body do with it? Hepatic metabolism
  • 50. • Frequency is reported to be anywhere from <1% to 50% in adults. • Treatment with benzodiazepines is the most effective way to prevent emergence reactions. But won’t it give him nightmares? Ketamine & Emergence Reactions
  • 51. Commonly Used Agents Ketamine How much do you need? 1 – 2 mg/kg IV How much midazolam? 0.7 mg/kg given at the time of ketamine injection.
  • 52. Mix & Match Commonly used combinations: Propofol + Fentanyl Fentanyl + Midazolam Propofol + Midazolam + Fentanyl Ketamine + Midazolam Ketamine + Propofol “Ketofol”
  • 53. If respiratory depression and/or hemodynamic instability occurs, consider use of reversal agents.
  • 54. Naloxone (Narcan®)  Opioid antagonist  Dosing: 0.4–2 mg q 2-3 min, up to 10 mg  Onset time: 1-2 min  Duration of effect: 30-60 min  Adverse effects: precipitate withdrawal, pulmonary edema
  • 55. Flumazenil (Romazicon®)  Benzodiazepine antagonist  Dosing: 0.2 mg q 1 min, up to 1 mg  Onset time: 1-2 min  Duration of effect: 30-90 min  Adverse effects: seizures  Reversing BZD-induced hypoventilation
  • 56. How low should you go? Depth of Procedural Sedation Minimal Sedation (Anxiolysis) Moderate Sedation/Analgesia Deep Sedation/Analgesia General Anaesthesia Normal LOC
  • 57. Considerations for PS in the ED Environmen tal Patient Agent
  • 59. PREPARATIO N Prepare for the worst…. What can go wrong?  Unexpected drug reaction or anaphylaxis  Vomit and aspirate  Obstructed airway (e.g. laryngospasm, tongue)  Apnoea, respiratory arrest  Profound hypotension
  • 60. PREPARATIO N Not quite the worst … What can go wrong?  Disinhibition / agitation  Terrors, nightmares  Unexpected drug reactions: dystonias  Inadequate sedation  Unsuccessful procedure… still needs GA
  • 61. PREPARATIO N ACEM POLICY DOCUMENT - USE OF INTRAVENOU S SEDATION FOR PROCEDURE S IN THE EMERGENCY DEPARTMENT © ACEM. 5 December
  • 62. PREPARATION Environment  Separate space to perform the procedure  A recovery space: ideally quiet, available for 1-2 hours, easily observed.
  • 63. PREPARATIO N ENVIRONMENT The procedure must be performed in a suitable clinical area with facilities for:  Monitoring,  Oxygen  Suction  Immediate access to emergency resuscitation equipment, drugs and
  • 65. PREPARATIO N MONITORING Cardiac rhythm,Non- invasive blood pressure, Pulse oximetry must be monitored “throughout the procedure and recovery period”
  • 66. PREPARATIO N PERSONNEL The involvement of at least two clinical staff is required:  PERSON PERFORMING PROCEDURE must understand the procedure and its potential complications.  PERSON GIVING DRUGS AND MONITORING PATIENT - must have training and experience of resuscitation, emergency drugs and …. (details of) the drugs used. This person is not involved in the performance of the procedure but is dedicated to
  • 68. Informed Consent * The person performing the procedure (clinician) is to review objectives, risks, benefits and alternatives of Procedural Sedation (informed consent) * This can be done at the same time as the procedure is explained * Informed consent for the sedation does not require a patient signature. Rather there is a check box on the Pre-Procedure/Pre-Sedation Assessment form. If paper forms are not available, it is the responsibility of the clinician to document this in the pre- procedure note. * If the person who will monitor the patient (assistant) finds that the patient has additional questions, the person performing the procedure (clinician) will be contacted to answer these questions before sedation is given.
  • 69. Assistant Responsibilities – Patient assessment and appropriate documentation throughout the procedure – Reassure patient and monitor patient awareness. – Provide comfort measures as needed – Notify clinician of changes / concerns. – Documentation of required parameters. The Assistant is not to leave patient bedside for any reason during the procedure (although may assist the clinician with short, interruptible tasks) The assistant must be able to drop those tasks if the patient needs attention)
  • 71. Pre-Procedure/Pre-Sedation Assessment form (required for all procedural sedation) includes documentation of the following: Review of Systems: *Can be completed by nursing or medical staff. If completed by nursing, must be reviewed by the clinician completing the pre-procedure assessment. Focused Assessment: Must be completed by a licensed independent practitioner according to Medical Staff Bylaws. It includes procedure-specific parameters, and addresses any new or pertinent data seen on the Review of Systems. Airway Assessment: * Aim is to plan for airway management if that would be necessary. * Assessment parameters may include * Assessing dentures, loose teeth, partials, etc. * When the patient opens his/her mouth, how easily can the cords and pharynx be visualized should intubation be necessary. * Are there physical limitations, which would impede proper
  • 72. Pre-Procedure/Pre-Sedation Assessment form (required for all procedural sedation) includes documentation of the following: Risk Assessment (ASA PS Score) *To be completed by clinician, even if you’re not Anesthesia personnel Risks/Benefits/Alternatives for Sedation *Required discussion with patient should be documented either on outpatientforms, or in procedure note Risks/Benefits/Alternatives for Procedure *As above, with the addition of signature on procedural consent Sedation Plan: *The level of sedation that was presented to, and accepted by the patient. This must be documented before initiation of the procedure.
  • 73. Prevent wrong site / wrong patient / wrong limb / wrong equipment • Site Verification / Marking “YES” on the procedure site – Must be completed before the procedure starts – Is the responsibility of the person performing the procedure (clinician) – Should be a process which includes patient input / verification / understanding • TIME OUT! – To be completed immediately before the first dose of sedation / start of the procedure. – Is the responsibility of the clinician, although may be documented by the assistant – Should be a group interaction (clinician, assistant, others present in the room) – Includes four questions: 1. Is this the Correct Patient? 2. Is this the Correct Procedure? 3. Is this the Correct Site? 4. Is this the Correct Equipment?
  • 74. Intra-procedure Monitoring requirements *BP, Pulse, Respiratory Rate, SpO2 Immediately before the procedure / first dose of sedation, monitored frequently and documented every 10 minutes throughout the procedure and recovery period. *Mechanical noninvasive blood pressure is preferred, however may use manual (cuff) method. *Continuous Pulse Oximetry *Sedation *Assessed and documented with vital signs *RASS Sedation Scale
  • 75. Richmond Agitation Sedation Scale (RASS) Score Term (not included on documentation forms) Description +4 Combative Overtly combative, violent, immediate danger to staff +3 Very agitated Pulls or removes tube(s) or catheter(s), aggressive +2 Agitated Frequent, non-purposeful movement. Fights ventilator +1 Restless Anxious, but movements not aggressive, vigorous 0 Alert and Calm -1 Drowsy Not fully alert, but has sustained awakening (Eye-opening/eye-contact) to voice, ≥ 10 seconds -2 Light sedation Briefly awakens with eye-contact to voice, <10 seconds -3 Moderate sedation Movement or eye-opening to voice, (but no eye contact) -4 Deep sedation No response to voice, but movement or eye opening to physical stimulation -5 Unarousable No response to voice or physical stimulation
  • 76. Intra-procedure Monitoring requirements EKG monitor *Assistants may not be able to perform rhythm interpretation *Identify when more in depth patient assessment is required 1). For example: heart rate drops, assistant may stimulate patient, check BP, or other 2). Another example: heart rate accelerates, assistant may ask patient about comfort level. *Assistants should notify the clinician for any noticeable changes in rhythm, rate, or other concerns noted on monitor for further medical
  • 77. Intra-procedure Monitoring requirements Capnography? *Although not essential this indicates if patient is ventilating adequately. *This will indicate hypoventilation before pulse oximetry. *Currently available to intubated patients only
  • 78. Responsible Individual for discharge planning • The person who will provide the patient’s ride home and be available to the patient after the procedure will be identified before the procedure begins. • This person may be an adult, or someone in their late teens that the patient feels comfortable with. • If the patient is an outpatient, this person frequently accompanies the patient to the hospital • If the responsible individual is not present, hospital staff need to verify the individual by telephone. • If the patient is an inpatient, it may not be necessary to identify this individual pre-procedure. • If the inpatient is discharged within 24 hours of the procedure, the patient must be discharged to a responsible individual.
  • 79. Responsible individual? • For outpatients: If either the clinician (person performing the procedure) or the assistant (person monitoring the patient) feels the individual present would not be appropriate in this role, or the patient has no one identified, the clinician needs to determine: – Can the procedure be cancelled (or postponed) until a responsible individual is available? – Should the procedure be completed and the patient kept an additional 4 hours after discharge criteria are reached, then released with appropriate transportation?
  • 80. Discharge to Responsible Person Guidelines: Best Practice: Patient accompanied by Responsible Adult If no responsible adult present at patient admission, staff should -Verify via phone the responsible adult who will be present at discharge -Or -Identify a responsible individual to whom the patient can be reasonably transported after the procedure -Or -Cancel the Procedure! How do I know the person is responsible? Use your professional judgment. If no responsible adult present after the procedure is completed, observe the patient for 4 hours after completion of the recovery period, then discharge (patient must not drive for 24 hours after sedation).
  • 81. READY TO GO… Explain Pre-oxygenate IV Access and IV fluid running Splints or plaster or equipment all ready to go Hand over your phone or pager…
  • 82. ALDRETE POST PROCEDURE RECOVERY SCORE Aldrete Post Procedure Recovery Score Base Line Post Procedure D/C Activity Moves 4 Extremities voluntarily or on command Moves 2 Extremities voluntarily or on command Moves 0 Extremities voluntarily or on command 2 1 0 2 1 0 2 1 0 Circulation SBP ± 20 mmHg of Preprocedure Level ± 20-50 mmHg of Preprocedure Level ± 50 mmHg of Preprocedure Level Preprocedure BP / . 2 1 0 2 1 0 2 1 0 Respirations Able to deep breath or cough freely Dyspnea, shallow, or limited breathing Apneic or Mechanical Vent 2 1 0 2 1 0 2 1 0 Consciousness Awake (oriented, answers questions approp.) Arousable on calling (responds to voice) Non-responsive 2 1 0 2 1 0 2 1 0 Color Normal Pale, dusky, mottled, jaundiced, other Cyanotic 2 1 0 2 1 0 2 1 0 Discharge score must be a minimum of pre-procedure score minus one, with stable vital signs to meet discharge criteria. TOTAL: Baseline must be done before sedation initiated. This is what post-procedure Aldretes are compared to. Post Procedure is done at the end of the procedure, then every 10 minutes until patient meets recovery criteria. A minimum of 3 aldrete scores must be completed before the patient can be identified as “recovered” When recovery criteria are met, the last (frequently the third) Aldrete can be the D/C score.
  • 83. Recovery criteria *A minimum of two consecutive Aldrete scores are baseline minus one with stable vital signs *The patient’s room air oxygen saturation must be back to baseline *Sufficient time (i.e., a minimum of 1 hour) should have elapsed after the last administration of reversal agents (naloxone, flumazenil) to ensure that the patient does not become resedated after reversal effects have abated. * Patients who will be discharged to home and receive IV medications for relief of pain, nausea, vomiting etc. must be observed no less than two consecutive Aldrete / vital sign assessments following administration of such medication
  • 84. Discharge criteria Vital signs stable (Vital signs include BP, HR, R,& O2 Sat. The VS are determined to be stable if they are consistent with the patient’s age and with the patient’s pre-operative VS) Swallow, cough present (patient demonstrates ability to swallow fluids and is able to cough Able to ambulate (patient demonstrates ability to ambulate at pre-procedure level) Nausea, vomiting, dizziness is minimal Absence of respiratory distress (patient’s respiratory effort consistent with pre-procedure status) State of consciousness (patient is alert, oriented to time, place and person consistent with pre-procedure level of consciousness). Level of comfort (Pain controlled as per BJH pain policy) Post-procedure (oral and written) discharge instructions are given to the patient and/or significant other regarding the following: purpose and expected effects of sedation, patient’s care, emergency phone number, medications, dietary or activity restrictions, and necessary precautions (e.g., no driving for 24 hours, avoid alcohol and use of power tools, etc.).
  • 85. Phone a friend… Consider sending the at-risk patient to the OR.
  • 87. Key Points Be prepared Know your drugs and your drug interactions Consider all your options Thank you so muc
  • 88.
  • 89. Procedural Sedation Post Test 1. Which treatment is an example of procedural sedation? A. Preventing anxiety prior to treatment without altering the patient’s level of consciousness. B. Providing comfort measures to the patient. C. Performing a simple dressing change. D. Administering medication to alter the level of consciousness prior to a procedure. 2. A Physician prescribes a one-time dose of Morphine and Ativan to reduce the patient’s pain and anxiety during a dressing change. This is considered procedural sedation.
  • 90. Procedural Sedation Post Test 3. To prepare for procedural sedation, the RN must: A. Obtain patient consent for both the procedure and the sedation. B. Confirm auscultation of heart, lungs, and airway assessment was performed by MD C. Be aware of sedation plan D. Perform patient identification and a “Time-Out” E. Perform a baseline PASS assessment. F. All of the above 4. To perform procedural sedation, the RN must: A. Have age-specific resuscitative equipment. B. Have a physician privileged in Procedural Sedation present in the room. C. Receive age specific advanced life support certification. D. Provide a cardiac monitor, O2 monitoring, and ET CO2 monitoring.
  • 91. Procedural Sedation Post Test 5. When performing procedural sedation, it is satisfactory to have the physician be available by pager during the procedure. A. True B. False 6. The nurse providing moderate sedation should remain with the patient at all times. A. True B. False • 7. Before a procedural sedation patient can be discharged, they need to be observed for a minimum of 30 minutes after the last dose of sedative or analgesic was administered. Longer periods of observation are required if reversal agents are used. A. True B. False
  • 92. Procedural Sedation Post Test 8. To discharge a patient following procedural sedation, a post-procedural assessment must be conducted (by a credentialed practitioner privileged in this procedure), the patient needs to receive written discharge instructions, and a responsible adult/driver must be identified. A. True B. False 9. A “time-out” is performed prior to the start of the procedure and typically includes: A. A description of the nature of the procedure, the patient’s condition, details of any abnormal history or condition, and any special patient needs. B. Use of two patient identifiers – patient name and medical record on arm band. C. Verification of the site, both physically and verbally, and if required, marking of the site. D. A review of the expected course of the procedure and recovery. E. All of the above
  • 93. Procedural Sedation Post Test 10. Development of chest wall rigidity (“wooden chest”) may result in serious respiratory compromise and is most often seen with the rapid administration of: A. Fentanyl (Sublimaze) B. Morphine C. Ketamine (Ketalar) D. Flumazenil (Romazicon) 11. The reversal agent and initial dose preferred for a 300-pound 18 year-old who has had Diazepam, Midazolam, and Lorazepam during a procedure is: A. Flumazenil (Romazicon) 0.2 mg, repeat every 1-2 minutes as needed B. Naloxone (Narcan) 0.4 mg, repeat every 2-3 minutes as needed C. Both a and b
  • 94. Procedural Sedation Post Test 12. A 60 year-old male patient with coronary artery disease undergoes a pacemaker implant under IV sedation. During the procedure, the patient’s oxygen saturation decreases to 84%. The patient is snoring and responds to vigorous stimulation. You should: A. Lift the chin and jaw, attempt to provide a better airway, notify the physician immediately after the change in the patient's condition, increase oxygen delivery, call for assistance and consider reversal agents. B. Continue to monitor for further changes; reduce the next dose of sedation medication by half. C. Document the patient's status on the assessment form; notify the MD at the conclusion of the procedure.

Editor's Notes

  1. ASA/Joint Commission of Accreditation of Healthcare Organizations – Definitions of Levels of Sedation Minimal sedation: normal response to verbal commands. Ventillatory & CV function unaffected. Moderate sedation: pt responds to verbal commons +/- light tactile stimulus. No interventions required to maintain airway. Spont resp. CV function maintained. Deep sedation: pt cannot be aroused, but responds purposefully to repeated or painful stimulation. May require assistance maintaining a patent airway. Spont vent may be inadequate. General anaesthesia: Pt is unarousable. Patient typically requires assistance maintaining an airway +/- PPV.
  2. CAD… Limited ability to tolerate hypotension
  3. Aspiration & airway reflexes: Will he protect his airway? No idea of NPO status Increased risk of aspiration Consent Double doctor is possible Consider timing of reduction
  4. Difficult intubation Difficult BVM Increased risk of aspiration
  5. Low inter-observer reliability.
  6. The ASA was developed to help identify patients at risk of developing complications as a result of undergoing general anesthesia. ASA: No formal support by emergency medicine associations; Supported by the American society of anestheologists
  7. The guidelines go on to say that for ASA III-IV patients, anesthesia should be consulted and OR management should be considered. ASA status was not addressed in the American guidelines.
  8. In addition, the ASA indicates that there is no role for the use of antacids and gastric motility agents to prevent aspiration during elective GA in healthy patients. The ACEP guidelines apply this recommendation to ED PSA patients, while the Cdn guidelines recommend their use in patients who do not meet NPO criteria. Green proposes a number of reasons why the the ASA guidelines should not be generalized to ED PSA Aspiration is most likely to occur during airway manipulation – this should not be happening during PSA. PSA is typically performed in younger patients. The risk of aspiration is higher in older patients. Most agents used during PSA are not pro-emetic, unlike the gases which are commonly used in the OR. Ideally, PSA should be in the range of moderate sedation with intact airway reflexes The use of dissociative amnestics (ketamine) theoretically reduces the risk of aspiration because airway reflexes are “intact”
  9. Actual half-life of propofol is 4-7 hrs Clearance is independent of renal or liver function and is not affected by renal or hepatic disease. Onset is one arm-brain circulation with peak affect at 90-100 s. Anti-emetic properties
  10. Symington and Thakore conducted a review of the safety of using propofol for procedural sedation in the ED and concluded that while the rate of “minor” adverse events (including transient hypoxia) was similar to other agents, the drug was overall very safe and offered advantages over other agents.
  11. Doses > 5 mcg/kg bolused rapidly are required to cause chest wall rigidity. Rigidity is managed with paralysis or reversal agents. May cause coughing in 50% of patients. Peak effect in 2-3 min
  12. Cardiology study using high dose fentanyl for cardiac surgery – patients were hemodynamically stable and pain free.
  13. Use with caution in patients with renal failure b/c of potential buildup of metabolite.
  14. Metabolite (norketamine) has 20-30% less activity than ketamine Onset within 30 s of administration (IV) Distribution half life is 11-16 minutes (two compartment metabolism)
  15. Emergence reaction: Anxiety, nightmares, hallucinations & delirium while waking up Ketamine is extensively used in developing countries with great success. Evidence for benzos is debateable – several peds trials show no benefit. Anecdotally, some people will wait for signs of emergence before giving midazolam while others give it with ketamine. Two trials from the 70’s show a reduction in the incidence of emergence reactions when adult patients were pretreated with midazolam
  16. Several authors pointed out that this dose of midazolam may be higher than required to prevent emergency reactions.
  17. Combinations of propofol + fentanyl, fentanyl + midazolam etc lead to synergistic effects on the cardiovascular system. This results in greater than expected amounts of hypotension, which is tolerated in the young health individual, but may be problematic in someone with less reserve. Midazolam may decrease the rate of ketamine metabolism, resulting in greater duration of sedation.
  18. ASA/Joint Commission of Accreditation of Healthcare Organizations – Definitions of Levels of Sedation Minimal sedation: normal response to verbal commands. Ventillatory & CV function unaffected. Moderate sedation: pt responds to verbal commons +/- light tactile stimulus. No interventions required to maintain airway. Spont resp. CV function maintained. Deep sedation: pt cannot be aroused, but responds purposefully to repeated or painful stimulation. May require assistance maintaining a patent airway. Spont vent may be inadequate. General anaesthesia: Pt is unarousable. Patient typically requires assistance maintaining an airway +/- PPV.