Combined effects of global climate change and toxicants are complex and can be exacerbated or compensated for at higher levels of biological organization. The study discusses 4 ecological mechanisms using 3 case studies: 1) Demographic processes can compensate or propagate individual impacts to population levels. 2) Climate change can reduce resistance and recovery from toxicants at population and community levels. 3) Acquired tolerance to stressors often comes at a cost of reduced genetic diversity and increased susceptibility. 4) Species vulnerability is influenced by traits and landscape changes from climate change altering toxicant exposures. Long-term experiments incorporating realistic climate projections are needed to make reliable predictions.