The document discusses various types of poisons including gas, heavy metal, and cyanide poisoning. It provides details on the causes, symptoms, and treatments for each type. Key points include that gas poisoning can cause difficulty breathing and cyanide poisoning stops cellular respiration. The document also defines different types of antidotes including physiological, chemical, and mechanical and provides examples like sodium nitrite, sodium thiosulfate, and activated charcoal which are used to treat specific poisonings.
DEFINATION
TYPES OF COUGH
CLASSIFICATION OF EXPECTORANT AND MECHANISM OF ACTION
DEFINATION OF EMETICS
MECHANISM OF ACTION OF EMETICS
COMPOUND RELATED TO EXPECTORANT.
DEFINATION
TYPES OF COUGH
CLASSIFICATION OF EXPECTORANT AND MECHANISM OF ACTION
DEFINATION OF EMETICS
MECHANISM OF ACTION OF EMETICS
COMPOUND RELATED TO EXPECTORANT.
Anatacid || B pharmacy First Year || Presentation || kkwagh ||
This presentation is helpful for your study
This Presentation Contain
• Introduction
• characteristics of ideal antacid
• classification of antacid
• Some common use antacid
This is chapter No 3 of Pharmaceutical Chemistry - I for Diploma in Pharmacy (D. Pharmacy) Details notes for Diploma in Pharmacy (D.Pharmacy) Students.
Types and Sources of impurities.pptx Pharmaceutical Inorganic chemistry UNIT-...Ms. Pooja Bhandare
Types and Sources of impurities. Pharmaceutical Inorganic chemistry UNIT-I (Part-II) Impurities:
Impure Chemical Compound
Pure Chemical Compound.
Types of impurities: Organic Impurity, Inorganic impurity, Residual solvent, Sources of Impurities in Pharmaceuticals
The different sources of impurities in pharmaceuticals are listed below:
Raw material used in manufacture
Reagents used in manufacturing process
Method/ process used in manufacture or method of manufacturing
Chemical processes used in the manufacture
Atmospheric contamination during the manufacturing process
Intermediate products in the manufacturing process
Defects in the manufacturing process
Manufacturing hazards
Inadequate Storage conditions
Decomposition of the product during storage
Accidental substitution or deliberate adulteration with spurious or useless materials.
Test for purity: Pharmacopoeia prescribes the “Test for purity” for pharmaceutical substances to check their freedom from undesirable impurities.
Pharmacopoeia will decide and fix the limit of tolerance for these impurities.
For certain common impurities for which pharmacopoeia prescribes the test of purity are:
Colour, odour, taste
Physicochemical constants (Iodine value, saponification value, melting point, refractive index etc.)
Acidity, alkalinity, pH
Humidity (Estimation of moisture)
Cations and anions
Insoluble Constituent or Residue.
Ash, Water insoluble ash
Arsenic or lead
Loss on drying
Loss on ignition.
Effect of Impurities
Anatacid || B pharmacy First Year || Presentation || kkwagh ||
This presentation is helpful for your study
This Presentation Contain
• Introduction
• characteristics of ideal antacid
• classification of antacid
• Some common use antacid
This is chapter No 3 of Pharmaceutical Chemistry - I for Diploma in Pharmacy (D. Pharmacy) Details notes for Diploma in Pharmacy (D.Pharmacy) Students.
Types and Sources of impurities.pptx Pharmaceutical Inorganic chemistry UNIT-...Ms. Pooja Bhandare
Types and Sources of impurities. Pharmaceutical Inorganic chemistry UNIT-I (Part-II) Impurities:
Impure Chemical Compound
Pure Chemical Compound.
Types of impurities: Organic Impurity, Inorganic impurity, Residual solvent, Sources of Impurities in Pharmaceuticals
The different sources of impurities in pharmaceuticals are listed below:
Raw material used in manufacture
Reagents used in manufacturing process
Method/ process used in manufacture or method of manufacturing
Chemical processes used in the manufacture
Atmospheric contamination during the manufacturing process
Intermediate products in the manufacturing process
Defects in the manufacturing process
Manufacturing hazards
Inadequate Storage conditions
Decomposition of the product during storage
Accidental substitution or deliberate adulteration with spurious or useless materials.
Test for purity: Pharmacopoeia prescribes the “Test for purity” for pharmaceutical substances to check their freedom from undesirable impurities.
Pharmacopoeia will decide and fix the limit of tolerance for these impurities.
For certain common impurities for which pharmacopoeia prescribes the test of purity are:
Colour, odour, taste
Physicochemical constants (Iodine value, saponification value, melting point, refractive index etc.)
Acidity, alkalinity, pH
Humidity (Estimation of moisture)
Cations and anions
Insoluble Constituent or Residue.
Ash, Water insoluble ash
Arsenic or lead
Loss on drying
Loss on ignition.
Effect of Impurities
Toxic effects of heavy metals : Lead and Arsenicsanjana502982
Heavy metals are naturally occuring metallic chemical elements that have relatively high density, and are toxic at even low concentrations. All toxic metals are termed as heavy metals irrespective of their atomic mass and density, eg. arsenic, lead, mercury, cadmium, thallium, chromium, etc.
Objectives, applications, Mechanism, official standards of powders, Sieve, Standard for Sieve, Principles, construction, working, uses, merits and demerits of Air separator.
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This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
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Artificial Intelligence (AI) technologies such as Generative AI, Image Generators and Large Language Models have had a dramatic impact on teaching, learning and assessment over the past 18 months. The most immediate threat AI posed was to Academic Integrity with Higher Education Institutes (HEIs) focusing their efforts on combating the use of GenAI in assessment. Guidelines were developed for staff and students, policies put in place too. Innovative educators have forged paths in the use of Generative AI for teaching, learning and assessments leading to pockets of transformation springing up across HEIs, often with little or no top-down guidance, support or direction.
This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
June 3, 2024 Anti-Semitism Letter Sent to MIT President Kornbluth and MIT Cor...Levi Shapiro
Letter from the Congress of the United States regarding Anti-Semitism sent June 3rd to MIT President Sally Kornbluth, MIT Corp Chair, Mark Gorenberg
Dear Dr. Kornbluth and Mr. Gorenberg,
The US House of Representatives is deeply concerned by ongoing and pervasive acts of antisemitic
harassment and intimidation at the Massachusetts Institute of Technology (MIT). Failing to act decisively to ensure a safe learning environment for all students would be a grave dereliction of your responsibilities as President of MIT and Chair of the MIT Corporation.
This Congress will not stand idly by and allow an environment hostile to Jewish students to persist. The House believes that your institution is in violation of Title VI of the Civil Rights Act, and the inability or
unwillingness to rectify this violation through action requires accountability.
Postsecondary education is a unique opportunity for students to learn and have their ideas and beliefs challenged. However, universities receiving hundreds of millions of federal funds annually have denied
students that opportunity and have been hijacked to become venues for the promotion of terrorism, antisemitic harassment and intimidation, unlawful encampments, and in some cases, assaults and riots.
The House of Representatives will not countenance the use of federal funds to indoctrinate students into hateful, antisemitic, anti-American supporters of terrorism. Investigations into campus antisemitism by the Committee on Education and the Workforce and the Committee on Ways and Means have been expanded into a Congress-wide probe across all relevant jurisdictions to address this national crisis. The undersigned Committees will conduct oversight into the use of federal funds at MIT and its learning environment under authorities granted to each Committee.
• The Committee on Education and the Workforce has been investigating your institution since December 7, 2023. The Committee has broad jurisdiction over postsecondary education, including its compliance with Title VI of the Civil Rights Act, campus safety concerns over disruptions to the learning environment, and the awarding of federal student aid under the Higher Education Act.
• The Committee on Oversight and Accountability is investigating the sources of funding and other support flowing to groups espousing pro-Hamas propaganda and engaged in antisemitic harassment and intimidation of students. The Committee on Oversight and Accountability is the principal oversight committee of the US House of Representatives and has broad authority to investigate “any matter” at “any time” under House Rule X.
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2. POISON
• Word come from French word Puison (drink).
• Poison is any substance administered by mouth, injection, inhalation, skin, cause illness or
some disease or may be death.
• Acute poisoning may be accidental or suicidal or criminal.
• Treatment of poison depend on identification of ingested poisonous substance so we can
choose specific antidote for this.
3. • Types of poisoning :
» Intentional poisoning – a person taking or giving such substance with
intention of causing harm to self or to other. E.g. suicide / assault
» Unintentional poisoning – if person taking or giving such substance
without knowing its side effect. E.g. accidentally
» Undetermined – when the difference between intentional and
unintentional is not clear . E.g. poison due to insecticide or pesticide.
4. • Other causes of poisoning :
» By heavy metal. Happen because of metallic contamination of food and
water by leaching process.
» Overdose of drug
» Intentionally cyanide poison
• Sign and symptoms :
» Reduced breath rate / Muscle cramp
» Nausea / vomit / diarrhea
» Increase or decrease heart rate / Dilation or contraction of pupil
5. GAS POISONING
• Common example is Carbon monoxide. Major hazardous for those who work in chemical
industry or fire fighter.
• Symptoms may occur immediately or after some time. Person looks like in cherry red color
and having difficulty in breath.
• Treatment – turn off supply of poisonous gas. Open windows to allow proper ventilation.
Place victim in fresh air. Loose the cloth of victim and give mouth to mouth respiration. Check
pulse. Give call to doctor to start medication to reduce swelling of respiratory tract of victim.
6. HEAVY METAL POISONING
• It happen because of intake of salt of arsenic, lead, mercury, iron or cadmium.
• Toxic effect depend on content and type of heavy metal. Most deadly form of arsenic
poisoning is arsine gas.
• Arsine interfere with cellular respiration by combining with –SH group of mitochondrial
enzyme.
• Within 30 minute, symptoms occur like metallic taste with odor of garlic.
• Sources of arsenic poison –
» tobacco, seafood, environmental (insecticide), skin contact (linseed oil)
and drinking water.
8. • Treatment –
» Laboratory test (tissue examination) as arsenic deposit mainly in nails
and hairs. Blood paralysis (to check serum arsenic level). Urine spot test
(using chelating agent like EDTA). Blood level of arsenic should be 50
microgram/liter
» Gastric lavage . Hemodialysis and chelation therapy to remove arsenic
» Transfusion to replace loss of blood and fluid. Vit. C by i.v.
» Dimercaprol used as chelating agent. Analgesic to remove pain.
9. CYNAID POISONING
• Occur if inhale fumes of hydrocyanic acid. Ingestion of inorganic salt of cyanide or cyanide
releasing substance like cyanamide, cyanogen chloride, peach of apricot, bitter almond,
photographic chemical and silver polishes.
• 300 mg potassium cyanide cause death.
• Types of cyanide –
Cyanide
Gas form Solid form
Hydrogen cyanide Potassium cyanide
Sodium cyanide
12. • Route of poisoning –
» Inhalation of cyanide gas
» Skin absorption
• Injury skin area
• Skin moist with sweat
» Ingestion
• Usually Potassium Cyanide
• Combine with gastric acid and form hydrogen cyanide gas
13. • What happen if cyanide goes in body ?
» Combined with ferric ion of cytochrome oxidase
» Stop respiration
» anoxia
14.
15. • Treatment -
– First aid follow by ABC (Airway / breath / CPR cardio pulmonary resuscitation)
– If cyanide inhale
» Give 100% oxygen
» Give space for clear airway
» antidote
16. – If ingested
» Administer activated charcoal
» Gastric lavage to remove all traces of cyanide from stomach
» Antidote
• Dicobalt edetate 300mg I.V
• Alternative - hydroxocobalamin 5mg I.V
• Sodium thiosulphate 12.5gm I.V.
• Sodium Nitrate 300mg I.V
17. ANTIDOTE
• Antidote are the substance that counteract the effect of poison or neutralize the effect of
poison.
• Classification –
» Physiological antidote
» Chemical antidote
» Mechanical antidote
18. Physiological Antidote
• Also called as antagonist.
• Produce effect opposite to that of poison.
• It used after some traces of poison get absorbed in circulation.
• E.g. sodium nitrate (used in cyanide poisoning) , atropine.
19. Chemical Antidote
• It react by combine with poison and change its chemical nature by converting poison into
inactive or harmless compound.
• E.g. Sodium thiosulphate (convert systemic toxic cyanide to non toxic thiocyanate) , EDTA
(chelating agent in heavy metal poison)
20. Mechanical Antidote
• It act by preventing absorption of poison into body or expel out the poison by emesis or by
urine.
• E.g. activated charcoal (absorb poison before absorption to intestine wall), copper sulphate,
magnesium sulphate.
21. Sodium Nitrite
• Chemical formula – NaNO2 Molecular weight – 69
• Synonym – etinitrit
• Properties –
» Color – yellow or white crystalline powder
» Odor – odorless
» Taste – saline taste
» Solubility – freely soluble in water and less soluble in alcohol
22. • Method of preparation –
It prepared by strongly heating sodium nitrate
2NaNO3 2NaNO2 + O2
• Uses –
– Release smooth muscle of blood vessel
– Used in cyanide poisoning
– Used as anti rust solution to prevent rusting of surgical instrument
23. SODIUM THIOSULPHATE
• Chemical formula – Na2S2O3 Molecular weight – 248.18
• Synonym – anti-chlor
• Properties –
» Color – large transparent crystalline powder
» Odor – odorless
» Taste – tasteless
» Solubility – practically soluble in water and insoluble in alcohol
24. • Method of preparation –
It prepared by boiling sodium sulphite with Sulphur.
Na2SO3 Na2S2O3
Also prepared by passing sulphur dioxide into sodium sulphide solution.
2Na2S + 3SO2 2Na2S2O3 + S
25. • Assay – it is based on iodometric type of titration. Take 0.5gm sample. dissolve it in 20ml water. Solution is
titrate against 0.05M iodine using starch indicator. At end point excess iodine react with starch turning in
blue color.
• Uses –
– Used as antioxidant . Used as a standard titratnt in iodometric analysis
– Used as antidote in cyanide poisoning also in iodine , lead, mercury, bismuth poisoning.
Used as fixer in photographic work.
– In textile industry, used as antichlor in bleaching process. (antichlor is a substance used
to remove excess chlorine)
– Topically used as antifungal
26. ACTIVATED CHARCOAL
• Chemical formula – C Molecular weight – 12.01
• Synonym – activated carbon / active coal / carbon canister
• Properties –
» Color – fine dark greyish or blackish residue powder
» Odor – odorless
» Taste – tasteless
» Solubility – insoluble in water and other solvent
27. • Method of preparation – It prepared by burning wood in absence of air. Collect residue.
• Uses –
– Used as emergency antidote in many type poisoning (lead, cyanide, digitalis, snake bite,
spider bite etc.)
– Used as protective and adsorbent.
– Used as burning fuel
– Used in making gun powder.
– Used as disinfectant
– Used to filter toxin from blood and kidney disease.
– Used to purify blood