This document provides an overview of radiological imaging techniques used to evaluate the urinary system, including their purposes and findings. It discusses plain radiography/KUB, intravenous pyelography, ultrasound, CT, MRI, and isotope scans. Common urinary system pathologies like stones, infections, cysts, tumors and congenital anomalies are described along with corresponding imaging appearances. Imaging features of renal cell carcinoma subtypes, angiomyolipomas, oncocytomas and transitional cell carcinomas are also summarized. Bosniak classification of renal cysts is explained.
A brief overview of Imaging of urinary bladder and urethra for medical students and residents with commonly encountered benign and neoplastic conditions of lower urinary tract.
A brief overview of Imaging of urinary bladder and urethra for medical students and residents with commonly encountered benign and neoplastic conditions of lower urinary tract.
presentation on ultrasound elastography-introduction ,techniques,physics,application, interpretation and future prospects.sourced from multiple articles.
presentation on ultrasound elastography-introduction ,techniques,physics,application, interpretation and future prospects.sourced from multiple articles.
Side of simple renal cysts usually solitary , but also showed a small but multiple or atrial rarely occurs in bilateral , compared with polycystic kidney disease, the clinical manifestations and pathological manifestations are different.
simple renal cyst lecture prepare by three medical student in Kerbala university / college of medicine department of surgery to presented as seminar
for download as ppt
https://drive.google.com/open?id=1bOP_UJuZl-dr6wJF6yv3reRw_uNqXGkt
3. Purpose of the KUB Radiography:
To determine the size, shape, and position of the kidneys and bladder
To detect obvious abnormalities of the urinary system, such as kidney stones
To help differentiate between urologic and gastrointestinal diseases, which
both produce abdominal pain
To locate a foreign object (e.g., that has been swallowed)
To detect air or fluid in the space surrounding the abdominal organs
(peritoneal space).
Plain film
Calcium containing stones are radiopaque
calcium oxalate +/- calcium phosphate
struvite (triple phosphate) - usually opaque but variable
pure calcium phosphate
Lucent stones include
uric acid
cystine
Indinavir stones
pure matrix stones.
KUB Radiography:
6. Intravenous Pyelography (IVP, Excretory Urography).
Purpose of the Intravenous Pyelography
To evaluate the size, shape, structure, and function of the kidneys, ureters, and
bladder
To aid in the diagnosis of urinary tract disorders, such as kidney stones, tumors,
recurring infections, cysts, congenital abnormalities, or traumatic injury.
To evaluate blood flow to the kidney and aid in the diagnosis of renovascular
hypertension (increased blood pressure due to narrowing of the artery that
leads to the kidney).
To identify damage to the urinary tract from injury or infection and other
problems causing kidney malfunction or obstruction.
This procedure is most common for patients who have unexplained microscopic
or macroscopic hematuria. It is used to ascertain the presence of a tumour or
similar anatomy-altering disorders. The sequence of images is roughly as
follows:
plain or Control KUB image;
immediate X-ray of just the renal area;
5 minute X-ray of just the renal area.
15 minute X-ray of just the renal area.
10. Ultrasonography
Generally ultrasonography is an excellent
imaging modality as it is noninvasive,
reliable and affordable.
It can be used to investigate the kidney,
bladder, and prostate gland. It can also be
combined with voiding, providing an
indication of the residual volume. This gives
an indirect measure of bladder function.
12. Computed tomography
scanning of the urinary tract.
CT Advantage.
Detection of radio-opaque and radio-lucent calculi.
Diagnosis of urinary obstruction and its level.
Congenital anomalies.
Detection and staging of urinary system neoplasm.
Differentiation between cystic and solid urinary neoplasm.
CT Urography.
CT Angiography in renal stenosis and vascular anomalies.
20. Radioisotope renography is a form of
kidney imaging involving radioisotopes.
The two most common radiolabelled pharmaceutical agents used are Tc99m-
MAG3 (Mercaptoacetyltriglycine) and Tc99m-DTPA (Diethylene Triamine
Pentacaetic Acid). Some other radiolabelled pharmaceuticals are EC (Ethyl
Cysteine) and 131-Iodine labelled OIH (Ortho Iodo Hippurate). MAG3 is by far a
better diagnostic agent than Tc-99m-DTPA, particularly in neonates, patients
with impaired function, and patients with suspected obstruction. The MAG3
clearance is highly correlated with the effective renal plasma flow (ERPF), and
the MAG3 clearance can be used as an independent measure of renal function.
After intravenous administration, about 40-50% of the MAG3 in the blood is
extracted by the proximal tubules with each pass through the kidneys; the
proximal tubules then secrete the MAG3 into the tubular lumen. DTPA is the
second most commonly used renal radiopharmaceutical in the United States,
primarily because it is the least expensive. Tc-99m-DTPA is filtered by the
glomerulus and may be used to measure the glomerular filtration rate (GFR).
The extraction fraction of DTPA is approximately 20%, less than half that of
MAG3. However, EC is preferred when the serum Creatinine is high.
21. Urinary system pathology.
Congenital anomalies.
Urinary stones.
Inflammatory disease.
Renal neoplasm(cystic and
solid masses).
Renal trauma.
Miscellaneous lesions.
22. Congenital anomalies:
1.Renal agenesis. Absence of the kidney
usually the left one
2.Renal hypoplasia.
3.Horse shoe kidney. Fused kidneys at their
poles.
4.Ectopic Kidney.
5. Aberrant renal artery.
6-Persisteuce of fetal lobulation.
7-Congenital polycystic kidney.
8-Congenital solitary cyst.
9-Double ureters and pelvis.
10-Megaureter. Due to absence of ganglion cells
11-Congenital stricture of the ureter.
23. CT Scan of right renal agenesis with non visualization
of the kidney and their blood vessels.
52. Acute Bacterial Pyelonephritis
Infection of collecting system and parenchyma
Ascending: Escherichia coli
Hematogenous: Staphylococcus aureus
Flank pain and fever
Usually a clinical diagnosis
Imaging of Acute Pyelonephritis: Modalities
Intravenous Urography.
Ultrasound.
Computed Tomography (CT Scan).
Nuclear Scanning.
53. Ultrasonography
Lower sensitivity than CT or nuclear scans
Modality of choice in pregnant women
Positive Findings:
Enlargement of entire kidney
Hypoechoic cortex: edema
Focal hyperechoic areas: early abscess
Acute Pyelonephritis.
66. Renal cystic and solid masses.
Kidney - Cystic masses.
Renal cysts can be classified according to the Bosniak classification
depending on their features.
Type I cysts are simple cysts.
Type II are the minimally complicated cysts.
Type I and II can be ignored.
Type II F are probably benign, but need to be followed.
Type III and IV both are surgical lesions.
Type IV is inevitably malignant and in the type III group about 80-90%
turn out to be malignant as well.
67.
68. Simple renal cysts are present in over 50% of the population older
than 50 years, thought to be caused by obstructed tubules or ducts.
Most are asymptomatic, though a large cyst can cause discomfort
and hypertension.
The simple cyst(Bosniak category 1 cyst) has 3 criteria.
1- Anechoic.
2- Shapely defined smooth non-measurable wall.
3- Posterior acoustic enhancement at US.
71. Bosniak category I. MDCT image, sagittal reconstruction demonstrating the presence
of homogeneous cystic lesions with fluid attenuation, without calcifications,
septations or enhancement after intravenous contrast injection. Simple cyst. Note
the presence of a major lesion (arrow) located in the superior renal pole.
72. Bosniak category II. MDCT images, axial (A) and coronal (B)
reconstructions demonstrating the presence of a cystic lesion with
thin septation inside (arrow on A). Minimally complicated cyst.
73. Bosniak category IIF. MDCT, coronal (A), axial (B) and sagittal (C) reconstructions
demonstrating the presence of a right renal cystic lesion with parietal thickening (arrow
on B) and a thin septum (arrow on C). Minimally complicated cyst requiring follow-up.
74. Bosniak category III. MDCT images axial (A), coronal (B) and sagittal (C)
reconstructions identifying a cystic lesion in the left kidney, with thin
septum and septal calcifications (arrows on B). Indeterminate cyst.
75. Bosniak category IV. MDCT images, sagittal (A,D) and axial (B,C) reconstructions
demonstrating a cystic lesion with gross and nodular parietal thickening.
76. Bosniak category IV. MDCT images, sagittal (A,B) and axial (C,D) reconstructions
demonstrating lobulated cystic lesions with contrast-enhanced, thickened septa.
77. The hallmark of Bosniak IV lesions is enhancement. Any enhancement
other than that of thin walls or septa places a lesion in this category.
86. Von Hippel-Lindau syndrome is an inherited disorder characterized by
the formation of tumors and fluid-filled sacs (cysts) in many different parts
of the body. Tumors may be either noncancerous or cancerous and most
frequently appear during young adulthood; however, the signs and
symptoms of von Hippel-Lindau syndrome can occur throughout life.
a | Bilateral multiple renal cysts and two renal carcinomas of the left kidney
(arrows). b | Left kidney with 'complicated' renal cysts (Bosniak class 3; arrow).
94. Renal oncocytoma is a type of relatively benign renal tumour. The main clinical
importance of this lesion is the difficulty in pre-operatively distinguishing it from
renal cell carcinomas, as epidemiology, presentation, imaging and even histology
can be very similar.
Intravenous pyelogram: Oncocytomas appear as sharply demarcated, often large
exophytic masses with enhancement during the nephrographic phase.
Ultrasound: Ultrasound demonstrates a well circumscribed mass with echogenicity similar
to the rest of the kidney. Occasionally a central scar may be visible.
CT: Generally tend be large well demarcated tumours at presentation.
Non contrast: if less than 3 cm - homogenous attenuation
if more than 3 cm - heterogenous attenuation
Post contrast: small tumours may enhance homogeneously, but usually enhancement is
heterogenous and the mass is larger central stellate non-enhancing scar is seen in
approximately a third of cases
MRI: Typical signal characteristics include
T1: hypo-intense compared to renal cortex .
T2: hyperintense compared to renal cortex
may demonstrate hypointense central stellate scar
T1 C+ (Gd): usually demonstrates homogeneous enhancement
Angiography: May demonstrate a spoke wheel pattern, of peripheral circumferential
vessels penetrating towards the center of the lesion, which again, although characteristic
of oncocytomas, may also be seen in renal cell carcinomas.
98. Renal angiomyolipomas (AMLs) are type of benign renal
neoplasm and are composed of vascular, smooth muscle and fat
elements. They can spontaneously hemorrhage, which can be fatal.
AMLs usually have characteristic radiographic appearances.
Ultrasound: tend to appear as hyperechoic lesions on ultrasound,
located in the cortex and with posterior acoustic shadowing
CT: Most lesions involve the cortex and demonstrate macroscopic fat
(less than -20 HU). When small, volume averaging may make
differentiation from a small cyst difficult. Calcification is rare.
MRI: MRI is excellent at evaluating fat containing lesions, and two
main set of sequences are employed. Firstly, and traditionally if you
will, fat saturated techniques demonstrate high signal intensity on non-
fat saturated sequences, and loss of signal following fat saturation.
DSA - angiography
Angiomyolipomas are hypervascular lesions demonstrating often
characteristic features:
micro or macro aneurysms, sharply marginated, dense early arterial
network
101. Renal cell carcinoma
Renal cell carcinoma (RCC), also known as renal cell cancer or renal cell
adenocarcinoma, is by far the most common type of kidney cancer. About 9 out of
10kidney cancers are renal cell carcinomas.
Although RCC usually grows as a single tumor within a kidney, sometimes there are 2
or more tumors in one kidney or even tumors in both kidneys at the same time.
There are several subtypes of RCC, based mainly on how the cancer cells look under a
microscope. Knowing the subtype of RCC can be a factor in deciding treatment and can
also help your doctor determine if your cancer might be due to an inherited genetic
syndrome.
Clear cell renal cell carcinoma
This is the most common form of renal cell carcinoma. About 7 out of 10 people with
RCC have this kind of cancer. When seen under a microscope, the cells that make up
clear cell RCC look very pale or clear.
Papillary renal cell carcinoma: This is the second most common subtype – about 1 in 10
RCCs are of this type. These cancers form little finger-like projections (called papillae)
in some, if not most, of the tumor. Some doctors call these cancers chromophilic
because the cells take in certain dyes and look pink under the microscope.
Chromophobe renal cell carcinoma: This subtype accounts for about 5% (5 cases in
100) of RCCs. The cells of these cancers are also pale, like the clear cells, but are much
larger and have certain other features that can be recognized.
110. Transitional cell carcinomas don’t start in the kidney itself,
but in the lining of the renal pelvis (where the urine goes before it
enters the ureter). This lining is made up of cells called transitional cells
that look like the cells that line the ureters and bladder. Cancers that
develop from these cells look like other urothelial carcinomas, such as
bladder cancer, under the microscope. Like bladder cancer, these
cancers are often linked to cigarette smoking and being exposed to
certain cancer-causing chemicals in the workplace.
People with TCC often have the same signs and symptoms as people
with renal cell cancer − blood in the urine and, sometimes, back pain.
These cancers are usually treated by surgically removing the whole
kidney and the ureter, as well as the portion of the bladder where the
ureter attaches. Smaller, less aggressive cancers can sometimes be
treated with less surgery. Chemotherapy (chemo) is sometimes given
before or after surgery, depending on how much cancer is found. The
chemo given is the same as that used for bladder cancer. It’s important
to talk with your doctor to be aware of your options and the benefits
and risks of each treatment.
111. US for cases of renal transitional cell carcinoma.
115. Wilms' tumor (nephroblastoma) is a rare type of kidney cancer.
It causes a tumor on one or both kidneys. It usually affects children, but
can happen in adults. Having certain genetic conditions or birth defects
can increase the risk of getting it. Children that are at risk should be
screened for Wilms' tumor every three months until they turn eight.
Symptoms include a lump in the abdomen, blood in the urine, and a
fever for no reason. Tests that examine the kidney and blood are used
to find the tumor.
Wilms' tumor is a malignant tumor containing metanephric blastema,
stromal and epithelial derivatives. Characteristic is the presence of
abortive tubules and glomeruli surrounded by a spindled cell stroma.
The stroma may include striated muscle, cartilage, bone, fat tissue,
fibrous tissue. The tumor is compressing the normal kidney
parenchyma.
The mesenchymal component may include cells showing rhabdomyoid
differentiation. The rhabdomyoid component may itself show features
of malignancy (rhabdomyosarcomatous Wilms).
116. Definitions of stages:
Stage I (43% of patients)
For stage I Wilms' tumor, all of the following criteria must be met: Tumor is limited to the kidney and
is completely excised. The surface of the renal capsule is intact. The tumor is not ruptured or biopsied
(open or needle) prior to removal. No involvement of extra-renal or renal sinus lymph-vascular
spaces. No residual tumor apparent beyond the margins of excision. Metastasis of tumor to lymph
nodes not identified.
Stage II (23% of patients)
For Stage II Wilms' tumor, 1 or more of the following criteria must be met: Tumor extends beyond the
kidney but is completely excised. No residual tumor apparent at or beyond the margins of excision.
Any of the following conditions may also exist: Tumor involvement of the blood vessels of the renal
sinus and/or outside the renal parenchyma. The tumor has been biopsied prior to removal or there is
local spillage of tumor during surgery, confined to the flank. Extensive tumor involvement of renal
sinus soft tissue.
Stage III (23% of patients)
For Stage III Wilms' tumor, 1 or more of the following criteria must be met: Unrespectable primary
tumor. Lymph node metastasis. Tumor is present at surgical margins. Tumor spillage involving
peritoneal surfaces either before or during surgery, or transected tumor thrombus.
Stage IV (10% of patients)
Stage IV Wilms' tumor is defined as the presence of hematogenous metastases (lung, liver, bone, or
brain), or lymph node metastases outside the abdomenopelvic region.
Stage V (5% of patients)
Stage V Wilms’ tumor is defined as bilateral renal involvement at the time of initial diagnosis. Note:
For patients with bilateral involvement, an attempt should be made to stage each side according to
the above criteria (stage I to III) on the basis of extent of disease prior to biopsy.
117.
118. Computed tomography showing the extent of a large, left-sided Wilms
tumor in a 2-year-old girl with thrombus extending the full length of
the inferior vena cava (IVC) and into the right atrium (between arrows).
119. Axial computed tomography scan showing bilateral Wilms' tumour with fullness of both flanks
and the right renal mass is seen crossing the midline. Heterogenous contrast enhancement is
noted. The bowel loops are displaced medially and sandwitched the two renal masses
124. Renal metastases.
Renal metastases were usually multifocal; however, metastases arising
from colon, lung, and breast carcinoma were sometimes large, solitary,
and otherwise indistinguishable from primary renal cell carcinoma
Bilateral renal metastases.
127. Axial post-contrast CT scans obtained in supine (A, B, C) and prone (D) positions
show minimal thickening and enhancement of the medial wall of a left-sided narrow
neck bladder diverticulum. The asterisk indicates the dilated lower left ureter.
128. A bladder exstrophy (also known as Ectopia vesicae) refers to a herniation of the urinary
bladder through an anterior abdominal wall defect. It can occur to variable severity.
129. Vesicoureteral Reflux.
Primary: (Congenital) defect of UVJ
(ureterovesical junction) – Most common –
deficient tunnel / laterally displaced orifices
Secondary (Acquired) increased intravesical
pressure secondary to neurogenic problems
or DES, bladder instability, bladder outlet
obstruction (PUVs)
UTIs (problem #1) do not cause reflux!!
Reflux (problem #2) does not cause UTIs!!
135. MRI: A. Coronal, B. Sagittal T2-weighted view of the latero-lateral incomplete bladder duplication.
136. Fistula.
Vesico-vaginal fistula (VVF) is a subtype of female
urogenital fistula (UGF). VVF is an abnormal
fistulous tract extending between the bladder and
the vagina that allows the continuous involuntary
discharge of urine into the vaginal vault.
Colovesical fistula (abnormal connection between
colon and bladder) may develop in men or women
with inflammatory bowel disease or diverticulitis
and can result in passage of gas or stool in the
urine, frequent UTI's and even sepsis (severe
infection that enters the bloodstream).
138. Bladder stones.
Bladder stones are hard buildups of minerals that form in the
urinary bladder.
Causes
Bladder stones are usually caused by another urinary system
problem, such as:
Bladder diverticulum
Enlarged prostate
Neurogenic bladder
Urinary tract infection
Almost all bladder stones occur in men. Bladder stones are much
less common than kidney stones.
Bladder stones may occur when urine in the bladder is
concentrated and materials crystallize. Bladder stones may also
result from foreign objects in the bladder.
141. Urinary tract infection.
A urinary tract infection (UTI) (also known as acute
cystitis or bladder infection) is an infection that affects
part of the urinary tract. When it affects the lower
urinary tract it is known as a simple cystitis (a bladder
infection).
Urinary tract infections occur more commonly in women
than men, with half of women having at least one
infection at some point in their lives. Recurrences are
common. Risk factors include female anatomy, sexual
intercourse and family history.
The main causal agent of both types is Escherichia coli,
though other bacteria, viruses or fungi may rarely be the
cause.
145. Neoplasm of the urinary bladder.
Benign Tumors of the Bladder.
There are numerous benign tumors of the bladder, but the more common ones
include epithelial metaplasia, leukoplakia, inverted papilloma, nephrogenic
adenoma, leiomyoma, cystitis cystica, cystitis glandularis and hemangioma .
Malignant tumour of the urinary bladder.
Transitional cell carcinoma: Cancer that begins in cells in the innermost tissue
layer of the bladder. Most bladder cancers begin in the transitional cells.
Transitional cell carcinoma can be low-grade or high-grade:
Low-grade transitional cell carcinoma often recurs (comes back) after
treatment, but rarely spreads into the muscle layer of the bladder or to other
parts of the body.
High-grade transitional cell carcinoma often recurs (comes back) after
treatment and often spreads into the muscle layer of the bladder, to other
parts of the body, and to lymph nodes. Almost all deaths from bladder cancer
are due to high-grade disease.
Squamous cell carcinoma: Cancer that begins in squamous cells, which are thin,
flat cells that may form in the bladder after long-term infection or irritation.
Adenocarcinoma: Cancer that begins in glandular (secretory) cells that are found
in the lining of the bladder. This is a very rare type of bladder cancer.
146. Bladder cancer is any of several types of malignancy arising from the epithelial
lining (i.e., the urothelium) of the urinary bladder. Rarely the bladder is involved
by non-epithelial cancers, such as lymphoma or sarcoma
Staging:
T (Primary tumour)
TX Primary tumour cannot be assessed
T0 No evidence of primary tumour
Ta Non-invasive papillary carcinoma
Tis Carcinoma in situ (‘flat tumour’)
T1 Tumour invades subepithelial connective tissue
T2a Tumour invades superficial muscle (inner half)
T2b Tumour invades deep muscle (outer half)
T3 Tumour invades perivesical tissue:
T3a Microscopically
T3b Macroscopically (extravesical mass)
T4a Tumour invades prostate, uterus or vagina
T4b Tumour invades pelvic wall or abdominal wall
147. N (Lymph nodes).
NX Regional lymph nodes cannot be assessed
N0 No regional lymph node metastasis
N1 Metastasis in a single lymph node 2 cm or less in
greatest dimension
N2 Metastasis in a single lymph node more than 2 cm but
not more than 5 cm in greatest dimension, or multiple
lymph nodes, none more than 5 cm in greatest dimension
N3 Metastasis in a lymph node more than 5 cm in
greatest dimension
M (Distant metastasis).
MX Distant metastasis cannot be assessed
M0 No distant metastasis
M1 Distant metastasis.
149. Hemangioma. Axial CT image shows an intramural
bladder mass (arrow) with marked enhancement.
150. Paraganglioma. Axial CT image of the bladder shows dense ring
calcification (arrows) around the circumference of a paraganglioma.
151. Paraganglioma. (a) Axial gadolinium-enhanced fat-suppressed T1-weighted MR image
shows a large bladder mass with significant extravesical extension. This appearance is
nonspecific and may be seen with many tumors. (b) Frontal 131I-MIBG scan shows uptake
in the mass (arrowhead), a finding that is highly specific for a paraganglioma.
152. Leiomyoma. Sagittal T1-weighted (a) and T2-weighted (b) MR images of the bladder show a
smooth, low-signal-intensity, intramural mass (arrows), an appearance typical of a leiomyoma.
153. Plexiform neurofibroma in a patient with known neurofibromatosis type 1. Axial
CT image shows low-attenuation, nodular thickening of the left lateral and
posterior bladder walls. MRI Several nodules have a low-signal-intensity center
surrounded by a high-signal-intensity rim (the target sign) (arrows).
156. Invasive urothelial carcinoma. Axial gadolinium-enhanced fat-suppressed T1-weighted
MR image of the bladder shows tumor invasion into the perivesical fat (arrows).
157. Squamous cell carcinoma in a paraplegic patient. Axial unenhanced CT image of
the bladder shows calcifications (arrow) encrusting a tumor. Axial contrast
material–enhanced CT cystogram shows the tumor (arrow) more clearly. Note the
loss of trabecular structure in the bones and the fatty infiltration of the muscles.
163. Leiomyosarcoma. (a) Axial T2-weighted MR image shows a large, heterogeneous
mass within the bladder wall. (b) Axial gadolinium-enhanced fat-suppressed T1-
weighted MR image shows irregular enhancement of the mass. The adjacent
bladder wall (arrow) is also abnormal and was found to be infiltrated by the tumor.
164. B-cell lymphoma. (a) Longitudinal US image shows intraluminal bladder
masses (white arrows) involving the posterior wall and ureteral orifice. The
latter mass is causing obstruction in the form of a hydroureter (black arrows).
(b) Axial CT image shows the thickening at the ureteral orifice (arrows).