Peripheral neuropathy is a condition caused by damage to peripheral nerves, affecting sensation and organ function, and commonly manifests as symptoms like tingling, numbness, and weakness. It can result from cancer treatments and is most frequently associated with diabetes, particularly diabetic polyneuropathy. Other potential causes include viral infections and various medications.

1. Peripheral Neuropathy

2. What is Peripheral Neuropathy
Peripheral neuropathy is
caused by damage to your
peripheral nerves.
Peripheral nerves are
nerves that are not located
in the brain or spinal cord.
They are found throughout
your body and help you feel
things. They also control the
function of your organs. The
damage is usually to nerves
in the hands, feet, arms,
and legs.

3. symptoms of peripheral neuropathy
Common symptoms are:
• Tingling
• Numbness
• Weakness
• Cramping
• Burning
• Pain
• Not being able to feel things that
are touched
• Not being able to sense cold or
heat
• Sensitivity to cold or heat or touch
• Feeling off balance
• Dizziness
• Having trouble walking
• Constipation

4. cancer treatments cause peripheral
neuropathy
Peripheral neuropathy can be a side effect of these drugs:
• Platinum drugs, such as cisplatin, oxaliplatin, carboplatin
• Taxanes, such as paclitaxel , docetaxel
• Vinca alkaloids, such as vincristine, vinorelbine, and vinblastine
• Podophyllotoxins, such as etoposide
• Epothilones, such as ixabepilone
• Thalidomide and lenalidomide
• Bortezomib
• Interferon
• Methotrexate
• Fluorouracil
• Cytarabine

5. causes of peripheral neuropathy
Diabetes (both type 1 and type 2) is the most
common cause of peripheral neuropathy. Over
time, the high blood sugar levels associated with
diabetes can damage the nerves. This type of
nerve damage is known as diabetic
polyneuropathy. It is estimated that around one
in five people with diabetes has diabetic
polyneuropathy. Peripheral neuropathy can have
a wide range of other causes. For example, it can
be caused by a viral infection, such as HIV, or as a
side effect of certain medications.