1. The document discusses radiological imaging of placenta accreta, specifically focusing on ultrasound and MRI findings.
2. Key ultrasound findings that suggest placenta accreta include placental lacunae, disruption of normal color Doppler blood flow patterns in the myometrium, loss of the retroplacental clear space, and reduced myometrial thickness.
3. Important MRI findings include uterine bulging, heterogeneous placental signal intensity, and dark intraplacental bands on T2-weighted images. Visualization of direct placental invasion of the bladder is also suggestive of placenta percreta.
In this presentation we will discuss
First trimester US especially TVS is an integral part for confirmation of intrauterine pregnancy and to rule out ectopic pregnancy.
First trimester US helps us in suggesting conceptus viability.
First trimester US especially TVS is very efficient in approaching and evaluating the cause of vaginal bleeding.
In this presentation we will discuss
First trimester US especially TVS is an integral part for confirmation of intrauterine pregnancy and to rule out ectopic pregnancy.
First trimester US helps us in suggesting conceptus viability.
First trimester US especially TVS is very efficient in approaching and evaluating the cause of vaginal bleeding.
Abnormalities of the placenta are important to recognize owing to the potential for maternal and fetal morbidity and mortality. Pathologic conditions of the placenta include
Placental causes of hemorrhage,
Gestational trophoblastic disease,
Retained products of conception,
Nontrophoblastic placental tumors, metastases, and
Cystic lesions..
MRI offers a great aid in diagnosis of abnormal placentation. This presentation describes the normal MRI appearance of the placenta and the MRI signs of placental adhesion disorders.
Similar to Presentation1, radiological imaging of placenta accreta. (20)
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
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NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
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TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
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Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
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micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
2. Placenta accreta (PA) is a general term applied to the abnormal placental
adherence and also the condition seen at the milder end of the spectrum of
abnormal placental adherence. This article focuses on the second, more specific
definition.
In a placenta accreta, the placental villi extend beyond the confines of the
endometrium and attach to the superficial aspect of the myometrium but without
deep invasion.
This entity is categorized into 3 types depending on the degree of myometrial
invasion: 1. Placenta accreta vera, the villi attach at the myometrium without
invading the myometrium. Placenta accreta vera is more commonly referred to as
placenta accreta and for the purposes of this exhibit will be referred to as placenta
accreta (PA) henceforth. This occurs in approximately 75% of cases.
2. Placenta increta there is direct invasion of the myometrium
3. Placenta percreta there is deeper invasion to the uterine serosa or adjacent
pelvic organs.
Epidemiology
It is the most common form of placental invasion (~75% of cases). It is thought to
occur in approximately 1 in 7,000 pregnancies. The incidence is increasing due to
increased practice of caesarean sections. The combination of previous caesarean
section and an anterior placenta previa should raise the possibility of a placenta
accreta. This disease has a maternal mortality of up to 7% depending on location.
3. Pathology
The abnormal implantation is thought to result from a deficiency in the
decidua basalis, in which the decidua is partially or completely replaced by
loose connective tissue. In a placenta accreta, chorionic villi and/or
cytotrophoblasts directly attach to the myometrium with little or no
intervening decidua.
Risk factors
Recognized primary risk factors for placenta accreta include:
placenta previa
Prior caesarean section.
Uterine anomalies.
Previous uterine surgery.
Dilation and curettage.
Myomectomy.
Maternal age greater than 35 years.
Multiparty.
Laboratory investigations
elevated levels of α-fetoprotein
elevated levels of human chorionic gonadotropin
5. Diagrammatic illustration
showing different degrees
of placental invasion (P,
placenta; M, myometrium).
Arrow shows stratum
basalis of endometrium. (A)
Low-lying placenta showing
normal stratum basalis of
endometrium (arrow). (B)
Placenta accreta vera
showing invasion of
stratum basalis of
endometrium and in
contact with myometrium.
(C) Placenta increta
showing partial invasion of
myometrium. (D) Placenta
percreta showing invasion
of myometrium and
extension beyond serosa.
6. Ultrasound evaluation:
US has been the primary diagnostic tool for PA and has been shown to
help detect this disorder in 50%–80% of cases. Most patients will
present for a US examination at 18–20 weeks gestation, which provides
an ideal opportunity to screen for the disorder. Inquiring whether the
patient previously underwent cesarean section or uterine surgery is
recommended practice. With high-risk patients, a targeted evaluation
of the anterior myometrium and bladder wall should be performed.
At our institution, the lower uterine segment is evaluated using the
highest-frequency transducer that can produce an adequate image,
which is often a 5-MHz transducer. Transabdominal imaging is
performed with the patient’s bladder full. Transvaginal US is always
performed when the placenta is low lying or placenta previa is present.
There has been a long-standing interest in US screening for PA. US
findings were first presented by Kerr de Mendonca in 1988 and Finberg
and Williams in 1992. The rising cesarean section rate and resultant
increased prevalence of PA have revived interest in the US features of
this disorder.
7. Normal US Appearance of the Placenta and Myometrium
The placenta is normally seen as a focal mass that causes
indentation of the gestational sac and is more hyperechoic than
the underlying myometrium. The myometrium is seen as a thin,
well-demarcated rim of hypoechoic tissue. In the second
trimester, the placenta is homogeneous and granular in
echotexture. By the third trimester, calcifications and multiple
vascular lakes are often seen, which can give the placenta a more
heterogeneous appearance. Adjacent to the myometrial side of
the placenta is a thin, subplacental clear space. Normal placental
blood flow patterns consist of a large amount of retroplacental
myometrial blood flow. This flow forms a regular continuous
pattern, with an occasional vessel dipping into the placental
parenchyma. This pattern is believed to correspond to the 15–20
cotyledons that are fed separately by the maternal spiral arteries
originating from the myometrium.
8. US Findings in PA
Placenta previa, placental lacunae, abnormal color Doppler imaging patterns, loss
of the retroplacental clear space, and reduced myometrial thickness have all been
described in PA. An irregular bladder wall has been described with placenta percreta.
Placenta Previa:
Multiple studies have confirmed that placenta previa significantly increases the risk for
PA (6.8%–10% among affected women). However, only 88% of cases of PA are
associated with placenta previa. A finding of placenta previa should elicit a detailed
evaluation for PA, including color Doppler imaging and a transvaginal examination.
Placental Lacunae:
First described by Finberg and Williams in 1992, placental lacunae have been the
most predictive US finding for PA. Intraplacental lacunae are vascular structures
of varying size and shape that are found in the placental parenchyma, creating
a “moth-eaten” or “Swiss cheese” placental appearance. They are indistinct and
often appear to be parallel linear vascular channels extending from the placental
parenchyma into the myometrium. These entities differ from vascular lakes in that
they appear more indistinct and show turbulent flow, whereas lakes appear more
rounded with laminar flow. The pathologic correlate and mechanism of
development are unknown. In our experience, lacunae become more prominent
in the third trimester.
9. According to the literature, visualization of lacunae has the highest
sensitivity in the diagnosis of PA, allowing identification in 78%–93% of
cases after 15 weeks gestation, with a specificity of 78.6%. Increasing
numbers of lacunae are associated with increased risk for PA. All cases
of PA in one study had at least four placental lacunae.
Abnormal Color Doppler Imaging Patterns:
Color Doppler imaging findings in PA consist mainly of case reports
describing turbulent flow in placental lacunae. Twickler et al mapped color
flow in 20 cases of PA using only US to evaluate turbulent lacunar blood
flow. They found that all cases of PA had turbulent flow in placental
lacunae. Whether color Doppler flow imaging added any sensitivity or
specificity to gray-scale imaging was not reported.
We have found that color flow mapping is more informative if it is used to
characterize the pattern of retroplacental blood flow. Settings should be
used that show continuous retroplacental blood flow away from the area
of interest. Disruption of the normal continuous color flow appearance
resulting in a gap in myometrial blood flow was seen in all of our cases of
PA evaluated with color Doppler imaging. This gap is thought to represent
the site of placental invasion into the myometrium.
10. In cases of placenta percreta, numerous large blood vessels are often seen
surrounding the myometrium, possibly caused by the invasion of
surrounding structures. However, increased vascularity is seen even in
milder forms of PA. This may be due to different levels of expression of
vascular endothelial growth factors and their receptors in the placentas
of patients with PA. Invasion can also create an irregular bladder wall
with extensive associated vascularity
Loss of Retroplacental Clear Space:
A retroplacental hypoechoic line is usually seen with normal placentation.
Absence of this hypoechoic line or clear space has been described with PA.
However, absence of the hypoechoic line has also been seen in normal
pregnancies. McGahan et al found that absence of the clear space alone
was not predictive for PA. In fact, its sensitivity and positive predictive
value were only 7% and 6%, respectively. We, too, have found that loss of
the retroplacental clear space is often seen in normal pregnancies and do
not consider it a useful finding when seen alone. However, it is one of the
more obvious findings at screening evaluation and should prompt a
detailed evaluation for other US markers.
11. Reduced Myometrial Thickness:
An anterior myometrial thickness less than 1 mm
(as measured between the echogenic serosa and the
retroplacental vessels) was also reported to be as
predictive as placental lacunae for PA by Twickler et al,
who discovered this finding in nine of 10 cases of PA. To
our knowledge, these results have not been repeated in
other studies. Our experience has shown this
measurement to be difficult to replicate, even with a
transvaginal technique. However, we have found that
loss of visualization of the myometrium is often seen in
cases of PA. Thus, at our institution we do not routinely
measure myometrial thickness, but evaluate the presence
and contour of the myometrium.
13. (a) Transverse transabdominal US image shows the hyperechoic placenta (*) surrounded by the hypoechoic
myometrium (arrowheads). (b) Sagittal transabdominal US image shows a thin, hypoechoic line (arrowheads)
at the inner aspect of the myometrium representing a subplacental clear space. (c) Sagittal transabdominal
US image shows a normal organized pattern of subplacental blood flow that parallels the myometrium.
14. Placental lacunae. (a) Transverse transvaginal US image shows multiple
tortuous hypoechoic structures within the placenta. (b) Transverse
transabdominal Doppler US image helps confirm that the hypoechoic
spaces are vascular and therefore represent placental lacunae.
15. (a) Sagittal transabdominal US image shows a gap in the myometrial blood
flow in the lower uterine segment. (b) Photomicrograph (original magnification,
×400; hematoxylin-eosin stain) shows chorionic villi (arrow) completely
surrounded by reactive myometrium (*), findings that are consistent with PA.
16. PA. Sagittal transvaginal Doppler US
image shows increased vascularity
around the uterus with placental lacunae.
PA. On a sagittal transabdominal
Doppler US image, extensive vascularity
is seen along the anterior portion of the
lower uterine segment and appears to
extend up to and around the bladder.
17. PA. On a sagittal transvaginal US image, the placenta is seen traversing the hypoechoic
subplacental zone (arrowheads) and appears to be bulging into the myometrium (arrow).
18. PA. On a sagittal transabdominal US image, the placenta is seen extending to the
serosal surface of the bladder without any intervening myometrium (arrow).
19. PA. Sagittal transvaginal US image shows the placenta extending
posteriorly without any normal myometrium (arrowheads). Loss
of the retroplacental clear space in this region is also noted.
20. PA. Sagittal transvaginal US image shows a lobulated placenta extending
to the bladder margin without any intervening myometrium (arrow).
21. 27 weeks’ gestation with complete placenta previa and placenta accreta in anterior
lower uterine segment. B, Transvaginal sonograms show placenta (PL) completely
covering internal cervical os. There is large placental lacuna, loss of retroplacental
echolucent zone, and increased vascularity at placenta-myometrium interface.
22. Normal MR Imaging Appearance of the Placenta and Myometrium
On T2-weighted images, the placenta has homogeneous intermediate signal
intensity and is usually clearly distinct from the underlying myometrium.
Linear areas of decreased T2 signal intensity can be seen running through the
myometrium, likely representing the normal placental septa. These normal
septa are usually regularly spaced and uniformly thin and should not be
confused with the thicker and more irregular placental bands that are
associated with PA. Placental septa are more often seen when imaging with
a 3-T system. The normal subplacental vascularity can be seen as numerous
flow voids just under the placenta. A few flow voids can also be seen within
the placenta and are usually in the region of the insertion point of the
umbilical cord.
The myometrium has a variable thickness and thins as the pregnancy
progresses. It can be seen as three distinct layers of signal intensity. The inner
and outer layers of the myometrium are seen as thin bands of decreased T2
signal intensity. The middle layer is thicker, has intermediate T2 signal
intensity, and often contains multiple flow voids representing the normal
myometrial vascularity. The gravid uterus should be pear shaped, with the
fundus and body being wider than the lower uterine segment. The uterine
contour is usually smooth, and focal bulging should not be present.
23. MR Imaging Findings in PA
Few studies in the literature have examined the specific MR imaging findings
in PA, perhaps because this diagnosis remains relatively rare and large series
are difficult to compile. A recent study by Lax et al found that the most useful
findings were uterine bulging, heterogeneous signal intensity within the
placenta, and dark intraplacental bands on T2-weighted images. When uterine
bulging is present, a focal outward contour bulge can be seen, or there can be
disruption of the normal pear shape of the uterus, with the lower uterine
segment being wider than the fundus. Heterogeneous signal intensity in the
placenta with increased vascularity is also associated with placental invasion,
especially when the heterogeneity is marked, and may represent either areas
of hemorrhage in the placenta or the lacunae that can be visualized at US.
Dark intraplacental bands can also be seen in patients with PA, appearing as
nodular or linear areas of low signal intensity on T2-weighted images. These
bands usually extend from the uterine-myometrial interface and have varying
thickness and a random distribution, features that help differentiate them
from normal placental septa. They are thought to represent areas of fibrin
deposition within the placenta. If the placenta is homogeneous and without
placental bands, it is unlikely that the patient has invasive placentation.
24. As the pregnancy progresses, the myometrium can become
quite thin and difficult to visualize even at technically adequate
examinations. However, when the myometrium is well visualized,
focal interruptions of the myometrial wall can be seen at the sites
of placental invasion. In cases of placenta percreta, placental
tissue can be seen extending through the myometrium with
occasional invasion of surrounding structures. Visualization of the
placenta directly invading or tenting the bladder is highly specific
for placenta percreta. However, this is not a sensitive finding,
since not all patients have this level of invasion. In our experience,
focal thinning of the myometrium is not a reliable sign of
invasion, and relying on this sign alone can lead to false-positive
interpretations. As at US, increased vascularity around the uterus
can be seen in PA. However, this is not a specific finding, since
similar levels of increased pelvic vascularity are seen in some
normal pregnancies.
29. Marginal placenta previa in a 32-year-old woman at 35 weeks of gestation. (A) Sagittal T2 HASTE MR image
shows a homogeneous placenta (+) with thin linear areas of decreased signal intensity (arrows) representing
normal placental septa. (B) Sagittal T2 HASTE MR image shows normal subplacental vascularity (arrows)
appearing as small hypointensities underneath the placenta. (C, D) Axial and coronal T2 HASTE MR images
show a homogeneous placenta (+) and triple-layered appearance of normal myometrium – peripheral thin
hypointense bands (arrowheads) and thickened vascular hyperintense middle layer (arrow)
30. (a) Coronal oblique T2-weighted half-Fourier RARE MR image shows a homogeneous placenta (P) with thin linear areas of
decreased signal intensity in a regular pattern (arrowheads) representing normal placental septa. (b) Sagittal T2-
weighted half-Fourier RARE MR image through the uterus shows a homogeneous placenta (P) with tortuous areas of
hypointensity underneath the placenta (arrowheads) representing normal sub-placental vascularity. (c) Coronal T2-
weighted MR image shows the three layers of the normal myometrium. The hypointense outer (arrowheads) and inner
(arrows) layers surround the more Hyperintense middle layer, which contains the vasculature.
31. Placenta percreta. (a) Sagittal T2-weighted half-Fourier RARE MR image shows anterior
bulging of the uterus (arrows) with widening of the lower uterine segment. (b) Axial T2-
weighted half-Fourier RARE MR image shows the higher-signal-intensity placenta
extending through the serosal surface along the left posterior and lateral uterine margin
with parametrial invasion (arrowheads). Note also the prominent vascularity
(represented by the numerous tortuous signal voids) around the uterus.
32. Placenta percreta. (a) Sagittal T2-weighted half-Fourier RARE MR image shows bulging of the uterus
(arrowheads). “Tenting” of the bladder is also seen along its superior margin (arrow). (b, c) Axial T2-
weighted (b) and contrast-enhanced T1-weighted (c) MR images show an area of low signal intensity (arrow)
representing hemorrhage in the placenta. (d) Axial T2-weighted half-Fourier RARE MR image shows low-
signal-intensity placental bands extending from the myometrial-placental interface (arrowhead).
33. PA. Coronal T2-weighted half-Fourier RARE MR image shows discontinuity of the
hypointense inner myometrial layer in the lower uterine segment (arrowheads).
34. PA. (a) On a sagittal T2-weighted MR image, the placenta (*) is posterior and partially
covers the internal os (arrow), findings that are consistent with placenta previa. (b) Axial
T2-weighted MR image shows loss of visualization of the T2 hypointense inner
myometrial layer along the right lower uterine segment (arrowheads).
35. False-positive finding of PA. MR image shows a thin strip of tissue (arrow) that is slightly hyperintense
relative to the placenta. This finding is consistent with thinned myometrium in the lower uterine
segment, which can be seen in normal pregnancies. The homogeneity of the placenta makes PA unlikely
36. MRI of normal placenta in 24-year-old woman at 27 weeks’ gestation shows focal loss
of retroplacental dark zone on T2 imaging and normal subplacental vascularity.
B, Axial T2 true fast imaging with steady-state precession image of placenta shows
gain in signal in subplacental vessel (arrowhead) that was shown as flow void on T2
HASTE (A). Retroplacental myometrial zone is again marked with arrow.
37. 27 weeks’ gestation with complete placenta previa and placenta accreta in anterior lower uterine
segment. F, Sagittal T2 HASTE (E) and sagittal T2 true FISP (F) images show abnormal intraplacental
dark bands (arrows) and abnormal dilated intraplacental vascularity (arrowheads).
38. 29 weeks’ gestation with placenta previa and placenta increta
adherent to lower uterine segment and portion of cervix.
44. Placental percreta. Coronal HASTE image shows uterine buldging and
indistinctness of the myometrium at the right uterine cornu, where
the operation had been performed for the interstitial pregnancy.
45. Placental percreta. Coronal HASTE image shows flow voids, which is more than
6 mm in the greatest diameter, indicating abnormal vessels in the deep placenta.
47. Placental accreta. Coronal HASTE image shows prominent flow void in
the deep placenta, which is 5 mm ( < 6mm)in the greatest diameter.
48. Low-lying anterior placenta percreta in a 32-year-old woman at 34 weeks of gestation. (A, B) Coronal and
axial T2 HASTE MR images show a heterogeneous placenta with thick, dark intraplacental bands (black
arrows). Focal interruption of the left inferolateral myometrium and subserosal extension of placental tissue
(white arrows). (C, D) Sagittal T2 HASTE and T2 fast spin echo (FSE) MR images show focal interruption of
anterior myometrium (black arrowheads), anterosuperior to the internal os and extending subserosally
(white arrowheads). Marked heterogeneity of the anterior myometrium, just superior to the invasion noted,
represents abnormal vascularity (arrow). (E) Surgical photograph showing the placenta extending through
uterine wall (+) and covered by thin serosal layer (arrow). No features of bladder invasion.
49. Summery.
The prevalence of PA is increasing, and practitioners should be
aware of this entity and its imaging features. Placenta previa and
a prior history of cesarean section are the most significant risk
factors for PA. Placenta previa in patients with two or more previous
cesarean sections raises the risk for PA to 40%–60%. Thus, obtaining
a thorough history is critical. US remains the primary screening
modality and can help detect PA in 50%–80% of cases. In our
experience, lacunae and an abnormal color Doppler imaging pattern
are the most helpful findings. Subplacental clear space and
myometrial thickness are less helpful and should be used in
conjunction with other findings as evidence for PA. MR imaging is
most clearly indicated when US findings are ambiguous or there is a
posterior placenta. According to the literature, the most reliable
findings are uterine bulging, heterogeneous placenta, and placental
bands. Focal interruptions in the hypointense myometrial border can
also be seen at sites of placental invasion at MR imaging.