Phospholipase C (PLC) is an enzyme that cleaves phospholipids just before the phosphate group. It plays an important role in signal transduction by binding to and activating G protein coupled receptors. There are several isozymes of PLC classified by type, and they are activated by heterotrimeric G proteins, protein tyrosine kinases, small G proteins, calcium, and phospholipids. PLC cleaves phosphatidylinositol 4,5-bisphosphate to produce inositol 1,4,5-trisphosphate and diacyl glycerol.

1. Presented by-
Mukul Sunil Tambe.
M. Pharm Sem.I
Pharmacology. 10/10/2017 1

2.  PLC is a class of membrane-associated enzymes that cleave
phospholipids just before the phosphate group.
 It has important role in Signal Transduction.
 Binds to Gαq subunit of G- Protein Coupled Receptor and
activates it.
 Activators - Heterotrimeric G protein subunits, Protein
Tyrosine kinases, Small G proteins, Ca2+ and Phospholipids.
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3. ISOTYPE TYPES
Beta (β) PLCB1, PLCB2, PLCB3, PLCB4
Gamma (γ) PLCG1, PLCG2
Delta (δ) PLCD1, PLCD3, PLCD4
Epsilon (ε) PLCE1
Eta(ζ) PLCH1, PLCH2
Zeta (η) PLCZ1
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4. Phosphatidylinositol 4,5-bisphosphate
Inositol 1,4,5-
trisphosphate
Diacyl glycerol
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6. 1. https://en.wikipedia.org/wiki/Phospholipase_C.
2. https://www.youtube.com/watch?v=2bbBrpgeheY.
3. https://www.google.co.in/search?q=phospholipase+c&bi
w=958&bih=548&source=lnms&tbm=isch&sa=X&ved
=0ahUKEwiUhpG7hc7PAhVLrI8KHUtsDssQ_AUIBig
B.
4. Medicinal Pharmacology by K. D. Tripathi, 7th edition,
Jaypee Publication, Page no. 45-49.
5. Principles of Pharmacology by HL Sharma and KK
Sharma, 2nd edition, Paras Publication, Pg. No. 252
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